Radiation therapy following nodal surgery for melanoma: An analysis of late toxicity
Identifieur interne : 005711 ( Istex/Corpus ); précédent : 005710; suivant : 005712Radiation therapy following nodal surgery for melanoma: An analysis of late toxicity
Auteurs : B. H. Burmeister ; B. M. Smithers ; S. Davis ; N. Spry ; C. Johnson ; H. Krawitz ; K. C. BaumannSource :
- ANZ Journal of Surgery [ 1445-1433 ] ; 2002-05.
Abstract
Background: The role of adjuvant radiation therapy following resection of malignant melanoma involving regional lymph nodes remains controversial. There is no published randomized trial comparing surgery alone to surgery with postoperative radiation therapy that shows a benefit in terms of local control. Some retrospective studies, however, suggest that radiation given postoperatively reduces local recurrence. One of the obstacles to patients routinely being offered radiation therapy is the concern over the added late toxicity that may occur. The present article is a report of the first 130 patients of a prospective phase II multicentre study in Australia and New Zealand.
Url:
DOI: 10.1046/j.1445-2197.2002.02405.x
Links to Exploration step
ISTEX:B9423793E5745E502A732D7EC4B5692B9A5B7148Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Radiation therapy following nodal surgery for melanoma: An analysis of late toxicity</title><author><name sortKey="Burmeister, B H" sort="Burmeister, B H" uniqKey="Burmeister B" first="B. H." last="Burmeister">B. H. Burmeister</name><affiliation><mods:affiliation>Queensland Radium Institute,</mods:affiliation></affiliation></author><author><name sortKey="Smithers, B M" sort="Smithers, B M" uniqKey="Smithers B" first="B. M." last="Smithers">B. M. Smithers</name><affiliation><mods:affiliation>Princess Alexandra Hospital, Brisbane, Queensland,</mods:affiliation></affiliation></author><author><name sortKey="Davis, S" sort="Davis, S" uniqKey="Davis S" first="S." last="Davis">S. Davis</name><affiliation><mods:affiliation>William Buckland Radiotherapy Centre, Melbourne, Victoria,</mods:affiliation></affiliation></author><author><name sortKey="Spry, N" sort="Spry, N" uniqKey="Spry N" first="N." last="Spry">N. Spry</name><affiliation><mods:affiliation>Sir Charles Gairdner Hospital, Perth, Western Australia, Australia,</mods:affiliation></affiliation></author><author><name sortKey="Johnson, C" sort="Johnson, C" uniqKey="Johnson C" first="C." last="Johnson">C. Johnson</name><affiliation><mods:affiliation>Wellington Oncology Unit, Wellington Hospital, Wellington and</mods:affiliation></affiliation></author><author><name sortKey="Krawitz, H" sort="Krawitz, H" uniqKey="Krawitz H" first="H." last="Krawitz">H. Krawitz</name><affiliation><mods:affiliation>Oncology Department, Auckland Hospital, Auckland, New Zealand</mods:affiliation></affiliation></author><author><name sortKey="Baumann, K C" sort="Baumann, K C" uniqKey="Baumann K" first="K. C." last="Baumann">K. C. Baumann</name><affiliation><mods:affiliation>Queensland Radium Institute,</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B9423793E5745E502A732D7EC4B5692B9A5B7148</idno><date when="2002" year="2002">2002</date><idno type="doi">10.1046/j.1445-2197.2002.02405.x</idno><idno type="url">https://api.istex.fr/document/B9423793E5745E502A732D7EC4B5692B9A5B7148/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">005711</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">005711</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Radiation therapy following nodal surgery for melanoma: An analysis of late toxicity</title><author><name sortKey="Burmeister, B H" sort="Burmeister, B H" uniqKey="Burmeister B" first="B. H." last="Burmeister">B. H. Burmeister</name><affiliation><mods:affiliation>Queensland Radium Institute,</mods:affiliation></affiliation></author><author><name sortKey="Smithers, B M" sort="Smithers, B M" uniqKey="Smithers B" first="B. M." last="Smithers">B. M. Smithers</name><affiliation><mods:affiliation>Princess Alexandra Hospital, Brisbane, Queensland,</mods:affiliation></affiliation></author><author><name sortKey="Davis, S" sort="Davis, S" uniqKey="Davis S" first="S." last="Davis">S. Davis</name><affiliation><mods:affiliation>William Buckland Radiotherapy Centre, Melbourne, Victoria,</mods:affiliation></affiliation></author><author><name sortKey="Spry, N" sort="Spry, N" uniqKey="Spry N" first="N." last="Spry">N. Spry</name><affiliation><mods:affiliation>Sir Charles Gairdner Hospital, Perth, Western Australia, Australia,</mods:affiliation></affiliation></author><author><name sortKey="Johnson, C" sort="Johnson, C" uniqKey="Johnson C" first="C." last="Johnson">C. Johnson</name><affiliation><mods:affiliation>Wellington Oncology Unit, Wellington Hospital, Wellington and</mods:affiliation></affiliation></author><author><name sortKey="Krawitz, H" sort="Krawitz, H" uniqKey="Krawitz H" first="H." last="Krawitz">H. Krawitz</name><affiliation><mods:affiliation>Oncology Department, Auckland Hospital, Auckland, New Zealand</mods:affiliation></affiliation></author><author><name sortKey="Baumann, K C" sort="Baumann, K C" uniqKey="Baumann K" first="K. C." last="Baumann">K. C. Baumann</name><affiliation><mods:affiliation>Queensland Radium Institute,</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">ANZ Journal of Surgery</title><title level="j" type="alt">ANZ JOURNAL SURGERY</title><idno type="ISSN">1445-1433</idno><idno type="eISSN">1445-2197</idno><imprint><biblScope unit="vol">72</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="344">344</biblScope><biblScope unit="page" to="348">348</biblScope><publisher>Blackwell Science Pty</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2002-05">2002-05</date></imprint><idno type="ISSN">1445-1433</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1445-1433</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Background: The role of adjuvant radiation therapy following resection of malignant melanoma involving regional lymph nodes remains controversial. There is no published randomized trial comparing surgery alone to surgery with postoperative radiation therapy that shows a benefit in terms of local control. Some retrospective studies, however, suggest that radiation given postoperatively reduces local recurrence. One of the obstacles to patients routinely being offered radiation therapy is the concern over the added late toxicity that may occur. The present article is a report of the first 130 patients of a prospective phase II multicentre study in Australia and New Zealand.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>melanoma</json:string><json:string>toxicity</json:string><json:string>node</json:string><json:string>lymphoedema</json:string><json:string>adjuvant</json:string><json:string>late toxicity</json:string><json:string>nodal</json:string><json:string>oncology</json:string><json:string>oncol</json:string><json:string>surg</json:string><json:string>postoperative</json:string><json:string>malignant</json:string><json:string>adjuvant radiation therapy</json:string><json:string>randomized</json:string><json:string>subcutaneous</json:string><json:string>malignant melanoma</json:string><json:string>radiation therapy</json:string><json:string>adjuvant therapy</json:string><json:string>recurrence</json:string><json:string>metastatic melanoma</json:string><json:string>high risk</json:string><json:string>local recurrence</json:string><json:string>fractionation schedule</json:string><json:string>postoperative radiation therapy</json:string><json:string>node site</json:string><json:string>late effects</json:string><json:string>skin changes</json:string><json:string>subcutaneous changes</json:string><json:string>randomized trial</json:string><json:string>present article</json:string><json:string>multiple node involvement</json:string><json:string>nodal basin</json:string><json:string>regional node basin</json:string><json:string>target volume</json:string><json:string>neck region</json:string><json:string>head neck surg</json:string><json:string>subcutaneous tissue</json:string><json:string>radiation oncologist</json:string><json:string>growth retardation</json:string><json:string>joint stiffness</json:string><json:string>spinal cord</json:string><json:string>radiation technique</json:string><json:string>nodal disease</json:string><json:string>regional lymph nodes</json:string><json:string>oncology group</json:string><json:string>trans tasman radiation oncology group</json:string><json:string>many patients</json:string><json:string>local control</json:string><json:string>conventional doses</json:string><json:string>brachial plexus injury</json:string><json:string>ilioinguinal region</json:string><json:string>randomized study</json:string><json:string>extracapsular extension</json:string><json:string>significant impact</json:string></teeft></keywords><author><json:item><name>B. H. Burmeister</name><affiliations><json:string>Queensland Radium Institute,</json:string></affiliations></json:item><json:item><name>B. M. Smithers</name><affiliations><json:string>Princess Alexandra Hospital, Brisbane, Queensland,</json:string></affiliations></json:item><json:item><name>S. Davis</name><affiliations><json:string>William Buckland Radiotherapy Centre, Melbourne, Victoria,</json:string></affiliations></json:item><json:item><name>N. Spry</name><affiliations><json:string>Sir Charles Gairdner Hospital, Perth, Western Australia, Australia,</json:string></affiliations></json:item><json:item><name>C. Johnson</name><affiliations><json:string>Wellington Oncology Unit, Wellington Hospital, Wellington and</json:string></affiliations></json:item><json:item><name>H. Krawitz</name><affiliations><json:string>Oncology Department, Auckland Hospital, Auckland, New Zealand</json:string></affiliations></json:item><json:item><name>K. C. Baumann</name><affiliations><json:string>Queensland Radium Institute,</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>adjuvant therapy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>lymphoedema</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>melanoma</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>radiation therapy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>toxicity</value></json:item></subject><articleId><json:string>ANS2405</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><qualityIndicators><score>4.371</score><pdfVersion>1.2</pdfVersion><pdfPageSize>595 x 780 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>680</abstractCharCount><pdfWordCount>3183</pdfWordCount><pdfCharCount>19713</pdfCharCount><pdfPageCount>5</pdfPageCount><abstractWordCount>99</abstractWordCount></qualityIndicators><title>Radiation therapy following nodal surgery for melanoma: An analysis of late toxicity</title><genre><json:string>article</json:string></genre><host><title>ANZ Journal of Surgery</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1445-2197</json:string></doi><issn><json:string>1445-1433</json:string></issn><eissn><json:string>1445-2197</json:string></eissn><publisherId><json:string>ANS</json:string></publisherId><volume>72</volume><issue>5</issue><pages><first>344</first><last>348</last></pages><genre><json:string>journal</json:string></genre></host><categories><wos><json:string>science</json:string><json:string>surgery</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>surgery</json:string></scienceMetrix></categories><publicationDate>2002</publicationDate><copyrightDate>2002</copyrightDate><doi><json:string>10.1046/j.1445-2197.2002.02405.x</json:string></doi><id>B9423793E5745E502A732D7EC4B5692B9A5B7148</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/B9423793E5745E502A732D7EC4B5692B9A5B7148/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/B9423793E5745E502A732D7EC4B5692B9A5B7148/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/B9423793E5745E502A732D7EC4B5692B9A5B7148/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Radiation therapy following nodal surgery for melanoma: An analysis of late toxicity</title></titleStmt><publicationStmt><publisher>Blackwell Science Pty</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2002-05"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Radiation therapy following nodal surgery for melanoma: An analysis of late toxicity</title><title level="a" type="short">Late toxicity of radiation after surgery for nodal melanoma</title><author xml:id="author-0000"><persName><forename type="first">B. H.</forename><surname>Burmeister</surname></persName><affiliation>Queensland Radium Institute,</affiliation></author><author xml:id="author-0001"><persName><forename type="first">B. M.</forename><surname>Smithers</surname></persName><affiliation>Princess Alexandra Hospital, Brisbane, Queensland,</affiliation></author><author xml:id="author-0002"><persName><forename type="first">S.</forename><surname>Davis</surname></persName><affiliation>William Buckland Radiotherapy Centre, Melbourne, Victoria,</affiliation></author><author xml:id="author-0003"><persName><forename type="first">N.</forename><surname>Spry</surname></persName><affiliation>Sir Charles Gairdner Hospital, Perth, Western Australia, Australia,<address><country key="AU"></country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">C.</forename><surname>Johnson</surname></persName><affiliation>Wellington Oncology Unit, Wellington Hospital, Wellington and</affiliation></author><author xml:id="author-0005"><persName><forename type="first">H.</forename><surname>Krawitz</surname></persName><affiliation>Oncology Department, Auckland Hospital, Auckland, New Zealand<address><country key="NZ"></country></address></affiliation></author><author xml:id="author-0006"><persName><forename type="first">K. C.</forename><surname>Baumann</surname></persName><affiliation>Queensland Radium Institute,</affiliation></author><idno type="istex">B9423793E5745E502A732D7EC4B5692B9A5B7148</idno><idno type="DOI">10.1046/j.1445-2197.2002.02405.x</idno><idno type="unit">ANS2405</idno><idno type="toTypesetVersion">file:ANS.ANS2405.pdf</idno></analytic><monogr><title level="j" type="main">ANZ Journal of Surgery</title><title level="j" type="alt">ANZ JOURNAL SURGERY</title><idno type="pISSN">1445-1433</idno><idno type="eISSN">1445-2197</idno><idno type="book-DOI">10.1111/(ISSN)1445-2197</idno><idno type="book-part-DOI">10.1111/ans.2002.72.issue-5</idno><idno type="product">ANS</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">72</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="344">344</biblScope><biblScope unit="page" to="348">348</biblScope><publisher>Blackwell Science Pty</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2002-05"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><p><hi rend="bold">Background:</hi> The role of adjuvant radiation therapy following resection of malignant melanoma involving regional lymph nodes remains controversial. There is no published randomized trial comparing surgery alone to surgery with postoperative radiation therapy that shows a benefit in terms of local control. Some retrospective studies, however, suggest that radiation given postoperatively reduces local recurrence. One of the obstacles to patients routinely being offered radiation therapy is the concern over the added late toxicity that may occur. The present article is a report of the first 130 patients of a prospective phase II multicentre study in Australia and New Zealand.</p><p><hi rend="bold">Methods:</hi> The study was aimed at patients who had had a resection of melanoma in regional nodes or in a regional node basin. The patients were given adjuvant radiation therapy to a recommended dose of 48 Gy in 20 fractions over 4 weeks using accepted radiation techniques for each of the major node sites. This report describes the late toxicity of the treatment received by these patients.</p><p><hi rend="bold">Results:</hi> The results of late toxicity experienced in the study were acceptable.</p><p><hi rend="bold">Conclusion: </hi> The regimen of radiation therapy used could form the basis for the treatment arm of a randomized trial.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">adjuvant therapy</term><term xml:id="k2">lymphoedema</term><term xml:id="k3">melanoma</term><term xml:id="k4">radiation therapy</term><term xml:id="k5">toxicity</term></keywords><classCode scheme="tocHeading1">Original Articles</classCode></textClass><langUsage><language ident="EN"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/B9423793E5745E502A732D7EC4B5692B9A5B7148/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Science Pty</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1445-2197</doi><issn type="print">1445-1433</issn><issn type="electronic">1445-2197</issn><idGroup><id type="product" value="ANS"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="ANZ JOURNAL SURGERY">ANZ Journal of Surgery</title></titleGroup></publicationMeta><publicationMeta level="part" position="05005"><doi origin="wiley">10.1111/ans.2002.72.issue-5</doi><numberingGroup><numbering type="journalVolume" number="72">72</numbering><numbering type="journalIssue" number="5">5</numbering></numberingGroup><coverDate startDate="2002-05">2002</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="0034400" status="forIssue"><doi origin="wiley">10.1046/j.1445-2197.2002.02405.x</doi><idGroup><id type="unit" value="ANS2405"></id></idGroup><titleGroup><title type="tocHeading1">Original Articles</title></titleGroup><eventGroup><event type="firstOnline" date="2002-05-27"></event><event type="publishedOnlineFinalForm" date="2002-05-27"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-02-28"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-04"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-14"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="344">344</numbering><numbering type="pageLast" number="348">348</numbering></numberingGroup><correspondenceTo> Dr Bryan Burmeister, Queensland Radium
Institute, Raymond Terrace, South Brisbane, Qld 4101, Australia. Email: <email>B.Burmeister@mailbox.uq.edu.au</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:ANS.ANS2405.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Accepted for publication 14 January 2002.</unparsedEditorialHistory><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="2"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="20"></count><count type="wordTotal" number="2414"></count><count type="linksPubMed" number="13"></count><count type="linksCrossRef" number="0"></count></countGroup><titleGroup><title type="main">Radiation therapy following nodal surgery for melanoma: An analysis of late toxicity</title><title type="shortAuthors">BURMEISTER <i>ET AL.</i></title><title type="short">Late toxicity of radiation after surgery for nodal melanoma</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>B. H.</givenNames><familyName>Burmeister</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2"><personName><givenNames>B. M.</givenNames><familyName>Smithers</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a3"><personName><givenNames>S.</givenNames><familyName>Davis</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a4"><personName><givenNames>N.</givenNames><familyName>Spry</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a5"><personName><givenNames>C.</givenNames><familyName>Johnson</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a6"><personName><givenNames>H.</givenNames><familyName>Krawitz</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a1"><personName><givenNames>K. C.</givenNames><familyName>Baumann</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>Queensland Radium Institute,</unparsedAffiliation></affiliation><affiliation xml:id="a2"><unparsedAffiliation>Princess Alexandra Hospital, Brisbane, Queensland,</unparsedAffiliation></affiliation><affiliation xml:id="a3"><unparsedAffiliation>William Buckland Radiotherapy Centre, Melbourne, Victoria,</unparsedAffiliation></affiliation><affiliation xml:id="a4" countryCode="AU"><unparsedAffiliation>Sir Charles Gairdner Hospital, Perth, Western Australia, Australia,</unparsedAffiliation></affiliation><affiliation xml:id="a5"><unparsedAffiliation>Wellington Oncology Unit, Wellington Hospital, Wellington and</unparsedAffiliation></affiliation><affiliation xml:id="a6" countryCode="NZ"><unparsedAffiliation>Oncology Department, Auckland Hospital, Auckland, New Zealand</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">adjuvant therapy</keyword><keyword xml:id="k2">lymphoedema</keyword><keyword xml:id="k3">melanoma</keyword><keyword xml:id="k4">radiation therapy</keyword><keyword xml:id="k5">toxicity</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b>Background:</b> The role of adjuvant radiation therapy following resection of malignant melanoma involving regional lymph nodes remains controversial. There is no published randomized trial comparing surgery alone to surgery with postoperative radiation therapy that shows a benefit in terms of local control. Some retrospective studies, however, suggest that radiation given postoperatively reduces local recurrence. One of the obstacles to patients routinely being offered radiation therapy is the concern over the added late toxicity that may occur. The present article is a report of the first 130 patients of a prospective phase II multicentre study in Australia and New Zealand.</p><p><b>Methods:</b> The study was aimed at patients who had had a resection of melanoma in regional nodes or in a regional node basin. The patients were given adjuvant radiation therapy to a recommended dose of 48 Gy in 20 fractions over 4 weeks using accepted radiation techniques for each of the major node sites. This report describes the late toxicity of the treatment received by these patients.</p><p><b>Results:</b> The results of late toxicity experienced in the study were acceptable.</p><p><b>Conclusion: </b> The regimen of radiation therapy used could form the basis for the treatment arm of a randomized trial.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="n-fnt-1" numbered="no"><p> <b>B. H. Burmeister</b> FF Rad (T) SA, FRACR; <b>B.
M. Smithers</b> FRCS (Eng), FRACS; <b>S. Davis</b> FF Rad (T) SA,
FRACR; <b>N. Spry</b> FRCR, FRACR; <b>C. Johnson</b> MB ChB, FF
Rad (T) SA; <b>H. Krawitz</b> MB ChB, FF Rad (T) SA; <b>K. C. Baumann</b> BSc.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Radiation therapy following nodal surgery for melanoma: An analysis of late toxicity</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Late toxicity of radiation after surgery for nodal melanoma</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Radiation therapy following nodal surgery for melanoma: An analysis of late toxicity</title></titleInfo><name type="personal"><namePart type="given">B. H.</namePart><namePart type="family">Burmeister</namePart><affiliation>Queensland Radium Institute,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B. M.</namePart><namePart type="family">Smithers</namePart><affiliation>Princess Alexandra Hospital, Brisbane, Queensland,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Davis</namePart><affiliation>William Buckland Radiotherapy Centre, Melbourne, Victoria,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Spry</namePart><affiliation>Sir Charles Gairdner Hospital, Perth, Western Australia, Australia,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Johnson</namePart><affiliation>Wellington Oncology Unit, Wellington Hospital, Wellington and</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Krawitz</namePart><affiliation>Oncology Department, Auckland Hospital, Auckland, New Zealand</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K. C.</namePart><namePart type="family">Baumann</namePart><affiliation>Queensland Radium Institute,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Science Pty</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2002-05</dateIssued><edition>Accepted for publication 14 January 2002.</edition><copyrightDate encoding="w3cdtf">2002</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">2</extent><extent unit="references">20</extent><extent unit="words">2414</extent></physicalDescription><abstract>Background: The role of adjuvant radiation therapy following resection of malignant melanoma involving regional lymph nodes remains controversial. There is no published randomized trial comparing surgery alone to surgery with postoperative radiation therapy that shows a benefit in terms of local control. Some retrospective studies, however, suggest that radiation given postoperatively reduces local recurrence. One of the obstacles to patients routinely being offered radiation therapy is the concern over the added late toxicity that may occur. The present article is a report of the first 130 patients of a prospective phase II multicentre study in Australia and New Zealand.</abstract><abstract>Methods: The study was aimed at patients who had had a resection of melanoma in regional nodes or in a regional node basin. The patients were given adjuvant radiation therapy to a recommended dose of 48 Gy in 20 fractions over 4 weeks using accepted radiation techniques for each of the major node sites. This report describes the late toxicity of the treatment received by these patients.</abstract><abstract>Results: The results of late toxicity experienced in the study were acceptable.</abstract><abstract>Conclusion: The regimen of radiation therapy used could form the basis for the treatment arm of a randomized trial.</abstract><subject lang="en"><genre>keywords</genre><topic>adjuvant therapy</topic><topic>lymphoedema</topic><topic>melanoma</topic><topic>radiation therapy</topic><topic>toxicity</topic></subject><relatedItem type="host"><titleInfo><title>ANZ Journal of Surgery</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">1445-1433</identifier><identifier type="eISSN">1445-2197</identifier><identifier type="DOI">10.1111/(ISSN)1445-2197</identifier><identifier type="PublisherID">ANS</identifier><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>72</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>344</start><end>348</end></extent></part></relatedItem><identifier type="istex">B9423793E5745E502A732D7EC4B5692B9A5B7148</identifier><identifier type="DOI">10.1046/j.1445-2197.2002.02405.x</identifier><identifier type="ArticleID">ANS2405</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Science Pty</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005711 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 005711 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:B9423793E5745E502A732D7EC4B5692B9A5B7148
|texte= Radiation therapy following nodal surgery for melanoma: An analysis of late toxicity
}}
| This area was generated with Dilib version V0.6.31. |  |