Contractility Patterns of Human Leg Lymphatics in Various Stages of Obstructive Lymphedema
Identifieur interne : 006020 ( Istex/Corpus ); précédent : 006019; suivant : 006021Contractility Patterns of Human Leg Lymphatics in Various Stages of Obstructive Lymphedema
Auteurs : Waldemar L. OlszewskiSource :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2008-05.
Abstract
In healthy human leg, lymphatics contract spontaneously, rhythmically propelling lymph. The pressures generated by lymphatic contractions constitute the main force for lymph flow. This mechanism is of utmost importance during night rest, anesthesia, and immobilization, as well as in those with damaged peripheral motor neurons. Under physiological conditions, limb muscular activity and position only slightly change lymph flow. In obstructive lymphedema, lymphatic wall muscular fibers become damaged and the spontaneous contractility becomes ineffective in lymph transport because of low generated pressures and lymphatic valve insufficiency. The lymph‐propelling task is taken over by leg muscle contractions. Measuring intralymphatic pressures and flow gives some insight into the mechanism of lymph flow in healthy limbs and loss of this function in lymphedema. This knowledge will be useful in the derivation of rational treatments for lymphedema.
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DOI: 10.1196/annals.1413.010
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Central Clinical Hospital, MIA, Warsaw, Poland
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Biological Principles of the Lymphatic System</classCode></textClass><langUsage><language ident="EN"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/CCE52DBD0A831E02D07C5501D7CA8F55EA2D983B/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Inc</publisherName><publisherLoc>Malden, USA</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1749-6632</doi><issn type="print">0077-8923</issn><issn type="electronic">1749-6632</issn><idGroup><id type="product" value="NYAS"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="ANNALS OF NEW YORK ACADEMY SCIENCES">Annals of the New York Academy of Sciences</title></titleGroup></publicationMeta><publicationMeta level="part" position="05001"><doi origin="wiley">10.1196/nyas.2008.1131.issue-1</doi><titleGroup><title type="main">The Lymphatic Continuum Revisited</title></titleGroup><numberingGroup><numbering type="journalVolume" number="1131">1131</numbering><numbering type="journalIssue">1</numbering></numberingGroup><coverDate startDate="2008-05">May 2008</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="11" status="forIssue"><doi origin="wiley">10.1196/annals.1413.010</doi><idGroup><id type="unit" value="NYAS1131010"></id></idGroup><countGroup><count type="pageTotal" number="9"></count></countGroup><titleGroup><title type="tocHeading1">Part II. Biological Principles of the Lymphatic System</title></titleGroup><copyright>© 2008 New York Academy of Sciences</copyright><eventGroup><event type="firstOnline" date="2008-05-28"></event><event type="publishedOnlineFinalForm" date="2008-05-28"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.5 mode:FullText source:FullText result:FullText" date="2010-04-07"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-19"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-14"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="110">110</numbering><numbering type="pageLast" number="118">118</numbering></numberingGroup><correspondenceTo>Address for correspondence: Waldemar L. Olszewski, Department of Surgical Research and Transplantology, Medical Research Center, Polish Academy of Sciences, 5 Pawinskiego Str., 02 106 Warsaw, Poland. Voice: +48‐22‐6685316; fax: +48‐22‐66855334.
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The pressures generated by lymphatic contractions constitute the main force for lymph flow. This mechanism is of utmost importance during night rest, anesthesia, and immobilization, as well as in those with damaged peripheral motor neurons. Under physiological conditions, limb muscular activity and position only slightly change lymph flow. In obstructive lymphedema, lymphatic wall muscular fibers become damaged and the spontaneous contractility becomes ineffective in lymph transport because of low generated pressures and lymphatic valve insufficiency. The lymph‐propelling task is taken over by leg muscle contractions. Measuring intralymphatic pressures and flow gives some insight into the mechanism of lymph flow in healthy limbs and loss of this function in lymphedema. This knowledge will be useful in the derivation of rational treatments for lymphedema.</abstract><subject lang="en"><genre>keywords</genre><topic>lymphatics</topic><topic>contractility</topic><topic>lymph</topic><topic>flow</topic><topic>pressure</topic></subject><relatedItem type="host"><titleInfo><title>Annals of the New York Academy of Sciences</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0077-8923</identifier><identifier type="eISSN">1749-6632</identifier><identifier type="DOI">10.1111/(ISSN)1749-6632</identifier><identifier type="PublisherID">NYAS</identifier><part><date>2008</date><detail type="title"><title>The Lymphatic Continuum Revisited</title></detail><detail type="volume"><caption>vol.</caption><number>1131</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>110</start><end>118</end><total>9</total></extent></part></relatedItem><identifier type="istex">CCE52DBD0A831E02D07C5501D7CA8F55EA2D983B</identifier><identifier type="DOI">10.1196/annals.1413.010</identifier><identifier type="ArticleID">NYAS1131010</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2008 New York Academy of Sciences</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Inc</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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