Altered expression of angiogenesis and lymphangiogenesis markers in the uninvolved skin of plaque‐type psoriasis
Identifieur interne : 006210 ( Istex/Corpus ); précédent : 006209; suivant : 006211Altered expression of angiogenesis and lymphangiogenesis markers in the uninvolved skin of plaque‐type psoriasis
Auteurs : A. Henno ; S. Blacher ; C. Lambert ; A. Colige ; L. Seidel ; A. Noël ; C. Lapière ; M. De La Brassinne ; B. V. NusgensSource :
- British Journal of Dermatology [ 0007-0963 ] ; 2009-03.
Abstract
Background Vascular alterations are significant events in the pathomechanism of psoriasis. A disorder in the mechanisms regulating skin angiogenesis and lymphangiogenesis could participate in the pathogenesis of the disease.
Url:
DOI: 10.1111/j.1365-2133.2008.08889.x
Links to Exploration step
ISTEX:D0D5499369704D67EFC5B6C1BA570626DA2364CFLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Altered expression of angiogenesis and lymphangiogenesis markers in the uninvolved skin of plaque‐type psoriasis</title><author><name sortKey="Henno, A" sort="Henno, A" uniqKey="Henno A" first="A." last="Henno">A. Henno</name><affiliation><mods:affiliation>Department of Dermatology</mods:affiliation></affiliation><affiliation><mods:affiliation>Laboratory of Connective Tissues Biology, GIGA‐R</mods:affiliation></affiliation></author><author><name sortKey="Blacher, S" sort="Blacher, S" uniqKey="Blacher S" first="S." last="Blacher">S. Blacher</name><affiliation><mods:affiliation>Laboratory of Tumor and Development Biology, GIGA‐R</mods:affiliation></affiliation></author><author><name sortKey="Lambert, C" sort="Lambert, C" uniqKey="Lambert C" first="C." last="Lambert">C. Lambert</name><affiliation><mods:affiliation>Laboratory of Connective Tissues Biology, GIGA‐R</mods:affiliation></affiliation></author><author><name sortKey="Colige, A" sort="Colige, A" uniqKey="Colige A" first="A." last="Colige">A. Colige</name><affiliation><mods:affiliation>Laboratory of Connective Tissues Biology, GIGA‐R</mods:affiliation></affiliation></author><author><name sortKey="Seidel, L" sort="Seidel, L" uniqKey="Seidel L" first="L." last="Seidel">L. Seidel</name><affiliation><mods:affiliation>Department of Biostatistics, University Hospital of Liège, University of Liège, B23, 4000 Liège, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Noel, A" sort="Noel, A" uniqKey="Noel A" first="A." last="Noël">A. Noël</name><affiliation><mods:affiliation>Laboratory of Tumor and Development Biology, GIGA‐R</mods:affiliation></affiliation></author><author><name sortKey="Lapiere, C" sort="Lapiere, C" uniqKey="Lapiere C" first="C." last="Lapière">C. Lapière</name><affiliation><mods:affiliation>Laboratory of Connective Tissues Biology, GIGA‐R</mods:affiliation></affiliation></author><author><name sortKey="De La Brassinne, M" sort="De La Brassinne, M" uniqKey="De La Brassinne M" first="M." last="De La Brassinne">M. De La Brassinne</name><affiliation><mods:affiliation>Department of Dermatology</mods:affiliation></affiliation></author><author><name sortKey="Nusgens, B V" sort="Nusgens, B V" uniqKey="Nusgens B" first="B. V." last="Nusgens">B. V. Nusgens</name><affiliation><mods:affiliation>Laboratory of Connective Tissues Biology, GIGA‐R</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:D0D5499369704D67EFC5B6C1BA570626DA2364CF</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1111/j.1365-2133.2008.08889.x</idno><idno type="url">https://api.istex.fr/document/D0D5499369704D67EFC5B6C1BA570626DA2364CF/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">006210</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">006210</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Altered expression of angiogenesis and lymphangiogenesis markers in the uninvolved skin of plaque‐type psoriasis</title><author><name sortKey="Henno, A" sort="Henno, A" uniqKey="Henno A" first="A." last="Henno">A. Henno</name><affiliation><mods:affiliation>Department of Dermatology</mods:affiliation></affiliation><affiliation><mods:affiliation>Laboratory of Connective Tissues Biology, GIGA‐R</mods:affiliation></affiliation></author><author><name sortKey="Blacher, S" sort="Blacher, S" uniqKey="Blacher S" first="S." last="Blacher">S. Blacher</name><affiliation><mods:affiliation>Laboratory of Tumor and Development Biology, GIGA‐R</mods:affiliation></affiliation></author><author><name sortKey="Lambert, C" sort="Lambert, C" uniqKey="Lambert C" first="C." last="Lambert">C. Lambert</name><affiliation><mods:affiliation>Laboratory of Connective Tissues Biology, GIGA‐R</mods:affiliation></affiliation></author><author><name sortKey="Colige, A" sort="Colige, A" uniqKey="Colige A" first="A." last="Colige">A. Colige</name><affiliation><mods:affiliation>Laboratory of Connective Tissues Biology, GIGA‐R</mods:affiliation></affiliation></author><author><name sortKey="Seidel, L" sort="Seidel, L" uniqKey="Seidel L" first="L." last="Seidel">L. Seidel</name><affiliation><mods:affiliation>Department of Biostatistics, University Hospital of Liège, University of Liège, B23, 4000 Liège, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Noel, A" sort="Noel, A" uniqKey="Noel A" first="A." last="Noël">A. Noël</name><affiliation><mods:affiliation>Laboratory of Tumor and Development Biology, GIGA‐R</mods:affiliation></affiliation></author><author><name sortKey="Lapiere, C" sort="Lapiere, C" uniqKey="Lapiere C" first="C." last="Lapière">C. Lapière</name><affiliation><mods:affiliation>Laboratory of Connective Tissues Biology, GIGA‐R</mods:affiliation></affiliation></author><author><name sortKey="De La Brassinne, M" sort="De La Brassinne, M" uniqKey="De La Brassinne M" first="M." last="De La Brassinne">M. De La Brassinne</name><affiliation><mods:affiliation>Department of Dermatology</mods:affiliation></affiliation></author><author><name sortKey="Nusgens, B V" sort="Nusgens, B V" uniqKey="Nusgens B" first="B. V." last="Nusgens">B. V. Nusgens</name><affiliation><mods:affiliation>Laboratory of Connective Tissues Biology, GIGA‐R</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">British Journal of Dermatology</title><title level="j" type="alt">BRITISH JOURNAL OF DERMATOLOGY</title><idno type="ISSN">0007-0963</idno><idno type="eISSN">1365-2133</idno><imprint><biblScope unit="vol">160</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="581">581</biblScope><biblScope unit="page" to="590">590</biblScope><biblScope unit="page-count">10</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2009-03">2009-03</date></imprint><idno type="ISSN">0007-0963</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0007-0963</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Background Vascular alterations are significant events in the pathomechanism of psoriasis. A disorder in the mechanisms regulating skin angiogenesis and lymphangiogenesis could participate in the pathogenesis of the disease.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>psoriasis</json:string><json:string>psoriatic</json:string><json:string>lymphatic</json:string><json:string>mrna</json:string><json:string>uninvolved psoriatic skin</json:string><json:string>nonlesional</json:string><json:string>angiogenesis</json:string><json:string>receptor</json:string><json:string>uninvolved</json:string><json:string>keratin</json:string><json:string>epidermal</json:string><json:string>vegfr3</json:string><json:string>healthy volunteers</json:string><json:string>lymphangiogenesis</json:string><json:string>vegf</json:string><json:string>dermal</json:string><json:string>gapdh</json:string><json:string>vegfr2</json:string><json:string>growth factor</json:string><json:string>uninvolved skin</json:string><json:string>dermatology</json:string><json:string>henno</json:string><json:string>dermatologists british journal</json:string><json:string>dermatologist</json:string><json:string>authors journal compilation</json:string><json:string>lesional</json:string><json:string>dermatol</json:string><json:string>british association</json:string><json:string>vascular markers</json:string><json:string>isoforms</json:string><json:string>rrna</json:string><json:string>nonlesional skin</json:string><json:string>lymphatic vessels</json:string><json:string>isoform</json:string><json:string>basal</json:string><json:string>basement membrane</json:string><json:string>healthy volunteer skin</json:string><json:string>neuropilin</json:string><json:string>semaphorin</json:string><json:string>lymphangiogenesis markers</json:string><json:string>lesional skin</json:string><json:string>lesion</json:string><json:string>vascular</json:string><json:string>healthy skin</json:string><json:string>mrna level</json:string><json:string>nonlesional psoriatic</json:string><json:string>placental growth factor</json:string><json:string>willebrand factor</json:string><json:string>psoriatic lesions</json:string><json:string>nonlesional psoriatic skin</json:string><json:string>psoriasis lesions</json:string><json:string>arbitrary units</json:string><json:string>chain reaction</json:string><json:string>marker</json:string><json:string>vascular plexus</json:string><json:string>basal membrane</json:string><json:string>unit volume</json:string><json:string>blood vessels</json:string><json:string>statistical difference</json:string><json:string>cell biol</json:string><json:string>biopsy</json:string></teeft></keywords><author><json:item><name>A. Henno</name><affiliations><json:string>Department of Dermatology</json:string><json:string>Laboratory of Connective Tissues Biology, GIGA‐R</json:string></affiliations></json:item><json:item><name>S. Blacher</name><affiliations><json:string>Laboratory of Tumor and Development Biology, GIGA‐R</json:string></affiliations></json:item><json:item><name>C. Lambert</name><affiliations><json:string>Laboratory of Connective Tissues Biology, GIGA‐R</json:string></affiliations></json:item><json:item><name>A. Colige</name><affiliations><json:string>Laboratory of Connective Tissues Biology, GIGA‐R</json:string></affiliations></json:item><json:item><name>L. Seidel</name><affiliations><json:string>Department of Biostatistics, University Hospital of Liège, University of Liège, B23, 4000 Liège, Belgium</json:string></affiliations></json:item><json:item><name>A. Noël</name><affiliations><json:string>Laboratory of Tumor and Development Biology, GIGA‐R</json:string></affiliations></json:item><json:item><name>C. Lapière</name><affiliations><json:string>Laboratory of Connective Tissues Biology, GIGA‐R</json:string></affiliations></json:item><json:item><name>M. De La Brassinne</name><affiliations><json:string>Department of Dermatology</json:string></affiliations></json:item><json:item><name>B.V. Nusgens</name><affiliations><json:string>Laboratory of Connective Tissues Biology, GIGA‐R</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>angiogenesis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>lymphangiogenesis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>psoriasis</value></json:item></subject><articleId><json:string>BJD8889</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><qualityIndicators><score>5.348</score><pdfVersion>1.3</pdfVersion><pdfPageSize>595.277 x 783.779 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>225</abstractCharCount><pdfWordCount>5609</pdfWordCount><pdfCharCount>36254</pdfCharCount><pdfPageCount>10</pdfPageCount><abstractWordCount>29</abstractWordCount></qualityIndicators><title>Altered expression of angiogenesis and lymphangiogenesis markers in the uninvolved skin of plaque‐type psoriasis</title><genre><json:string>article</json:string></genre><host><title>British Journal of Dermatology</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1365-2133</json:string></doi><issn><json:string>0007-0963</json:string></issn><eissn><json:string>1365-2133</json:string></eissn><publisherId><json:string>BJD</json:string></publisherId><volume>160</volume><issue>3</issue><pages><first>581</first><last>590</last><total>10</total></pages><genre><json:string>journal</json:string></genre></host><categories><wos><json:string>science</json:string><json:string>dermatology</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>dermatology & venereal diseases</json:string></scienceMetrix></categories><publicationDate>2009</publicationDate><copyrightDate>2009</copyrightDate><doi><json:string>10.1111/j.1365-2133.2008.08889.x</json:string></doi><id>D0D5499369704D67EFC5B6C1BA570626DA2364CF</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/D0D5499369704D67EFC5B6C1BA570626DA2364CF/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/D0D5499369704D67EFC5B6C1BA570626DA2364CF/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/D0D5499369704D67EFC5B6C1BA570626DA2364CF/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Altered expression of angiogenesis and lymphangiogenesis markers in the uninvolved skin of plaque‐type psoriasis</title></titleStmt><publicationStmt><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><licence>© 2008 The Authors. Journal Compilation © 2008 British Association of Dermatologists</licence></availability><date type="published" when="2009-03"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Altered expression of angiogenesis and lymphangiogenesis markers in the uninvolved skin of plaque‐type psoriasis</title><title level="a" type="short">Vascular markers in uninvolved psoriatic skin</title><author xml:id="author-0000"><persName><forename type="first">A.</forename><surname>Henno</surname></persName><affiliation>Department of Dermatology</affiliation><affiliation>Laboratory of Connective Tissues Biology, GIGA‐R</affiliation></author><author xml:id="author-0001"><persName><forename type="first">S.</forename><surname>Blacher</surname></persName><affiliation>Laboratory of Tumor and Development Biology, GIGA‐R</affiliation></author><author xml:id="author-0002"><persName><forename type="first">C.</forename><surname>Lambert</surname></persName><affiliation>Laboratory of Connective Tissues Biology, GIGA‐R</affiliation></author><author xml:id="author-0003"><persName><forename type="first">A.</forename><surname>Colige</surname></persName><affiliation>Laboratory of Connective Tissues Biology, GIGA‐R</affiliation></author><author xml:id="author-0004"><persName><forename type="first">L.</forename><surname>Seidel</surname></persName><affiliation>Department of Biostatistics, University Hospital of Liège, University of Liège, B23, 4000 Liège, Belgium<address><country key="BE"></country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">A.</forename><surname>Noël</surname></persName><affiliation>Laboratory of Tumor and Development Biology, GIGA‐R</affiliation></author><author xml:id="author-0006"><persName><forename type="first">C.</forename><surname>Lapière</surname></persName><affiliation>Laboratory of Connective Tissues Biology, GIGA‐R</affiliation></author><author xml:id="author-0007"><persName><forename type="first">M.</forename><surname>De La Brassinne</surname></persName><affiliation>Department of Dermatology</affiliation></author><author xml:id="author-0008"><persName><forename type="first">B.V.</forename><surname>Nusgens</surname></persName><affiliation>Laboratory of Connective Tissues Biology, GIGA‐R</affiliation></author><idno type="istex">D0D5499369704D67EFC5B6C1BA570626DA2364CF</idno><idno type="DOI">10.1111/j.1365-2133.2008.08889.x</idno><idno type="unit">BJD8889</idno><idno type="toTypesetVersion">file:BJD.BJD8889.pdf</idno></analytic><monogr><title level="j" type="main">British Journal of Dermatology</title><title level="j" type="alt">BRITISH JOURNAL OF DERMATOLOGY</title><idno type="pISSN">0007-0963</idno><idno type="eISSN">1365-2133</idno><idno type="book-DOI">10.1111/(ISSN)1365-2133</idno><idno type="book-part-DOI">10.1111/bjd.2009.160.issue-3</idno><idno type="product">BJD</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">160</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="581">581</biblScope><biblScope unit="page" to="590">590</biblScope><biblScope unit="page-count">10</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2009-03"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><head>Summary</head><p><hi rend="bold">Background </hi> Vascular alterations are significant events in the pathomechanism of psoriasis. A disorder in the mechanisms regulating skin angiogenesis and lymphangiogenesis could participate in the pathogenesis of the disease.</p><p><hi rend="bold">Objectives </hi> To quantify differences in the expression of angiogenesis and lymphangiogenesis growth factors, receptors, coreceptors as well as their antagonists in the uninvolved skin of patients with psoriasis compared with the skin of nonpsoriatic volunteers.</p><p><hi rend="bold">Methods </hi> Skin biopsies were collected from the involved skin of 13 patients with untreated plaque‐type psoriasis, from their nonlesional skin at distance from the lesions and from the skin of 16 healthy volunteers. The mRNA steady‐state level of keratins 10, 14 and 16, glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH), vimentin, collagen I and IV, proliferating cell nuclear antigen, the various splice variants of vascular endothelial growth factor, VEGF‐A, VEGF‐C and VEGF‐D, their receptors VEGFR1, VEGFR2 and VEGFR3, neuropilin (NRP)‐1 and its soluble forms, NRP‐2, semaphorin 3A and prox‐1, was measured by reverse transcription–polymerase chain reaction. Immunohistochemistry was performed for Ki‐67, von Willebrand factor and D2‐40. Blood and lymphatic vessel density, area and distance from epidermis were estimated by morphological analysis coupled to an original computer‐assisted method of quantification.</p><p><hi rend="bold">Results </hi> Skin from healthy volunteers and nonlesional skin from patients with psoriasis displayed similar histological, morphometric and proliferative features. However, a significant overexpression of VEGFR3, the VEGF‐A isoform VEGF121, soluble 12 NRP‐1 and GAPDH was observed in the nonlesional psoriatic skin as compared with that of normal volunteers.</p><p><hi rend="bold">Conclusions </hi> These data point to significant differences in the blood and lymphatic vascular transcriptome between the clinically normal‐appearing skin of patients with psoriasis and the skin of volunteers without psoriasis.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">angiogenesis</term><term xml:id="k2">lymphangiogenesis</term><term xml:id="k3">psoriasis</term></keywords><classCode scheme="tocHeading1">Original articles</classCode><classCode scheme="tocHeading2">Dermatopathology</classCode></textClass><langUsage><language ident="EN"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/D0D5499369704D67EFC5B6C1BA570626DA2364CF/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1365-2133</doi><issn type="print">0007-0963</issn><issn type="electronic">1365-2133</issn><idGroup><id type="product" value="BJD"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="BRITISH JOURNAL OF DERMATOLOGY">British Journal of Dermatology</title></titleGroup></publicationMeta><publicationMeta level="part" position="03003"><doi origin="wiley">10.1111/bjd.2009.160.issue-3</doi><numberingGroup><numbering type="journalVolume" number="160">160</numbering><numbering type="journalIssue" number="3">3</numbering></numberingGroup><coverDate startDate="2009-03">March 2009</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="16" status="forIssue"><doi origin="wiley">10.1111/j.1365-2133.2008.08889.x</doi><idGroup><id type="unit" value="BJD8889"></id></idGroup><countGroup><count type="pageTotal" number="10"></count></countGroup><titleGroup><title type="tocHeading1">Original articles</title><title type="tocHeading2">Dermatopathology</title></titleGroup><copyright>© 2008 The Authors. Journal Compilation © 2008 British Association of Dermatologists</copyright><eventGroup><event type="firstOnline" date="2008-10-20"></event><event type="publishedOnlineFinalForm" date="2009-02-17"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-08"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-15"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-15"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="581">581</numbering><numbering type="pageLast" number="590">590</numbering></numberingGroup><correspondenceTo>Audrey Henno.
E‐mail: <email>audrey.henno@student.ulg.ac.be</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:BJD.BJD8889.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Accepted for publication 30 July 2008</unparsedEditorialHistory><countGroup><count type="figureTotal" number="4"></count><count type="tableTotal" number="4"></count></countGroup><titleGroup><title type="main">Altered expression of angiogenesis and lymphangiogenesis markers in the uninvolved skin of plaque‐type psoriasis</title><title type="shortAuthors">A. Henno <i>et al.</i></title><title type="short">Vascular markers in uninvolved psoriatic skin</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1 #a2"><personName><givenNames>A.</givenNames><familyName>Henno</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a3"><personName><givenNames>S.</givenNames><familyName>Blacher</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a2"><personName><givenNames>C.</givenNames><familyName>Lambert</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a2"><personName><givenNames>A.</givenNames><familyName>Colige</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a4"><personName><givenNames>L.</givenNames><familyName>Seidel</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a3"><personName><givenNames>A.</givenNames><familyName>Noël</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a2"><personName><givenNames>C.</givenNames><familyName>Lapière</familyName></personName></creator><creator creatorRole="author" xml:id="cr8" affiliationRef="#a1"><personName><givenNames>M.</givenNames><familyName>De La Brassinne</familyName></personName></creator><creator creatorRole="author" xml:id="cr9" affiliationRef="#a2"><personName><givenNames>B.V.</givenNames><familyName>Nusgens</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>Department of Dermatology</unparsedAffiliation></affiliation><affiliation xml:id="a2"><unparsedAffiliation>Laboratory of Connective Tissues Biology, GIGA‐R</unparsedAffiliation></affiliation><affiliation xml:id="a3"><unparsedAffiliation>Laboratory of Tumor and Development Biology, GIGA‐R</unparsedAffiliation></affiliation><affiliation xml:id="a4" countryCode="BE"><unparsedAffiliation>Department of Biostatistics, University Hospital of Liège, University of Liège, B23, 4000 Liège, Belgium</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">angiogenesis</keyword><keyword xml:id="k2">lymphangiogenesis</keyword><keyword xml:id="k3">psoriasis</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Summary</title><p><b>Background </b> Vascular alterations are significant events in the pathomechanism of psoriasis. A disorder in the mechanisms regulating skin angiogenesis and lymphangiogenesis could participate in the pathogenesis of the disease.</p><p><b>Objectives </b> To quantify differences in the expression of angiogenesis and lymphangiogenesis growth factors, receptors, coreceptors as well as their antagonists in the uninvolved skin of patients with psoriasis compared with the skin of nonpsoriatic volunteers.</p><p><b>Methods </b> Skin biopsies were collected from the involved skin of 13 patients with untreated plaque‐type psoriasis, from their nonlesional skin at distance from the lesions and from the skin of 16 healthy volunteers. The mRNA steady‐state level of keratins 10, 14 and 16, glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH), vimentin, collagen I and IV, proliferating cell nuclear antigen, the various splice variants of vascular endothelial growth factor, VEGF‐A, VEGF‐C and VEGF‐D, their receptors VEGFR1, VEGFR2 and VEGFR3, neuropilin (NRP)‐1 and its soluble forms, NRP‐2, semaphorin 3A and prox‐1, was measured by reverse transcription–polymerase chain reaction. Immunohistochemistry was performed for Ki‐67, von Willebrand factor and D2‐40. Blood and lymphatic vessel density, area and distance from epidermis were estimated by morphological analysis coupled to an original computer‐assisted method of quantification.</p><p><b>Results </b> Skin from healthy volunteers and nonlesional skin from patients with psoriasis displayed similar histological, morphometric and proliferative features. However, a significant overexpression of VEGFR3, the VEGF‐A isoform VEGF121, soluble 12 NRP‐1 and GAPDH was observed in the nonlesional psoriatic skin as compared with that of normal volunteers.</p><p><b>Conclusions </b> These data point to significant differences in the blood and lymphatic vascular transcriptome between the clinically normal‐appearing skin of patients with psoriasis and the skin of volunteers without psoriasis.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1" numbered="no"><p>Conflicts of interest
None declared.</p></note><note xml:id="fn2" numbered="no"><p>Part of this work has been presented in abstract form at the 36th European Society of Dermatological Research meeting held in Paris, 7–9 September 2006.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Altered expression of angiogenesis and lymphangiogenesis markers in the uninvolved skin of plaque‐type psoriasis</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Vascular markers in uninvolved psoriatic skin</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Altered expression of angiogenesis and lymphangiogenesis markers in the uninvolved skin of plaque‐type psoriasis</title></titleInfo><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Henno</namePart><affiliation>Department of Dermatology</affiliation><affiliation>Laboratory of Connective Tissues Biology, GIGA‐R</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Blacher</namePart><affiliation>Laboratory of Tumor and Development Biology, GIGA‐R</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Lambert</namePart><affiliation>Laboratory of Connective Tissues Biology, GIGA‐R</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Colige</namePart><affiliation>Laboratory of Connective Tissues Biology, GIGA‐R</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Seidel</namePart><affiliation>Department of Biostatistics, University Hospital of Liège, University of Liège, B23, 4000 Liège, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Noël</namePart><affiliation>Laboratory of Tumor and Development Biology, GIGA‐R</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Lapière</namePart><affiliation>Laboratory of Connective Tissues Biology, GIGA‐R</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">De La Brassinne</namePart><affiliation>Department of Dermatology</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.V.</namePart><namePart type="family">Nusgens</namePart><affiliation>Laboratory of Connective Tissues Biology, GIGA‐R</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2009-03</dateIssued><edition>Accepted for publication 30 July 2008</edition><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">4</extent><extent unit="tables">4</extent></physicalDescription><abstract>Background Vascular alterations are significant events in the pathomechanism of psoriasis. A disorder in the mechanisms regulating skin angiogenesis and lymphangiogenesis could participate in the pathogenesis of the disease.</abstract><abstract>Objectives To quantify differences in the expression of angiogenesis and lymphangiogenesis growth factors, receptors, coreceptors as well as their antagonists in the uninvolved skin of patients with psoriasis compared with the skin of nonpsoriatic volunteers.</abstract><abstract>Methods Skin biopsies were collected from the involved skin of 13 patients with untreated plaque‐type psoriasis, from their nonlesional skin at distance from the lesions and from the skin of 16 healthy volunteers. The mRNA steady‐state level of keratins 10, 14 and 16, glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH), vimentin, collagen I and IV, proliferating cell nuclear antigen, the various splice variants of vascular endothelial growth factor, VEGF‐A, VEGF‐C and VEGF‐D, their receptors VEGFR1, VEGFR2 and VEGFR3, neuropilin (NRP)‐1 and its soluble forms, NRP‐2, semaphorin 3A and prox‐1, was measured by reverse transcription–polymerase chain reaction. Immunohistochemistry was performed for Ki‐67, von Willebrand factor and D2‐40. Blood and lymphatic vessel density, area and distance from epidermis were estimated by morphological analysis coupled to an original computer‐assisted method of quantification.</abstract><abstract>Results Skin from healthy volunteers and nonlesional skin from patients with psoriasis displayed similar histological, morphometric and proliferative features. However, a significant overexpression of VEGFR3, the VEGF‐A isoform VEGF121, soluble 12 NRP‐1 and GAPDH was observed in the nonlesional psoriatic skin as compared with that of normal volunteers.</abstract><abstract>Conclusions These data point to significant differences in the blood and lymphatic vascular transcriptome between the clinically normal‐appearing skin of patients with psoriasis and the skin of volunteers without psoriasis.</abstract><subject lang="en"><genre>keywords</genre><topic>angiogenesis</topic><topic>lymphangiogenesis</topic><topic>psoriasis</topic></subject><relatedItem type="host"><titleInfo><title>British Journal of Dermatology</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0007-0963</identifier><identifier type="eISSN">1365-2133</identifier><identifier type="DOI">10.1111/(ISSN)1365-2133</identifier><identifier type="PublisherID">BJD</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>160</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>581</start><end>590</end><total>10</total></extent></part></relatedItem><identifier type="istex">D0D5499369704D67EFC5B6C1BA570626DA2364CF</identifier><identifier type="DOI">10.1111/j.1365-2133.2008.08889.x</identifier><identifier type="ArticleID">BJD8889</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2008 The Authors. Journal Compilation © 2008 British Association of Dermatologists</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 006210 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 006210 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:D0D5499369704D67EFC5B6C1BA570626DA2364CF
|texte= Altered expression of angiogenesis and lymphangiogenesis markers in the uninvolved skin of plaque‐type psoriasis
}}
| This area was generated with Dilib version V0.6.31. |  |