Assessment of skin barrier function in podoconiosis: measurement of stratum corneum hydration and transepidermal water loss
Identifieur interne : 003617 ( Istex/Corpus ); précédent : 003616; suivant : 003618Assessment of skin barrier function in podoconiosis: measurement of stratum corneum hydration and transepidermal water loss
Auteurs : J. S. Ferguson ; W. Yeshanehe ; P. Matts ; G. Davey ; P. Mortimer ; C. FullerSource :
- British Journal of Dermatology [ 0007-0963 ] ; 2013-03.
Abstract
Background Podoconiosis is a common cause of lymphoedema in barefoot workers in Ethiopia and other countries. It has severe consequences for patients’ physical function, quality of life and economic status.
Url:
DOI: 10.1111/bjd.12134
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ISTEX:73BC583E760B273AC3B97D8B0C45754F95D0BF73Le document en format XML
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Matts</name><affiliation><mods:affiliation>Procter and Gamble – Skin Care, London, U.K.</mods:affiliation></affiliation></author><author><name sortKey="Davey, G" sort="Davey, G" uniqKey="Davey G" first="G." last="Davey">G. Davey</name><affiliation><mods:affiliation>Brighton and Sussex Medical School, University of Sussex, Brighton, U.K.</mods:affiliation></affiliation></author><author><name sortKey="Mortimer, P" sort="Mortimer, P" uniqKey="Mortimer P" first="P." last="Mortimer">P. Mortimer</name><affiliation><mods:affiliation>Lymphovascular Medicine, St George’s Hospital, London, U.K.</mods:affiliation></affiliation></author><author><name sortKey="Fuller, C" sort="Fuller, C" uniqKey="Fuller C" first="C." last="Fuller">C. 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Ferguson</name><affiliation><mods:affiliation>Department of Dermatology</mods:affiliation></affiliation></author><author><name sortKey="Yeshanehe, W" sort="Yeshanehe, W" uniqKey="Yeshanehe W" first="W." last="Yeshanehe">W. Yeshanehe</name><affiliation><mods:affiliation>Department of Dermatology, Bahir Dar University, Bahir Dar, Ethiopia</mods:affiliation></affiliation></author><author><name sortKey="Matts, P" sort="Matts, P" uniqKey="Matts P" first="P." last="Matts">P. Matts</name><affiliation><mods:affiliation>Procter and Gamble – Skin Care, London, U.K.</mods:affiliation></affiliation></author><author><name sortKey="Davey, G" sort="Davey, G" uniqKey="Davey G" first="G." last="Davey">G. Davey</name><affiliation><mods:affiliation>Brighton and Sussex Medical School, University of Sussex, Brighton, U.K.</mods:affiliation></affiliation></author><author><name sortKey="Mortimer, P" sort="Mortimer, P" uniqKey="Mortimer P" first="P." last="Mortimer">P. 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Fuller</name><affiliation><mods:affiliation>Department of Dermatology, Chelsea and Westminster Hospital, London, U.K.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">British Journal of Dermatology</title><title level="j" type="alt">BRITISH JOURNAL OF DERMATOLOGY</title><idno type="ISSN">0007-0963</idno><idno type="eISSN">1365-2133</idno><imprint><biblScope unit="vol">168</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="550">550</biblScope><biblScope unit="page" to="554">554</biblScope><biblScope unit="page-count">5</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2013-03">2013-03</date></imprint><idno type="ISSN">0007-0963</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0007-0963</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Background Podoconiosis is a common cause of lymphoedema in barefoot workers in Ethiopia and other countries. 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BJD © 2012 British Association of Dermatologists</licence></availability><date type="published" when="2013-03"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Assessment of skin barrier function in podoconiosis: measurement of stratum corneum hydration and transepidermal water loss</title><title level="a" type="short">Skin barrier function in podoconiosis</title><author xml:id="author-0000"><persName><forename type="first">J.S.</forename><surname>Ferguson</surname></persName><affiliation>Department of Dermatology</affiliation></author><author xml:id="author-0001"><persName><forename type="first">W.</forename><surname>Yeshanehe</surname></persName><affiliation>Department of Dermatology, Bahir Dar University, Bahir Dar, Ethiopia<address><country key="ET"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">P.</forename><surname>Matts</surname></persName><affiliation>Procter and Gamble – Skin Care, London, U.K.</affiliation></author><author xml:id="author-0003"><persName><forename type="first">G.</forename><surname>Davey</surname></persName><affiliation>Brighton and Sussex Medical School, University of Sussex, Brighton, U.K.</affiliation></author><author xml:id="author-0004"><persName><forename type="first">P.</forename><surname>Mortimer</surname></persName><affiliation>Lymphovascular Medicine, St George’s Hospital, London, U.K.</affiliation></author><author xml:id="author-0005"><persName><forename type="first">C.</forename><surname>Fuller</surname></persName><affiliation>Department of Dermatology, Chelsea and Westminster Hospital, London, U.K.</affiliation></author><idno type="istex">73BC583E760B273AC3B97D8B0C45754F95D0BF73</idno><idno type="DOI">10.1111/bjd.12134</idno><idno type="unit">BJD12134</idno><idno type="toTypesetVersion">file:BJD.BJD12134.pdf</idno></analytic><monogr><title level="j" type="main">British Journal of Dermatology</title><title level="j" type="alt">BRITISH JOURNAL OF DERMATOLOGY</title><idno type="pISSN">0007-0963</idno><idno type="eISSN">1365-2133</idno><idno type="book-DOI">10.1111/(ISSN)1365-2133</idno><idno type="book-part-DOI">10.1111/bjd.2013.168.issue-3</idno><idno type="product">BJD</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">168</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="550">550</biblScope><biblScope unit="page" to="554">554</biblScope><biblScope unit="page-count">5</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2013-03"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><head>Summary</head><p><hi rend="bold">Background </hi> Podoconiosis is a common cause of lymphoedema in barefoot workers in Ethiopia and other countries. It has severe consequences for patients’ physical function, quality of life and economic status.</p><p><hi rend="bold">Aims </hi> To investigate stratum corneum (SC) hydration and transepidermal water loss (TEWL) in patients with podoconiosis compared with controls.</p><p><hi rend="bold">Methods </hi> In total, 55 patients and 20 controls were recruited. For each study subject, SC and TEWL measurements were taken, along with foot and lower leg circumferences. Measurements were compared between the patient and control groups.</p><p><hi rend="bold">Results </hi> Foot circumferences tended to be higher in patients with podoconiosis, with the mean foot:leg circumference ratio being 1·19 (95% confidence interval 1·11–1·28) times that for controls (<hi rend="italic">P </hi>=<hi rend="italic"> </hi>0·001). There was no detectable difference between patients and controls in TEWL values (<hi rend="italic">P </hi>><hi rend="italic"> </hi>0·05); however, SC hydration was significantly lower in patients vs. controls for the foot (<hi rend="italic">P </hi>=<hi rend="italic"> </hi>0·004) and lower leg (<hi rend="italic">P </hi>=<hi rend="italic"> </hi>0·046) sites.</p><p><hi rend="bold">Conclusions </hi> Patients with podoconiosis have significantly lower SC hydration in the skin of their lower legs and feet than controls, which may lead to cracking and splitting, and increased risk of lymphoedema and infection.</p></abstract><abstract style="short"><p><hi rend="bold">What’s already known about this topic?</hi></p><p><list xml:id="l1" style="custom"><item n="•"><p> Podoconiosis is a common cause of lymphoedema in Ethiopia, and is found among individuals who work barefoot in areas that share the same volcanic soil type.</p></item><item n="•"><p> Podoconiosis has a known association with human leucocyte antigen.</p></item><item n="•"><p> The disease is known to have a massive impact on the quality of life of sufferers and on their economic activity.</p></item></list></p><p><hi rend="bold">What does this study add?</hi></p><p><list xml:id="l2" style="custom"><item n="•"><p> This study suggests that patients with podoconiosis have impaired skin barrier function.</p></item><item n="•"><p> Patients were shown to have significantly reduced stratum corneum hydration compared with controls, particularly on the feet and shins.</p></item><item n="•"><p> Impaired barrier function may have a role in the pathogenesis of the disease.</p></item></list></p></abstract><textClass><classCode scheme="tocHeading1">Original articles</classCode><classCode scheme="tocHeading2">Clinical and laboratory investigations</classCode><classCode scheme="articleCategory">CLINICAL AND LABORATORY INVESTIGATIONS</classCode></textClass><langUsage><language ident="EN"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/73BC583E760B273AC3B97D8B0C45754F95D0BF73/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1365-2133</doi><issn type="print">0007-0963</issn><issn type="electronic">1365-2133</issn><idGroup><id type="product" value="BJD"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="BRITISH JOURNAL OF DERMATOLOGY">British Journal of Dermatology</title></titleGroup></publicationMeta><publicationMeta level="part" position="03103"><doi origin="wiley">10.1111/bjd.2013.168.issue-3</doi><numberingGroup><numbering type="journalVolume" number="168">168</numbering><numbering type="journalIssue" number="3">3</numbering></numberingGroup><coverDate startDate="2013-03">March 2013</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="18" status="forIssue"><doi origin="wiley">10.1111/bjd.12134</doi><idGroup><id type="unit" value="BJD12134"></id></idGroup><countGroup><count type="pageTotal" number="5"></count></countGroup><titleGroup><title type="tocHeading1">Original articles</title><title type="tocHeading2">Clinical and laboratory investigations</title><title type="articleCategory">CLINICAL AND LABORATORY INVESTIGATIONS</title></titleGroup><copyright>© 2012 The Authors. BJD © 2012 British Association of Dermatologists</copyright><eventGroup><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:3.2.0 mode:FullText" date="2013-02-26"></event><event agent="SPS" date="2013-02-27" type="xmlCorrected"></event><event type="firstOnline" date="2013-02-28"></event><event type="publishedOnlineFinalForm" date="2013-02-28"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-15"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-02"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="550">550</numbering><numbering type="pageLast" number="554">554</numbering></numberingGroup><correspondenceTo>John S. Ferguson.
E‐mail: <email>jsferg@gmail.com</email></correspondenceTo><objectNameGroup><objectName elementName="appendix">Appendix</objectName></objectNameGroup><linkGroup><link type="toTypesetVersion" href="file:BJD.BJD12134.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Accepted for publication 3 November 2012</unparsedEditorialHistory><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="3"></count></countGroup><titleGroup><title type="main">Assessment of skin barrier function in podoconiosis: measurement of stratum corneum hydration and transepidermal water loss</title><title type="shortAuthors">J.S. Ferguson <i>et al.</i></title><title type="short">Skin barrier function in podoconiosis</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>J.S.</givenNames><familyName>Ferguson</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2"><personName><givenNames>W.</givenNames><familyName>Yeshanehe</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a3"><personName><givenNames>P.</givenNames><familyName>Matts</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a4"><personName><givenNames>G.</givenNames><familyName>Davey</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a5"><personName><givenNames>P.</givenNames><familyName>Mortimer</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a6"><personName><givenNames>C.</givenNames><familyName>Fuller</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>Department of Dermatology</unparsedAffiliation></affiliation><affiliation xml:id="a5"><unparsedAffiliation>Lymphovascular Medicine, St George’s Hospital, London, U.K.</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="ET"><unparsedAffiliation>Department of Dermatology, Bahir Dar University, Bahir Dar, Ethiopia</unparsedAffiliation></affiliation><affiliation xml:id="a3"><unparsedAffiliation>Procter and Gamble – Skin Care, London, U.K.</unparsedAffiliation></affiliation><affiliation xml:id="a4"><unparsedAffiliation>Brighton and Sussex Medical School, University of Sussex, Brighton, U.K.</unparsedAffiliation></affiliation><affiliation xml:id="a6"><unparsedAffiliation>Department of Dermatology, Chelsea and Westminster Hospital, London, U.K.</unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Summary</title><p><b>Background </b> Podoconiosis is a common cause of lymphoedema in barefoot workers in Ethiopia and other countries. It has severe consequences for patients’ physical function, quality of life and economic status.</p><p><b>Aims </b> To investigate stratum corneum (SC) hydration and transepidermal water loss (TEWL) in patients with podoconiosis compared with controls.</p><p><b>Methods </b> In total, 55 patients and 20 controls were recruited. For each study subject, SC and TEWL measurements were taken, along with foot and lower leg circumferences. Measurements were compared between the patient and control groups.</p><p><b>Results </b> Foot circumferences tended to be higher in patients with podoconiosis, with the mean foot:leg circumference ratio being 1·19 (95% confidence interval 1·11–1·28) times that for controls (<i>P </i>=<i> </i>0·001). There was no detectable difference between patients and controls in TEWL values (<i>P </i>><i> </i>0·05); however, SC hydration was significantly lower in patients vs. controls for the foot (<i>P </i>=<i> </i>0·004) and lower leg (<i>P </i>=<i> </i>0·046) sites.</p><p><b>Conclusions </b> Patients with podoconiosis have significantly lower SC hydration in the skin of their lower legs and feet than controls, which may lead to cracking and splitting, and increased risk of lymphoedema and infection.</p></abstract><abstract type="short"><p><b>What’s already known about this topic?</b></p><p><list xml:id="l1" style="custom"><listItem><label>•</label><p> Podoconiosis is a common cause of lymphoedema in Ethiopia, and is found among individuals who work barefoot in areas that share the same volcanic soil type.</p></listItem><listItem><label>•</label><p> Podoconiosis has a known association with human leucocyte antigen.</p></listItem><listItem><label>•</label><p> The disease is known to have a massive impact on the quality of life of sufferers and on their economic activity.</p></listItem></list></p><p><b>What does this study add?</b></p><p><list xml:id="l2" style="custom"><listItem><label>•</label><p> This study suggests that patients with podoconiosis have impaired skin barrier function.</p></listItem><listItem><label>•</label><p> Patients were shown to have significantly reduced stratum corneum hydration compared with controls, particularly on the feet and shins.</p></listItem><listItem><label>•</label><p> Impaired barrier function may have a role in the pathogenesis of the disease.</p></listItem></list></p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Funding sources
Some funding for travel and accommodation was provided by the lymphoedema research fund at St George’s Hospital. The Procter and Gamble Company Ltd kindly lent us equipment.</p></note><note xml:id="fn2"><p>Conflicts of interest
None declared.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Assessment of skin barrier function in podoconiosis: measurement of stratum corneum hydration and transepidermal water loss</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Skin barrier function in podoconiosis</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Assessment of skin barrier function in podoconiosis: measurement of stratum corneum hydration and transepidermal water loss</title></titleInfo><name type="personal"><namePart type="given">J.S.</namePart><namePart type="family">Ferguson</namePart><affiliation>Department of Dermatology</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Yeshanehe</namePart><affiliation>Department of Dermatology, Bahir Dar University, Bahir Dar, Ethiopia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Matts</namePart><affiliation>Procter and Gamble – Skin Care, London, U.K.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Davey</namePart><affiliation>Brighton and Sussex Medical School, University of Sussex, Brighton, U.K.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Mortimer</namePart><affiliation>Lymphovascular Medicine, St George’s Hospital, London, U.K.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Fuller</namePart><affiliation>Department of Dermatology, Chelsea and Westminster Hospital, London, U.K.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2013-03</dateIssued><edition>Accepted for publication 3 November 2012</edition><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">3</extent></physicalDescription><abstract>Background Podoconiosis is a common cause of lymphoedema in barefoot workers in Ethiopia and other countries. It has severe consequences for patients’ physical function, quality of life and economic status.</abstract><abstract>Aims To investigate stratum corneum (SC) hydration and transepidermal water loss (TEWL) in patients with podoconiosis compared with controls.</abstract><abstract>Methods In total, 55 patients and 20 controls were recruited. For each study subject, SC and TEWL measurements were taken, along with foot and lower leg circumferences. Measurements were compared between the patient and control groups.</abstract><abstract>Results Foot circumferences tended to be higher in patients with podoconiosis, with the mean foot:leg circumference ratio being 1·19 (95% confidence interval 1·11–1·28) times that for controls (P = 0·001). There was no detectable difference between patients and controls in TEWL values (P > 0·05); however, SC hydration was significantly lower in patients vs. controls for the foot (P = 0·004) and lower leg (P = 0·046) sites.</abstract><abstract>Conclusions Patients with podoconiosis have significantly lower SC hydration in the skin of their lower legs and feet than controls, which may lead to cracking and splitting, and increased risk of lymphoedema and infection.</abstract><abstract>What’s already known about this topic?</abstract><abstract>• Podoconiosis is a common cause of lymphoedema in Ethiopia, and is found among individuals who work barefoot in areas that share the same volcanic soil type. • Podoconiosis has a known association with human leucocyte antigen. • The disease is known to have a massive impact on the quality of life of sufferers and on their economic activity.</abstract><abstract>What does this study add?</abstract><abstract>• This study suggests that patients with podoconiosis have impaired skin barrier function. • Patients were shown to have significantly reduced stratum corneum hydration compared with controls, particularly on the feet and shins. • Impaired barrier function may have a role in the pathogenesis of the disease.</abstract><relatedItem type="host"><titleInfo><title>British Journal of Dermatology</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>CLINICAL AND LABORATORY INVESTIGATIONS</topic></subject><identifier type="ISSN">0007-0963</identifier><identifier type="eISSN">1365-2133</identifier><identifier type="DOI">10.1111/(ISSN)1365-2133</identifier><identifier type="PublisherID">BJD</identifier><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>168</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>550</start><end>554</end><total>5</total></extent></part></relatedItem><identifier type="istex">73BC583E760B273AC3B97D8B0C45754F95D0BF73</identifier><identifier type="DOI">10.1111/bjd.12134</identifier><identifier type="ArticleID">BJD12134</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2012 The Authors. 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