Efficacy of neck treatment in patients with head and neck squamous cell carcinoma
Identifieur interne : 006425 ( Istex/Corpus ); précédent : 006424; suivant : 006426Efficacy of neck treatment in patients with head and neck squamous cell carcinoma
Auteurs : Gabriela Buck ; Pia Huguenin ; Sandro J. StoeckliSource :
- Head & Neck [ 1043-3074 ] ; 2008-01.
Abstract
Treatment of head and neck squamous cell carcinoma (HNSCC) addresses the primary tumor and the lymphatic drainage. Modalities for the neck are neck dissection and/or radiation therapy. In most cases, the neck is treated by the modality that seems more appropriate for the primary. The aim of this study was to analyze the results of the neck treatments either by neck dissection alone, by radiation therapy alone or by neck dissection followed by radiation therapy.
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DOI: 10.1002/hed.20657
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ISTEX:D5E496807BE543182124FB382A7D834E7D6B04C6Le document en format XML
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Stoeckli</name><affiliation><mods:affiliation>University Hospital Zurich, Clinic of Otorhinolaryngology, Head and Neck Surgery, Frauenklinikstrasse 24, 8091 Zurich, Switzerland</mods:affiliation></affiliation><affiliation><mods:affiliation>University Hospital Zurich, Clinic of Otorhinolaryngology, Head and Neck Surgery, Frauenklinikstrasse 24, 8091 Zurich, Switzerland</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Head & Neck</title><title level="j" type="alt">HEAD AND NECK</title><idno type="ISSN">1043-3074</idno><idno type="eISSN">1097-0347</idno><imprint><biblScope unit="vol">30</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="50">50</biblScope><biblScope unit="page" to="57">57</biblScope><biblScope unit="page-count">8</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-01">2008-01</date></imprint><idno type="ISSN">1043-3074</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1043-3074</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Treatment of head and neck squamous cell carcinoma (HNSCC) addresses the primary tumor and the lymphatic drainage. Modalities for the neck are neck dissection and/or radiation therapy. In most cases, the neck is treated by the modality that seems more appropriate for the primary. 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type="degree">MD</roleName></persName><affiliation>Spital Zollikerberg, Department of Internal Medicine, Zollikerberg, Switzerland<address><country key="CH"></country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Pia</forename><surname>Huguenin</surname><roleName type="degree">MD</roleName></persName><affiliation>Rätisches Kantons‐und Regionalspital, Department of Radiation‐Oncology, Chur, Switzerland<address><country key="CH"></country></address></affiliation></author><author xml:id="author-0002" role="corresp"><persName><forename type="first">Sandro J.</forename><surname>Stoeckli</surname><roleName type="degree">MD</roleName></persName><email>sandro.stoeckli@usz.ch</email><affiliation>University Hospital Zurich, Clinic of Otorhinolaryngology, Head and Neck Surgery, Frauenklinikstrasse 24, 8091 Zurich, Switzerland<address><country key="CH"></country></address></affiliation><affiliation>University Hospital Zurich, Clinic of 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when="2008-01"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><head>Abstract</head>
Background.
<p>Treatment of head and neck squamous cell carcinoma (HNSCC) addresses the primary tumor and the lymphatic drainage. Modalities for the neck are neck dissection and/or radiation therapy. In most cases, the neck is treated by the modality that seems more appropriate for the primary. The aim of this study was to analyze the results of the neck treatments either by neck dissection alone, by radiation therapy alone or by neck dissection followed by radiation therapy.</p>
Methods.
<p>This was a retrospective chart analysis of 699 patients treated for a previously untreated HNSCC. The primary endpoint was recurrence at the treated neck.</p>
Results.
<p>Two hundred eighty‐one (40%) patients underwent primary neck irradiation, 219 (31%) neck dissection alone, and 199 (29%) neck dissection followed by adjuvant irradiation. The 5‐year regional control rates after neck dissection alone were 83% for pN0, 75% for pN1, 60% for pN2a, 59% for pN2b, and 50% for pN2c; after radiation alone, 89% for cN0, 87% for cN1, 40% for cN2a, 60% for cN2b, and 48% for cN2c; and after neck dissection with adjuvant radiation, 86% for pN0, 96% for pN1, 100% for pN2a, 88% for pN2b, and 88% for pN2c.</p>
Conclusions.
<p>Radiation or neck dissection alone are efficient to control early neck disease. For advanced N2/3 neck disease, neck dissection followed by adjuvant radiation is highly efficient, whereas primary radiation results in a high number of regional failures. The literature suggests planned neck dissection to improve regional control for these patients. © 2007 Wiley Periodicals, Inc. Head Neck, 2008</p></abstract><textClass><keywords xml:lang="en"><term xml:id="kwd1">neck dissection</term><term xml:id="kwd2">head and neck squamous cell carcinoma</term><term xml:id="kwd3">adjuvant radiation</term><term xml:id="kwd4">neck treatment</term><term xml:id="kwd5">lymph node metastasis</term></keywords><classCode scheme="articleCategory">Original Article</classCode><classCode scheme="tocHeading1">Original Articles</classCode></textClass><langUsage><language ident="EN"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/D5E496807BE543182124FB382A7D834E7D6B04C6/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" 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affiliationRef="#af1"><personName><givenNames>Gabriela</givenNames><familyName>Buck</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Pia</givenNames><familyName>Huguenin</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2" corresponding="yes"><personName><givenNames>Sandro J.</givenNames><familyName>Stoeckli</familyName><degrees>MD</degrees></personName><contactDetails><email>sandro.stoeckli@usz.ch</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="CH" type="organization"><unparsedAffiliation>Spital Zollikerberg, Department of Internal Medicine, Zollikerberg, Switzerland</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="CH" type="organization"><unparsedAffiliation>University Hospital Zurich, Clinic of Otorhinolaryngology, Head and Neck Surgery, Frauenklinikstrasse 24, 8091 Zurich, Switzerland</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="CH" type="organization"><unparsedAffiliation>Rätisches Kantons‐und Regionalspital, Department of Radiation‐Oncology, Chur, Switzerland</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">neck dissection</keyword><keyword xml:id="kwd2">head and neck squamous cell carcinoma</keyword><keyword xml:id="kwd3">adjuvant radiation</keyword><keyword xml:id="kwd4">neck treatment</keyword><keyword xml:id="kwd5">lymph node metastasis</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><section xml:id="abs1-1"><title type="main">Background.</title><p>Treatment of head and neck squamous cell carcinoma (HNSCC) addresses the primary tumor and the lymphatic drainage. Modalities for the neck are neck dissection and/or radiation therapy. In most cases, the neck is treated by the modality that seems more appropriate for the primary. The aim of this study was to analyze the results of the neck treatments either by neck dissection alone, by radiation therapy alone or by neck dissection followed by radiation therapy.</p></section><section xml:id="abs1-2"><title type="main">Methods.</title><p>This was a retrospective chart analysis of 699 patients treated for a previously untreated HNSCC. The primary endpoint was recurrence at the treated neck.</p></section><section xml:id="abs1-3"><title type="main">Results.</title><p>Two hundred eighty‐one (40%) patients underwent primary neck irradiation, 219 (31%) neck dissection alone, and 199 (29%) neck dissection followed by adjuvant irradiation. The 5‐year regional control rates after neck dissection alone were 83% for pN0, 75% for pN1, 60% for pN2a, 59% for pN2b, and 50% for pN2c; after radiation alone, 89% for cN0, 87% for cN1, 40% for cN2a, 60% for cN2b, and 48% for cN2c; and after neck dissection with adjuvant radiation, 86% for pN0, 96% for pN1, 100% for pN2a, 88% for pN2b, and 88% for pN2c.</p></section><section xml:id="abs1-4"><title type="main">Conclusions.</title><p>Radiation or neck dissection alone are efficient to control early neck disease. For advanced N2/3 neck disease, neck dissection followed by adjuvant radiation is highly efficient, whereas primary radiation results in a high number of regional failures. The literature suggests planned neck dissection to improve regional control for these patients. © 2007 Wiley Periodicals, Inc. Head Neck, 2008</p></section></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Efficacy of neck treatment in patients with head and neck squamous cell carcinoma</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Efficacy of Neck Treatment in Patients with HNSCC</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Efficacy of neck treatment in patients with head and neck squamous cell carcinoma</title></titleInfo><name type="personal"><namePart type="given">Gabriela</namePart><namePart type="family">Buck</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Spital Zollikerberg, Department of Internal Medicine, Zollikerberg, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pia</namePart><namePart type="family">Huguenin</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Rätisches Kantons‐und Regionalspital, Department of Radiation‐Oncology, Chur, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sandro J.</namePart><namePart type="family">Stoeckli</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>University Hospital Zurich, Clinic of Otorhinolaryngology, Head and Neck Surgery, Frauenklinikstrasse 24, 8091 Zurich, Switzerland</affiliation><affiliation>University Hospital Zurich, Clinic of Otorhinolaryngology, Head and Neck Surgery, Frauenklinikstrasse 24, 8091 Zurich, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2008-01</dateIssued><dateValid encoding="w3cdtf">2007-02-28</dateValid><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">2</extent><extent unit="references">35</extent><extent unit="words">5188</extent></physicalDescription><abstract>Treatment of head and neck squamous cell carcinoma (HNSCC) addresses the primary tumor and the lymphatic drainage. Modalities for the neck are neck dissection and/or radiation therapy. In most cases, the neck is treated by the modality that seems more appropriate for the primary. The aim of this study was to analyze the results of the neck treatments either by neck dissection alone, by radiation therapy alone or by neck dissection followed by radiation therapy.</abstract><abstract>This was a retrospective chart analysis of 699 patients treated for a previously untreated HNSCC. The primary endpoint was recurrence at the treated neck.</abstract><abstract>Two hundred eighty‐one (40%) patients underwent primary neck irradiation, 219 (31%) neck dissection alone, and 199 (29%) neck dissection followed by adjuvant irradiation. The 5‐year regional control rates after neck dissection alone were 83% for pN0, 75% for pN1, 60% for pN2a, 59% for pN2b, and 50% for pN2c; after radiation alone, 89% for cN0, 87% for cN1, 40% for cN2a, 60% for cN2b, and 48% for cN2c; and after neck dissection with adjuvant radiation, 86% for pN0, 96% for pN1, 100% for pN2a, 88% for pN2b, and 88% for pN2c.</abstract><abstract>Radiation or neck dissection alone are efficient to control early neck disease. For advanced N2/3 neck disease, neck dissection followed by adjuvant radiation is highly efficient, whereas primary radiation results in a high number of regional failures. The literature suggests planned neck dissection to improve regional control for these patients. © 2007 Wiley Periodicals, Inc. Head Neck, 2008</abstract><subject lang="en"><genre>keywords</genre><topic>neck dissection</topic><topic>head and neck squamous cell carcinoma</topic><topic>adjuvant radiation</topic><topic>neck treatment</topic><topic>lymph node metastasis</topic></subject><relatedItem type="host"><titleInfo><title>Head & Neck</title><subTitle>Journal for the Sciences and Specialties of the Head and Neck</subTitle></titleInfo><titleInfo type="abbreviated"><title>Head Neck</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Original Article</topic></subject><identifier type="ISSN">1043-3074</identifier><identifier type="eISSN">1097-0347</identifier><identifier type="DOI">10.1002/(ISSN)1097-0347</identifier><identifier type="PublisherID">HED</identifier><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>30</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>50</start><end>57</end><total>8</total></extent></part></relatedItem><identifier type="istex">D5E496807BE543182124FB382A7D834E7D6B04C6</identifier><identifier type="DOI">10.1002/hed.20657</identifier><identifier type="ArticleID">HED20657</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2007 Wiley Periodicals, Inc.</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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