Iontophoretic delivery of drugs: Fundamentals, developments and biomedical applications
Identifieur interne : 005216 ( Istex/Corpus ); précédent : 005215; suivant : 005217Iontophoretic delivery of drugs: Fundamentals, developments and biomedical applications
Auteurs : Ajay K. Banga ; Yie W. ChienSource :
- Journal of Controlled Release [ 0168-3659 ] ; 1988.
Abstract
Iontophoretic drug delivery implies the delivery of ionic (charged) drugs into the body by the use of electric current. The technique is not new and has been used clinically in delivering medication to surface tissues for several decades. However, its potential is recently being rediscovered for transdermal systemic delivery of ionic drugs including peptide/protein drugs which are normally difficult to administer except by parenteral route. The technique has been observed to enhance the transdermal permeation of ionic drugs severalfold, and this can expand the horizon of transdermal controlled drug delivery for systemic medication. However, miniaturization of iontophoretic devices and electrodes and prevention of any possibility of skin burns are required to make this technique useful for biomedical applications. While the literature on iontophoretic systemic drug delivery is relatively recent and not extensive, the published results on clinical usage and other related aspects can be quite informative and could stimulate and assist the readers to explore other biomedical applications. This article is intended to review old as well as very recent literature on the technique, methodology, clinical findings, influencing factors, relevant electronics and other related aspects of iontophoretic drug delivery, and to provide the readers a comprehensive overview of the state-of-art of this potential new area of biomedical research.
Url:
DOI: 10.1016/0168-3659(88)90075-2
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Box 789, Piscataway, NJ 08855-0789 U.S.A.</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Yie W.</forename><surname>Chien</surname></persName><affiliation>To whom correspondence should be addressed.</affiliation><affiliation>Controlled Drug-Delivery Research Center, College of Pharmacy, Rutgers—The State University of New Jersey, P.O. Box 789, Piscataway, NJ 08855-0789 U.S.A.</affiliation></author><idno type="istex">AEFF47B9965D33DBB16CB856A4AC4FA98EC60866</idno><idno type="DOI">10.1016/0168-3659(88)90075-2</idno><idno type="PII">0168-3659(88)90075-2</idno></analytic><monogr><title level="j">Journal of Controlled Release</title><title level="j" type="abbrev">COREL</title><idno type="pISSN">0168-3659</idno><idno type="PII">S0168-3659(00)X0121-6</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1988"></date><biblScope unit="volume">7</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="1">1</biblScope><biblScope unit="page" to="24">24</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1988</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Iontophoretic drug delivery implies the delivery of ionic (charged) drugs into the body by the use of electric current. The technique is not new and has been used clinically in delivering medication to surface tissues for several decades. However, its potential is recently being rediscovered for transdermal systemic delivery of ionic drugs including peptide/protein drugs which are normally difficult to administer except by parenteral route. The technique has been observed to enhance the transdermal permeation of ionic drugs severalfold, and this can expand the horizon of transdermal controlled drug delivery for systemic medication. However, miniaturization of iontophoretic devices and electrodes and prevention of any possibility of skin burns are required to make this technique useful for biomedical applications. While the literature on iontophoretic systemic drug delivery is relatively recent and not extensive, the published results on clinical usage and other related aspects can be quite informative and could stimulate and assist the readers to explore other biomedical applications. This article is intended to review old as well as very recent literature on the technique, methodology, clinical findings, influencing factors, relevant electronics and other related aspects of iontophoretic drug delivery, and to provide the readers a comprehensive overview of the state-of-art of this potential new area of biomedical research.</p></abstract></profileDesc><revisionDesc><change when="1988">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/AEFF47B9965D33DBB16CB856A4AC4FA98EC60866/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="rev"><item-info><jid>COREL</jid><aid>88900752</aid><ce:pii>0168-3659(88)90075-2</ce:pii><ce:doi>10.1016/0168-3659(88)90075-2</ce:doi><ce:copyright type="unknown" year="1988"></ce:copyright></item-info><head><ce:dochead><ce:textfn>Review</ce:textfn></ce:dochead><ce:title>Iontophoretic delivery of drugs: Fundamentals, developments and biomedical applications</ce:title><ce:author-group><ce:author><ce:given-name>Ajay K.</ce:given-name><ce:surname>Banga</ce:surname></ce:author><ce:author><ce:given-name>Yie W.</ce:given-name><ce:surname>Chien</ce:surname><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref></ce:author><ce:affiliation><ce:textfn>Controlled Drug-Delivery Research Center, College of Pharmacy, Rutgers—The State University of New Jersey, P.O. Box 789, Piscataway, NJ 08855-0789 U.S.A.</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>To whom correspondence should be addressed.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="24" month="8" year="1987"></ce:date-received><ce:date-accepted day="13" month="11" year="1987"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Iontophoretic drug delivery implies the delivery of ionic (charged) drugs into the body by the use of electric current. The technique is not new and has been used clinically in delivering medication to surface tissues for several decades. However, its potential is recently being rediscovered for transdermal systemic delivery of ionic drugs including peptide/protein drugs which are normally difficult to administer except by parenteral route. The technique has been observed to enhance the transdermal permeation of ionic drugs severalfold, and this can expand the horizon of transdermal controlled drug delivery for systemic medication. However, miniaturization of iontophoretic devices and electrodes and prevention of any possibility of skin burns are required to make this technique useful for biomedical applications. While the literature on iontophoretic systemic drug delivery is relatively recent and not extensive, the published results on clinical usage and other related aspects can be quite informative and could stimulate and assist the readers to explore other biomedical applications. 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Box 789, Piscataway, NJ 08855-0789 U.S.A.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yie W.</namePart><namePart type="family">Chien</namePart><affiliation>Controlled Drug-Delivery Research Center, College of Pharmacy, Rutgers—The State University of New Jersey, P.O. Box 789, Piscataway, NJ 08855-0789 U.S.A.</affiliation><description>To whom correspondence should be addressed.</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="Review article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1988</dateIssued><copyrightDate encoding="w3cdtf">1988</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Iontophoretic drug delivery implies the delivery of ionic (charged) drugs into the body by the use of electric current. The technique is not new and has been used clinically in delivering medication to surface tissues for several decades. However, its potential is recently being rediscovered for transdermal systemic delivery of ionic drugs including peptide/protein drugs which are normally difficult to administer except by parenteral route. The technique has been observed to enhance the transdermal permeation of ionic drugs severalfold, and this can expand the horizon of transdermal controlled drug delivery for systemic medication. However, miniaturization of iontophoretic devices and electrodes and prevention of any possibility of skin burns are required to make this technique useful for biomedical applications. While the literature on iontophoretic systemic drug delivery is relatively recent and not extensive, the published results on clinical usage and other related aspects can be quite informative and could stimulate and assist the readers to explore other biomedical applications. This article is intended to review old as well as very recent literature on the technique, methodology, clinical findings, influencing factors, relevant electronics and other related aspects of iontophoretic drug delivery, and to provide the readers a comprehensive overview of the state-of-art of this potential new area of biomedical research.</abstract><note type="content">Section title: Review</note><relatedItem type="host"><titleInfo><title>Journal of Controlled Release</title></titleInfo><titleInfo type="abbreviated"><title>COREL</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">198804</dateIssued></originInfo><identifier type="ISSN">0168-3659</identifier><identifier type="PII">S0168-3659(00)X0121-6</identifier><part><date>198804</date><detail type="volume"><number>7</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue pages"><start>1</start><end>100</end></extent><extent unit="pages"><start>1</start><end>24</end></extent></part></relatedItem><identifier type="istex">AEFF47B9965D33DBB16CB856A4AC4FA98EC60866</identifier><identifier type="DOI">10.1016/0168-3659(88)90075-2</identifier><identifier type="PII">0168-3659(88)90075-2</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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