Inconsistent immunohistochemical expression of lymphatic and blood endothelial cell markers in cutaneous lymphangiomas
Identifieur interne : 003B90 ( Istex/Corpus ); précédent : 003B89; suivant : 003B91Inconsistent immunohistochemical expression of lymphatic and blood endothelial cell markers in cutaneous lymphangiomas
Auteurs : Jag Bhawan ; Claudine Silva ; Wirach Matt TaungjaruwinaiSource :
- Journal of Cutaneous Pathology [ 0303-6987 ] ; 2013-09.
Abstract
We sought to describe expression of the immunohistochemical markers, CD31, D2‐40 and LYVE‐1 (lymphatic vessel hyaluronan receptor‐1), that may assist in differentiating cutaneous lymphangioma and cutaneous hemangioma.
Url:
DOI: 10.1111/cup.12184
Links to Exploration step
ISTEX:7F430942626270BB69763D49374A8FBF25FCADDELe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Inconsistent immunohistochemical expression of lymphatic and blood endothelial cell markers in cutaneous lymphangiomas</title><author><name sortKey="Bhawan, Jag" sort="Bhawan, Jag" uniqKey="Bhawan J" first="Jag" last="Bhawan">Jag Bhawan</name><affiliation><mods:affiliation>Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, MA, Boston, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Jag Bhawan,Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, Boston, MA, USATel: 617‐638‐5570Fax: 617‐638‐5575e‐mail:</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: jbhawan@bu.edu</mods:affiliation></affiliation></author><author><name sortKey="Silva, Claudine" sort="Silva, Claudine" uniqKey="Silva C" first="Claudine" last="Silva">Claudine Silva</name><affiliation><mods:affiliation>Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, MA, Boston, USA</mods:affiliation></affiliation></author><author><name sortKey="Taungjaruwinai, Wirach Matt" sort="Taungjaruwinai, Wirach Matt" uniqKey="Taungjaruwinai W" first="Wirach Matt" last="Taungjaruwinai">Wirach Matt Taungjaruwinai</name><affiliation><mods:affiliation>Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, MA, Boston, USA</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:7F430942626270BB69763D49374A8FBF25FCADDE</idno><date when="2013" year="2013">2013</date><idno type="doi">10.1111/cup.12184</idno><idno type="url">https://api.istex.fr/document/7F430942626270BB69763D49374A8FBF25FCADDE/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">003B90</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">003B90</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Inconsistent immunohistochemical expression of lymphatic and blood endothelial cell markers in cutaneous lymphangiomas</title><author><name sortKey="Bhawan, Jag" sort="Bhawan, Jag" uniqKey="Bhawan J" first="Jag" last="Bhawan">Jag Bhawan</name><affiliation><mods:affiliation>Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, MA, Boston, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Jag Bhawan,Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, Boston, MA, USATel: 617‐638‐5570Fax: 617‐638‐5575e‐mail:</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: jbhawan@bu.edu</mods:affiliation></affiliation></author><author><name sortKey="Silva, Claudine" sort="Silva, Claudine" uniqKey="Silva C" first="Claudine" last="Silva">Claudine Silva</name><affiliation><mods:affiliation>Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, MA, Boston, USA</mods:affiliation></affiliation></author><author><name sortKey="Taungjaruwinai, Wirach Matt" sort="Taungjaruwinai, Wirach Matt" uniqKey="Taungjaruwinai W" first="Wirach Matt" last="Taungjaruwinai">Wirach Matt Taungjaruwinai</name><affiliation><mods:affiliation>Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, MA, Boston, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Cutaneous Pathology</title><title level="j" type="alt">JOURNAL OF CUTANEOUS PATHOLOGY</title><idno type="ISSN">0303-6987</idno><idno type="eISSN">1600-0560</idno><imprint><biblScope unit="vol">40</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="801">801</biblScope><biblScope unit="page" to="806">806</biblScope><biblScope unit="page-count">6</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2013-09">2013-09</date></imprint><idno type="ISSN">0303-6987</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0303-6987</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">We sought to describe expression of the immunohistochemical markers, CD31, D2‐40 and LYVE‐1 (lymphatic vessel hyaluronan receptor‐1), that may assist in differentiating cutaneous lymphangioma and cutaneous hemangioma.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>lymphangioma</json:string><json:string>lymphatic</json:string><json:string>hemangioma</json:string><json:string>cutaneous</json:string><json:string>immunohistochemical</json:string><json:string>endothelium</json:string><json:string>cutaneous lymphangiomas</json:string><json:string>malformation</json:string><json:string>pathol</json:string><json:string>lymphatic endothelium</json:string><json:string>john wiley sons</json:string><json:string>lymphatic vessels</json:string><json:string>lymphangioma circumscriptum</json:string><json:string>cutaneous lymphangioma</json:string><json:string>hematoxylin eosin</json:string><json:string>cell markers</json:string><json:string>immunohistochemical staining</json:string><json:string>immunohistochemical expression</json:string><json:string>boston university school</json:string><json:string>blood vessels</json:string><json:string>inconsistent immunohistochemical expression</json:string><json:string>vascular tumors</json:string><json:string>dermatopathology section</json:string></teeft></keywords><author><json:item><name>Jag Bhawan</name><affiliations><json:string>Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, MA, Boston, USA</json:string><json:string>Jag Bhawan,Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, Boston, MA, USATel: 617‐638‐5570Fax: 617‐638‐5575e‐mail:</json:string><json:string>E-mail: jbhawan@bu.edu</json:string></affiliations></json:item><json:item><name>Claudine Silva</name><affiliations><json:string>Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, MA, Boston, USA</json:string></affiliations></json:item><json:item><name>Wirach Matt Taungjaruwinai</name><affiliations><json:string>Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, MA, Boston, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>D2‐40</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>hemangioma</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>immunohistochemistry</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>lymphangioma</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>LYVE‐1</value></json:item></subject><articleId><json:string>CUP12184</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><qualityIndicators><score>2.874</score><pdfVersion>1.3</pdfVersion><pdfPageSize>595.276 x 782.362 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>217</abstractCharCount><pdfWordCount>2550</pdfWordCount><pdfCharCount>18018</pdfCharCount><pdfPageCount>6</pdfPageCount><abstractWordCount>27</abstractWordCount></qualityIndicators><title>Inconsistent immunohistochemical expression of lymphatic and blood endothelial cell markers in cutaneous lymphangiomas</title><genre><json:string>article</json:string></genre><host><title>Journal of Cutaneous Pathology</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1600-0560</json:string></doi><issn><json:string>0303-6987</json:string></issn><eissn><json:string>1600-0560</json:string></eissn><publisherId><json:string>CUP</json:string></publisherId><volume>40</volume><issue>9</issue><pages><first>801</first><last>806</last><total>6</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Original Article</value></json:item></subject></host><categories><wos><json:string>science</json:string><json:string>pathology</json:string><json:string>dermatology</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>dermatology & venereal diseases</json:string></scienceMetrix></categories><publicationDate>2013</publicationDate><copyrightDate>2013</copyrightDate><doi><json:string>10.1111/cup.12184</json:string></doi><id>7F430942626270BB69763D49374A8FBF25FCADDE</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/7F430942626270BB69763D49374A8FBF25FCADDE/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/7F430942626270BB69763D49374A8FBF25FCADDE/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/7F430942626270BB69763D49374A8FBF25FCADDE/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Inconsistent immunohistochemical expression of lymphatic and blood endothelial cell markers in cutaneous lymphangiomas</title></titleStmt><publicationStmt><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><licence>© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</licence></availability><date type="published" when="2013-09"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Inconsistent immunohistochemical expression of lymphatic and blood endothelial cell markers in cutaneous lymphangiomas</title><title level="a" type="short">Inconsistent immunohistochemical expression of lymphatic and blood endothelial cell markers</title><author xml:id="author-0000" role="corresp"><persName><forename type="first">Jag</forename><surname>Bhawan</surname></persName><affiliation><orgName>Dermatopathology Section, Department of Dermatology</orgName><orgName>Boston University School of Medicine</orgName><address><settlement type="city">Boston</settlement><region>MA</region><country key="US">USA</country></address></affiliation><affiliation>Jag Bhawan, Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, Boston, MA, USA Tel: 617‐638‐5570 Fax: 617‐638‐5575 e‐mail: jbhawan@bu.edu</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Claudine</forename><surname>Silva</surname></persName><affiliation><orgName>Dermatopathology Section, Department of Dermatology</orgName><orgName>Boston University School of Medicine</orgName><address><settlement type="city">Boston</settlement><region>MA</region><country key="US">USA</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Wirach Matt</forename><surname>Taungjaruwinai</surname></persName><affiliation><orgName>Dermatopathology Section, Department of Dermatology</orgName><orgName>Boston University School of Medicine</orgName><address><settlement type="city">Boston</settlement><region>MA</region><country key="US">USA</country></address></affiliation></author><idno type="istex">7F430942626270BB69763D49374A8FBF25FCADDE</idno><idno type="DOI">10.1111/cup.12184</idno><idno type="unit">CUP12184</idno><idno type="toTypesetVersion">file:CUP.CUP12184.pdf</idno></analytic><monogr><title level="j" type="main">Journal of Cutaneous Pathology</title><title level="j" type="alt">JOURNAL OF CUTANEOUS PATHOLOGY</title><idno type="pISSN">0303-6987</idno><idno type="eISSN">1600-0560</idno><idno type="book-DOI">10.1111/(ISSN)1600-0560</idno><idno type="book-part-DOI">10.1111/cup.2013.40.issue-9</idno><idno type="product">CUP</idno><imprint><biblScope unit="vol">40</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="801">801</biblScope><biblScope unit="page" to="806">806</biblScope><biblScope unit="page-count">6</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2013-09"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract style="main" xml:id="cup12184-abs-0001">
Purpose
<p xml:id="cup12184-para-0001">We sought to describe expression of the immunohistochemical markers, <hi rend="fc">CD31</hi>, <hi rend="fc">D2</hi>‐40 and <hi rend="fc">LYVE</hi>‐1 (lymphatic vessel hyaluronan receptor‐1), that may assist in differentiating cutaneous lymphangioma and cutaneous hemangioma.</p>
Methods
<p xml:id="cup12184-para-0002">Immunohistochemical staining of lymphangioma and hemangioma specimens was completed with <hi rend="fc">CD31</hi>, <hi rend="fc">D2</hi>‐40 and <hi rend="fc">LYVE</hi>‐1 antibodies.</p>
Results
<p xml:id="cup12184-para-0003">Thirty‐three examples of lymphangioma and 13 examples of hemangioma were evaluated. <hi rend="fc">CD31</hi> was positive in 91% of lymphangioma and 100% of hemangioma (sensitivity 0.91, 95% confidence interval 0.75‐0.98; specificity 0, 95% confidence interval 0‐0.28). <hi rend="fc">D2</hi>‐40 was positive in 54% of lymphangioma and 23% in hemangioma (sensitivity 0.50 95% confidence interval 0.32‐0.68; specificity 0.50 95% confidence interval 0.28‐0.72). <hi rend="fc">LYVE</hi>‐1 was positive in 6% in lymphangioma and 15% hemangioma (sensitivity 0.06 95% confidence interval 0.01‐0.22, specificity 0.85 95% confidence interval 0.54‐0.97).</p>
Conclusions
<p xml:id="cup12184-para-0004">Due to the similar embryonic origins, it is unlikely that a single marker may accurately differentiate the lymphangioma from hemangioma. A combination of immunohistochemical stains such <hi rend="fc">CD31</hi>, <hi rend="fc">D2</hi>‐40 and <hi rend="fc">LYVE</hi>‐1 testing may potentially increase the diagnostic accuracy in differentiating lymphangioma from hemangioma. However, our findings suggest that there is no advantage in performing immunohistochemical staining to differentiate lymphangioma from hemangioma.</p></abstract><textClass><keywords><term xml:id="cup12184-kwd-0001"><hi rend="fc">D2</hi>‐40</term><term xml:id="cup12184-kwd-0002">hemangioma</term><term xml:id="cup12184-kwd-0003">immunohistochemistry</term><term xml:id="cup12184-kwd-0004">lymphangioma</term><term xml:id="cup12184-kwd-0005"><hi rend="fc">LYVE</hi>‐1</term></keywords><classCode scheme="articleCategory">Original Article</classCode><classCode scheme="tocHeading1">Original Articles</classCode></textClass><langUsage><language ident="EN"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/7F430942626270BB69763D49374A8FBF25FCADDE/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component type="serialArticle" version="2.0" xml:lang="en" xml:id="cup12184"><header xml:id="cup12184-hdr-0001"><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi>10.1111/(ISSN)1600-0560</doi><issn type="print">0303-6987</issn><issn type="electronic">1600-0560</issn><idGroup><id type="product" value="CUP"></id></idGroup><titleGroup><title type="main" sort="JOURNAL OF CUTANEOUS PATHOLOGY">Journal of Cutaneous Pathology</title><title type="short">J Cutan Pathol</title></titleGroup></publicationMeta><publicationMeta level="part" position="90"><doi origin="wiley">10.1111/cup.2013.40.issue-9</doi><copyright ownership="publisher">© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</copyright><numberingGroup><numbering type="journalVolume" number="40">40</numbering><numbering type="journalIssue">9</numbering></numberingGroup><coverDate startDate="2013-09">September 2013</coverDate></publicationMeta><publicationMeta level="unit" position="60" type="article" status="forIssue"><doi>10.1111/cup.12184</doi><idGroup><id type="unit" value="CUP12184"></id></idGroup><countGroup><count type="pageTotal" number="6"></count></countGroup><titleGroup><title type="articleCategory">Original Article</title><title type="tocHeading1">Original Articles</title></titleGroup><copyright ownership="publisher">© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</copyright><eventGroup><event type="manuscriptReceived" date="2012-10-30"></event><event type="manuscriptRevised" date="2013-04-23"></event><event type="manuscriptAccepted" date="2013-05-05"></event><event type="xmlCreated" agent="Laserwords Private Ltd." date="2013-06-03"></event><event type="publishedOnlineAccepted" date="2013-05-29"></event><event type="publishedOnlineEarlyUnpaginated" date="2013-06-20"></event><event type="firstOnline" date="2013-06-20"></event><event type="publishedOnlineFinalForm" date="2013-08-21"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-16"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-01"></event></eventGroup><numberingGroup><numbering type="pageFirst">801</numbering><numbering type="pageLast">806</numbering></numberingGroup><correspondenceTo><lineatedText xml:id="cup12184-lntxt-0001"><line xml:id="cup12184-line-0001">Jag Bhawan,</line><line xml:id="cup12184-line-0002">Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, Boston, MA, USA</line><line xml:id="cup12184-line-0003">Tel: 617‐638‐5570</line><line xml:id="cup12184-line-0004">Fax: 617‐638‐5575</line><line xml:id="cup12184-line-0005">e‐mail: <email>jbhawan@bu.edu</email></line></lineatedText></correspondenceTo><selfCitationGroup><citation type="self" xml:id="cup12184-cit-0000"><author><familyName>Bhawan</familyName> <givenNames>J</givenNames></author>, <author><familyName>Silva</familyName> <givenNames>C</givenNames></author>, <author><familyName>Taungjaruwinai</familyName> <givenNames>WM</givenNames></author>. <articleTitle>Inconsistent immunohistochemical expression of lymphatic and blood endothelial cell markers in cutaneous lymphangiomas</articleTitle>.</citation></selfCitationGroup><linkGroup><link type="toTypesetVersion" href="file:CUP.CUP12184.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Inconsistent immunohistochemical expression of lymphatic and blood endothelial cell markers in cutaneous lymphangiomas</title><title type="short">Inconsistent immunohistochemical expression of lymphatic and blood endothelial cell markers</title><title type="shortAuthors">Bhawan et al</title></titleGroup><creators><creator creatorRole="author" xml:id="cup12184-cr-0001" affiliationRef="#cup12184-aff-0001" corresponding="yes"><personName><givenNames>Jag</givenNames> <familyName>Bhawan</familyName></personName></creator><creator creatorRole="author" xml:id="cup12184-cr-0002" affiliationRef="#cup12184-aff-0001"><personName><givenNames>Claudine</givenNames> <familyName>Silva</familyName></personName></creator><creator creatorRole="author" xml:id="cup12184-cr-0003" affiliationRef="#cup12184-aff-0001"><personName><givenNames>Wirach Matt</givenNames> <familyName>Taungjaruwinai</familyName></personName></creator></creators><affiliationGroup xml:id="cup12184-affgp-0001"><affiliation countryCode="US" type="organization" xml:id="cup12184-aff-0001"><orgDiv>Dermatopathology Section, Department of Dermatology</orgDiv><orgName>Boston University School of Medicine</orgName><address><city>Boston</city><countryPart>MA</countryPart><country>USA</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="cup12184-kwd-0001"><fc>D2</fc>‐40</keyword><keyword xml:id="cup12184-kwd-0002">hemangioma</keyword><keyword xml:id="cup12184-kwd-0003">immunohistochemistry</keyword><keyword xml:id="cup12184-kwd-0004">lymphangioma</keyword><keyword xml:id="cup12184-kwd-0005"><fc>LYVE</fc>‐1</keyword></keywordGroup><abstractGroup><abstract type="main" xml:id="cup12184-abs-0001"><section xml:id="cup12184-sec-0001"><title type="main">Purpose</title><p xml:id="cup12184-para-0001">We sought to describe expression of the immunohistochemical markers, <fc>CD31</fc>, <fc>D2</fc>‐40 and <fc>LYVE</fc>‐1 (lymphatic vessel hyaluronan receptor‐1), that may assist in differentiating cutaneous lymphangioma and cutaneous hemangioma.</p></section><section xml:id="cup12184-sec-0002"><title type="main">Methods</title><p xml:id="cup12184-para-0002">Immunohistochemical staining of lymphangioma and hemangioma specimens was completed with <fc>CD31</fc>, <fc>D2</fc>‐40 and <fc>LYVE</fc>‐1 antibodies.</p></section><section xml:id="cup12184-sec-0003"><title type="main">Results</title><p xml:id="cup12184-para-0003">Thirty‐three examples of lymphangioma and 13 examples of hemangioma were evaluated. <fc>CD31</fc> was positive in 91% of lymphangioma and 100% of hemangioma (sensitivity 0.91, 95% confidence interval 0.75‐0.98; specificity 0, 95% confidence interval 0‐0.28). <fc>D2</fc>‐40 was positive in 54% of lymphangioma and 23% in hemangioma (sensitivity 0.50 95% confidence interval 0.32‐0.68; specificity 0.50 95% confidence interval 0.28‐0.72). <fc>LYVE</fc>‐1 was positive in 6% in lymphangioma and 15% hemangioma (sensitivity 0.06 95% confidence interval 0.01‐0.22, specificity 0.85 95% confidence interval 0.54‐0.97).</p></section><section xml:id="cup12184-sec-0004"><title type="main">Conclusions</title><p xml:id="cup12184-para-0004">Due to the similar embryonic origins, it is unlikely that a single marker may accurately differentiate the lymphangioma from hemangioma. A combination of immunohistochemical stains such <fc>CD31</fc>, <fc>D2</fc>‐40 and <fc>LYVE</fc>‐1 testing may potentially increase the diagnostic accuracy in differentiating lymphangioma from hemangioma. However, our findings suggest that there is no advantage in performing immunohistochemical staining to differentiate lymphangioma from hemangioma.</p></section></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Inconsistent immunohistochemical expression of lymphatic and blood endothelial cell markers in cutaneous lymphangiomas</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Inconsistent immunohistochemical expression of lymphatic and blood endothelial cell markers</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Inconsistent immunohistochemical expression of lymphatic and blood endothelial cell markers in cutaneous lymphangiomas</title></titleInfo><name type="personal"><namePart type="given">Jag</namePart><namePart type="family">Bhawan</namePart><affiliation>Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, MA, Boston, USA</affiliation><affiliation>Jag Bhawan,Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, Boston, MA, USATel: 617‐638‐5570Fax: 617‐638‐5575e‐mail:</affiliation><affiliation>E-mail: jbhawan@bu.edu</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Claudine</namePart><namePart type="family">Silva</namePart><affiliation>Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, MA, Boston, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Wirach Matt</namePart><namePart type="family">Taungjaruwinai</namePart><affiliation>Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, MA, Boston, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2013-09</dateIssued><dateCreated encoding="w3cdtf">2013-06-03</dateCreated><dateCaptured encoding="w3cdtf">2012-10-30</dateCaptured><dateValid encoding="w3cdtf">2013-05-05</dateValid><edition>Bhawan J, Silva C, Taungjaruwinai WM. Inconsistent immunohistochemical expression of lymphatic and blood endothelial cell markers in cutaneous lymphangiomas.</edition><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>We sought to describe expression of the immunohistochemical markers, CD31, D2‐40 and LYVE‐1 (lymphatic vessel hyaluronan receptor‐1), that may assist in differentiating cutaneous lymphangioma and cutaneous hemangioma.</abstract><abstract>Immunohistochemical staining of lymphangioma and hemangioma specimens was completed with CD31, D2‐40 and LYVE‐1 antibodies.</abstract><abstract>Thirty‐three examples of lymphangioma and 13 examples of hemangioma were evaluated. CD31 was positive in 91% of lymphangioma and 100% of hemangioma (sensitivity 0.91, 95% confidence interval 0.75‐0.98; specificity 0, 95% confidence interval 0‐0.28). D2‐40 was positive in 54% of lymphangioma and 23% in hemangioma (sensitivity 0.50 95% confidence interval 0.32‐0.68; specificity 0.50 95% confidence interval 0.28‐0.72). LYVE‐1 was positive in 6% in lymphangioma and 15% hemangioma (sensitivity 0.06 95% confidence interval 0.01‐0.22, specificity 0.85 95% confidence interval 0.54‐0.97).</abstract><abstract>Due to the similar embryonic origins, it is unlikely that a single marker may accurately differentiate the lymphangioma from hemangioma. A combination of immunohistochemical stains such CD31, D2‐40 and LYVE‐1 testing may potentially increase the diagnostic accuracy in differentiating lymphangioma from hemangioma. However, our findings suggest that there is no advantage in performing immunohistochemical staining to differentiate lymphangioma from hemangioma.</abstract><subject><genre>keywords</genre><topic>D2‐40</topic><topic>hemangioma</topic><topic>immunohistochemistry</topic><topic>lymphangioma</topic><topic>LYVE‐1</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Cutaneous Pathology</title></titleInfo><titleInfo type="abbreviated"><title>J Cutan Pathol</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Original Article</topic></subject><identifier type="ISSN">0303-6987</identifier><identifier type="eISSN">1600-0560</identifier><identifier type="DOI">10.1111/(ISSN)1600-0560</identifier><identifier type="PublisherID">CUP</identifier><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>40</number></detail><detail type="issue"><caption>no.</caption><number>9</number></detail><extent unit="pages"><start>801</start><end>806</end><total>6</total></extent></part></relatedItem><identifier type="istex">7F430942626270BB69763D49374A8FBF25FCADDE</identifier><identifier type="DOI">10.1111/cup.12184</identifier><identifier type="ArticleID">CUP12184</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003B90 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 003B90 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:7F430942626270BB69763D49374A8FBF25FCADDE
|texte= Inconsistent immunohistochemical expression of lymphatic and blood endothelial cell markers in cutaneous lymphangiomas
}}
| This area was generated with Dilib version V0.6.31. |  |