Onchocercal lymphadenitis: clinicopathologic study of 34 patients
Identifieur interne : 004634 ( Istex/Corpus ); précédent : 004633; suivant : 004635Onchocercal lymphadenitis: clinicopathologic study of 34 patients
Auteurs : Dean W. Gibson ; Daniel H. ConnorSource :
- Transactions of the Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ] ; 1978.
Abstract
Clinicopathological studies on lymph nodes of 32 Africans with onchocerciasis—some complicated by hanging groin and elephantiasis of the genitalia—revealed atrophic lymphoid tissue, lymphoedema, chronic inflammation and fibrosis. We identified microfilariae of Onchocerca volvulus in nodes of 24 of 32 Africans (75%). There microfilariae were most numerous in the capsule and in the fibrous tissue of the medulla, but smaller numbers were also found within lymphoid tissue, in dilated lymphatics and in blood vessels. We believe that in Africans, antigens released from microfilariae of O. volvulus lead to the deposition of immune complex in tissues, which in turn causes inflammation and fibrosis and eventually obstructive lymphadenitis. This causes hanging groin and, possibly, also elephantiasis. A distinctive pattern of perivascular fibrosis contains “fibrinoid material” that we interpret as immune complexes involving microfilarial antigens. In contrast, nodes from two Yemenites with severe onchocercal dermatitis of the lower limbs (sowda) had hyperplastic follicles, minimal fibrosis and no microfilariae.
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DOI: 10.1016/0035-9203(78)90049-4
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Connor</name><affiliation><mods:affiliation>Department of Infectious and Parasitic Disease Pathology, Armed Forces Institute of Pathology, Washington, D.C., U.S.A.</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:9514B0116E49216240DFA14C921C593772C17DC8</idno><date when="1978" year="1978">1978</date><idno type="doi">10.1016/0035-9203(78)90049-4</idno><idno type="url">https://api.istex.fr/document/9514B0116E49216240DFA14C921C593772C17DC8/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">004634</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">004634</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Onchocercal lymphadenitis: clinicopathologic study of 34 patients</title><author><name sortKey="Gibson, Dean W" sort="Gibson, Dean W" uniqKey="Gibson D" first="Dean W." last="Gibson">Dean W. Gibson</name><affiliation><mods:affiliation>Department of Infectious and Parasitic Disease Pathology, Armed Forces Institute of Pathology, Washington, D.C., U.S.A.</mods:affiliation></affiliation></author><author><name sortKey="Connor, Daniel H" sort="Connor, Daniel H" uniqKey="Connor D" first="Daniel H." last="Connor">Daniel H. Connor</name><affiliation><mods:affiliation>Department of Infectious and Parasitic Disease Pathology, Armed Forces Institute of Pathology, Washington, D.C., U.S.A.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Transactions of the Royal Society of Tropical Medicine and Hygiene</title><title level="j" type="abbrev">TRSTMH</title><idno type="ISSN">0035-9203</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1978">1978</date><biblScope unit="volume">72</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="137">137</biblScope><biblScope unit="page" to="154">154</biblScope></imprint><idno type="ISSN">0035-9203</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0035-9203</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Clinicopathological studies on lymph nodes of 32 Africans with onchocerciasis—some complicated by hanging groin and elephantiasis of the genitalia—revealed atrophic lymphoid tissue, lymphoedema, chronic inflammation and fibrosis. We identified microfilariae of Onchocerca volvulus in nodes of 24 of 32 Africans (75%). There microfilariae were most numerous in the capsule and in the fibrous tissue of the medulla, but smaller numbers were also found within lymphoid tissue, in dilated lymphatics and in blood vessels. We believe that in Africans, antigens released from microfilariae of O. volvulus lead to the deposition of immune complex in tissues, which in turn causes inflammation and fibrosis and eventually obstructive lymphadenitis. This causes hanging groin and, possibly, also elephantiasis. A distinctive pattern of perivascular fibrosis contains “fibrinoid material” that we interpret as immune complexes involving microfilarial antigens. In contrast, nodes from two Yemenites with severe onchocercal dermatitis of the lower limbs (sowda) had hyperplastic follicles, minimal fibrosis and no microfilariae.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>node</json:string><json:string>inguinal</json:string><json:string>microfilariae</json:string><json:string>onchocercal</json:string><json:string>femoral</json:string><json:string>afip</json:string><json:string>lymphadenitis</json:string><json:string>onchocerciasis</json:string><json:string>lymph nodes</json:string><json:string>elephantiasis</json:string><json:string>lymphoid</json:string><json:string>zaire</json:string><json:string>volvulus</json:string><json:string>dermatitis</json:string><json:string>perivascular</json:string><json:string>lymphoid tissue</json:string><json:string>inguinal node</json:string><json:string>lupus</json:string><json:string>rodhain</json:string><json:string>immune</json:string><json:string>lymph</json:string><json:string>vozvuzus</json:string><json:string>erythematosus</json:string><json:string>femoral node</json:string><json:string>fibrinoid</json:string><json:string>sinusoid</json:string><json:string>nodule</json:string><json:string>axillary</json:string><json:string>sowda</json:string><json:string>subcapsular</json:string><json:string>onchocerca</json:string><json:string>tropical medicine</json:string><json:string>yemenites</json:string><json:string>onchocercal lymphadenitis</json:string><json:string>fibrous tissue</json:string><json:string>fibrotic</json:string><json:string>lymphatics</json:string><json:string>yemen</json:string><json:string>colour</json:string><json:string>colour plate</json:string><json:string>degenerating</json:string><json:string>scrotum</json:string><json:string>postauricular</json:string><json:string>fibrinoid material</json:string><json:string>germinal centres</json:string><json:string>perivascular fibrosis</json:string><json:string>systemic lupus erythematosus</json:string><json:string>immune complexes</json:string><json:string>subcapsular sinusoids</json:string><json:string>sinus histiocytosis</json:string><json:string>american journal</json:string><json:string>early stage</json:string><json:string>northern zaire</json:string><json:string>femoral nodes</json:string><json:string>central african republic</json:string><json:string>axillary node</json:string><json:string>plasma cells</json:string><json:string>femoral lymph nodes</json:string><json:string>lupus erythematosus</json:string><json:string>field studies</json:string><json:string>germinal</json:string><json:string>nigeria</json:string><json:string>intermediate stage</json:string><json:string>late stage</json:string><json:string>onchocercal dermatitis</json:string><json:string>onchocercal nodules</json:string><json:string>degenerating microfilariae</json:string><json:string>independent contributors</json:string><json:string>microfilarial antigens</json:string><json:string>scar tissue</json:string><json:string>world health organization</json:string><json:string>afip negs</json:string><json:string>patkologie exotique</json:string><json:string>onchocerca volvulus</json:string><json:string>royal society</json:string><json:string>wuchereria bancrofti</json:string><json:string>congo belge</json:string><json:string>severe onchocercal dermatitis</json:string><json:string>groin</json:string></teeft></keywords><author><json:item><name>Dean W. Gibson</name><affiliations><json:string>Department of Infectious and Parasitic Disease Pathology, Armed Forces Institute of Pathology, Washington, D.C., U.S.A.</json:string></affiliations></json:item><json:item><name>Daniel H. Connor</name><affiliations><json:string>Department of Infectious and Parasitic Disease Pathology, Armed Forces Institute of Pathology, Washington, D.C., U.S.A.</json:string></affiliations></json:item></author><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Clinicopathological studies on lymph nodes of 32 Africans with onchocerciasis—some complicated by hanging groin and elephantiasis of the genitalia—revealed atrophic lymphoid tissue, lymphoedema, chronic inflammation and fibrosis. We identified microfilariae of Onchocerca volvulus in nodes of 24 of 32 Africans (75%). There microfilariae were most numerous in the capsule and in the fibrous tissue of the medulla, but smaller numbers were also found within lymphoid tissue, in dilated lymphatics and in blood vessels. We believe that in Africans, antigens released from microfilariae of O. volvulus lead to the deposition of immune complex in tissues, which in turn causes inflammation and fibrosis and eventually obstructive lymphadenitis. This causes hanging groin and, possibly, also elephantiasis. A distinctive pattern of perivascular fibrosis contains “fibrinoid material” that we interpret as immune complexes involving microfilarial antigens. 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The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army, Department of Defence, U.S.A., WHO, or MRC.</note><note type="content">Section title: Communication</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Onchocercal lymphadenitis: clinicopathologic study of 34 patients</title><author xml:id="author-0000"><persName><forename type="first">Dean W.</forename><surname>Gibson</surname></persName><affiliation>Department of Infectious and Parasitic Disease Pathology, Armed Forces Institute of Pathology, Washington, D.C., U.S.A.</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Daniel H.</forename><surname>Connor</surname></persName><affiliation>Department of Infectious and Parasitic Disease Pathology, Armed Forces Institute of Pathology, Washington, D.C., U.S.A.</affiliation></author><idno type="istex">9514B0116E49216240DFA14C921C593772C17DC8</idno><idno type="DOI">10.1016/0035-9203(78)90049-4</idno><idno type="PII">0035-9203(78)90049-4</idno></analytic><monogr><title level="j">Transactions of the Royal Society of Tropical Medicine and Hygiene</title><title level="j" type="abbrev">TRSTMH</title><idno type="pISSN">0035-9203</idno><idno type="PII">S0035-9203(00)X0015-6</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1978"></date><biblScope unit="volume">72</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="137">137</biblScope><biblScope unit="page" to="154">154</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1978</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Clinicopathological studies on lymph nodes of 32 Africans with onchocerciasis—some complicated by hanging groin and elephantiasis of the genitalia—revealed atrophic lymphoid tissue, lymphoedema, chronic inflammation and fibrosis. We identified microfilariae of Onchocerca volvulus in nodes of 24 of 32 Africans (75%). There microfilariae were most numerous in the capsule and in the fibrous tissue of the medulla, but smaller numbers were also found within lymphoid tissue, in dilated lymphatics and in blood vessels. We believe that in Africans, antigens released from microfilariae of O. volvulus lead to the deposition of immune complex in tissues, which in turn causes inflammation and fibrosis and eventually obstructive lymphadenitis. This causes hanging groin and, possibly, also elephantiasis. A distinctive pattern of perivascular fibrosis contains “fibrinoid material” that we interpret as immune complexes involving microfilarial antigens. In contrast, nodes from two Yemenites with severe onchocercal dermatitis of the lower limbs (sowda) had hyperplastic follicles, minimal fibrosis and no microfilariae.</p></abstract></profileDesc><revisionDesc><change when="1978">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/9514B0116E49216240DFA14C921C593772C17DC8/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>TRSTMH</jid><aid>78900494</aid><ce:pii>0035-9203(78)90049-4</ce:pii><ce:doi>10.1016/0035-9203(78)90049-4</ce:doi><ce:copyright type="unknown" year="1978"></ce:copyright></item-info><head><ce:article-footnote><ce:label>☆</ce:label><ce:note-para>This work was supported in part by the World Health Organization (WHO), Geneva, and in part by the Medical Research Council (MRC), London. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army, Department of Defence, U.S.A., WHO, or MRC.</ce:note-para></ce:article-footnote><ce:dochead><ce:textfn>Communication</ce:textfn></ce:dochead><ce:title>Onchocercal lymphadenitis: clinicopathologic study of 34 patients</ce:title><ce:author-group><ce:author><ce:given-name>Dean W.</ce:given-name><ce:surname>Gibson</ce:surname></ce:author><ce:author><ce:given-name>Daniel H.</ce:given-name><ce:surname>Connor</ce:surname></ce:author><ce:affiliation><ce:textfn>Department of Infectious and Parasitic Disease Pathology, Armed Forces Institute of Pathology, Washington, D.C., U.S.A.</ce:textfn></ce:affiliation></ce:author-group><ce:date-accepted day="6" month="10" year="1977"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Clinicopathological studies on lymph nodes of 32 Africans with onchocerciasis—some complicated by hanging groin and elephantiasis of the genitalia—revealed atrophic lymphoid tissue, lymphoedema, chronic inflammation and fibrosis. We identified microfilariae of <ce:italic>Onchocerca volvulus</ce:italic> in nodes of 24 of 32 Africans (75%). There microfilariae were most numerous in the capsule and in the fibrous tissue of the medulla, but smaller numbers were also found within lymphoid tissue, in dilated lymphatics and in blood vessels. We believe that in Africans, antigens released from microfilariae of <ce:italic>O. volvulus</ce:italic> lead to the deposition of immune complex in tissues, which in turn causes inflammation and fibrosis and eventually obstructive lymphadenitis. This causes hanging groin and, possibly, also elephantiasis. A distinctive pattern of perivascular fibrosis contains “fibrinoid material” that we interpret as immune complexes involving microfilarial antigens. In contrast, nodes from two Yemenites with severe onchocercal dermatitis of the lower limbs (sowda) had hyperplastic follicles, minimal fibrosis and no microfilariae.</ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Onchocercal lymphadenitis: clinicopathologic study of 34 patients</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Onchocercal lymphadenitis: clinicopathologic study of 34 patients</title></titleInfo><name type="personal"><namePart type="given">Dean W.</namePart><namePart type="family">Gibson</namePart><affiliation>Department of Infectious and Parasitic Disease Pathology, Armed Forces Institute of Pathology, Washington, D.C., U.S.A.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Daniel H.</namePart><namePart type="family">Connor</namePart><affiliation>Department of Infectious and Parasitic Disease Pathology, Armed Forces Institute of Pathology, Washington, D.C., U.S.A.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1978</dateIssued><copyrightDate encoding="w3cdtf">1978</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Clinicopathological studies on lymph nodes of 32 Africans with onchocerciasis—some complicated by hanging groin and elephantiasis of the genitalia—revealed atrophic lymphoid tissue, lymphoedema, chronic inflammation and fibrosis. We identified microfilariae of Onchocerca volvulus in nodes of 24 of 32 Africans (75%). There microfilariae were most numerous in the capsule and in the fibrous tissue of the medulla, but smaller numbers were also found within lymphoid tissue, in dilated lymphatics and in blood vessels. We believe that in Africans, antigens released from microfilariae of O. volvulus lead to the deposition of immune complex in tissues, which in turn causes inflammation and fibrosis and eventually obstructive lymphadenitis. This causes hanging groin and, possibly, also elephantiasis. A distinctive pattern of perivascular fibrosis contains “fibrinoid material” that we interpret as immune complexes involving microfilarial antigens. In contrast, nodes from two Yemenites with severe onchocercal dermatitis of the lower limbs (sowda) had hyperplastic follicles, minimal fibrosis and no microfilariae.</abstract><note>This work was supported in part by the World Health Organization (WHO), Geneva, and in part by the Medical Research Council (MRC), London. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army, Department of Defence, U.S.A., WHO, or MRC.</note><note type="content">Section title: Communication</note><relatedItem type="host"><titleInfo><title>Transactions of the Royal Society of Tropical Medicine and Hygiene</title></titleInfo><titleInfo type="abbreviated"><title>TRSTMH</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">1978</dateIssued></originInfo><identifier type="ISSN">0035-9203</identifier><identifier type="PII">S0035-9203(00)X0015-6</identifier><part><date>1978</date><detail type="volume"><number>72</number><caption>vol.</caption></detail><detail type="issue"><number>2</number><caption>no.</caption></detail><extent unit="issue pages"><start>109</start><end>216</end></extent><extent unit="pages"><start>137</start><end>154</end></extent></part></relatedItem><identifier type="istex">9514B0116E49216240DFA14C921C593772C17DC8</identifier><identifier type="DOI">10.1016/0035-9203(78)90049-4</identifier><identifier type="PII">0035-9203(78)90049-4</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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