Brugia pahangi: Quantitative Analysis of Infection in Several Inbred Rat Strains
Identifieur interne : 004714 ( Istex/Corpus ); précédent : 004713; suivant : 004715Brugia pahangi: Quantitative Analysis of Infection in Several Inbred Rat Strains
Auteurs : R. G. Bell ; L. Adams ; S. Coleman ; D. Negrao-Correa ; T. KleiSource :
- Experimental Parasitology [ 0014-4894 ] ; 1999.
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Abstract
Bell, R. G., Adams, L., Coleman, S., Negrao-Correa, D., and Klei, T. 1999. Brugia pahangi: Quantitative analysis of infection in several inbred rat strains. Experimental Parasitology92, 120–130. We report a comprehensive study of the infectivity of Brugia pahangi in male and female rats of eight different inbred strains. A single infection of any inbred rat strain will produce rats that become microfilaremic, have occult infection, or clear the primary infection. The proportion belonging to any category is determined by the basic susceptibility level of that strain. Patency rates (blood microfilaria+) ranged from 24% (AO rats) to 73% (WKA rats). The period for which microfilaria were in the circulation was directly related to microfilarial burden, with rats carrying less than 50 mf/ml of blood patent for 11.8 weeks ± 12.2; for 50–499 mf/ml it was 37.6 ± 14.8 and for 500+ mf/ml it was 63.3 ± 34.2 weeks. Suckling rats were resistant to infection (0 patent) and weanlings were intermediate in resistance between suckling and adult rats. Female rats were highly resistant to infection. Approximately half of amicrofilaremic rats have occult infections. A high proportion of patent infections involve the testes or testicular lymphatics. In the most susceptible rat strains, more than 95% of the administered L3 or developing L4 parasites were killed within 28 days. During the course of the first 6 months, the ratio of males to females fell significantly, suggesting a shorter life span in male worms. The features of the infectivity/patency patterns in rats are compared with recognized patterns obtaining in human populations. We conclude that rats provide a valuable and underutilized model for the experimental analysis of filarial infections.
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DOI: 10.1006/expr.1999.4411
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Coleman</name><affiliation><mods:affiliation>Louisiana State University, Veterinary Microbiology and Parasitology, School of Veterinary Medicine, Baton Rouge, Louisiana, 70803, U.S.A.</mods:affiliation></affiliation></author><author><name sortKey="Negrao Correa, D" sort="Negrao Correa, D" uniqKey="Negrao Correa D" first="D." last="Negrao-Correa">D. Negrao-Correa</name><affiliation><mods:affiliation>James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York, 14853, U.S.A.</mods:affiliation></affiliation></author><author><name sortKey="Klei, T" sort="Klei, T" uniqKey="Klei T" first="T." last="Klei">T. 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Klei</name><affiliation><mods:affiliation>Louisiana State University, Veterinary Microbiology and Parasitology, School of Veterinary Medicine, Baton Rouge, Louisiana, 70803, U.S.A.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Experimental Parasitology</title><title level="j" type="abbrev">YEXPR</title><idno type="ISSN">0014-4894</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999">1999</date><biblScope unit="volume">92</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="120">120</biblScope><biblScope unit="page" to="130">130</biblScope></imprint><idno type="ISSN">0014-4894</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0014-4894</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Brugia pahangi</term><term>age resistance</term><term>age resistance.</term><term>gender</term><term>human infection</term><term>inbred strains</term><term>microfilaria mf</term><term>occult infection</term><term>patency rates</term><term>rats</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Bell, R. G., Adams, L., Coleman, S., Negrao-Correa, D., and Klei, T. 1999. Brugia pahangi: Quantitative analysis of infection in several inbred rat strains. Experimental Parasitology92, 120–130. We report a comprehensive study of the infectivity of Brugia pahangi in male and female rats of eight different inbred strains. A single infection of any inbred rat strain will produce rats that become microfilaremic, have occult infection, or clear the primary infection. The proportion belonging to any category is determined by the basic susceptibility level of that strain. Patency rates (blood microfilaria+) ranged from 24% (AO rats) to 73% (WKA rats). The period for which microfilaria were in the circulation was directly related to microfilarial burden, with rats carrying less than 50 mf/ml of blood patent for 11.8 weeks ± 12.2; for 50–499 mf/ml it was 37.6 ± 14.8 and for 500+ mf/ml it was 63.3 ± 34.2 weeks. Suckling rats were resistant to infection (0 patent) and weanlings were intermediate in resistance between suckling and adult rats. Female rats were highly resistant to infection. Approximately half of amicrofilaremic rats have occult infections. A high proportion of patent infections involve the testes or testicular lymphatics. In the most susceptible rat strains, more than 95% of the administered L3 or developing L4 parasites were killed within 28 days. During the course of the first 6 months, the ratio of males to females fell significantly, suggesting a shorter life span in male worms. The features of the infectivity/patency patterns in rats are compared with recognized patterns obtaining in human populations. 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Bell</name><affiliations><json:string>James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York, 14853, U.S.A.</json:string></affiliations></json:item><json:item><name>L. Adams</name><affiliations><json:string>James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York, 14853, U.S.A.</json:string></affiliations></json:item><json:item><name>S. Coleman</name><affiliations><json:string>Louisiana State University, Veterinary Microbiology and Parasitology, School of Veterinary Medicine, Baton Rouge, Louisiana, 70803, U.S.A.</json:string></affiliations></json:item><json:item><name>D. Negrao-Correa</name><affiliations><json:string>James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York, 14853, U.S.A.</json:string></affiliations></json:item><json:item><name>T. Klei</name><affiliations><json:string>Louisiana State University, Veterinary Microbiology and Parasitology, School of Veterinary Medicine, Baton Rouge, Louisiana, 70803, U.S.A.</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Brugia pahangi</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>rats</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>inbred strains</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>gender</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>age resistance</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>patency rates</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>occult infection</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>human infection</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>microfilaria mf</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>age resistance.</value></json:item></subject><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Bell, R. G., Adams, L., Coleman, S., Negrao-Correa, D., and Klei, T. 1999. Brugia pahangi: Quantitative analysis of infection in several inbred rat strains. Experimental Parasitology92, 120–130. We report a comprehensive study of the infectivity of Brugia pahangi in male and female rats of eight different inbred strains. A single infection of any inbred rat strain will produce rats that become microfilaremic, have occult infection, or clear the primary infection. The proportion belonging to any category is determined by the basic susceptibility level of that strain. Patency rates (blood microfilaria+) ranged from 24% (AO rats) to 73% (WKA rats). The period for which microfilaria were in the circulation was directly related to microfilarial burden, with rats carrying less than 50 mf/ml of blood patent for 11.8 weeks ± 12.2; for 50–499 mf/ml it was 37.6 ± 14.8 and for 500+ mf/ml it was 63.3 ± 34.2 weeks. Suckling rats were resistant to infection (0 patent) and weanlings were intermediate in resistance between suckling and adult rats. Female rats were highly resistant to infection. Approximately half of amicrofilaremic rats have occult infections. A high proportion of patent infections involve the testes or testicular lymphatics. In the most susceptible rat strains, more than 95% of the administered L3 or developing L4 parasites were killed within 28 days. During the course of the first 6 months, the ratio of males to females fell significantly, suggesting a shorter life span in male worms. The features of the infectivity/patency patterns in rats are compared with recognized patterns obtaining in human populations. 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Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York, 14853, U.S.A.</affiliation></author><author xml:id="author-0001"><persName><forename type="first">L.</forename><surname>Adams</surname></persName><affiliation>James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York, 14853, U.S.A.</affiliation></author><author xml:id="author-0002"><persName><forename type="first">S.</forename><surname>Coleman</surname></persName><affiliation>Louisiana State University, Veterinary Microbiology and Parasitology, School of Veterinary Medicine, Baton Rouge, Louisiana, 70803, U.S.A.</affiliation></author><author xml:id="author-0003"><persName><forename type="first">D.</forename><surname>Negrao-Correa</surname></persName><note type="biography">Present address: Departamento de Parasitologia, Instituto de Ciências Biológicas da Universidade Federal de Minas Gerais, Avenida Antonio Carlos 6627, Barrio Pampulha, Belo Horizonte, MG, C.P. 486, Brazil.</note><affiliation>Present address: Departamento de Parasitologia, Instituto de Ciências Biológicas da Universidade Federal de Minas Gerais, Avenida Antonio Carlos 6627, Barrio Pampulha, Belo Horizonte, MG, C.P. 486, Brazil.</affiliation><affiliation>James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York, 14853, U.S.A.</affiliation></author><author xml:id="author-0004"><persName><forename type="first">T.</forename><surname>Klei</surname></persName><affiliation>Louisiana State University, Veterinary Microbiology and Parasitology, School of Veterinary Medicine, Baton Rouge, Louisiana, 70803, U.S.A.</affiliation></author><idno type="istex">967E4990D908A8685634982F4AD52379F760E28D</idno><idno type="DOI">10.1006/expr.1999.4411</idno><idno type="PII">S0014-4894(99)94411-9</idno></analytic><monogr><title level="j">Experimental Parasitology</title><title level="j" type="abbrev">YEXPR</title><idno type="pISSN">0014-4894</idno><idno type="PII">S0014-4894(00)X0035-5</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999"></date><biblScope unit="volume">92</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="120">120</biblScope><biblScope unit="page" to="130">130</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1999</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Bell, R. G., Adams, L., Coleman, S., Negrao-Correa, D., and Klei, T. 1999. Brugia pahangi: Quantitative analysis of infection in several inbred rat strains. Experimental Parasitology92, 120–130. We report a comprehensive study of the infectivity of Brugia pahangi in male and female rats of eight different inbred strains. A single infection of any inbred rat strain will produce rats that become microfilaremic, have occult infection, or clear the primary infection. The proportion belonging to any category is determined by the basic susceptibility level of that strain. Patency rates (blood microfilaria+) ranged from 24% (AO rats) to 73% (WKA rats). The period for which microfilaria were in the circulation was directly related to microfilarial burden, with rats carrying less than 50 mf/ml of blood patent for 11.8 weeks ± 12.2; for 50–499 mf/ml it was 37.6 ± 14.8 and for 500+ mf/ml it was 63.3 ± 34.2 weeks. Suckling rats were resistant to infection (0 patent) and weanlings were intermediate in resistance between suckling and adult rats. Female rats were highly resistant to infection. Approximately half of amicrofilaremic rats have occult infections. A high proportion of patent infections involve the testes or testicular lymphatics. In the most susceptible rat strains, more than 95% of the administered L3 or developing L4 parasites were killed within 28 days. During the course of the first 6 months, the ratio of males to females fell significantly, suggesting a shorter life span in male worms. The features of the infectivity/patency patterns in rats are compared with recognized patterns obtaining in human populations. We conclude that rats provide a valuable and underutilized model for the experimental analysis of filarial infections.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Abbreviations</head><item><term>Brugia pahangi</term></item><item><term>rats</term></item><item><term>inbred strains</term></item><item><term>gender</term></item><item><term>age resistance</term></item><item><term>patency rates</term></item><item><term>occult infection</term></item><item><term>human infection</term></item><item><term>microfilaria mf</term></item><item><term>age resistance.</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1999">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/967E4990D908A8685634982F4AD52379F760E28D/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla" xml:lang="en"><item-info><jid>YEXPR</jid><aid>94411</aid><ce:pii>S0014-4894(99)94411-9</ce:pii><ce:doi>10.1006/expr.1999.4411</ce:doi><ce:copyright type="full-transfer" year="1999">Academic Press</ce:copyright></item-info><head><ce:dochead><ce:textfn>Regular Article</ce:textfn></ce:dochead><ce:title><ce:italic>Brugia pahangi:</ce:italic> Quantitative Analysis of Infection in Several Inbred Rat Strains</ce:title><ce:author-group><ce:author><ce:given-name>R.G.</ce:given-name><ce:surname>Bell</ce:surname><ce:cross-ref refid="A1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>L.</ce:given-name><ce:surname>Adams</ce:surname><ce:cross-ref refid="A1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>S.</ce:given-name><ce:surname>Coleman</ce:surname><ce:cross-ref refid="A2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>D.</ce:given-name><ce:surname>Negrao-Correa</ce:surname><ce:cross-ref refid="A1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="FN1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>T.</ce:given-name><ce:surname>Klei</ce:surname><ce:cross-ref refid="A2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="A1"><ce:label>a</ce:label><ce:textfn>James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York, 14853, U.S.A.</ce:textfn></ce:affiliation><ce:affiliation id="A2"><ce:label>b</ce:label><ce:textfn>Louisiana State University, Veterinary Microbiology and Parasitology, School of Veterinary Medicine, Baton Rouge, Louisiana, 70803, U.S.A.</ce:textfn></ce:affiliation><ce:footnote id="FN1"><ce:label>f1</ce:label><ce:note-para>Present address: Departamento de Parasitologia, Instituto de Ciências Biológicas da Universidade Federal de Minas Gerais, Avenida Antonio Carlos 6627, Barrio Pampulha, Belo Horizonte, MG, C.P. 486, Brazil.</ce:note-para></ce:footnote></ce:author-group><ce:date-received day="17" month="9" year="1998"></ce:date-received><ce:date-accepted day="15" month="3" year="1999"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Bell, R. G., Adams, L., Coleman, S., Negrao-Correa, D., and Klei, T. 1999. <ce:italic>Brugia pahangi:</ce:italic> Quantitative analysis of infection in several inbred rat strains. <ce:italic>Experimental Parasitology</ce:italic><ce:bold>92,</ce:bold> 120–130. We report a comprehensive study of the infectivity of <ce:italic>Brugia pahangi</ce:italic> in male and female rats of eight different inbred strains. A single infection of any inbred rat strain will produce rats that become microfilaremic, have occult infection, or clear the primary infection. The proportion belonging to any category is determined by the basic susceptibility level of that strain. Patency rates (blood microfilaria+) ranged from 24% (AO rats) to 73% (WKA rats). The period for which microfilaria were in the circulation was directly related to microfilarial burden, with rats carrying less than 50 mf/ml of blood patent for 11.8 weeks ± 12.2; for 50–499 mf/ml it was 37.6 ± 14.8 and for 500+ mf/ml it was 63.3 ± 34.2 weeks. Suckling rats were resistant to infection (0 patent) and weanlings were intermediate in resistance between suckling and adult rats. Female rats were highly resistant to infection. Approximately half of amicrofilaremic rats have occult infections. A high proportion of patent infections involve the testes or testicular lymphatics. In the most susceptible rat strains, more than 95% of the administered L3 or developing L4 parasites were killed within 28 days. During the course of the first 6 months, the ratio of males to females fell significantly, suggesting a shorter life span in male worms. The features of the infectivity/patency patterns in rats are compared with recognized patterns obtaining in human populations. We conclude that rats provide a valuable and underutilized model for the experimental analysis of filarial infections.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="abr"><ce:section-title>Abbreviations</ce:section-title><ce:keyword><ce:text><ce:italic>Brugia pahangi</ce:italic></ce:text></ce:keyword><ce:keyword><ce:text>rats</ce:text></ce:keyword><ce:keyword><ce:text>inbred strains</ce:text></ce:keyword><ce:keyword><ce:text>gender</ce:text></ce:keyword><ce:keyword><ce:text>age resistance</ce:text></ce:keyword><ce:keyword><ce:text>patency rates</ce:text></ce:keyword><ce:keyword><ce:text>occult infection</ce:text></ce:keyword><ce:keyword><ce:text>human infection</ce:text></ce:keyword><ce:keyword><ce:text>microfilaria mf</ce:text></ce:keyword><ce:keyword><ce:text>age resistance.</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Brugia pahangi: Quantitative Analysis of Infection in Several Inbred Rat Strains</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Quantitative Analysis of Infection in Several Inbred Rat Strains</title></titleInfo><name type="personal"><namePart type="given">R.G.</namePart><namePart type="family">Bell</namePart><affiliation>James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York, 14853, U.S.A.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Adams</namePart><affiliation>James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York, 14853, U.S.A.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Coleman</namePart><affiliation>Louisiana State University, Veterinary Microbiology and Parasitology, School of Veterinary Medicine, Baton Rouge, Louisiana, 70803, U.S.A.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Negrao-Correa</namePart><affiliation>James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York, 14853, U.S.A.</affiliation><description>Present address: Departamento de Parasitologia, Instituto de Ciências Biológicas da Universidade Federal de Minas Gerais, Avenida Antonio Carlos 6627, Barrio Pampulha, Belo Horizonte, MG, C.P. 486, Brazil.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Klei</namePart><affiliation>Louisiana State University, Veterinary Microbiology and Parasitology, School of Veterinary Medicine, Baton Rouge, Louisiana, 70803, U.S.A.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1999</dateIssued><copyrightDate encoding="w3cdtf">1999</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Bell, R. G., Adams, L., Coleman, S., Negrao-Correa, D., and Klei, T. 1999. Brugia pahangi: Quantitative analysis of infection in several inbred rat strains. Experimental Parasitology92, 120–130. We report a comprehensive study of the infectivity of Brugia pahangi in male and female rats of eight different inbred strains. A single infection of any inbred rat strain will produce rats that become microfilaremic, have occult infection, or clear the primary infection. The proportion belonging to any category is determined by the basic susceptibility level of that strain. Patency rates (blood microfilaria+) ranged from 24% (AO rats) to 73% (WKA rats). The period for which microfilaria were in the circulation was directly related to microfilarial burden, with rats carrying less than 50 mf/ml of blood patent for 11.8 weeks ± 12.2; for 50–499 mf/ml it was 37.6 ± 14.8 and for 500+ mf/ml it was 63.3 ± 34.2 weeks. Suckling rats were resistant to infection (0 patent) and weanlings were intermediate in resistance between suckling and adult rats. Female rats were highly resistant to infection. Approximately half of amicrofilaremic rats have occult infections. A high proportion of patent infections involve the testes or testicular lymphatics. In the most susceptible rat strains, more than 95% of the administered L3 or developing L4 parasites were killed within 28 days. During the course of the first 6 months, the ratio of males to females fell significantly, suggesting a shorter life span in male worms. The features of the infectivity/patency patterns in rats are compared with recognized patterns obtaining in human populations. We conclude that rats provide a valuable and underutilized model for the experimental analysis of filarial infections.</abstract><note type="content">Section title: Regular Article</note><subject lang="en"><genre>Abbreviations</genre><topic>Brugia pahangi</topic><topic>rats</topic><topic>inbred strains</topic><topic>gender</topic><topic>age resistance</topic><topic>patency rates</topic><topic>occult infection</topic><topic>human infection</topic><topic>microfilaria mf</topic><topic>age resistance.</topic></subject><relatedItem type="host"><titleInfo><title>Experimental Parasitology</title></titleInfo><titleInfo type="abbreviated"><title>YEXPR</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">199906</dateIssued></originInfo><identifier type="ISSN">0014-4894</identifier><identifier type="PII">S0014-4894(00)X0035-5</identifier><part><date>199906</date><detail type="volume"><number>92</number><caption>vol.</caption></detail><detail type="issue"><number>2</number><caption>no.</caption></detail><extent unit="issue pages"><start>87</start><end>160</end></extent><extent unit="pages"><start>120</start><end>130</end></extent></part></relatedItem><identifier type="istex">967E4990D908A8685634982F4AD52379F760E28D</identifier><identifier type="DOI">10.1006/expr.1999.4411</identifier><identifier type="PII">S0014-4894(99)94411-9</identifier><accessCondition type="use and reproduction" contentType="copyright">©1999 Academic Press</accessCondition><recordInfo><recordContentSource>ELSEVIER</recordContentSource><recordOrigin>Academic Press, ©1999</recordOrigin></recordInfo></mods></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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