Depression is associated with some patient‐perceived cosmetic changes, but not with radiotherapy‐induced late toxicity, in long‐term breast cancer survivors
Identifieur interne : 003687 ( Istex/Corpus ); précédent : 003686; suivant : 003688Depression is associated with some patient‐perceived cosmetic changes, but not with radiotherapy‐induced late toxicity, in long‐term breast cancer survivors
Auteurs : Paul Brunault ; Isabelle Suzanne ; Magdalena Trzepidur-Edom ; Pascal Garaud ; Gilles Calais ; Alain Toledano ; Vincent CamusSource :
- Psycho‐Oncology [ 1057-9249 ] ; 2013-03.
Abstract
Although depression is prevalent in long‐term breast cancer survivors (LTBCS; ≥5 years since diagnosis), it is underdiagnosed and undertreated. A better understanding of factors associated with depression could improve depression screening, treatment, and prevention in this population. Our study aimed to assess the link between patient and doctor ratings of breast cosmetic outcomes, late radiotherapy toxicity, and depression in LTBCS.
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DOI: 10.1002/pon.3038
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Trzepidur-Edom</name><affiliation><mods:affiliation>CHRU de Tours, Tours, France</mods:affiliation></affiliation></author><author><name sortKey="Garaud, Pascal" sort="Garaud, Pascal" uniqKey="Garaud P" first="Pascal" last="Garaud">Pascal Garaud</name><affiliation><mods:affiliation>CHRU de Tours, Tours, France</mods:affiliation></affiliation></author><author><name sortKey="Calais, Gilles" sort="Calais, Gilles" uniqKey="Calais G" first="Gilles" last="Calais">Gilles Calais</name><affiliation><mods:affiliation>CHRU de Tours, Tours, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Université François Rabelais de Tours, Tours, France</mods:affiliation></affiliation></author><author><name sortKey="Toledano, Alain" sort="Toledano, Alain" uniqKey="Toledano A" first="Alain" last="Toledano">Alain Toledano</name><affiliation><mods:affiliation>Hôpital Américain de Paris‐Clinique Hartmann, Neuilly sur Seine, France</mods:affiliation></affiliation></author><author><name sortKey="Camus, Vincent" sort="Camus, Vincent" uniqKey="Camus V" first="Vincent" last="Camus">Vincent Camus</name><affiliation><mods:affiliation>CHRU de Tours, Tours, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Université François Rabelais de Tours, Tours, France</mods:affiliation></affiliation><affiliation><mods:affiliation>UMR INSERM U930 & CNRS ERL 3106, Tours, France</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:75014EFCF929DA611AFB29B74E8F9A20E97FF339</idno><date when="2013" year="2013">2013</date><idno type="doi">10.1002/pon.3038</idno><idno type="url">https://api.istex.fr/document/75014EFCF929DA611AFB29B74E8F9A20E97FF339/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">003687</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">003687</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Depression is associated with some patient‐perceived cosmetic changes, but not with radiotherapy‐induced late toxicity, in long‐term breast cancer survivors</title><author><name sortKey="Brunault, Paul" sort="Brunault, Paul" uniqKey="Brunault P" first="Paul" last="Brunault">Paul Brunault</name><affiliation><mods:affiliation>CHRU de Tours, Tours, France</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: paul.brunault@gmail.com</mods:affiliation></affiliation></author><author><name sortKey="Suzanne, Isabelle" sort="Suzanne, Isabelle" uniqKey="Suzanne I" first="Isabelle" last="Suzanne">Isabelle Suzanne</name><affiliation><mods:affiliation>CHRU de Tours, Tours, France</mods:affiliation></affiliation></author><author><name sortKey="Trzepidur Dom, Magdalena" sort="Trzepidur Dom, Magdalena" uniqKey="Trzepidur Dom M" first="Magdalena" last="Trzepidur-Edom">Magdalena Trzepidur-Edom</name><affiliation><mods:affiliation>CHRU de Tours, Tours, France</mods:affiliation></affiliation></author><author><name sortKey="Garaud, Pascal" sort="Garaud, Pascal" uniqKey="Garaud P" first="Pascal" last="Garaud">Pascal Garaud</name><affiliation><mods:affiliation>CHRU de Tours, Tours, France</mods:affiliation></affiliation></author><author><name sortKey="Calais, Gilles" sort="Calais, Gilles" uniqKey="Calais G" first="Gilles" last="Calais">Gilles Calais</name><affiliation><mods:affiliation>CHRU de Tours, Tours, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Université François Rabelais de Tours, Tours, France</mods:affiliation></affiliation></author><author><name sortKey="Toledano, Alain" sort="Toledano, Alain" uniqKey="Toledano A" first="Alain" last="Toledano">Alain Toledano</name><affiliation><mods:affiliation>Hôpital Américain de Paris‐Clinique Hartmann, Neuilly sur Seine, France</mods:affiliation></affiliation></author><author><name sortKey="Camus, Vincent" sort="Camus, Vincent" uniqKey="Camus V" first="Vincent" last="Camus">Vincent Camus</name><affiliation><mods:affiliation>CHRU de Tours, Tours, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Université François Rabelais de Tours, Tours, France</mods:affiliation></affiliation><affiliation><mods:affiliation>UMR INSERM U930 & CNRS ERL 3106, Tours, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Psycho‐Oncology</title><title level="j" type="alt">PSYCHO-ONCOLOGY</title><idno type="ISSN">1057-9249</idno><idno type="eISSN">1099-1611</idno><imprint><biblScope unit="vol">22</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="590">590</biblScope><biblScope unit="page" to="597">597</biblScope><biblScope unit="page-count">8</biblScope><publisher>John Wiley & Sons, Ltd</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2013-03">2013-03</date></imprint><idno 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A better understanding of factors associated with depression could improve depression screening, treatment, and prevention in this population. Our study aimed to assess the link between patient and doctor ratings of breast cosmetic outcomes, late radiotherapy toxicity, and depression in LTBCS.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>toxicity</json:string><json:string>ltbcs</json:string><json:string>radiotherapy</json:string><json:string>oncol</json:string><json:string>breast cancer</json:string><json:string>body image</json:string><json:string>arcosein</json:string><json:string>chemoradiotherapy</json:string><json:string>breast cancer survivors</json:string><json:string>survivor</json:string><json:string>copyright</json:string><json:string>john wiley sons</json:string><json:string>doctor ratings</json:string><json:string>arcosein study</json:string><json:string>late radiotherapy toxicity</json:string><json:string>probable 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oncol</json:string><json:string>cosmetic outcome</json:string><json:string>primary breast cancer</json:string><json:string>surg oncol</json:string><json:string>breastconserving surgery</json:string><json:string>nondepressed patients</json:string><json:string>axillary dissection</json:string></teeft></keywords><author><json:item><name>Paul Brunault</name><affiliations><json:string>CHRU de Tours, Tours, France</json:string><json:string>E-mail: paul.brunault@gmail.com</json:string></affiliations></json:item><json:item><name>Isabelle Suzanne</name><affiliations><json:string>CHRU de Tours, Tours, France</json:string></affiliations></json:item><json:item><name>Magdalena Trzepidur‐Edom</name><affiliations><json:string>CHRU de Tours, Tours, France</json:string></affiliations></json:item><json:item><name>Pascal Garaud</name><affiliations><json:string>CHRU de Tours, Tours, France</json:string></affiliations></json:item><json:item><name>Gilles Calais</name><affiliations><json:string>CHRU de 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survivors</title></titleStmt><publicationStmt><publisher>John Wiley & Sons, Ltd</publisher><pubPlace>Chichester, UK</pubPlace><availability><licence>Copyright © 2012 John Wiley & Sons, Ltd.</licence></availability><date type="published" when="2013-03"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Depression is associated with some patient‐perceived cosmetic changes, but not with radiotherapy‐induced late toxicity, in long‐term breast cancer survivors</title><title level="a" type="short">Depression‐associated factors in long‐term breast cancer survivors</title><author xml:id="author-0000" role="corresp"><persName><forename type="first">Paul</forename><surname>Brunault</surname></persName><affiliation><orgName>CHRU de Tours</orgName><address><settlement type="city">Tours</settlement><country key="FR">France</country></address></affiliation><affiliation>Correspondence to: CHRU de Tours, Tours, France. E‐mail: paul.brunault@gmail.com</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Isabelle</forename><surname>Suzanne</surname></persName><affiliation><orgName>CHRU de Tours</orgName><address><settlement type="city">Tours</settlement><country key="FR">France</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Magdalena</forename><surname>Trzepidur‐Edom</surname></persName><affiliation><orgName>CHRU de Tours</orgName><address><settlement type="city">Tours</settlement><country key="FR">France</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Pascal</forename><surname>Garaud</surname></persName><affiliation><orgName>CHRU de Tours</orgName><address><settlement type="city">Tours</settlement><country key="FR">France</country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Gilles</forename><surname>Calais</surname></persName><affiliation><orgName>CHRU de Tours</orgName><address><settlement type="city">Tours</settlement><country key="FR">France</country></address></affiliation><affiliation><orgName>Université François Rabelais de Tours</orgName><address><settlement type="city">Tours</settlement><country key="FR">France</country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Alain</forename><surname>Toledano</surname></persName><affiliation><orgName>Hôpital Américain de Paris‐Clinique Hartmann</orgName><address><settlement type="city">Neuilly sur Seine</settlement><country key="FR">France</country></address></affiliation></author><author xml:id="author-0006"><persName><forename type="first">Vincent</forename><surname>Camus</surname></persName><affiliation><orgName>CHRU de Tours</orgName><address><settlement type="city">Tours</settlement><country key="FR">France</country></address></affiliation><affiliation><orgName>Université François Rabelais de Tours</orgName><address><settlement type="city">Tours</settlement><country key="FR">France</country></address></affiliation><affiliation><orgName>UMR INSERM U930 & CNRS ERL 3106</orgName><address><settlement type="city">Tours</settlement><country key="FR">France</country></address></affiliation></author><idno type="istex">75014EFCF929DA611AFB29B74E8F9A20E97FF339</idno><idno type="DOI">10.1002/pon.3038</idno><idno type="unit">PON3038</idno><idno type="toTypesetVersion">file:PON.PON3038.pdf</idno></analytic><monogr><title level="j" type="main">Psycho‐Oncology</title><title level="j" type="alt">PSYCHO-ONCOLOGY</title><idno type="pISSN">1057-9249</idno><idno type="eISSN">1099-1611</idno><idno type="book-DOI">10.1002/(ISSN)1099-1611</idno><idno type="book-part-DOI">10.1002/pon.v22.3</idno><idno type="product">PON</idno><imprint><biblScope unit="vol">22</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="590">590</biblScope><biblScope unit="page" to="597">597</biblScope><biblScope unit="page-count">8</biblScope><publisher>John Wiley & Sons, Ltd</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2013-03"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract style="main"><head>Abstract</head>
Objective
<p>Although depression is prevalent in long‐term breast cancer survivors (LTBCS; ≥5 years since diagnosis), it is underdiagnosed and undertreated. A better understanding of factors associated with depression could improve depression screening, treatment, and prevention in this population. Our study aimed to assess the link between patient and doctor ratings of breast cosmetic outcomes, late radiotherapy toxicity, and depression in LTBCS.</p>
Methods
<p>In all, 214 patients recruited from the ARCOSEIN study were assessed for late radiotherapy toxicity (by using the LENT‐SOMA scale) and patient and doctor ratings of breast cosmetic outcomes (mean = 6.7 years since the end of treatment). We reassessed 120 of these patients for depression (HAD) during a second wave of long‐term assessment (mean = 8.1 years since the end of treatment). We used univariate analyses and polytomous logistic regression analyses to predict the HAD depression, which was defined as follows: normal, 0–7 points; and significant depression, ≥8 points (8–10 points, possible depression; ≥11 points, probable depression).</p>
Results
<p>The mean HAD depression score was 4.5 ± 3.6. 19. 2% of our population had significant depression, 6.7% with probable depression, and 12.5% with possible depression. Significant depression was not associated with late radiotherapy toxicity or initial cancer‐related variables. Patients with probable depression reported worse cosmetic outcomes than nondepressed patients in terms of perceived breast largeness (<hi rend="italic">p</hi> = 0.04), breast deformation (<hi rend="italic">p</hi> = 0.02), and changes in skin pigmentation (<hi rend="italic">p</hi> = 0.03).</p>
Conclusions
<p>In LTBCS, depression seems to be more strongly associated with changes in some patients' perceived breast cosmetic outcome than late treatment toxicity or initial cancer‐related variables. Copyright © 2012 John Wiley & Sons, Ltd.</p></abstract><textClass><keywords><term xml:id="pon3038-kwd-0001">cancer</term><term xml:id="pon3038-kwd-0002">oncology</term><term xml:id="pon3038-kwd-0003">long‐term survivors</term><term xml:id="pon3038-kwd-0004">depression</term><term xml:id="pon3038-kwd-0005">body image</term></keywords><classCode scheme="articleCategory">Paper</classCode><classCode scheme="tocHeading1">Papers</classCode></textClass><langUsage><language ident="EN"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/75014EFCF929DA611AFB29B74E8F9A20E97FF339/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component type="serialArticle" version="2.0" xml:lang="en" xml:id="pon3038"><header><publicationMeta level="product"><publisherInfo><publisherName>John Wiley & Sons, Ltd</publisherName><publisherLoc>Chichester, UK</publisherLoc></publisherInfo><doi>10.1002/(ISSN)1099-1611</doi><issn type="print">1057-9249</issn><issn type="electronic">1099-1611</issn><idGroup><id type="product" value="PON"></id></idGroup><titleGroup><title type="main" sort="PSYCHO-ONCOLOGY">Psycho‐Oncology</title><title type="short">Psycho‐Oncology</title></titleGroup></publicationMeta><publicationMeta level="part" position="03103"><doi>10.1002/pon.v22.3</doi><copyright ownership="publisher">Copyright © 2013 John Wiley & Sons, Ltd.</copyright><numberingGroup><numbering type="journalVolume" number="22">22</numbering><numbering type="journalIssue">3</numbering></numberingGroup><coverDate startDate="2013-03">March 2013</coverDate></publicationMeta><publicationMeta level="unit" position="150" type="article" status="forIssue"><doi>10.1002/pon.3038</doi><idGroup><id type="unit" value="PON3038"></id></idGroup><countGroup><count type="pageTotal" number="8"></count></countGroup><titleGroup><title type="articleCategory">Paper</title><title type="tocHeading1">Papers</title></titleGroup><copyright ownership="publisher">Copyright © 2012 John Wiley & Sons, Ltd.</copyright><eventGroup><event type="manuscriptReceived" date="2011-06-15"></event><event type="manuscriptRevised" date="2012-01-03"></event><event type="manuscriptAccepted" date="2012-01-07"></event><event type="xmlCreated" agent="SPi Global" date="2012-01-16"></event><event type="publishedOnlineEarlyUnpaginated" date="2012-02-07"></event><event type="firstOnline" date="2012-02-07"></event><event type="publishedOnlineFinalForm" date="2013-03-01"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-07"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-03"></event></eventGroup><numberingGroup><numbering type="pageFirst">590</numbering><numbering type="pageLast">597</numbering></numberingGroup><correspondenceTo>Correspondence to: CHRU de Tours, Tours, France. E‐mail: <email>paul.brunault@gmail.com</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:PON.PON3038.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Depression is associated with some patient‐perceived cosmetic changes, but not with radiotherapy‐induced late toxicity, in long‐term breast cancer survivors</title><title type="short">Depression‐associated factors in long‐term breast cancer survivors</title><title type="shortAuthors">P. Brunault <i>et al.</i></title></titleGroup><creators><creator creatorRole="author" xml:id="pon3038-cr-0001" affiliationRef="#pon3038-aff-0001" corresponding="yes"><personName><givenNames>Paul</givenNames><familyName>Brunault</familyName></personName></creator><creator creatorRole="author" xml:id="pon3038-cr-0002" affiliationRef="#pon3038-aff-0001"><personName><givenNames>Isabelle</givenNames><familyName>Suzanne</familyName></personName></creator><creator creatorRole="author" xml:id="pon3038-cr-0003" affiliationRef="#pon3038-aff-0001"><personName><givenNames>Magdalena</givenNames><familyName>Trzepidur‐Edom</familyName></personName></creator><creator creatorRole="author" xml:id="pon3038-cr-0004" affiliationRef="#pon3038-aff-0001"><personName><givenNames>Pascal</givenNames><familyName>Garaud</familyName></personName></creator><creator creatorRole="author" xml:id="pon3038-cr-0005" affiliationRef="#pon3038-aff-0001 #pon3038-aff-0002"><personName><givenNames>Gilles</givenNames><familyName>Calais</familyName></personName></creator><creator creatorRole="author" xml:id="pon3038-cr-0006" affiliationRef="#pon3038-aff-0003"><personName><givenNames>Alain</givenNames><familyName>Toledano</familyName></personName></creator><creator creatorRole="author" xml:id="pon3038-cr-0007" affiliationRef="#pon3038-aff-0001 #pon3038-aff-0002 #pon3038-aff-0004"><personName><givenNames>Vincent</givenNames><familyName>Camus</familyName></personName></creator></creators><affiliationGroup><affiliation countryCode="FR" type="organization" xml:id="pon3038-aff-0001"><orgName>CHRU de Tours</orgName><address><city>Tours</city><country>France</country></address></affiliation><affiliation countryCode="FR" type="organization" xml:id="pon3038-aff-0002"><orgName>Université François Rabelais de Tours</orgName><address><city>Tours</city><country>France</country></address></affiliation><affiliation countryCode="FR" type="organization" xml:id="pon3038-aff-0003"><orgName>Hôpital Américain de Paris‐Clinique Hartmann</orgName><address><city>Neuilly sur Seine</city><country>France</country></address></affiliation><affiliation countryCode="FR" type="organization" xml:id="pon3038-aff-0004"><orgName>UMR INSERM U930 & CNRS ERL 3106</orgName><address><city>Tours</city><country>France</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="pon3038-kwd-0001">cancer</keyword><keyword xml:id="pon3038-kwd-0002">oncology</keyword><keyword xml:id="pon3038-kwd-0003">long‐term survivors</keyword><keyword xml:id="pon3038-kwd-0004">depression</keyword><keyword xml:id="pon3038-kwd-0005">body image</keyword></keywordGroup><abstractGroup><abstract type="main"><title type="main">Abstract</title><section xml:id="pon3038-sec-0001"><title type="main">Objective</title><p>Although depression is prevalent in long‐term breast cancer survivors (LTBCS; ≥5 years since diagnosis), it is underdiagnosed and undertreated. A better understanding of factors associated with depression could improve depression screening, treatment, and prevention in this population. Our study aimed to assess the link between patient and doctor ratings of breast cosmetic outcomes, late radiotherapy toxicity, and depression in LTBCS.</p></section><section xml:id="pon3038-sec-0002"><title type="main">Methods</title><p>In all, 214 patients recruited from the ARCOSEIN study were assessed for late radiotherapy toxicity (by using the LENT‐SOMA scale) and patient and doctor ratings of breast cosmetic outcomes (mean = 6.7 years since the end of treatment). We reassessed 120 of these patients for depression (HAD) during a second wave of long‐term assessment (mean = 8.1 years since the end of treatment). We used univariate analyses and polytomous logistic regression analyses to predict the HAD depression, which was defined as follows: normal, 0–7 points; and significant depression, ≥8 points (8–10 points, possible depression; ≥11 points, probable depression).</p></section><section xml:id="pon3038-sec-0003"><title type="main">Results</title><p>The mean HAD depression score was 4.5 ± 3.6. 19. 2% of our population had significant depression, 6.7% with probable depression, and 12.5% with possible depression. Significant depression was not associated with late radiotherapy toxicity or initial cancer‐related variables. Patients with probable depression reported worse cosmetic outcomes than nondepressed patients in terms of perceived breast largeness (<i>p</i> = 0.04), breast deformation (<i>p</i> = 0.02), and changes in skin pigmentation (<i>p</i> = 0.03).</p></section><section xml:id="pon3038-sec-0004"><title type="main">Conclusions</title><p>In LTBCS, depression seems to be more strongly associated with changes in some patients' perceived breast cosmetic outcome than late treatment toxicity or initial cancer‐related variables. Copyright © 2012 John Wiley & Sons, Ltd.</p></section></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Depression is associated with some patient‐perceived cosmetic changes, but not with radiotherapy‐induced late toxicity, in long‐term breast cancer survivors</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Depression‐associated factors in long‐term breast cancer survivors</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Depression is associated with some patient‐perceived cosmetic changes, but not with radiotherapy‐induced late toxicity, in long‐term breast cancer survivors</title></titleInfo><name type="personal"><namePart type="given">Paul</namePart><namePart type="family">Brunault</namePart><affiliation>CHRU de Tours, Tours, France</affiliation><affiliation>E-mail: paul.brunault@gmail.com</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Isabelle</namePart><namePart type="family">Suzanne</namePart><affiliation>CHRU de Tours, Tours, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Magdalena</namePart><namePart type="family">Trzepidur‐Edom</namePart><affiliation>CHRU de Tours, Tours, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pascal</namePart><namePart type="family">Garaud</namePart><affiliation>CHRU de Tours, Tours, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gilles</namePart><namePart type="family">Calais</namePart><affiliation>CHRU de Tours, Tours, France</affiliation><affiliation>Université François Rabelais de Tours, Tours, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alain</namePart><namePart type="family">Toledano</namePart><affiliation>Hôpital Américain de Paris‐Clinique Hartmann, Neuilly sur Seine, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Vincent</namePart><namePart type="family">Camus</namePart><affiliation>CHRU de Tours, Tours, France</affiliation><affiliation>Université François Rabelais de Tours, Tours, France</affiliation><affiliation>UMR INSERM U930 & CNRS ERL 3106, Tours, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>John Wiley & Sons, Ltd</publisher><place><placeTerm type="text">Chichester, UK</placeTerm></place><dateIssued encoding="w3cdtf">2013-03</dateIssued><dateCreated encoding="w3cdtf">2012-01-16</dateCreated><dateCaptured encoding="w3cdtf">2011-06-15</dateCaptured><dateValid encoding="w3cdtf">2012-01-07</dateValid><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>Although depression is prevalent in long‐term breast cancer survivors (LTBCS; ≥5 years since diagnosis), it is underdiagnosed and undertreated. A better understanding of factors associated with depression could improve depression screening, treatment, and prevention in this population. Our study aimed to assess the link between patient and doctor ratings of breast cosmetic outcomes, late radiotherapy toxicity, and depression in LTBCS.</abstract><abstract>In all, 214 patients recruited from the ARCOSEIN study were assessed for late radiotherapy toxicity (by using the LENT‐SOMA scale) and patient and doctor ratings of breast cosmetic outcomes (mean = 6.7 years since the end of treatment). We reassessed 120 of these patients for depression (HAD) during a second wave of long‐term assessment (mean = 8.1 years since the end of treatment). We used univariate analyses and polytomous logistic regression analyses to predict the HAD depression, which was defined as follows: normal, 0–7 points; and significant depression, ≥8 points (8–10 points, possible depression; ≥11 points, probable depression).</abstract><abstract>The mean HAD depression score was 4.5 ± 3.6. 19. 2% of our population had significant depression, 6.7% with probable depression, and 12.5% with possible depression. Significant depression was not associated with late radiotherapy toxicity or initial cancer‐related variables. Patients with probable depression reported worse cosmetic outcomes than nondepressed patients in terms of perceived breast largeness (p = 0.04), breast deformation (p = 0.02), and changes in skin pigmentation (p = 0.03).</abstract><abstract>In LTBCS, depression seems to be more strongly associated with changes in some patients' perceived breast cosmetic outcome than late treatment toxicity or initial cancer‐related variables. Copyright © 2012 John Wiley & Sons, Ltd.</abstract><subject><genre>keywords</genre><topic>cancer</topic><topic>oncology</topic><topic>long‐term survivors</topic><topic>depression</topic><topic>body image</topic></subject><relatedItem type="host"><titleInfo><title>Psycho‐Oncology</title></titleInfo><titleInfo type="abbreviated"><title>Psycho‐Oncology</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Paper</topic></subject><identifier type="ISSN">1057-9249</identifier><identifier type="eISSN">1099-1611</identifier><identifier type="DOI">10.1002/(ISSN)1099-1611</identifier><identifier type="PublisherID">PON</identifier><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>590</start><end>597</end><total>8</total></extent></part></relatedItem><identifier type="istex">75014EFCF929DA611AFB29B74E8F9A20E97FF339</identifier><identifier type="DOI">10.1002/pon.3038</identifier><identifier type="ArticleID">PON3038</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2013 John Wiley & Sons, Ltd.Copyright © 2012 John Wiley & Sons, Ltd.</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>John Wiley & Sons, Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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