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Giant cell angiofibroma or localized periorbital lymphedema?

Identifieur interne : 006386 ( Istex/Corpus ); précédent : 006385; suivant : 006387

Giant cell angiofibroma or localized periorbital lymphedema?

Auteurs : Michael C. Lynch ; Catherine G. Chung ; Charles S. Specht ; Michael Wilkinson ; Loren E. Clarke

Source :

RBID : ISTEX:D4EA5C723196CCF27BF3340577107CE2599821FF

Abstract

Giant cell angiofibroma represents a rare soft tissue neoplasm with a predilection for the orbit. We recently encountered a mass removed from the lower eyelid of a 56‐year‐old female that histopathologically resembled giant cell angiofibroma. The process consisted of haphazardly arranged CD34‐positive spindled and multinucleated cells within an edematous, densely vascular stroma. However, the patient had recently undergone laryngectomy and radiotherapy for a laryngeal squamous cell carcinoma. A similar mass had arisen on the contralateral eyelid, and both had developed several months post‐therapy. Lymphedema of the orbit can present as tumor‐like nodules and in some cases may share histopathologic features purported to be characteristic of giant cell angiofibroma. A relationship between giant cell angiofibroma and lymphedema has not been established, but our case suggests there may be one. The potential overlap of these two conditions should be recognized, as should other entities that may enter the differential diagnosis.

Url:
DOI: 10.1111/cup.12225

Links to Exploration step

ISTEX:D4EA5C723196CCF27BF3340577107CE2599821FF

Le document en format XML

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<line xml:id="cup12225-line-0001">Michael C. Lynch, MD</line>
<line xml:id="cup12225-line-0002">Department of Pathology, Penn State Hershey Medical Center, H179, 500 University Drive, PO Box 850, Hershey, PA 17033, USA</line>
<line xml:id="cup12225-line-0003">Tel: +1 717 531 8993</line>
<line xml:id="cup12225-line-0004">Fax: +1 717 531 7741</line>
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<title type="main">Giant cell angiofibroma or localized periorbital lymphedema?</title>
<title type="short">Giant cell angiofibroma</title>
<title type="shortAuthors">Lynch
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<p xml:id="cup12225-para-0001">Giant cell angiofibroma represents a rare soft tissue neoplasm with a predilection for the orbit. We recently encountered a mass removed from the lower eyelid of a 56‐year‐old female that histopathologically resembled giant cell angiofibroma. The process consisted of haphazardly arranged
<fc>CD34</fc>
‐positive spindled and multinucleated cells within an edematous, densely vascular stroma. However, the patient had recently undergone laryngectomy and radiotherapy for a laryngeal squamous cell carcinoma. A similar mass had arisen on the contralateral eyelid, and both had developed several months post‐therapy. Lymphedema of the orbit can present as tumor‐like nodules and in some cases may share histopathologic features purported to be characteristic of giant cell angiofibroma. A relationship between giant cell angiofibroma and lymphedema has not been established, but our case suggests there may be one. The potential overlap of these two conditions should be recognized, as should other entities that may enter the differential diagnosis.</p>
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<abstract>Giant cell angiofibroma represents a rare soft tissue neoplasm with a predilection for the orbit. We recently encountered a mass removed from the lower eyelid of a 56‐year‐old female that histopathologically resembled giant cell angiofibroma. The process consisted of haphazardly arranged CD34‐positive spindled and multinucleated cells within an edematous, densely vascular stroma. However, the patient had recently undergone laryngectomy and radiotherapy for a laryngeal squamous cell carcinoma. A similar mass had arisen on the contralateral eyelid, and both had developed several months post‐therapy. Lymphedema of the orbit can present as tumor‐like nodules and in some cases may share histopathologic features purported to be characteristic of giant cell angiofibroma. A relationship between giant cell angiofibroma and lymphedema has not been established, but our case suggests there may be one. The potential overlap of these two conditions should be recognized, as should other entities that may enter the differential diagnosis.</abstract>
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<topic>herniated orbital fat</topic>
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<title>Journal of Cutaneous Pathology</title>
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<topic>Case Report</topic>
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<identifier type="ISSN">0303-6987</identifier>
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<identifier type="DOI">10.1111/(ISSN)1600-0560</identifier>
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<part>
<date>2013</date>
<detail type="volume">
<caption>vol.</caption>
<number>40</number>
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<caption>no.</caption>
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