Post-treatment sarcoma in breast cancer patients
Identifieur interne : 004A05 ( Istex/Corpus ); précédent : 004A04; suivant : 004A06Post-treatment sarcoma in breast cancer patients
Auteurs : Mary S. Brady ; Carol F. Garfein ; Jeanne A. Petrek ; Murray F. BrennanSource :
- Annals of Surgical Oncology [ 1068-9265 ] ; 1994-01-01.
Abstract
Abstract: Background: Many patients treated for breast cancer with radiotherapy will survive their disease and be at risk for treatment-related sarcoma for many years. Methods: In order to identify patients with post-treatment sarcoma and define this disease, we examined the records of 99 patients treated for sarcoma with a history of antecedent breast carcinoma. Of these patients, 51 were felt to have a sarcoma unrelated to breast cancer treatment and 48 were felt to have a treatment-related sarcoma (secondary to lymphedema and/or radiation). Results: Lymphangiosarcoma of the extremity was the most common histologic subtype of post-treatment sarcoma, accounting for 22 of 48 cases (46%). Twenty-six patients (54%) developed nonlymphangiosarcoma post-treatment sarcoma; all of these were radiation-associated sarcomas. The median latency interval between the diagnosis of breast cancer and the development of sarcoma was 11 years (range 4–44) and was not different between the two groups. However, patients with nonlymphangiosarcoma were significantly younger when diagnosed with breast cancer than were those with lymphangiosarcoma of the extremity (median 43 vs. 51 years, p<0.001). The survival of all 48 patients was poor: 5-year survival was 29%. Five-year survival of patients with other types of post-treatment sarcoma was just as poor as those with lymphangiosarcoma of the extremity (30% vs. 28%, p=0.98). Conclusions: Patients who develop sarcoma after treatment for breast cancer have a poor prognosis whether it occurs as Stewart-Treves syndrome or other types of post-treatment sarcoma. Younger patients may be at higher risk than are older patients for the development of nonlymphangiosarcoma post-treatment sarcoma.
Url:
DOI: 10.1007/BF02303543
Links to Exploration step
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<front><div type="abstract" xml:lang="en">Abstract: Background: Many patients treated for breast cancer with radiotherapy will survive their disease and be at risk for treatment-related sarcoma for many years. Methods: In order to identify patients with post-treatment sarcoma and define this disease, we examined the records of 99 patients treated for sarcoma with a history of antecedent breast carcinoma. Of these patients, 51 were felt to have a sarcoma unrelated to breast cancer treatment and 48 were felt to have a treatment-related sarcoma (secondary to lymphedema and/or radiation). Results: Lymphangiosarcoma of the extremity was the most common histologic subtype of post-treatment sarcoma, accounting for 22 of 48 cases (46%). Twenty-six patients (54%) developed nonlymphangiosarcoma post-treatment sarcoma; all of these were radiation-associated sarcomas. The median latency interval between the diagnosis of breast cancer and the development of sarcoma was 11 years (range 4–44) and was not different between the two groups. However, patients with nonlymphangiosarcoma were significantly younger when diagnosed with breast cancer than were those with lymphangiosarcoma of the extremity (median 43 vs. 51 years, p<0.001). The survival of all 48 patients was poor: 5-year survival was 29%. Five-year survival of patients with other types of post-treatment sarcoma was just as poor as those with lymphangiosarcoma of the extremity (30% vs. 28%, p=0.98). Conclusions: Patients who develop sarcoma after treatment for breast cancer have a poor prognosis whether it occurs as Stewart-Treves syndrome or other types of post-treatment sarcoma. Younger patients may be at higher risk than are older patients for the development of nonlymphangiosarcoma post-treatment sarcoma.</div>
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<abstract xml:lang="en"><p>Abstract: Background: Many patients treated for breast cancer with radiotherapy will survive their disease and be at risk for treatment-related sarcoma for many years. Methods: In order to identify patients with post-treatment sarcoma and define this disease, we examined the records of 99 patients treated for sarcoma with a history of antecedent breast carcinoma. Of these patients, 51 were felt to have a sarcoma unrelated to breast cancer treatment and 48 were felt to have a treatment-related sarcoma (secondary to lymphedema and/or radiation). Results: Lymphangiosarcoma of the extremity was the most common histologic subtype of post-treatment sarcoma, accounting for 22 of 48 cases (46%). Twenty-six patients (54%) developed nonlymphangiosarcoma post-treatment sarcoma; all of these were radiation-associated sarcomas. The median latency interval between the diagnosis of breast cancer and the development of sarcoma was 11 years (range 4–44) and was not different between the two groups. However, patients with nonlymphangiosarcoma were significantly younger when diagnosed with breast cancer than were those with lymphangiosarcoma of the extremity (median 43 vs. 51 years, p<0.001). The survival of all 48 patients was poor: 5-year survival was 29%. Five-year survival of patients with other types of post-treatment sarcoma was just as poor as those with lymphangiosarcoma of the extremity (30% vs. 28%, p=0.98). Conclusions: Patients who develop sarcoma after treatment for breast cancer have a poor prognosis whether it occurs as Stewart-Treves syndrome or other types of post-treatment sarcoma. Younger patients may be at higher risk than are older patients for the development of nonlymphangiosarcoma post-treatment sarcoma.</p>
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<Para><Emphasis Type="Bold">Background:</Emphasis>
Many patients treated for breast cancer with radiotherapy will survive their disease and be at risk for treatment-related sarcoma for many years.</Para>
<Para><Emphasis Type="Bold">Methods:</Emphasis>
In order to identify patients with post-treatment sarcoma and define this disease, we examined the records of 99 patients treated for sarcoma with a history of antecedent breast carcinoma. Of these patients, 51 were felt to have a sarcoma unrelated to breast cancer treatment and 48 were felt to have a treatment-related sarcoma (secondary to lymphedema and/or radiation).</Para>
<Para><Emphasis Type="Bold">Results:</Emphasis>
Lymphangiosarcoma of the extremity was the most common histologic subtype of post-treatment sarcoma, accounting for 22 of 48 cases (46%). Twenty-six patients (54%) developed nonlymphangiosarcoma post-treatment sarcoma; all of these were radiation-associated sarcomas. The median latency interval between the diagnosis of breast cancer and the development of sarcoma was 11 years (range 4–44) and was not different between the two groups. However, patients with nonlymphangiosarcoma were significantly younger when diagnosed with breast cancer than were those with lymphangiosarcoma of the extremity (median 43 vs. 51 years, p<0.001). The survival of all 48 patients was poor: 5-year survival was 29%. Five-year survival of patients with other types of post-treatment sarcoma was just as poor as those with lymphangiosarcoma of the extremity (30% vs. 28%, p=0.98).</Para>
<Para><Emphasis Type="Bold">Conclusions:</Emphasis>
Patients who develop sarcoma after treatment for breast cancer have a poor prognosis whether it occurs as Stewart-Treves syndrome or other types of post-treatment sarcoma. Younger patients may be at higher risk than are older patients for the development of nonlymphangiosarcoma post-treatment sarcoma.</Para>
</Abstract>
<KeywordGroup Language="En"><Heading>Key Words</Heading>
<Keyword>Sarcoma</Keyword>
<Keyword>Breast cancer</Keyword>
<Keyword>Radiation</Keyword>
<Keyword>Lymphangiosarcoma</Keyword>
</KeywordGroup>
<ArticleNote Type="PresentedAt"><SimplePara>Presented at the 46th Annual Cancer Symposium of the Society of Surgical Oncology, Los Angeles, March 18–21, 1993.</SimplePara>
</ArticleNote>
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<mods version="3.6"><titleInfo lang="en"><title>Post-treatment sarcoma in breast cancer patients</title>
</titleInfo>
<titleInfo type="alternative" contentType="CDATA" lang="en"><title>Post-treatment sarcoma in breast cancer patients</title>
</titleInfo>
<name type="personal" displayLabel="corresp"><namePart type="termsOfAddress">Dr.</namePart>
<namePart type="given">Mary</namePart>
<namePart type="given">S.</namePart>
<namePart type="family">Brady</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>From the Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Carol</namePart>
<namePart type="given">F.</namePart>
<namePart type="family">Garfein</namePart>
<namePart type="termsOfAddress">MBA</namePart>
<affiliation>Mt. Sinai School of Medicine, New York, New York, USA</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
<description>medical student</description>
</name>
<name type="personal"><namePart type="given">Jeanne</namePart>
<namePart type="given">A.</namePart>
<namePart type="family">Petrek</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>From the Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Murray</namePart>
<namePart type="given">F.</namePart>
<namePart type="family">Brennan</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>From the Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA</affiliation>
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<originInfo><publisher>Springer-Verlag</publisher>
<place><placeTerm type="text">New York</placeTerm>
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<dateCreated encoding="w3cdtf">1993-03-30</dateCreated>
<dateIssued encoding="w3cdtf">1994-01-01</dateIssued>
<copyrightDate encoding="w3cdtf">1994</copyrightDate>
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<abstract lang="en">Abstract: Background: Many patients treated for breast cancer with radiotherapy will survive their disease and be at risk for treatment-related sarcoma for many years. Methods: In order to identify patients with post-treatment sarcoma and define this disease, we examined the records of 99 patients treated for sarcoma with a history of antecedent breast carcinoma. Of these patients, 51 were felt to have a sarcoma unrelated to breast cancer treatment and 48 were felt to have a treatment-related sarcoma (secondary to lymphedema and/or radiation). Results: Lymphangiosarcoma of the extremity was the most common histologic subtype of post-treatment sarcoma, accounting for 22 of 48 cases (46%). Twenty-six patients (54%) developed nonlymphangiosarcoma post-treatment sarcoma; all of these were radiation-associated sarcomas. The median latency interval between the diagnosis of breast cancer and the development of sarcoma was 11 years (range 4–44) and was not different between the two groups. However, patients with nonlymphangiosarcoma were significantly younger when diagnosed with breast cancer than were those with lymphangiosarcoma of the extremity (median 43 vs. 51 years, p<0.001). The survival of all 48 patients was poor: 5-year survival was 29%. Five-year survival of patients with other types of post-treatment sarcoma was just as poor as those with lymphangiosarcoma of the extremity (30% vs. 28%, p=0.98). Conclusions: Patients who develop sarcoma after treatment for breast cancer have a poor prognosis whether it occurs as Stewart-Treves syndrome or other types of post-treatment sarcoma. Younger patients may be at higher risk than are older patients for the development of nonlymphangiosarcoma post-treatment sarcoma.</abstract>
<note>Original Articles</note>
<relatedItem type="host"><titleInfo><title>Annals of Surgical Oncology</title>
</titleInfo>
<titleInfo type="abbreviated"><title>Annals of Surgical Oncology</title>
</titleInfo>
<genre type="journal" displayLabel="Archive Journal"></genre>
<originInfo><dateIssued encoding="w3cdtf">1994-01-01</dateIssued>
<copyrightDate encoding="w3cdtf">1994</copyrightDate>
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<subject><genre>Medicine & Public Health</genre>
<topic>Surgery</topic>
<topic>Oncology</topic>
<topic>Surgical Oncology</topic>
</subject>
<identifier type="ISSN">1068-9265</identifier>
<identifier type="eISSN">1534-4681</identifier>
<identifier type="JournalID">10434</identifier>
<identifier type="IssueArticleCount">15</identifier>
<identifier type="VolumeIssueCount">6</identifier>
<part><date>1994</date>
<detail type="volume"><number>1</number>
<caption>vol.</caption>
</detail>
<detail type="issue"><number>1</number>
<caption>no.</caption>
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<extent unit="pages"><start>66</start>
<end>72</end>
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<identifier type="istex">9CFFAFC6993307B5581FFAEE00BE9D95F4CDE9E7</identifier>
<identifier type="DOI">10.1007/BF02303543</identifier>
<identifier type="ArticleID">BF02303543</identifier>
<identifier type="ArticleID">Art11</identifier>
<accessCondition type="use and reproduction" contentType="copyright">The Society of Surgical Oncology, Inc., 1994</accessCondition>
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