Active lymphangiogenesis is a major risk factor for anastomotic leakage following sphincter‐sparing resection of rectal cancer
Identifieur interne : 005411 ( Istex/Corpus ); précédent : 005410; suivant : 005412Active lymphangiogenesis is a major risk factor for anastomotic leakage following sphincter‐sparing resection of rectal cancer
Auteurs : Weirong Chen ; Yanchon Li ; Ziqun Liao ; Guangrong Lin ; Gaoyang Cai ; Kaihuang Lin ; Qinhua Zhan ; Caoyang ChenSource :
- Journal of Surgical Oncology [ 0022-4790 ] ; 2011-10-01.
Abstract
Anastomotic leakage is a major complication of rectal surgery and controversy about its risk factors still exists. The aim of present study was to identify risk factors for anastomotic leakage following sphincter‐sparing resection of rectal cancer, focusing on the role of tissular lymphatic vessel density (LVD) in tumorous margin and distal clearance margin.
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DOI: 10.1002/jso.21965
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Fax: +86‐754‐88346543.===</mods:affiliation></affiliation></author><author><name sortKey="Li, Yanchon" sort="Li, Yanchon" uniqKey="Li Y" first="Yanchon" last="Li">Yanchon Li</name><affiliation><mods:affiliation>Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou, China</mods:affiliation></affiliation></author><author><name sortKey="Liao, Ziqun" sort="Liao, Ziqun" uniqKey="Liao Z" first="Ziqun" last="Liao">Ziqun Liao</name><affiliation><mods:affiliation>Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou, China</mods:affiliation></affiliation></author><author><name sortKey="Lin, Guangrong" sort="Lin, Guangrong" uniqKey="Lin G" first="Guangrong" last="Lin">Guangrong Lin</name><affiliation><mods:affiliation>Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou, China</mods:affiliation></affiliation></author><author><name sortKey="Cai, Gaoyang" sort="Cai, Gaoyang" uniqKey="Cai G" first="Gaoyang" last="Cai">Gaoyang Cai</name><affiliation><mods:affiliation>Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou, China</mods:affiliation></affiliation></author><author><name sortKey="Lin, Kaihuang" sort="Lin, Kaihuang" uniqKey="Lin K" first="Kaihuang" last="Lin">Kaihuang Lin</name><affiliation><mods:affiliation>Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou, China</mods:affiliation></affiliation></author><author><name sortKey="Zhan, Qinhua" sort="Zhan, Qinhua" uniqKey="Zhan Q" first="Qinhua" last="Zhan">Qinhua Zhan</name><affiliation><mods:affiliation>Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou, China</mods:affiliation></affiliation></author><author><name sortKey="Chen, Caoyang" sort="Chen, Caoyang" uniqKey="Chen C" first="Caoyang" last="Chen">Caoyang Chen</name><affiliation><mods:affiliation>Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou, China</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Surgical Oncology</title><title level="j" type="alt">JOURNAL OF SURGICAL ONCOLOGY</title><idno type="ISSN">0022-4790</idno><idno type="eISSN">1096-9098</idno><imprint><biblScope unit="vol">104</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="493">493</biblScope><biblScope unit="page" to="498">498</biblScope><biblScope unit="page-count">6</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-10-01">2011-10-01</date></imprint><idno type="ISSN">0022-4790</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-4790</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Anastomotic leakage is a major complication of rectal surgery and controversy about its risk factors still exists. The aim of present study was to identify risk factors for anastomotic leakage following sphincter‐sparing resection of rectal cancer, focusing on the role of tissular lymphatic vessel density (LVD) in tumorous margin and distal clearance margin.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>anastomotic leakage</json:string><json:string>lymphatic</json:string><json:string>rectal</json:string><json:string>leakage</json:string><json:string>rectal cancer</json:string><json:string>resection</json:string><json:string>anastomotic</json:string><json:string>tumorous</json:string><json:string>risk factors</json:string><json:string>surg</json:string><json:string>distal clearance margin</json:string><json:string>lymphangiogenesis</json:string><json:string>colorectal</json:string><json:string>lymphatic vessels</json:string><json:string>excision</json:string><json:string>mesorectal</json:string><json:string>rectum</json:string><json:string>tumorous margin</json:string><json:string>anterior resection</json:string><json:string>stoma</json:string><json:string>univariate</json:string><json:string>metastasis</json:string><json:string>shantou</json:string><json:string>present study</json:string><json:string>surgical</json:string><json:string>surgical oncology</json:string><json:string>total mesorectal excision</json:string><json:string>anastomosis</json:string><json:string>multivariate analysis</json:string><json:string>lymphatic vessel density</json:string><json:string>univariate analysis</json:string><json:string>coronary heart disease</json:string><json:string>shantou university</json:string><json:string>protective stoma</json:string><json:string>more lymphatic vessels</json:string><json:string>colon rectum</json:string><json:string>mesorectal excision</json:string><json:string>colorectal anastomosis</json:string><json:string>colorectal surgery</json:string><json:string>lymphatic vessel</json:string><json:string>independent factors</json:string><json:string>general surgery</json:string><json:string>blood capillaries</json:string><json:string>second hospital</json:string><json:string>lower tumor localization</json:string><json:string>tumor size</json:string><json:string>independent risk factors</json:string><json:string>lymph node metastasis</json:string><json:string>risk factor</json:string></teeft></keywords><author><json:item><name>Weirong Chen MD, PhD</name><affiliations><json:string>Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou, China</json:string><json:string>Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, China. Fax: +86‐754‐88346543.===</json:string></affiliations></json:item><json:item><name>Yanchon Li MD</name><affiliations><json:string>Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou, China</json:string></affiliations></json:item><json:item><name>Ziqun Liao MD</name><affiliations><json:string>Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou, China</json:string></affiliations></json:item><json:item><name>Guangrong Lin MD</name><affiliations><json:string>Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou, China</json:string></affiliations></json:item><json:item><name>Gaoyang Cai MD</name><affiliations><json:string>Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou, China</json:string></affiliations></json:item><json:item><name>Kaihuang Lin MD</name><affiliations><json:string>Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou, China</json:string></affiliations></json:item><json:item><name>Qinhua Zhan MD</name><affiliations><json:string>Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou, China</json:string></affiliations></json:item><json:item><name>Caoyang Chen MD</name><affiliations><json:string>Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou, China</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>lymphangiogenesis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>rectal cancer</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>anastomotic 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carcinogenesis</json:string></scienceMetrix></categories><publicationDate>2011</publicationDate><copyrightDate>2011</copyrightDate><doi><json:string>10.1002/jso.21965</json:string></doi><id>B30B033F2C2EE6A14A1060BFBE6733997DFCF052</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/B30B033F2C2EE6A14A1060BFBE6733997DFCF052/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/B30B033F2C2EE6A14A1060BFBE6733997DFCF052/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/B30B033F2C2EE6A14A1060BFBE6733997DFCF052/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Active lymphangiogenesis is a major risk factor for anastomotic leakage following sphincter‐sparing resection of rectal cancer</title></titleStmt><publicationStmt><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><licence>Copyright © 2011 Wiley‐Liss, Inc.</licence></availability><date type="published" when="2011-10-01"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main" xml:lang="en">Active lymphangiogenesis is a major risk factor for anastomotic leakage following sphincter‐sparing resection of rectal cancer</title><title level="a" type="short" xml:lang="en">Lymphangiogenesis is Factor for Leakage</title><author xml:id="author-0000" role="corresp"><persName><forename type="first">Weirong</forename><surname>Chen</surname><roleName type="degree">MD, PhD</roleName></persName><email>chen93662@163.com</email><affiliation>Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou, China<address><country key="CN"></country></address></affiliation><affiliation>Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, China. Fax: +86‐754‐88346543.===</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Yanchon</forename><surname>Li</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou, China<address><country key="CN"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Ziqun</forename><surname>Liao</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou, China<address><country key="CN"></country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Guangrong</forename><surname>Lin</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou, China<address><country key="CN"></country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Gaoyang</forename><surname>Cai</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou, China<address><country key="CN"></country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Kaihuang</forename><surname>Lin</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou, China<address><country key="CN"></country></address></affiliation></author><author xml:id="author-0006"><persName><forename type="first">Qinhua</forename><surname>Zhan</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou, China<address><country key="CN"></country></address></affiliation></author><author xml:id="author-0007"><persName><forename type="first">Caoyang</forename><surname>Chen</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou, China<address><country key="CN"></country></address></affiliation></author><idno type="istex">B30B033F2C2EE6A14A1060BFBE6733997DFCF052</idno><idno type="DOI">10.1002/jso.21965</idno><idno type="unit">JSO21965</idno><idno type="toTypesetVersion">file:JSO.JSO21965.pdf</idno></analytic><monogr><title level="j" type="main">Journal of Surgical Oncology</title><title level="j" type="alt">JOURNAL OF SURGICAL ONCOLOGY</title><idno type="pISSN">0022-4790</idno><idno type="eISSN">1096-9098</idno><idno type="book-DOI">10.1002/(ISSN)1096-9098</idno><idno type="book-part-DOI">10.1002/jso.v104.5</idno><idno type="product">JSO</idno><imprint><biblScope unit="vol">104</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="493">493</biblScope><biblScope unit="page" to="498">498</biblScope><biblScope unit="page-count">6</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-10-01"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><head>Abstract</head>
Objective
<p>Anastomotic leakage is a major complication of rectal surgery and controversy about its risk factors still exists. The aim of present study was to identify risk factors for anastomotic leakage following sphincter‐sparing resection of rectal cancer, focusing on the role of tissular lymphatic vessel density (LVD) in tumorous margin and distal clearance margin.</p>
Methods
<p>In a 9‐year period, from September 1999 to September 2009, 750 consecutive patients who underwent anterior resection with restoration of the bowel continuity were included. Univariate and multivariate analysis were applied to identify risk facrors for anastomotic leakage.</p>
Results
<p>The rate of anastomotic leakage was 7.6% (57 of 750 patients). In a multivariate analysis, high LVD in tumorous margin [<hi rend="italic">P</hi> = 0.0017; odds ratio (OR) = 5.93; 95% confidence interval (CI) = 2.61–8.514], high LVD in distal clearance margin (<hi rend="italic">P</hi> = 0.0011; OR = 6.05; 95% CI = 2.72–10.108) and lower tumor location (<hi rend="italic">P</hi> = 0.006; OR = 4.620; 95% CI = 1.76–6.97) were identified as independent factors for anastomotic leakage. A significant LVD correlation was shown by Spearman′s rank test between the tumorous and distal clearance margin (r = 0.796).</p>
Conclusions
<p>Tissular LVD in tumorous or distal clearance margin and lower tumor location are important risk factors for anastomotic leakage. J. Surg. Oncol. 2011; 104:493–498. © 2011 Wiley‐Liss, Inc.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="kwd1">lymphangiogenesis</term><term xml:id="kwd2">rectal cancer</term><term xml:id="kwd3">anastomotic leakage</term></keywords><classCode scheme="articleCategory">Research Article</classCode><classCode scheme="tocHeading1">Research Articles</classCode></textClass><langUsage><language ident="EN"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/B30B033F2C2EE6A14A1060BFBE6733997DFCF052/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1096-9098</doi><issn type="print">0022-4790</issn><issn type="electronic">1096-9098</issn><idGroup><id type="product" value="JSO"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="JOURNAL OF SURGICAL ONCOLOGY">Journal of Surgical Oncology</title><title type="short">J. Surg. Oncol.</title></titleGroup></publicationMeta><publicationMeta level="part" position="50"><doi origin="wiley" registered="yes">10.1002/jso.v104.5</doi><numberingGroup><numbering type="journalVolume" number="104">104</numbering><numbering type="journalIssue">5</numbering></numberingGroup><coverDate startDate="2011-10-01">1 October 2011</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="80" status="forIssue"><doi origin="wiley" registered="yes">10.1002/jso.21965</doi><idGroup><id type="unit" value="JSO21965"></id></idGroup><countGroup><count type="pageTotal" number="6"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="publisher">Copyright © 2011 Wiley‐Liss, Inc.</copyright><eventGroup><event type="manuscriptReceived" date="2011-01-02"></event><event type="manuscriptAccepted" date="2011-04-06"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:3.3.3 mode:FullText" date="2014-08-12"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.3.3 mode:FullText" date="2014-08-12"></event><event type="publishedOnlineEarlyUnpaginated" date="2011-04-25"></event><event type="publishedOnlineFinalForm" date="2011-09-06"></event><event type="firstOnline" date="2011-04-25"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-30"></event></eventGroup><numberingGroup><numbering type="pageFirst">493</numbering><numbering type="pageLast">498</numbering></numberingGroup><correspondenceTo>Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, China. Fax: +86‐754‐88346543.===</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JSO.JSO21965.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="3"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="44"></count><count type="wordTotal" number="4408"></count></countGroup><titleGroup><title type="main" xml:lang="en">Active lymphangiogenesis is a major risk factor for anastomotic leakage following sphincter‐sparing resection of rectal cancer</title><title type="short" xml:lang="en">Lymphangiogenesis is Factor for Leakage</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Weirong</givenNames><familyName>Chen</familyName><degrees>MD, PhD</degrees></personName><contactDetails><email>chen93662@163.com</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Yanchon</givenNames><familyName>Li</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Ziqun</givenNames><familyName>Liao</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Guangrong</givenNames><familyName>Lin</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Gaoyang</givenNames><familyName>Cai</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Kaihuang</givenNames><familyName>Lin</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Qinhua</givenNames><familyName>Zhan</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Caoyang</givenNames><familyName>Chen</familyName><degrees>MD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="CN" type="organization"><unparsedAffiliation>Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou, China</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">lymphangiogenesis</keyword><keyword xml:id="kwd2">rectal cancer</keyword><keyword xml:id="kwd3">anastomotic leakage</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><section xml:id="abs1-1"><title type="main">Objective</title><p>Anastomotic leakage is a major complication of rectal surgery and controversy about its risk factors still exists. The aim of present study was to identify risk factors for anastomotic leakage following sphincter‐sparing resection of rectal cancer, focusing on the role of tissular lymphatic vessel density (LVD) in tumorous margin and distal clearance margin.</p></section><section xml:id="abs1-2"><title type="main">Methods</title><p>In a 9‐year period, from September 1999 to September 2009, 750 consecutive patients who underwent anterior resection with restoration of the bowel continuity were included. Univariate and multivariate analysis were applied to identify risk facrors for anastomotic leakage.</p></section><section xml:id="abs1-3"><title type="main">Results</title><p>The rate of anastomotic leakage was 7.6% (57 of 750 patients). In a multivariate analysis, high LVD in tumorous margin [<i>P</i> = 0.0017; odds ratio (OR) = 5.93; 95% confidence interval (CI) = 2.61–8.514], high LVD in distal clearance margin (<i>P</i> = 0.0011; OR = 6.05; 95% CI = 2.72–10.108) and lower tumor location (<i>P</i> = 0.006; OR = 4.620; 95% CI = 1.76–6.97) were identified as independent factors for anastomotic leakage. A significant LVD correlation was shown by Spearman′s rank test between the tumorous and distal clearance margin (r = 0.796).</p></section><section xml:id="abs1-4"><title type="main">Conclusions</title><p>Tissular LVD in tumorous or distal clearance margin and lower tumor location are important risk factors for anastomotic leakage. J. Surg. Oncol. 2011; 104:493–498. © 2011 Wiley‐Liss, Inc.</p></section></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Active lymphangiogenesis is a major risk factor for anastomotic leakage following sphincter‐sparing resection of rectal cancer</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Lymphangiogenesis is Factor for Leakage</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Active lymphangiogenesis is a major risk factor for anastomotic leakage following sphincter‐sparing resection of rectal cancer</title></titleInfo><name type="personal"><namePart type="given">Weirong</namePart><namePart type="family">Chen</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou, China</affiliation><affiliation>Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, China. Fax: +86‐754‐88346543.===</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yanchon</namePart><namePart type="family">Li</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ziqun</namePart><namePart type="family">Liao</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Guangrong</namePart><namePart type="family">Lin</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gaoyang</namePart><namePart type="family">Cai</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kaihuang</namePart><namePart type="family">Lin</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Qinhua</namePart><namePart type="family">Zhan</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Caoyang</namePart><namePart type="family">Chen</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of General Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2011-10-01</dateIssued><dateCaptured encoding="w3cdtf">2011-01-02</dateCaptured><dateValid encoding="w3cdtf">2011-04-06</dateValid><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">2</extent><extent unit="references">44</extent><extent unit="words">4408</extent></physicalDescription><abstract>Anastomotic leakage is a major complication of rectal surgery and controversy about its risk factors still exists. The aim of present study was to identify risk factors for anastomotic leakage following sphincter‐sparing resection of rectal cancer, focusing on the role of tissular lymphatic vessel density (LVD) in tumorous margin and distal clearance margin.</abstract><abstract>In a 9‐year period, from September 1999 to September 2009, 750 consecutive patients who underwent anterior resection with restoration of the bowel continuity were included. Univariate and multivariate analysis were applied to identify risk facrors for anastomotic leakage.</abstract><abstract>The rate of anastomotic leakage was 7.6% (57 of 750 patients). In a multivariate analysis, high LVD in tumorous margin [P = 0.0017; odds ratio (OR) = 5.93; 95% confidence interval (CI) = 2.61–8.514], high LVD in distal clearance margin (P = 0.0011; OR = 6.05; 95% CI = 2.72–10.108) and lower tumor location (P = 0.006; OR = 4.620; 95% CI = 1.76–6.97) were identified as independent factors for anastomotic leakage. A significant LVD correlation was shown by Spearman′s rank test between the tumorous and distal clearance margin (r = 0.796).</abstract><abstract>Tissular LVD in tumorous or distal clearance margin and lower tumor location are important risk factors for anastomotic leakage. J. Surg. Oncol. 2011; 104:493–498. © 2011 Wiley‐Liss, Inc.</abstract><subject lang="en"><genre>keywords</genre><topic>lymphangiogenesis</topic><topic>rectal cancer</topic><topic>anastomotic leakage</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Surgical Oncology</title></titleInfo><titleInfo type="abbreviated"><title>J. Surg. Oncol.</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0022-4790</identifier><identifier type="eISSN">1096-9098</identifier><identifier type="DOI">10.1002/(ISSN)1096-9098</identifier><identifier type="PublisherID">JSO</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>104</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>493</start><end>498</end><total>6</total></extent></part></relatedItem><identifier type="istex">B30B033F2C2EE6A14A1060BFBE6733997DFCF052</identifier><identifier type="DOI">10.1002/jso.21965</identifier><identifier type="ArticleID">JSO21965</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2011 Wiley‐Liss, Inc.</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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