Toxicity of venalot (a mixture of coumarin and troxerutin) in the baboon
Identifieur interne : 003427 ( Istex/Corpus ); précédent : 003426; suivant : 003428Toxicity of venalot (a mixture of coumarin and troxerutin) in the baboon
Auteurs : A. H. Pulsford ; R. Heywood ; A. E. Street ; S. K. MajeedSource :
- Toxicology Letters [ 0378-4274 ] ; 1983.
Abstract
Venalot, a mixture of coumarin and troxerutin, in the proportion 1 to 6 respectively, was given orally to baboons at dosages of 0, 100, 300 and 1000 mgkgday for 26 weeks. Vomiting, usually within 3 h of administration and considered to be of central origin, in addition to vomiting immediately after dosing, was noted in animals receiving 1000 mgkgday. At this level, collapse on several occasions in two animals, one of which died, was also observed. Another animal receiving 1000 mgkgday was killed for humane reasons following a period of weight loss, reduced appetite and deterioration in body condition. However, no adverse effect on body weight gain, food or water consumption, ophthalmoscopic or electrocardiographic examinations were noted in any other animals during this study. Increased levels of liver function (serum leucine amino-peptidase (LAP), and serum ornithine carbamyl transferase (OCT)) were noted during the dosing period, together with slightly increased liver weights terminally for animals receiving 1000 mgkgday; however, as no morphological or ultrastructural changes were noted, these findings were considered to be attributable to hypertrophy.
Url:
DOI: 10.1016/0378-4274(83)90211-4
Links to Exploration step
ISTEX:6FB6D26495195C48A56C730678CB9E1B2EEEC311Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Toxicity of venalot (a mixture of coumarin and troxerutin) in the baboon</title><author><name sortKey="Pulsford, A H" sort="Pulsford, A H" uniqKey="Pulsford A" first="A. H." last="Pulsford">A. H. Pulsford</name><affiliation><mods:affiliation>Huntingdon Research Centre, Huntingdon, Cambridgeshire, PE18 6ES U.K.</mods:affiliation></affiliation></author><author><name sortKey="Heywood, R" sort="Heywood, R" uniqKey="Heywood R" first="R." last="Heywood">R. Heywood</name><affiliation><mods:affiliation>Huntingdon Research Centre, Huntingdon, Cambridgeshire, PE18 6ES U.K.</mods:affiliation></affiliation></author><author><name sortKey="Street, A E" sort="Street, A E" uniqKey="Street A" first="A. E." last="Street">A. E. Street</name><affiliation><mods:affiliation>Huntingdon Research Centre, Huntingdon, Cambridgeshire, PE18 6ES U.K.</mods:affiliation></affiliation></author><author><name sortKey="Majeed, S K" sort="Majeed, S K" uniqKey="Majeed S" first="S. K." last="Majeed">S. K. Majeed</name><affiliation><mods:affiliation>Huntingdon Research Centre, Huntingdon, Cambridgeshire, PE18 6ES U.K.</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:6FB6D26495195C48A56C730678CB9E1B2EEEC311</idno><date when="1983" year="1983">1983</date><idno type="doi">10.1016/0378-4274(83)90211-4</idno><idno type="url">https://api.istex.fr/document/6FB6D26495195C48A56C730678CB9E1B2EEEC311/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">003427</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">003427</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Toxicity of venalot (a mixture of coumarin and troxerutin) in the baboon</title><author><name sortKey="Pulsford, A H" sort="Pulsford, A H" uniqKey="Pulsford A" first="A. H." last="Pulsford">A. H. Pulsford</name><affiliation><mods:affiliation>Huntingdon Research Centre, Huntingdon, Cambridgeshire, PE18 6ES U.K.</mods:affiliation></affiliation></author><author><name sortKey="Heywood, R" sort="Heywood, R" uniqKey="Heywood R" first="R." last="Heywood">R. Heywood</name><affiliation><mods:affiliation>Huntingdon Research Centre, Huntingdon, Cambridgeshire, PE18 6ES U.K.</mods:affiliation></affiliation></author><author><name sortKey="Street, A E" sort="Street, A E" uniqKey="Street A" first="A. E." last="Street">A. E. Street</name><affiliation><mods:affiliation>Huntingdon Research Centre, Huntingdon, Cambridgeshire, PE18 6ES U.K.</mods:affiliation></affiliation></author><author><name sortKey="Majeed, S K" sort="Majeed, S K" uniqKey="Majeed S" first="S. K." last="Majeed">S. K. Majeed</name><affiliation><mods:affiliation>Huntingdon Research Centre, Huntingdon, Cambridgeshire, PE18 6ES U.K.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Toxicology Letters</title><title level="j" type="abbrev">TOXLET</title><idno type="ISSN">0378-4274</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1983">1983</date><biblScope unit="volume">15</biblScope><biblScope unit="issue">2–3</biblScope><biblScope unit="page" from="167">167</biblScope><biblScope unit="page" to="174">174</biblScope></imprint><idno type="ISSN">0378-4274</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0378-4274</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Venalot, a mixture of coumarin and troxerutin, in the proportion 1 to 6 respectively, was given orally to baboons at dosages of 0, 100, 300 and 1000 mgkgday for 26 weeks. Vomiting, usually within 3 h of administration and considered to be of central origin, in addition to vomiting immediately after dosing, was noted in animals receiving 1000 mgkgday. At this level, collapse on several occasions in two animals, one of which died, was also observed. Another animal receiving 1000 mgkgday was killed for humane reasons following a period of weight loss, reduced appetite and deterioration in body condition. However, no adverse effect on body weight gain, food or water consumption, ophthalmoscopic or electrocardiographic examinations were noted in any other animals during this study. Increased levels of liver function (serum leucine amino-peptidase (LAP), and serum ornithine carbamyl transferase (OCT)) were noted during the dosing period, together with slightly increased liver weights terminally for animals receiving 1000 mgkgday; however, as no morphological or ultrastructural changes were noted, these findings were considered to be attributable to hypertrophy.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>coumarin</json:string><json:string>dosing</json:string><json:string>venalot</json:string><json:string>baboon</json:string><json:string>toxicity</json:string><json:string>troxerutin</json:string><json:string>control group</json:string><json:string>dosing period</json:string><json:string>humane reasons</json:string><json:string>therapeutic dose</json:string><json:string>water consumption</json:string><json:string>body weight gain</json:string><json:string>weight loss</json:string><json:string>ultrastructural changes</json:string><json:string>dose levels</json:string><json:string>laboratory investigations</json:string><json:string>adverse effect</json:string><json:string>histological examination</json:string><json:string>liver function</json:string><json:string>different strains</json:string><json:string>chronic toxicity</json:string><json:string>propylene glycol</json:string><json:string>experimental period</json:string><json:string>food consumption</json:string><json:string>body weight</json:string><json:string>coumarin content</json:string><json:string>urine samples</json:string><json:string>food cosmet</json:string><json:string>macroscopic examination</json:string><json:string>liver sections</json:string><json:string>bodily condition</json:string><json:string>other groups</json:string><json:string>central stimulation</json:string><json:string>emetic centre</json:string><json:string>oral dosing</json:string><json:string>rodent species</json:string><json:string>metabolism</json:string></teeft></keywords><author><json:item><name>A.H. Pulsford</name><affiliations><json:string>Huntingdon Research Centre, Huntingdon, Cambridgeshire, PE18 6ES U.K.</json:string></affiliations></json:item><json:item><name>R. Heywood</name><affiliations><json:string>Huntingdon Research Centre, Huntingdon, Cambridgeshire, PE18 6ES U.K.</json:string></affiliations></json:item><json:item><name>A.E. Street</name><affiliations><json:string>Huntingdon Research Centre, Huntingdon, Cambridgeshire, PE18 6ES U.K.</json:string></affiliations></json:item><json:item><name>S.K. Majeed</name><affiliations><json:string>Huntingdon Research Centre, Huntingdon, Cambridgeshire, PE18 6ES U.K.</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Vomiting</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>collapse</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>liver function</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>hypertrophy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>LAP : leucine amino peptidase</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>OCT : ornithine carbamyl transferase</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>SALT : serum alanine trausaminase</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>SAP : serum alkaline phosphatase</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>SAsT : serum aspartate transaminase</value></json:item></subject><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Venalot, a mixture of coumarin and troxerutin, in the proportion 1 to 6 respectively, was given orally to baboons at dosages of 0, 100, 300 and 1000 mgkgday for 26 weeks. Vomiting, usually within 3 h of administration and considered to be of central origin, in addition to vomiting immediately after dosing, was noted in animals receiving 1000 mgkgday. At this level, collapse on several occasions in two animals, one of which died, was also observed. Another animal receiving 1000 mgkgday was killed for humane reasons following a period of weight loss, reduced appetite and deterioration in body condition. However, no adverse effect on body weight gain, food or water consumption, ophthalmoscopic or electrocardiographic examinations were noted in any other animals during this study. Increased levels of liver function (serum leucine amino-peptidase (LAP), and serum ornithine carbamyl transferase (OCT)) were noted during the dosing period, together with slightly increased liver weights terminally for animals receiving 1000 mgkgday; however, as no morphological or ultrastructural changes were noted, these findings were considered to be attributable to hypertrophy.</abstract><qualityIndicators><score>4.795</score><pdfVersion>1.2</pdfVersion><pdfPageSize>432 x 648 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>9</keywordCount><abstractCharCount>1173</abstractCharCount><pdfWordCount>2695</pdfWordCount><pdfCharCount>18788</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>175</abstractWordCount></qualityIndicators><title>Toxicity of venalot (a mixture of coumarin and troxerutin) in the baboon</title><pii><json:string>0378-4274(83)90211-4</json:string></pii><genre><json:string>research-article</json:string></genre><host><title>Toxicology Letters</title><language><json:string>unknown</json:string></language><publicationDate>1983</publicationDate><issn><json:string>0378-4274</json:string></issn><pii><json:string>S0378-4274(00)X0271-8</json:string></pii><volume>15</volume><issue>2–3</issue><pages><first>167</first><last>174</last></pages><genre><json:string>journal</json:string></genre></host><categories><wos><json:string>science</json:string><json:string>toxicology</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>biomedical research</json:string><json:string>toxicology</json:string></scienceMetrix><inist><json:string>sciences appliquees, technologies et medecines</json:string><json:string>sciences biologiques et medicales</json:string><json:string>sciences medicales</json:string></inist></categories><publicationDate>1983</publicationDate><copyrightDate>1983</copyrightDate><doi><json:string>10.1016/0378-4274(83)90211-4</json:string></doi><id>6FB6D26495195C48A56C730678CB9E1B2EEEC311</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/6FB6D26495195C48A56C730678CB9E1B2EEEC311/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/6FB6D26495195C48A56C730678CB9E1B2EEEC311/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/6FB6D26495195C48A56C730678CB9E1B2EEEC311/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Toxicity of venalot (a mixture of coumarin and troxerutin) in the baboon</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1983</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Toxicity of venalot (a mixture of coumarin and troxerutin) in the baboon</title><author xml:id="author-0000"><persName><forename type="first">A.H.</forename><surname>Pulsford</surname></persName><affiliation>Huntingdon Research Centre, Huntingdon, Cambridgeshire, PE18 6ES U.K.</affiliation></author><author xml:id="author-0001"><persName><forename type="first">R.</forename><surname>Heywood</surname></persName><affiliation>Huntingdon Research Centre, Huntingdon, Cambridgeshire, PE18 6ES U.K.</affiliation></author><author xml:id="author-0002"><persName><forename type="first">A.E.</forename><surname>Street</surname></persName><affiliation>Huntingdon Research Centre, Huntingdon, Cambridgeshire, PE18 6ES U.K.</affiliation></author><author xml:id="author-0003"><persName><forename type="first">S.K.</forename><surname>Majeed</surname></persName><affiliation>Huntingdon Research Centre, Huntingdon, Cambridgeshire, PE18 6ES U.K.</affiliation></author><idno type="istex">6FB6D26495195C48A56C730678CB9E1B2EEEC311</idno><idno type="DOI">10.1016/0378-4274(83)90211-4</idno><idno type="PII">0378-4274(83)90211-4</idno></analytic><monogr><title level="j">Toxicology Letters</title><title level="j" type="abbrev">TOXLET</title><idno type="pISSN">0378-4274</idno><idno type="PII">S0378-4274(00)X0271-8</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1983"></date><biblScope unit="volume">15</biblScope><biblScope unit="issue">2–3</biblScope><biblScope unit="page" from="167">167</biblScope><biblScope unit="page" to="174">174</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1983</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Venalot, a mixture of coumarin and troxerutin, in the proportion 1 to 6 respectively, was given orally to baboons at dosages of 0, 100, 300 and 1000 mgkgday for 26 weeks. Vomiting, usually within 3 h of administration and considered to be of central origin, in addition to vomiting immediately after dosing, was noted in animals receiving 1000 mgkgday. At this level, collapse on several occasions in two animals, one of which died, was also observed. Another animal receiving 1000 mgkgday was killed for humane reasons following a period of weight loss, reduced appetite and deterioration in body condition. However, no adverse effect on body weight gain, food or water consumption, ophthalmoscopic or electrocardiographic examinations were noted in any other animals during this study. Increased levels of liver function (serum leucine amino-peptidase (LAP), and serum ornithine carbamyl transferase (OCT)) were noted during the dosing period, together with slightly increased liver weights terminally for animals receiving 1000 mgkgday; however, as no morphological or ultrastructural changes were noted, these findings were considered to be attributable to hypertrophy.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Vomiting</term></item><item><term>collapse</term></item><item><term>liver function</term></item><item><term>hypertrophy</term></item></list></keywords></textClass><textClass><keywords scheme="keyword"><list><head>Abbreviations</head><item><term>LAP</term><term>leucine amino peptidase</term></item><item><term>OCT</term><term>ornithine carbamyl transferase</term></item><item><term>SALT</term><term>serum alanine trausaminase</term></item><item><term>SAP</term><term>serum alkaline phosphatase</term></item><item><term>SAsT</term><term>serum aspartate transaminase</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1982-08-26">Modified</change><change when="1983">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/6FB6D26495195C48A56C730678CB9E1B2EEEC311/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>TOXLET</jid><aid>83902114</aid><ce:pii>0378-4274(83)90211-4</ce:pii><ce:doi>10.1016/0378-4274(83)90211-4</ce:doi><ce:copyright type="unknown" year="1983"></ce:copyright></item-info><head><ce:title>Toxicity of venalot (a mixture of coumarin and troxerutin) in the baboon</ce:title><ce:author-group><ce:author><ce:given-name>A.H.</ce:given-name><ce:surname>Pulsford</ce:surname></ce:author><ce:author><ce:given-name>R.</ce:given-name><ce:surname>Heywood</ce:surname></ce:author><ce:author><ce:given-name>A.E.</ce:given-name><ce:surname>Street</ce:surname></ce:author><ce:author><ce:given-name>S.K.</ce:given-name><ce:surname>Majeed</ce:surname></ce:author><ce:affiliation><ce:textfn>Huntingdon Research Centre, Huntingdon, Cambridgeshire, PE18 6ES U.K.</ce:textfn></ce:affiliation></ce:author-group><ce:date-received day="7" month="6" year="1982"></ce:date-received><ce:date-revised day="26" month="8" year="1982"></ce:date-revised><ce:date-accepted day="3" month="9" year="1982"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Venalot, a mixture of coumarin and troxerutin, in the proportion 1 to 6 respectively, was given orally to baboons at dosages of 0, 100, 300 and <math altimg="si1.gif">1000 <rm><fr shape="sol"><nu>mg</nu><de><fr shape="sol"><nu>kg</nu><de>day</de></fr></de></fr></rm></math> for 26 weeks. Vomiting, usually within 3 h of administration and considered to be of central origin, in addition to vomiting immediately after dosing, was noted in animals receiving <math altimg="si2.gif">1000 <rm><fr shape="sol"><nu>mg</nu><de><fr shape="sol"><nu>kg</nu><de>day</de></fr></de></fr></rm></math>. At this level, collapse on several occasions in two animals, one of which died, was also observed. Another animal receiving <math altimg="si3.gif">1000 <rm><fr shape="sol"><nu>mg</nu><de><fr shape="sol"><nu>kg</nu><de>day</de></fr></de></fr></rm></math> was killed for humane reasons following a period of weight loss, reduced appetite and deterioration in body condition. However, no adverse effect on body weight gain, food or water consumption, ophthalmoscopic or electrocardiographic examinations were noted in any other animals during this study. Increased levels of liver function (serum leucine amino-peptidase (LAP), and serum ornithine carbamyl transferase (OCT)) were noted during the dosing period, together with slightly increased liver weights terminally for animals receiving <math altimg="si4.gif">1000 <rm><fr shape="sol"><nu>mg</nu><de><fr shape="sol"><nu>kg</nu><de>day</de></fr></de></fr></rm></math>; however, as no morphological or ultrastructural changes were noted, these findings were considered to be attributable to hypertrophy.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Vomiting</ce:text></ce:keyword><ce:keyword><ce:text>collapse</ce:text></ce:keyword><ce:keyword><ce:text>liver function</ce:text></ce:keyword><ce:keyword><ce:text>hypertrophy</ce:text></ce:keyword></ce:keywords><ce:keywords class="abr"><ce:section-title>Abbreviations</ce:section-title><ce:keyword><ce:text>LAP</ce:text><ce:keyword><ce:text>leucine amino peptidase</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>OCT</ce:text><ce:keyword><ce:text>ornithine carbamyl transferase</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>SALT</ce:text><ce:keyword><ce:text>serum alanine trausaminase</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>SAP</ce:text><ce:keyword><ce:text>serum alkaline phosphatase</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>SAsT</ce:text><ce:keyword><ce:text>serum aspartate transaminase</ce:text></ce:keyword></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Toxicity of venalot (a mixture of coumarin and troxerutin) in the baboon</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Toxicity of venalot (a mixture of coumarin and troxerutin) in the baboon</title></titleInfo><name type="personal"><namePart type="given">A.H.</namePart><namePart type="family">Pulsford</namePart><affiliation>Huntingdon Research Centre, Huntingdon, Cambridgeshire, PE18 6ES U.K.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Heywood</namePart><affiliation>Huntingdon Research Centre, Huntingdon, Cambridgeshire, PE18 6ES U.K.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.E.</namePart><namePart type="family">Street</namePart><affiliation>Huntingdon Research Centre, Huntingdon, Cambridgeshire, PE18 6ES U.K.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.K.</namePart><namePart type="family">Majeed</namePart><affiliation>Huntingdon Research Centre, Huntingdon, Cambridgeshire, PE18 6ES U.K.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1983</dateIssued><dateModified encoding="w3cdtf">1982-08-26</dateModified><copyrightDate encoding="w3cdtf">1983</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Venalot, a mixture of coumarin and troxerutin, in the proportion 1 to 6 respectively, was given orally to baboons at dosages of 0, 100, 300 and 1000 mgkgday for 26 weeks. Vomiting, usually within 3 h of administration and considered to be of central origin, in addition to vomiting immediately after dosing, was noted in animals receiving 1000 mgkgday. At this level, collapse on several occasions in two animals, one of which died, was also observed. Another animal receiving 1000 mgkgday was killed for humane reasons following a period of weight loss, reduced appetite and deterioration in body condition. However, no adverse effect on body weight gain, food or water consumption, ophthalmoscopic or electrocardiographic examinations were noted in any other animals during this study. Increased levels of liver function (serum leucine amino-peptidase (LAP), and serum ornithine carbamyl transferase (OCT)) were noted during the dosing period, together with slightly increased liver weights terminally for animals receiving 1000 mgkgday; however, as no morphological or ultrastructural changes were noted, these findings were considered to be attributable to hypertrophy.</abstract><subject><genre>Keywords</genre><topic>Vomiting</topic><topic>collapse</topic><topic>liver function</topic><topic>hypertrophy</topic></subject><subject><genre>Abbreviations</genre><topic>LAP : leucine amino peptidase</topic><topic>OCT : ornithine carbamyl transferase</topic><topic>SALT : serum alanine trausaminase</topic><topic>SAP : serum alkaline phosphatase</topic><topic>SAsT : serum aspartate transaminase</topic></subject><relatedItem type="host"><titleInfo><title>Toxicology Letters</title></titleInfo><titleInfo type="abbreviated"><title>TOXLET</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">198302</dateIssued></originInfo><identifier type="ISSN">0378-4274</identifier><identifier type="PII">S0378-4274(00)X0271-8</identifier><part><date>198302</date><detail type="volume"><number>15</number><caption>vol.</caption></detail><detail type="issue"><number>2–3</number><caption>no.</caption></detail><extent unit="issue pages"><start>95</start><end>274</end></extent><extent unit="pages"><start>167</start><end>174</end></extent></part></relatedItem><identifier type="istex">6FB6D26495195C48A56C730678CB9E1B2EEEC311</identifier><identifier type="DOI">10.1016/0378-4274(83)90211-4</identifier><identifier type="PII">0378-4274(83)90211-4</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003427 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 003427 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:6FB6D26495195C48A56C730678CB9E1B2EEEC311
|texte= Toxicity of venalot (a mixture of coumarin and troxerutin) in the baboon
}}
| This area was generated with Dilib version V0.6.31. |  |