Humoral immune response during filarial fever in Bancroftian filariasis
Identifieur interne : 005050 ( Istex/Corpus ); précédent : 005049; suivant : 005051Humoral immune response during filarial fever in Bancroftian filariasis
Auteurs : S. K. Kar ; J. Mania ; P. K. KarSource :
- Transactions of the Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ] ; 1993.
Abstract
Humoral immune responses against filarial parasitic infection were studied in 62 cases of acute filarial disease presenting with filarial fever with adenolymphangitis, in a community where Bancroftian filariasis was endemic, during and about one month before and after the febrile episode. Their total leucocyte and differential peripheral blood cell counts and anti-streptolysin O titre were determined and compared. Polymorphonuclear cellular responses and anti-streptolysin O titre did not show any significant alteration during and after fever. Three of 53 previously amicrofilaraemic subjects (9 of whom were initially microfilaraemic) had microfilaria in their circulation during fever, with a significant increase in their geometric mean microfilaria count. Titres of specific immunoglobulin (Ig) G and IgG4 antibody to Wuchereria bancrofti microfilarial excretory/secretory antigens (measured by enzyme-linked immunosorbent assay) decreased significantly during the fever and the lower levels were maintained one month after fever. The mean circulating immune complex level increased significantly during fever, and a significant percentage of cases demonstrated circulating filarial antigen during fever, which declined after one month, suggesting the release of filarial antigen into the circulation during fever which bound to antibodies to form immune complexes. These observations do not support the suggestion that bacterial infection is the aetiology of filarial fever. It is postulated that antigens released from parasites into the circulation during parturition by adult worms may evoke an allergic response in the host, causing periodic febrile episodes.
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DOI: 10.1016/0035-9203(93)90505-K
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Chandrasekharpur, Nandan Kanan Road, Bhubaneswar-751 016, Orissa, India</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Transactions of the Royal Society of Tropical Medicine and Hygiene</title><title level="j" type="abbrev">TRSTMH</title><idno type="ISSN">0035-9203</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1993">1993</date><biblScope unit="volume">87</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="230">230</biblScope><biblScope unit="page" to="233">233</biblScope></imprint><idno type="ISSN">0035-9203</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0035-9203</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Humoral immune responses against filarial parasitic infection were studied in 62 cases of acute filarial disease presenting with filarial fever with adenolymphangitis, in a community where Bancroftian filariasis was endemic, during and about one month before and after the febrile episode. Their total leucocyte and differential peripheral blood cell counts and anti-streptolysin O titre were determined and compared. Polymorphonuclear cellular responses and anti-streptolysin O titre did not show any significant alteration during and after fever. Three of 53 previously amicrofilaraemic subjects (9 of whom were initially microfilaraemic) had microfilaria in their circulation during fever, with a significant increase in their geometric mean microfilaria count. Titres of specific immunoglobulin (Ig) G and IgG4 antibody to Wuchereria bancrofti microfilarial excretory/secretory antigens (measured by enzyme-linked immunosorbent assay) decreased significantly during the fever and the lower levels were maintained one month after fever. The mean circulating immune complex level increased significantly during fever, and a significant percentage of cases demonstrated circulating filarial antigen during fever, which declined after one month, suggesting the release of filarial antigen into the circulation during fever which bound to antibodies to form immune complexes. These observations do not support the suggestion that bacterial infection is the aetiology of filarial fever. It is postulated that antigens released from parasites into the circulation during parturition by adult worms may evoke an allergic response in the host, causing periodic febrile episodes.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>filarial</json:string><json:string>immune</json:string><json:string>igg4</json:string><json:string>filariasis</json:string><json:string>filarial fever</json:string><json:string>significant rise</json:string><json:string>filarial antigen</json:string><json:string>tropical medicine</json:string><json:string>royal society</json:string><json:string>bancroftian filariasis</json:string><json:string>immune complexes</json:string><json:string>fever episode</json:string><json:string>febrile</json:string><json:string>febrile episode</json:string><json:string>borate buffer</json:string><json:string>positive reaction</json:string><json:string>total leucocyte count</json:string><json:string>chequerboard titration</json:string><json:string>significant difference</json:string><json:string>cell control</json:string><json:string>blood samples</json:string><json:string>lilarial fever</json:string><json:string>test sera</json:string><json:string>optical density</json:string><json:string>allergic responsein</json:string><json:string>serum dilution</json:string><json:string>human sera</json:string><json:string>room temperature</json:string><json:string>bacterial infection</json:string><json:string>microfilaria count</json:string><json:string>sodium azide</json:string><json:string>febrile state</json:string><json:string>clinical division</json:string><json:string>microfilarial density</json:string><json:string>world health organization</json:string><json:string>standard errors</json:string><json:string>present study</json:string><json:string>fever episodes</json:string><json:string>immune response</json:string><json:string>lymphatic filariasis</json:string><json:string>further information</json:string><json:string>fever</json:string></teeft></keywords><author><json:item><name>S.K. 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Three of 53 previously amicrofilaraemic subjects (9 of whom were initially microfilaraemic) had microfilaria in their circulation during fever, with a significant increase in their geometric mean microfilaria count. Titres of specific immunoglobulin (Ig) G and IgG4 antibody to Wuchereria bancrofti microfilarial excretory/secretory antigens (measured by enzyme-linked immunosorbent assay) decreased significantly during the fever and the lower levels were maintained one month after fever. The mean circulating immune complex level increased significantly during fever, and a significant percentage of cases demonstrated circulating filarial antigen during fever, which declined after one month, suggesting the release of filarial antigen into the circulation during fever which bound to antibodies to form immune complexes. These observations do not support the suggestion that bacterial infection is the aetiology of filarial fever. 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Chandrasekharpur, Nandan Kanan Road, Bhubaneswar-751 016, Orissa, India</affiliation></author><idno type="istex">AB341FB02430C68AADE9C1AFAEDF83D797E3FD4D</idno><idno type="DOI">10.1016/0035-9203(93)90505-K</idno><idno type="PII">0035-9203(93)90505-K</idno></analytic><monogr><title level="j">Transactions of the Royal Society of Tropical Medicine and Hygiene</title><title level="j" type="abbrev">TRSTMH</title><idno type="pISSN">0035-9203</idno><idno type="PII">S0035-9203(00)X0117-4</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1993"></date><biblScope unit="volume">87</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="230">230</biblScope><biblScope unit="page" to="233">233</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1993</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Humoral immune responses against filarial parasitic infection were studied in 62 cases of acute filarial disease presenting with filarial fever with adenolymphangitis, in a community where Bancroftian filariasis was endemic, during and about one month before and after the febrile episode. Their total leucocyte and differential peripheral blood cell counts and anti-streptolysin O titre were determined and compared. Polymorphonuclear cellular responses and anti-streptolysin O titre did not show any significant alteration during and after fever. Three of 53 previously amicrofilaraemic subjects (9 of whom were initially microfilaraemic) had microfilaria in their circulation during fever, with a significant increase in their geometric mean microfilaria count. Titres of specific immunoglobulin (Ig) G and IgG4 antibody to Wuchereria bancrofti microfilarial excretory/secretory antigens (measured by enzyme-linked immunosorbent assay) decreased significantly during the fever and the lower levels were maintained one month after fever. The mean circulating immune complex level increased significantly during fever, and a significant percentage of cases demonstrated circulating filarial antigen during fever, which declined after one month, suggesting the release of filarial antigen into the circulation during fever which bound to antibodies to form immune complexes. These observations do not support the suggestion that bacterial infection is the aetiology of filarial fever. It is postulated that antigens released from parasites into the circulation during parturition by adult worms may evoke an allergic response in the host, causing periodic febrile episodes.</p></abstract><textClass><keywords scheme="keyword"><list><head>article-category</head><item><term>Immunobiology</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1992-06-25">Modified</change><change when="1993">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/AB341FB02430C68AADE9C1AFAEDF83D797E3FD4D/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="sco"><item-info><jid>TRSTMH</jid><aid>9390505K</aid><ce:pii>0035-9203(93)90505-K</ce:pii><ce:doi>10.1016/0035-9203(93)90505-K</ce:doi><ce:copyright type="unknown" year="1993"></ce:copyright><ce:doctopics><ce:doctopic><ce:text>Immunobiology</ce:text></ce:doctopic></ce:doctopics></item-info><head><ce:title>Humoral immune response during filarial fever in Bancroftian filariasis</ce:title><ce:author-group><ce:author><ce:given-name>S.K.</ce:given-name><ce:surname>Kar</ce:surname><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>J.</ce:given-name><ce:surname>Mania</ce:surname></ce:author><ce:author><ce:given-name>P.K.</ce:given-name><ce:surname>Kar</ce:surname></ce:author><ce:affiliation><ce:textfn>Clinical Division, Regional Medical Research Centre (ICMR), P.O. Chandrasekharpur, Nandan Kanan Road, Bhubaneswar-751 016, Orissa, India</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Author for correspondence.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="2" month="1" year="1992"></ce:date-received><ce:date-revised day="25" month="6" year="1992"></ce:date-revised><ce:date-accepted day="26" month="6" year="1992"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Humoral immune responses against filarial parasitic infection were studied in 62 cases of acute filarial disease presenting with filarial fever with adenolymphangitis, in a community where Bancroftian filariasis was endemic, during and about one month before and after the febrile episode. Their total leucocyte and differential peripheral blood cell counts and anti-streptolysin O titre were determined and compared. Polymorphonuclear cellular responses and anti-streptolysin O titre did not show any significant alteration during and after fever. Three of 53 previously amicrofilaraemic subjects (9 of whom were initially microfilaraemic) had microfilaria in their circulation during fever, with a significant increase in their geometric mean microfilaria count. Titres of specific immunoglobulin (Ig) G and IgG<ce:inf>4</ce:inf> antibody to <ce:italic>Wuchereria bancrofti</ce:italic> microfilarial excretory/secretory antigens (measured by enzyme-linked immunosorbent assay) decreased significantly during the fever and the lower levels were maintained one month after fever. The mean circulating immune complex level increased significantly during fever, and a significant percentage of cases demonstrated circulating filarial antigen during fever, which declined after one month, suggesting the release of filarial antigen into the circulation during fever which bound to antibodies to form immune complexes. These observations do not support the suggestion that bacterial infection is the aetiology of filarial fever. It is postulated that antigens released from parasites into the circulation during parturition by adult worms may evoke an allergic response in the host, causing periodic febrile episodes.</ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Humoral immune response during filarial fever in Bancroftian filariasis</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Humoral immune response during filarial fever in Bancroftian filariasis</title></titleInfo><name type="personal"><namePart type="given">S.K.</namePart><namePart type="family">Kar</namePart><affiliation>Clinical Division, Regional Medical Research Centre (ICMR), P.O. Chandrasekharpur, Nandan Kanan Road, Bhubaneswar-751 016, Orissa, India</affiliation><description>Author for correspondence.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Mania</namePart><affiliation>Clinical Division, Regional Medical Research Centre (ICMR), P.O. Chandrasekharpur, Nandan Kanan Road, Bhubaneswar-751 016, Orissa, India</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.K.</namePart><namePart type="family">Kar</namePart><affiliation>Clinical Division, Regional Medical Research Centre (ICMR), P.O. Chandrasekharpur, Nandan Kanan Road, Bhubaneswar-751 016, Orissa, India</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="brief-communication" displayLabel="Short communication"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1993</dateIssued><dateModified encoding="w3cdtf">1992-06-25</dateModified><copyrightDate encoding="w3cdtf">1993</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Humoral immune responses against filarial parasitic infection were studied in 62 cases of acute filarial disease presenting with filarial fever with adenolymphangitis, in a community where Bancroftian filariasis was endemic, during and about one month before and after the febrile episode. Their total leucocyte and differential peripheral blood cell counts and anti-streptolysin O titre were determined and compared. Polymorphonuclear cellular responses and anti-streptolysin O titre did not show any significant alteration during and after fever. Three of 53 previously amicrofilaraemic subjects (9 of whom were initially microfilaraemic) had microfilaria in their circulation during fever, with a significant increase in their geometric mean microfilaria count. Titres of specific immunoglobulin (Ig) G and IgG4 antibody to Wuchereria bancrofti microfilarial excretory/secretory antigens (measured by enzyme-linked immunosorbent assay) decreased significantly during the fever and the lower levels were maintained one month after fever. The mean circulating immune complex level increased significantly during fever, and a significant percentage of cases demonstrated circulating filarial antigen during fever, which declined after one month, suggesting the release of filarial antigen into the circulation during fever which bound to antibodies to form immune complexes. These observations do not support the suggestion that bacterial infection is the aetiology of filarial fever. It is postulated that antigens released from parasites into the circulation during parturition by adult worms may evoke an allergic response in the host, causing periodic febrile episodes.</abstract><subject><genre>article-category</genre><topic>Immunobiology</topic></subject><relatedItem type="host"><titleInfo><title>Transactions of the Royal Society of Tropical Medicine and Hygiene</title></titleInfo><titleInfo type="abbreviated"><title>TRSTMH</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">199303</dateIssued></originInfo><identifier type="ISSN">0035-9203</identifier><identifier type="PII">S0035-9203(00)X0117-4</identifier><part><date>199303</date><detail type="volume"><number>87</number><caption>vol.</caption></detail><detail type="issue"><number>2</number><caption>no.</caption></detail><extent unit="issue pages"><start>129</start><end>240</end></extent><extent unit="pages"><start>230</start><end>233</end></extent></part></relatedItem><identifier type="istex">AB341FB02430C68AADE9C1AFAEDF83D797E3FD4D</identifier><identifier type="DOI">10.1016/0035-9203(93)90505-K</identifier><identifier type="PII">0035-9203(93)90505-K</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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