Verruciform xanthoma of the oral cavity: clinicopathological study relating to pathogenesis
Identifieur interne : 003E78 ( Istex/Corpus ); précédent : 003E77; suivant : 003E79Verruciform xanthoma of the oral cavity: clinicopathological study relating to pathogenesis
Auteurs : Ji-An Hu ; Yining Li ; Songying LiSource :
- APMIS [ 0903-4641 ] ; 2005-09.
Abstract
Verruciform xanthoma is a rare condition that was first reported in the oral cavity in 1971. Its histopathology is distinctive on account of the presence of foamy histiocytes within elongated dermal papillae. Three cases of oral mucosal verruciform xanthoma were studied. Immunohistochemical staining by streptavidin‐peroxidase and in situ hybridization to detect human papillomavirus (HPV types 6, 11, 16, 18) DNA and matrix metalloproteinase (MMP‐2, ‐9) RNA were performed to investigate the pathogenesis of verruciform xanthoma. This study showed that the foam cells were strongly positive for CD68 (KP1) and vimentin. Cytokeratin, PCNA and S‐100 stained focally negative in foam cells. In situ hybridization failed to detect HPV (types 6, 11, 16, 18) in any of the three cases. Based on our findings we conclude that verruciform xanthoma is most likely not a human papillomavirus‐associated lesion; the foam cells, as a histological hallmark of the lesion, are most likely derived from the monocyte‐macrophage lineage, and verruciform xanthoma is, at least partly, mediated by an immune mechanism. MMPs degrade basilar membrane that promotes the reciprocal induction between epithelium and mesenchyme. However, as yet unrecognized factors may play a role in the development of epithelium‐mesenchyme reciprocal induction.
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DOI: 10.1111/j.1600-0463.2005.apm_238.x
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Verruciform xanthoma of the oral cavity: clinicopathological study relating to pathogenesis</title><author><name sortKey="Hu, Ji N" sort="Hu, Ji N" uniqKey="Hu J" first="Ji-An" last="Hu">Ji-An Hu</name><affiliation><mods:affiliation>Department of Oral Pathology, Affiliated Hospital of Stomatology, School of Medicine, Zhejiang University, Hangzhou, China</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: hja@zju.edu.cn</mods:affiliation></affiliation></author><author><name sortKey="Li, Yining" sort="Li, Yining" uniqKey="Li Y" first="Yining" last="Li">Yining Li</name><affiliation><mods:affiliation>Department of Oral Pathology, Affiliated Hospital of Stomatology, School of Medicine, Zhejiang University, Hangzhou, China</mods:affiliation></affiliation></author><author><name sortKey="Li, Songying" sort="Li, Songying" uniqKey="Li S" first="Songying" last="Li">Songying Li</name><affiliation><mods:affiliation>Department of Oral Pathology, Affiliated Hospital of Stomatology, School of Medicine, Zhejiang University, Hangzhou, China</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:84FC539B4700014CBEBBE0EF7C58F807D2EAB262</idno><date when="2005" year="2005">2005</date><idno type="doi">10.1111/j.1600-0463.2005.apm_238.x</idno><idno type="url">https://api.istex.fr/document/84FC539B4700014CBEBBE0EF7C58F807D2EAB262/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">003E78</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">003E78</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Verruciform xanthoma of the oral cavity: clinicopathological study relating to pathogenesis<ref type="note" target="#fn1"></ref></title><author><name sortKey="Hu, Ji N" sort="Hu, Ji N" uniqKey="Hu J" first="Ji-An" last="Hu">Ji-An Hu</name><affiliation><mods:affiliation>Department of Oral Pathology, Affiliated Hospital of Stomatology, School of Medicine, Zhejiang University, Hangzhou, China</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: hja@zju.edu.cn</mods:affiliation></affiliation></author><author><name sortKey="Li, Yining" sort="Li, Yining" uniqKey="Li Y" first="Yining" last="Li">Yining Li</name><affiliation><mods:affiliation>Department of Oral Pathology, Affiliated Hospital of Stomatology, School of Medicine, Zhejiang University, Hangzhou, China</mods:affiliation></affiliation></author><author><name sortKey="Li, Songying" sort="Li, Songying" uniqKey="Li S" first="Songying" last="Li">Songying Li</name><affiliation><mods:affiliation>Department of Oral Pathology, Affiliated Hospital of Stomatology, School of Medicine, Zhejiang University, Hangzhou, China</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">APMIS</title><title level="j" type="alt">APMIS</title><idno type="ISSN">0903-4641</idno><idno type="eISSN">1600-0463</idno><imprint><biblScope unit="vol">113</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="629">629</biblScope><biblScope unit="page" to="634">634</biblScope><biblScope unit="page-count">6</biblScope><publisher>Munksgaard International Publishers</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2005-09">2005-09</date></imprint><idno type="ISSN">0903-4641</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0903-4641</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Verruciform xanthoma is a rare condition that was first reported in the oral cavity in 1971. Its histopathology is distinctive on account of the presence of foamy histiocytes within elongated dermal papillae. Three cases of oral mucosal verruciform xanthoma were studied. Immunohistochemical staining by streptavidin‐peroxidase and in situ hybridization to detect human papillomavirus (HPV types 6, 11, 16, 18) DNA and matrix metalloproteinase (MMP‐2, ‐9) RNA were performed to investigate the pathogenesis of verruciform xanthoma. This study showed that the foam cells were strongly positive for CD68 (KP1) and vimentin. Cytokeratin, PCNA and S‐100 stained focally negative in foam cells. In situ hybridization failed to detect HPV (types 6, 11, 16, 18) in any of the three cases. Based on our findings we conclude that verruciform xanthoma is most likely not a human papillomavirus‐associated lesion; the foam cells, as a histological hallmark of the lesion, are most likely derived from the monocyte‐macrophage lineage, and verruciform xanthoma is, at least partly, mediated by an immune mechanism. MMPs degrade basilar membrane that promotes the reciprocal induction between epithelium and mesenchyme. 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Based on our findings we conclude that verruciform xanthoma is most likely not a human papillomavirus‐associated lesion; the foam cells, as a histological hallmark of the lesion, are most likely derived from the monocyte‐macrophage lineage, and verruciform xanthoma is, at least partly, mediated by an immune mechanism. MMPs degrade basilar membrane that promotes the reciprocal induction between epithelium and mesenchyme. 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type="first">JI‐AN</forename><surname>HU</surname></persName><affiliation>Department of Oral Pathology, Affiliated Hospital of Stomatology, School of Medicine, Zhejiang University, Hangzhou, China<address><country key="CN"></country></address></affiliation><affiliation>Ji‐an Hu, Department of Oral Pathology, Affiliated Hospital of Stomatology, School of Medicine, Zhejiang University, Yan‐an Road 395, Hangzhou, Zhejiang Province, China, 310031. e‐mail: hja@zju.edu.cn</affiliation></author><author xml:id="author-0001"><persName><forename type="first">YINING</forename><surname>LI</surname></persName><affiliation>Department of Oral Pathology, Affiliated Hospital of Stomatology, School of Medicine, Zhejiang University, Hangzhou, China<address><country key="CN"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">SONGYING</forename><surname>LI</surname></persName><affiliation>Department of Oral Pathology, Affiliated Hospital of Stomatology, 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Publishers</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2005-09"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><p>Verruciform xanthoma is a rare condition that was first reported in the oral cavity in 1971. Its histopathology is distinctive on account of the presence of foamy histiocytes within elongated dermal papillae. Three cases of oral mucosal verruciform xanthoma were studied. Immunohistochemical staining by streptavidin‐peroxidase and <hi rend="italic">in situ</hi> hybridization to detect human papillomavirus (HPV types 6, 11, 16, 18) DNA and matrix metalloproteinase (MMP‐2, ‐9) RNA were performed to investigate the pathogenesis of verruciform xanthoma. This study showed that the foam cells were strongly positive for CD68 (KP1) and vimentin. Cytokeratin, PCNA and S‐100 stained focally negative in foam cells. <hi rend="italic">In situ</hi> hybridization failed to detect HPV (types 6, 11, 16, 18) in any of the three cases. Based on our findings we conclude that verruciform xanthoma is most likely not a human papillomavirus‐associated lesion; the foam cells, as a histological hallmark of the lesion, are most likely derived from the monocyte‐macrophage lineage, and verruciform xanthoma is, at least partly, mediated by an immune mechanism. MMPs degrade basilar membrane that promotes the reciprocal induction between epithelium and mesenchyme. However, as yet unrecognized factors may play a role in the development of epithelium‐mesenchyme reciprocal induction.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">Verruciform xanthoma</term><term xml:id="k2">foam cells</term><term xml:id="k3">oral cavity</term><term xml:id="k4">lesion</term></keywords><classCode scheme="tocHeading1">Original Articles</classCode></textClass><langUsage><language ident="EN"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/84FC539B4700014CBEBBE0EF7C58F807D2EAB262/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Munksgaard International Publishers</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-0463</doi><issn type="print">0903-4641</issn><issn type="electronic">1600-0463</issn><idGroup><id type="product" value="APM"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="APMIS">APMIS</title></titleGroup></publicationMeta><publicationMeta level="part" position="09009"><doi origin="wiley">10.1111/apm.2005.113.issue-9</doi><numberingGroup><numbering type="journalVolume" number="113">113</numbering><numbering type="journalIssue" number="9">9</numbering></numberingGroup><coverDate startDate="2005-09">September 2005</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="0062900" status="forIssue"><doi origin="wiley">10.1111/j.1600-0463.2005.apm_238.x</doi><idGroup><id type="supplier" value="apm238"></id><id type="unit" value="APM238"></id></idGroup><countGroup><count type="pageTotal" number="6"></count></countGroup><titleGroup><title type="tocHeading1">Original Articles</title></titleGroup><eventGroup><event type="firstOnline" date="2005-10-10"></event><event type="publishedOnlineFinalForm" date="2005-10-10"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.4 mode:FullText source:FullText result:FullText" date="2010-03-30"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-04"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-14"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="629">629</numbering><numbering type="pageLast" number="634">634</numbering></numberingGroup><correspondenceTo>Ji‐an Hu, Department of Oral Pathology, Affiliated Hospital of Stomatology, School of Medicine, Zhejiang University, Yan‐an Road 395, Hangzhou, Zhejiang Province, China, 310031. e‐mail: <email>hja@zju.edu.cn</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:APM.APM238.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="1"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="26"></count><count type="wordTotal" number="2763"></count><count type="linksPubMed" number="0"></count><count type="linksCrossRef" number="0"></count></countGroup><titleGroup><title type="main">Verruciform xanthoma of the oral cavity: clinicopathological study relating to pathogenesis<link href="#fn1"></link></title><title type="subtitle">Report of three cases</title><title type="shortAuthors">HU <i>et al.</i></title><title type="short">VERRUCIFORM XANTHOMA OF THE ORAL CAVITY</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1" corresponding="yes"><personName><givenNames>JI‐AN</givenNames><familyName>HU</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>YINING</givenNames><familyName>LI</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>SONGYING</givenNames><familyName>LI</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="CN"><unparsedAffiliation>Department of Oral Pathology, Affiliated Hospital of Stomatology, School of Medicine, Zhejiang University, Hangzhou, China</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">Verruciform xanthoma</keyword><keyword xml:id="k2">foam cells</keyword><keyword xml:id="k3">oral cavity</keyword><keyword xml:id="k4">lesion</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><!--
Hu JA, Li Y, Li S. Verruciform xanthoma of the oral cavity: clinicopathological study relating to pathogenesis. Report of three cases. APMIS 2005;113:629–34.
--><p>Verruciform xanthoma is a rare condition that was first reported in the oral cavity in 1971. Its histopathology is distinctive on account of the presence of foamy histiocytes within elongated dermal papillae. Three cases of oral mucosal verruciform xanthoma were studied. Immunohistochemical staining by streptavidin‐peroxidase and <i>in situ</i> hybridization to detect human papillomavirus (HPV types 6, 11, 16, 18) DNA and matrix metalloproteinase (MMP‐2, ‐9) RNA were performed to investigate the pathogenesis of verruciform xanthoma. This study showed that the foam cells were strongly positive for CD68 (KP1) and vimentin. Cytokeratin, PCNA and S‐100 stained focally negative in foam cells. <i>In situ</i> hybridization failed to detect HPV (types 6, 11, 16, 18) in any of the three cases. Based on our findings we conclude that verruciform xanthoma is most likely not a human papillomavirus‐associated lesion; the foam cells, as a histological hallmark of the lesion, are most likely derived from the monocyte‐macrophage lineage, and verruciform xanthoma is, at least partly, mediated by an immune mechanism. MMPs degrade basilar membrane that promotes the reciprocal induction between epithelium and mesenchyme. However, as yet unrecognized factors may play a role in the development of epithelium‐mesenchyme reciprocal induction.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1" numbered="no"><p>Received 23 March 2005.</p><p>Accepted 13 July 2005.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Verruciform xanthoma of the oral cavity: clinicopathological study relating to pathogenesis</title><subTitle>Report of three cases</subTitle></titleInfo><titleInfo type="abbreviated" lang="en"><title>VERRUCIFORM XANTHOMA OF THE ORAL CAVITY</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Verruciform xanthoma of the oral cavity: clinicopathological study relating to pathogenesis</title></titleInfo><name type="personal"><namePart type="given">JI‐AN</namePart><namePart type="family">HU</namePart><affiliation>Department of Oral Pathology, Affiliated Hospital of Stomatology, School of Medicine, Zhejiang University, Hangzhou, China</affiliation><affiliation>E-mail: hja@zju.edu.cn</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">YINING</namePart><namePart type="family">LI</namePart><affiliation>Department of Oral Pathology, Affiliated Hospital of Stomatology, School of Medicine, Zhejiang University, Hangzhou, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SONGYING</namePart><namePart type="family">LI</namePart><affiliation>Department of Oral Pathology, Affiliated Hospital of Stomatology, School of Medicine, Zhejiang University, Hangzhou, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Munksgaard International Publishers</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2005-09</dateIssued><copyrightDate encoding="w3cdtf">2005</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">1</extent><extent unit="references">26</extent><extent unit="words">2763</extent></physicalDescription><abstract lang="en">Verruciform xanthoma is a rare condition that was first reported in the oral cavity in 1971. Its histopathology is distinctive on account of the presence of foamy histiocytes within elongated dermal papillae. Three cases of oral mucosal verruciform xanthoma were studied. Immunohistochemical staining by streptavidin‐peroxidase and in situ hybridization to detect human papillomavirus (HPV types 6, 11, 16, 18) DNA and matrix metalloproteinase (MMP‐2, ‐9) RNA were performed to investigate the pathogenesis of verruciform xanthoma. This study showed that the foam cells were strongly positive for CD68 (KP1) and vimentin. Cytokeratin, PCNA and S‐100 stained focally negative in foam cells. In situ hybridization failed to detect HPV (types 6, 11, 16, 18) in any of the three cases. Based on our findings we conclude that verruciform xanthoma is most likely not a human papillomavirus‐associated lesion; the foam cells, as a histological hallmark of the lesion, are most likely derived from the monocyte‐macrophage lineage, and verruciform xanthoma is, at least partly, mediated by an immune mechanism. MMPs degrade basilar membrane that promotes the reciprocal induction between epithelium and mesenchyme. However, as yet unrecognized factors may play a role in the development of epithelium‐mesenchyme reciprocal induction.</abstract><note type="content">*Received 23 March 2005. Accepted 13 July 2005.</note><subject lang="en"><genre>keywords</genre><topic>Verruciform xanthoma</topic><topic>foam cells</topic><topic>oral cavity</topic><topic>lesion</topic></subject><relatedItem type="host"><titleInfo><title>APMIS</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0903-4641</identifier><identifier type="eISSN">1600-0463</identifier><identifier type="DOI">10.1111/(ISSN)1600-0463</identifier><identifier type="PublisherID">APM</identifier><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>113</number></detail><detail type="issue"><caption>no.</caption><number>9</number></detail><extent unit="pages"><start>629</start><end>634</end><total>6</total></extent></part></relatedItem><identifier type="istex">84FC539B4700014CBEBBE0EF7C58F807D2EAB262</identifier><identifier type="DOI">10.1111/j.1600-0463.2005.apm_238.x</identifier><identifier type="ArticleID">apm238</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Munksgaard International Publishers</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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