Assessment of respiratory function in patients with podoconiosis
Identifieur interne : 005323 ( Istex/Corpus ); précédent : 005322; suivant : 005324Assessment of respiratory function in patients with podoconiosis
Auteurs : Chiara Morrison ; Gail DaveySource :
- Transactions of The Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ] ; 2009-03.
English descriptors
Abstract
The respiratory effects of silicate particles have never been studied in patients with podoconiosis (a lower limb silicosis). We assessed whether lung function in patients differed from that of controls in the same silica-exposed environment. We assessed lung function using portable turbine spirometers on 110 adult patients with podoconiosis and 110 controls, and compared mean percentage predicted forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) between these groups. Percentage predicted FEV1 and FVC were low in both groups, but the difference between groups was not statistically significant (FEV1 82.24 vs. 85.32, P = 0.187; FVC 70.93 vs. 73.59, P = 0.197). The mean FEV1 of both groups was significantly lower than that of Ethiopian adults living on low-silica soil.
Url:
DOI: 10.1016/j.trstmh.2008.10.021
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ISTEX:B14685499C6B3CDCC8E236AC32DC7FFFEEA04265Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Assessment of respiratory function in patients with podoconiosis</title><author><name sortKey="Morrison, Chiara" sort="Morrison, Chiara" uniqKey="Morrison C" first="Chiara" last="Morrison">Chiara Morrison</name><affiliation><mods:affiliation>St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK</mods:affiliation></affiliation></author><author><name sortKey="Davey, Gail" sort="Davey, Gail" uniqKey="Davey G" first="Gail" last="Davey">Gail Davey</name><affiliation><mods:affiliation>School of Public Health, Addis Ababa University, P.O. Box 26905/1000, Addis Ababa, Ethiopia</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: nerurkar@ethionet.et, gailinaddis@hotmail.com</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B14685499C6B3CDCC8E236AC32DC7FFFEEA04265</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1016/j.trstmh.2008.10.021</idno><idno type="url">https://api.istex.fr/document/B14685499C6B3CDCC8E236AC32DC7FFFEEA04265/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">005323</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">005323</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Assessment of respiratory function in patients with podoconiosis</title><author><name sortKey="Morrison, Chiara" sort="Morrison, Chiara" uniqKey="Morrison C" first="Chiara" last="Morrison">Chiara Morrison</name><affiliation><mods:affiliation>St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK</mods:affiliation></affiliation></author><author><name sortKey="Davey, Gail" sort="Davey, Gail" uniqKey="Davey G" first="Gail" last="Davey">Gail Davey</name><affiliation><mods:affiliation>School of Public Health, Addis Ababa University, P.O. Box 26905/1000, Addis Ababa, Ethiopia</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: nerurkar@ethionet.et, gailinaddis@hotmail.com</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Transactions of The Royal Society of Tropical Medicine and Hygiene</title><title level="j" type="abbrev">Trans R Soc Trop Med Hyg</title><idno type="ISSN">0035-9203</idno><idno type="eISSN">1878-3503</idno><imprint><publisher>Royal Society of Tropical Medicine and Hygiene</publisher><date type="published" when="2009-03">2009-03</date><biblScope unit="volume">103</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="315">315</biblScope><biblScope unit="page" to="317">317</biblScope></imprint><idno type="ISSN">0035-9203</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0035-9203</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Elephantiasis</term><term>Ethiopia</term><term>Lymphoedema</term><term>Podoconiosis</term><term>Respiratory function tests</term><term>Silicosis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">The respiratory effects of silicate particles have never been studied in patients with podoconiosis (a lower limb silicosis). We assessed whether lung function in patients differed from that of controls in the same silica-exposed environment. We assessed lung function using portable turbine spirometers on 110 adult patients with podoconiosis and 110 controls, and compared mean percentage predicted forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) between these groups. Percentage predicted FEV1 and FVC were low in both groups, but the difference between groups was not statistically significant (FEV1 82.24 vs. 85.32, P = 0.187; FVC 70.93 vs. 73.59, P = 0.197). The mean FEV1 of both groups was significantly lower than that of Ethiopian adults living on low-silica soil.</div></front></TEI><istex><corpusName>oup</corpusName><author><json:item><name>Chiara Morrison</name><affiliations><json:string>St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK</json:string></affiliations></json:item><json:item><name>Gail Davey</name><affiliations><json:string>School of Public Health, Addis Ababa University, P.O. Box 26905/1000, Addis Ababa, Ethiopia</json:string><json:string>E-mail: nerurkar@ethionet.et, gailinaddis@hotmail.com</json:string></affiliations></json:item></author><subject><json:item><value>Elephantiasis</value></json:item><json:item><value>Lymphoedema</value></json:item><json:item><value>Podoconiosis</value></json:item><json:item><value>Respiratory function tests</value></json:item><json:item><value>Silicosis</value></json:item><json:item><value>Ethiopia</value></json:item></subject><language><json:string>unknown</json:string></language><originalGenre><json:string>rapid-communication</json:string></originalGenre><abstract>The respiratory effects of silicate particles have never been studied in patients with podoconiosis (a lower limb silicosis). We assessed whether lung function in patients differed from that of controls in the same silica-exposed environment. We assessed lung function using portable turbine spirometers on 110 adult patients with podoconiosis and 110 controls, and compared mean percentage predicted forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) between these groups. Percentage predicted FEV1 and FVC were low in both groups, but the difference between groups was not statistically significant (FEV1 82.24 vs. 85.32, P = 0.187; FVC 70.93 vs. 73.59, P = 0.197). The mean FEV1 of both groups was significantly lower than that of Ethiopian adults living on low-silica soil.</abstract><qualityIndicators><score>4.742</score><pdfWordCount>1314</pdfWordCount><pdfCharCount>8448</pdfCharCount><pdfVersion>1.4</pdfVersion><pdfPageCount>3</pdfPageCount><pdfPageSize>595.3 x 793.8 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>119</abstractWordCount><abstractCharCount>803</abstractCharCount><keywordCount>6</keywordCount></qualityIndicators><title>Assessment of respiratory function in patients with podoconiosis</title><genre><json:string>brief-communication</json:string></genre><host><title>Transactions of The Royal Society of Tropical Medicine and Hygiene</title><language><json:string>unknown</json:string></language><issn><json:string>0035-9203</json:string></issn><eissn><json:string>1878-3503</json:string></eissn><publisherId><json:string>trstmh</json:string></publisherId><volume>103</volume><issue>3</issue><pages><first>315</first><last>317</last></pages><genre><json:string>journal</json:string></genre></host><categories><wos><json:string>social science</json:string><json:string>public, environmental & occupational health</json:string><json:string>science</json:string><json:string>tropical medicine</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>tropical medicine</json:string></scienceMetrix></categories><publicationDate>2009</publicationDate><copyrightDate>2009</copyrightDate><doi><json:string>10.1016/j.trstmh.2008.10.021</json:string></doi><id>B14685499C6B3CDCC8E236AC32DC7FFFEEA04265</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/B14685499C6B3CDCC8E236AC32DC7FFFEEA04265/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/B14685499C6B3CDCC8E236AC32DC7FFFEEA04265/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/B14685499C6B3CDCC8E236AC32DC7FFFEEA04265/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Assessment of respiratory function in patients with podoconiosis</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Royal Society of Tropical Medicine and Hygiene</publisher><availability><p>OUP</p></availability><date>2009</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Assessment of respiratory function in patients with podoconiosis</title><author xml:id="author-0000"><persName><forename type="first">Chiara</forename><surname>Morrison</surname></persName><affiliation>St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK</affiliation></author><author xml:id="author-0001" corresp="yes"><persName><forename type="first">Gail</forename><surname>Davey</surname></persName><email>nerurkar@ethionet.et, gailinaddis@hotmail.com</email><affiliation>School of Public Health, Addis Ababa University, P.O. Box 26905/1000, Addis Ababa, Ethiopia</affiliation></author><idno type="istex">B14685499C6B3CDCC8E236AC32DC7FFFEEA04265</idno><idno type="DOI">10.1016/j.trstmh.2008.10.021</idno></analytic><monogr><title level="j">Transactions of The Royal Society of Tropical Medicine and Hygiene</title><title level="j" type="abbrev">Trans R Soc Trop Med Hyg</title><idno type="pISSN">0035-9203</idno><idno type="eISSN">1878-3503</idno><idno type="PublisherID">trstmh</idno><idno type="PublisherID-hwp">trstmh</idno><imprint><publisher>Royal Society of Tropical Medicine and Hygiene</publisher><date type="published" when="2009-03"></date><biblScope unit="volume">103</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="315">315</biblScope><biblScope unit="page" to="317">317</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2009</date></creation><abstract><p>The respiratory effects of silicate particles have never been studied in patients with podoconiosis (a lower limb silicosis). We assessed whether lung function in patients differed from that of controls in the same silica-exposed environment. We assessed lung function using portable turbine spirometers on 110 adult patients with podoconiosis and 110 controls, and compared mean percentage predicted forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) between these groups. Percentage predicted FEV1 and FVC were low in both groups, but the difference between groups was not statistically significant (FEV1 82.24 vs. 85.32, P = 0.187; FVC 70.93 vs. 73.59, P = 0.197). The mean FEV1 of both groups was significantly lower than that of Ethiopian adults living on low-silica soil.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Elephantiasis</term></item><item><term>Lymphoedema</term></item><item><term>Podoconiosis</term></item><item><term>Respiratory function tests</term></item><item><term>Silicosis</term></item><item><term>Ethiopia</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2009-03">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/B14685499C6B3CDCC8E236AC32DC7FFFEEA04265/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus oup, element #text not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="rapid-communication">
<front>
<journal-meta>
<journal-id journal-id-type="hwp">trstmh</journal-id>
<journal-id journal-id-type="publisher-id">trstmh</journal-id>
<journal-title>Transactions of The Royal Society of Tropical Medicine and Hygiene</journal-title>
<abbrev-journal-title>Trans R Soc Trop Med Hyg</abbrev-journal-title>
<issn pub-type="ppub">0035-9203</issn>
<issn pub-type="epub">1878-3503</issn>
<publisher>
<publisher-name>Royal Society of Tropical Medicine and Hygiene</publisher-name>
</publisher>
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<article-meta>
<article-id pub-id-type="doi">10.1016/j.trstmh.2008.10.021</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Short Communication</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Assessment of respiratory function in patients with podoconiosis</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name><surname>Morrison</surname><given-names>Chiara</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref>
</contrib>
<contrib contrib-type="author" corresp="yes">
<name><surname>Davey</surname><given-names>Gail</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref><xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
<aff id="aff1">
<label>a</label>St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK</aff>
<aff id="aff2">
<label>b</label>School of Public Health, Addis Ababa University, P.O. Box 26905/1000, Addis Ababa, Ethiopia</aff>
</contrib-group>
<author-notes>
<corresp id="cor1">
<label>*</label>Corresponding author. Tel.: +251 911 388835; fax: +251 116 627876. <italic>E-mail addresses:</italic> <email>nerurkar@ethionet.et, gailinaddis@hotmail.com</email> (G. Davey).</corresp>
</author-notes>
<pub-date pub-type="ppub">
<month>3</month>
<year>2009</year>
</pub-date>
<volume>103</volume>
<issue>3</issue>
<fpage>315</fpage>
<lpage>317</lpage>
<history>
<date date-type="received">
<day>9</day>
<month>9</month>
<year>2008</year></date>
<date date-type="rev-recd">
<day>17</day>
<month>10</month>
<year>2008</year></date>
<date date-type="accepted">
<day>17</day>
<month>10</month>
<year>2008</year></date>
</history>
<permissions>
<copyright-year>2008</copyright-year>
<copyright-holder>Royal Society of Tropical Medicine and Hygiene</copyright-holder>
</permissions>
<abstract>
<title>Summary</title>
<p>The respiratory effects of silicate particles have never been studied in patients with podoconiosis (a lower limb silicosis). We assessed whether lung function in patients differed from that of controls in the same silica-exposed environment. We assessed lung function using portable turbine spirometers on 110 adult patients with podoconiosis and 110 controls, and compared mean percentage predicted forced expiratory volume in 1 second (FEV<sub>1</sub>) and forced vital capacity (FVC) between these groups. Percentage predicted FEV<sub>1</sub> and FVC were low in both groups, but the difference between groups was not statistically significant (FEV<sub>1</sub> 82.24 vs. 85.32, <italic>P</italic> = 0.187; FVC 70.93 vs. 73.59, <italic>P</italic> = 0.197). The mean FEV<sub>1</sub> of both groups was significantly lower than that of Ethiopian adults living on low-silica soil.</p>
</abstract>
<kwd-group xml:lang="en">
<title>Keywords</title>
<kwd>Elephantiasis</kwd>
<kwd>Lymphoedema</kwd>
<kwd>Podoconiosis</kwd>
<kwd>Respiratory function tests</kwd>
<kwd>Silicosis</kwd>
<kwd>Ethiopia</kwd>
</kwd-group>
</article-meta>
</front>
<body>
<sec sec-type="intro">
<label>1</label>
<title>Introduction</title>
<p>Podoconiosis (endemic non-filarial elephantiasis) is a geochemical disease occurring in individuals exposed to red clay soil derived from alkalic volcanic rock.<sup><xref ref-type="bibr" rid="bib1">1</xref></sup> It is a chronic and debilitating disorder that exerts a large economic burden in areas of high prevalence.<sup><xref ref-type="bibr" rid="bib2">2</xref></sup></p>
<p>Our understanding of the pathogenesis of podoconiosis dates back to the 1980s, when silicate particles were demonstrated in the skin, lymphatics and lymph nodes of both podoconiosis-affected and -unaffected individuals living and working barefoot on red clay soils.<sup><xref ref-type="bibr" rid="bib3">3</xref></sup> In the lower limbs, these silicate particles cause endolymphangitis and ultimately a disfiguring lymphoedema.<sup><xref ref-type="bibr" rid="bib4">4</xref></sup> Whereas the biological effects of silicate particles and dusts on the lungs have been studied in detail in a range of air pollution studies over the past 50 years,<sup><xref ref-type="bibr" rid="bib5">5</xref></sup> these studies have not yet been extended to patients with what is in effect a lower limb silicosis. We assessed whether lung function in patients with podoconiosis in southern Ethiopia differed from that of controls in the same silica-exposed environment.</p>
</sec>
<sec sec-type="materials|methods">
<label>2</label>
<title>Materials and methods</title>
<sec>
<label>2.1</label>
<title>Study area</title>
<p>The study was conducted in Wolaita Zone, Southern Ethiopia. The Mossy Foot Treatment and Prevention Association (a local non-governmental organization) is based in the zonal capital, Sodo, and when the study was performed, ran 14 outreach clinics at distances between 15 and 65 km from Sodo town.</p>
</sec>
<sec>
<label>2.2</label>
<title>Sample size</title>
<p>We estimated that 100 patients with confirmed podoconiosis and 100 controls would give us 90% power to identify a difference in mean height- and age-adjusted FEV<sub>1</sub> of 15% between patients and controls, assuming mean forced expiratory volume in 1 second (FEV<sub>1</sub>) of 2.58 and SD of 0.83 (unpublished data from study in comparable adult Ethiopian population).</p>
</sec>
<sec>
<label>2.3</label>
<title>Study subjects</title>
<p>We randomly selected five study sites, and recruited consecutive adult patients, up to one-quarter of the sample size at each site. Controls were selected from the same community and had no signs or symptoms of podoconiosis. Patients or controls with known respiratory conditions were excluded, as were those in late pregnancy.</p>
</sec>
<sec>
<label>2.4</label>
<title>Data collection</title>
<p>Information on age and sex was recorded, and patients were given a demonstration on how to use a spirometer. MicroMedical portable turbine spirometers were used to make three measurements each of FEV<sub>1</sub> and forced vital capacity (FVC) on each individual, and the best of these was recorded. Turbine spirometers are not affected by changes in altitude and have proven feasible to use with Ethiopians unfamiliar with medical technology. Height was measured using a measuring tape fixed to a vertical surface, and the average of two readings was recorded. Percentage of FEV<sub>1</sub> and FVC predicted for given sex, height and age were calculated using the converter supplied by the manufacturers.</p>
</sec>
<sec>
<label>2.5</label>
<title>Statistical analysis</title>
<p>Data were entered, cleaned and analysed using SPSS version 14 (SPSS Inc., Chicago, IL, USA). Cross-tabulations of sex, age and height were made by patient status, and χ<sup>2</sup> tests performed to check for significant differences between patient and control groups. Having checked distributions of mean percentage predicted FEV<sub>1</sub> and FVC by group for normality and similar variance, the two-sample <italic>t</italic> test was used to compare patients and controls.</p>
</sec>
</sec>
<sec sec-type="results|discussion">
<label>3</label>
<title>Results and discussion</title>
<p>In total, 220 individuals (110 patients, 110 controls) were assessed in July 2008. Participants' characteristics are summarized by patient/control status in <xref ref-type="fig" rid="tbl1">Table 1</xref>
<fig id="tbl1">
<label>Table 1</label>
<caption>
<p>Study participant characteristics.</p>
</caption>
<graphic mimetype="image" xlink:href="103-3-315-tbl001.tif"></graphic>
</fig>. Controls were significantly younger than patients, but sex and height did not vary significantly by patient status. Mean (SD) percentage predicted FEV<sub>1</sub> for sex, height and age were 82.24 (16.85) and 85.32 (17.66) among patients and controls, respectively (<italic>P</italic> = 0.187), whereas the figures for FVC were 70.93 (15.06) and 73.59 (15.47), respectively (<italic>P</italic> = 0.197). Mean FEV/FVC ratio was 0.97, suggesting a restrictive respiratory defect rather than an obstructive one.</p>
<p>We found no statistical evidence that age-, sex- and height-adjusted lung function differed in podoconiosis patients and controls living in the same environment. We subsequently compared FEV<sub>1</sub> figures with those of adults living in another area of southern Ethiopia (Butajira) in which the soil is not of the irritant red clay type, and found that both patients and controls in Wolaita had lower percentage predicted FEV<sub>1</sub> than did adults in Butajira (mean percentage predicted FEV<sub>1</sub> 90.5%, 95% CI 88.5–92.5, unpublished data). This difference is unlikely to be due to chance (the 95% CIs do not overlap), differences in technique (both populations were equally unfamiliar with the spirometer) or differences in reporting of age (there is no obvious reason why people in Wolaita should underestimate their age more than people in Butajira). If the finding is real, it may relate to one of a number of environmental explanations that we did not measure: for example, nutrition or indoor air pollution. In both populations, food is typically cooked inside the main living house, which is windowless and thatched, so differences in indoor smoke exposure are unlikely to explain our findings. It is thus possible that the reduced lung function reported here is related to long-term exposure of the lungs to silicate particles.</p>
<p>In conclusion, adult podoconiosis patients and controls living in an area of silica-rich soil have reduced lung function compared with adults living in similar circumstances in an area of low silica exposure. Further studies are required to establish the exact nature of these irritant soil particles and their effects on human respiratory and lymphatic tissues.</p>
</sec>
<sec>
<title>Funding</title>
<p>This project was funded through a Wellcome Trust Medical Student Elective Award.</p>
</sec>
<sec>
<title>Conflicts of interest</title>
<p>None declared.</p>
</sec>
<sec>
<title>Ethical approval</title>
<p>Ethical approval for the study was granted by the Addis Ababa University School of Public Health Research and Publications Committee, Addis Ababa, Ethiopia.</p>
</sec>
<sec>
<title>Authors' contributions</title>
<p>GD had the idea for the study, and designed it with CM; CM conducted the fieldwork and entered the data; GD and CM performed the analyses; GD wrote the first draft of the paper, which was reviewed by CM. Both authors read and approved the final manuscript. GD is guarantor of the paper.</p>
</sec>
</body>
<back>
<ack>
<title>Acknowledgements</title>
<p>We thank Emily Burridge, Meskele Ashine, Zewdie Zeleke and Mabrat Borku for assistance during fieldwork, and all participants for being willing to take part in this research.</p>
</ack>
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</article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Assessment of respiratory function in patients with podoconiosis</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Assessment of respiratory function in patients with podoconiosis</title></titleInfo><name type="personal"><namePart type="given">Chiara</namePart><namePart type="family">Morrison</namePart><affiliation>St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal" displayLabel="corresp"><namePart type="given">Gail</namePart><namePart type="family">Davey</namePart><affiliation>School of Public Health, Addis Ababa University, P.O. Box 26905/1000, Addis Ababa, Ethiopia</affiliation><affiliation>E-mail: nerurkar@ethionet.et, gailinaddis@hotmail.com</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="brief-communication" displayLabel="rapid-communication"></genre><originInfo><publisher>Royal Society of Tropical Medicine and Hygiene</publisher><dateIssued encoding="w3cdtf">2009-03</dateIssued><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>The respiratory effects of silicate particles have never been studied in patients with podoconiosis (a lower limb silicosis). We assessed whether lung function in patients differed from that of controls in the same silica-exposed environment. We assessed lung function using portable turbine spirometers on 110 adult patients with podoconiosis and 110 controls, and compared mean percentage predicted forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) between these groups. Percentage predicted FEV1 and FVC were low in both groups, but the difference between groups was not statistically significant (FEV1 82.24 vs. 85.32, P = 0.187; FVC 70.93 vs. 73.59, P = 0.197). The mean FEV1 of both groups was significantly lower than that of Ethiopian adults living on low-silica soil.</abstract><subject lang="en"><genre>Keywords</genre><topic>Elephantiasis</topic><topic>Lymphoedema</topic><topic>Podoconiosis</topic><topic>Respiratory function tests</topic><topic>Silicosis</topic><topic>Ethiopia</topic></subject><relatedItem type="host"><titleInfo><title>Transactions of The Royal Society of Tropical Medicine and Hygiene</title></titleInfo><titleInfo type="abbreviated"><title>Trans R Soc Trop Med Hyg</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0035-9203</identifier><identifier type="eISSN">1878-3503</identifier><identifier type="PublisherID">trstmh</identifier><identifier type="PublisherID-hwp">trstmh</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>103</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>315</start><end>317</end></extent></part></relatedItem><identifier type="istex">B14685499C6B3CDCC8E236AC32DC7FFFEEA04265</identifier><identifier type="DOI">10.1016/j.trstmh.2008.10.021</identifier><recordInfo><recordContentSource>OUP</recordContentSource><recordOrigin>Royal Society of Tropical Medicine and Hygiene</recordOrigin></recordInfo></mods></metadata><covers><json:item><extension>tiff</extension><original>true</original><mimetype>image/tiff</mimetype><uri>https://api.istex.fr/document/B14685499C6B3CDCC8E236AC32DC7FFFEEA04265/covers/tiff</uri></json:item></covers><annexes><json:item><extension>jpeg</extension><original>true</original><mimetype>image/jpeg</mimetype><uri>https://api.istex.fr/document/B14685499C6B3CDCC8E236AC32DC7FFFEEA04265/annexes/jpeg</uri></json:item><json:item><extension>gif</extension><original>true</original><mimetype>image/gif</mimetype><uri>https://api.istex.fr/document/B14685499C6B3CDCC8E236AC32DC7FFFEEA04265/annexes/gif</uri></json:item></annexes><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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