Lymphatic system: a vital link between metabolic syndrome and inflammation
Identifieur interne : 003586 ( Istex/Corpus ); précédent : 003585; suivant : 003587Lymphatic system: a vital link between metabolic syndrome and inflammation
Auteurs : Sanjukta Chakraborty ; Scott Zawieja ; Wei Wang ; David C. Zawieja ; Mariappan MuthuchamySource :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2010-10.
Abstract
Metabolic syndrome is defined by a cluster of different metabolic risk factors that include overall and central obesity, elevated fasting glucose levels, dyslipidemia, hypertension, and intimal atherogenesis. Metabolic syndrome leads to increased risk for the development of type 2 diabetes and cardiovascular disease (e.g., heart disease and stroke). The exacerbated progression of metabolic syndrome to cardiovascular disease has lead to intense study of the physiological ramifications of metabolic syndrome on the blood vasculature. These studies have particularly focused on the signaling and architectural alterations that manifest in hypertension and atherosclerosis. However, despite the overlap of metabolic syndrome pathology with lymphatic function, tangent effects on the lymphatic system have not been extensively documented. In this review, we discuss the current status of metabolic syndrome and provide evidence for, and the remaining challenges in studying, the connections among the lymphatic system, lipid transport, obesity, insulin resistance, and general inflammation.
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DOI: 10.1111/j.1749-6632.2010.05752.x
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date="2014-10-14"></event></eventGroup><numberingGroup><numbering type="pageFirst">E94</numbering><numbering type="pageLast">E102</numbering></numberingGroup><correspondenceTo>Address for correspondence: Mariappan Muthuchamy, Division of Lymphatic Biology, Department of Systems Biology and Translational Medicine, Cardiovascular Research Institute, Texas A&M Health Science Center College of Medicine, 336 Reynolds Medical Building, College Station, TX 77843. <email>marim@tamu.edu</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:NYAS.NYAS5752.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="0"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="89"></count><count type="linksCrossRef" number="90"></count></countGroup><titleGroup><title type="main">Lymphatic system: a vital link between metabolic syndrome and 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affiliationRef="#a1"><personName><givenNames>Mariappan</givenNames><familyName>Muthuchamy</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="US"><unparsedAffiliation>Division of Lymphatic Biology, Department of Systems Biology and Translational Medicine, Cardiovascular Research Institute, Texas A&M Health Science Center College of Medicine, College Station, Texas</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">metabolic syndrome</keyword><keyword xml:id="k2">lymphatic pump</keyword><keyword xml:id="k3">lymphatics and lipid transport</keyword><keyword xml:id="k4">inflammation</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p>Metabolic syndrome is defined by a cluster of different metabolic risk factors that include overall and central obesity, elevated fasting glucose levels, dyslipidemia, hypertension, and intimal atherogenesis. Metabolic syndrome leads to increased risk for the development of type 2 diabetes and cardiovascular disease (e.g., heart disease and stroke). The exacerbated progression of metabolic syndrome to cardiovascular disease has lead to intense study of the physiological ramifications of metabolic syndrome on the blood vasculature. These studies have particularly focused on the signaling and architectural alterations that manifest in hypertension and atherosclerosis. However, despite the overlap of metabolic syndrome pathology with lymphatic function, tangent effects on the lymphatic system have not been extensively documented. In this review, we discuss the current status of metabolic syndrome and provide evidence for, and the remaining challenges in studying, the connections among the lymphatic system, lipid transport, obesity, insulin resistance, and general inflammation.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Lymphatic system: a vital link between metabolic syndrome and inflammation</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Roles of lymphatics in metabolic syndrome</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Lymphatic system: a vital link between metabolic syndrome and inflammation</title></titleInfo><name type="personal"><namePart type="given">Sanjukta</namePart><namePart type="family">Chakraborty</namePart><affiliation>Division of Lymphatic Biology, Department of Systems Biology and Translational Medicine, Cardiovascular Research Institute, Texas A&M Health Science Center College of Medicine, College Station, Texas</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Scott</namePart><namePart type="family">Zawieja</namePart><affiliation>Division of Lymphatic Biology, Department of Systems Biology and Translational Medicine, Cardiovascular Research Institute, Texas A&M Health Science Center College of Medicine, College Station, Texas</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Wei</namePart><namePart type="family">Wang</namePart><affiliation>Division of Lymphatic Biology, Department of Systems Biology and Translational Medicine, Cardiovascular Research Institute, Texas A&M Health Science Center College of Medicine, College Station, Texas</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">David C.</namePart><namePart type="family">Zawieja</namePart><affiliation>Division of Lymphatic Biology, Department of Systems Biology and Translational Medicine, Cardiovascular Research Institute, Texas A&M Health Science Center College of Medicine, College Station, Texas</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mariappan</namePart><namePart type="family">Muthuchamy</namePart><affiliation>Division of Lymphatic Biology, Department of Systems Biology and Translational Medicine, Cardiovascular Research Institute, Texas A&M Health Science Center College of Medicine, College Station, Texas</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Inc</publisher><place><placeTerm type="text">Malden, USA</placeTerm></place><dateIssued encoding="w3cdtf">2010-10</dateIssued><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="references">89</extent></physicalDescription><abstract lang="en">Metabolic syndrome is defined by a cluster of different metabolic risk factors that include overall and central obesity, elevated fasting glucose levels, dyslipidemia, hypertension, and intimal atherogenesis. Metabolic syndrome leads to increased risk for the development of type 2 diabetes and cardiovascular disease (e.g., heart disease and stroke). The exacerbated progression of metabolic syndrome to cardiovascular disease has lead to intense study of the physiological ramifications of metabolic syndrome on the blood vasculature. These studies have particularly focused on the signaling and architectural alterations that manifest in hypertension and atherosclerosis. However, despite the overlap of metabolic syndrome pathology with lymphatic function, tangent effects on the lymphatic system have not been extensively documented. In this review, we discuss the current status of metabolic syndrome and provide evidence for, and the remaining challenges in studying, the connections among the lymphatic system, lipid transport, obesity, insulin resistance, and general inflammation.</abstract><subject lang="en"><genre>keywords</genre><topic>metabolic syndrome</topic><topic>lymphatic pump</topic><topic>lymphatics and lipid transport</topic><topic>inflammation</topic></subject><relatedItem type="host"><titleInfo><title>Annals of the New York Academy of Sciences</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0077-8923</identifier><identifier type="eISSN">1749-6632</identifier><identifier type="DOI">10.1111/(ISSN)1749-6632</identifier><identifier type="PublisherID">NYAS</identifier><part><date>2010</date><detail type="title"><title>S1 Lymphatics in the Digestive System: Physiology, Health, and Disease</title></detail><detail type="volume"><caption>vol.</caption><number>1207</number></detail><detail type="supplement"><caption>Suppl. no.</caption><number>s1</number></detail><extent unit="pages"><start>E94</start><end>E102</end><total>9</total></extent></part></relatedItem><identifier type="istex">733541892B23D3C3751ABF46C479153F225CF3F8</identifier><identifier type="DOI">10.1111/j.1749-6632.2010.05752.x</identifier><identifier type="ArticleID">NYAS5752</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2010 New York Academy of Sciences</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Inc</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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