Comparison of Different Wound Dressings on Cultured Human Fibroblasts and Collagen Lattices
Identifieur interne : 003413 ( Istex/Corpus ); précédent : 003412; suivant : 003414Comparison of Different Wound Dressings on Cultured Human Fibroblasts and Collagen Lattices
Auteurs : P. Humbert ; J. Viennet ; J. Bride ; Ac GabiotSource :
- Wound Repair and Regeneration [ 1067-1927 ] ; 2005-01.
Abstract
Introduction: The cellular phases (granulation, reepithelialization, and dermal remodelling) of the healing process involve many cell types. Fibroblasts and myofibroblasts are the key cells in granulation tissue formation and wound contraction.
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DOI: 10.1111/j.1067-1927.2005.130117o.x
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ISTEX:6F6CE84C905C965D7B17E37A0C94471277445685Le document en format XML
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type="first">P</forename><surname>Humbert</surname></persName><affiliation>Engineering and Cutaneous Biology Laboratory, Besançon, France<address><country key="FR"></country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">J</forename><surname>Viennet</surname></persName><affiliation>Engineering and Cutaneous Biology Laboratory, Besançon, France<address><country key="FR"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">J</forename><surname>Bride</surname></persName><affiliation>Engineering and Cutaneous Biology Laboratory, Besançon, France<address><country key="FR"></country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">AC</forename><surname>Gabiot</surname></persName><affiliation>Engineering and Cutaneous Biology Laboratory, Besançon, France<address><country key="FR"></country></address></affiliation></author><idno 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when="2005-01"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><p><hi rend="bold">Introduction: </hi> The cellular phases (granulation, reepithelialization, and dermal remodelling) of the healing process involve many cell types. Fibroblasts and myofibroblasts are the key cells in granulation tissue formation and wound contraction.</p><p><hi rend="bold">Objective: </hi> To compare the effects on cultured human fibroblasts of a new nonadhesive lipidocolloid wound dressing, Urgotul<hi rend="superscript">®</hi>, with five other wound dressings including impregnated gauzes and some other modern wound dressings.</p><p><hi rend="bold">Method: </hi> Cultures in monolayer were used to study the morphology and growth of fibroblasts. The Bell model of cultured dermis equivalents was used to investigate myofibroblast differentiation. These cultures were labelled α‐SM actin and F‐actin.</p><p><hi rend="bold">Results: </hi> Two of the tested dressings induced cytotoxic effects on the fibroblasts. They were found to inhibit cell growth (greater than 60%) and to disturb cell shape and cytoskeletal differentiation. Urgotul<hi rend="superscript">®</hi> and the remaining three dressings showed no effect on proliferation. However some of them modified fibroblast morphology and affected F‐actin distribution.</p><p><hi rend="bold">Conclusion: </hi> Depending on their nature and components, wound dressings may respect or affect in vitro fibroblast behaviour (proliferation, morphology, and α‐SM actin and F‐actin distribution). The observed in vitro findings require further investigations.</p></abstract><textClass><classCode scheme="tocHeading1">Abstracts ‐ European Tissue Repair Society Focus Meeting</classCode></textClass><langUsage><language ident="EN"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/6F6CE84C905C965D7B17E37A0C94471277445685/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley component found"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Science Inc</publisherName><publisherLoc>Oxford, UK; Malden, USA</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1524-475X</doi><issn type="print">1067-1927</issn><issn type="electronic">1524-475X</issn><idGroup><id type="product" value="WRR"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="WOUND REPAIR REGENERATION">Wound Repair and Regeneration</title></titleGroup></publicationMeta><publicationMeta level="part" position="01101"><doi origin="wiley">10.1111/wrr.2005.13.issue-1</doi><numberingGroup><numbering type="journalVolume" number="13">13</numbering><numbering type="journalIssue" number="1">1</numbering></numberingGroup><coverDate startDate="2005-01">January 2005</coverDate></publicationMeta><publicationMeta level="unit" type="abstract" position="0002100" status="forIssue"><doi origin="wiley">10.1111/j.1067-1927.2005.130117o.x</doi><idGroup><id type="unit" value="WRR130117O"></id></idGroup><countGroup><count type="pageTotal" number="1"></count></countGroup><titleGroup><title type="tocHeading1">Abstracts ‐ European Tissue Repair Society Focus Meeting</title></titleGroup><eventGroup><event type="firstOnline" date="2005-01-17"></event><event type="publishedOnlineFinalForm" date="2005-01-17"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.17 mode:FullText" date="2010-09-08"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-10"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-11-04"></event></eventGroup><numberingGroup><numbering type="pageFirst">A21</numbering><numbering type="pageLast">A21</numbering></numberingGroup><linkGroup><link type="toTypesetVersion" href="file:WRR.WRR130117O.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="0"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="0"></count><count type="wordTotal" number="4249"></count><count type="linksPubMed" number="0"></count><count type="linksCrossRef" number="0"></count></countGroup><titleGroup><title type="main">Comparison of Different Wound Dressings on Cultured Human Fibroblasts and Collagen Lattices</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>P</givenNames><familyName>Humbert</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>J</givenNames><familyName>Viennet</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>J</givenNames><familyName>Bride</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>AC</givenNames><familyName>Gabiot</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="FR"><unparsedAffiliation>Engineering and Cutaneous Biology Laboratory, Besançon, France</unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b>Introduction: </b> The cellular phases (granulation, reepithelialization, and dermal remodelling) of the healing process involve many cell types. Fibroblasts and myofibroblasts are the key cells in granulation tissue formation and wound contraction.</p><p><b>Objective: </b> To compare the effects on cultured human fibroblasts of a new nonadhesive lipidocolloid wound dressing, Urgotul<sup>®</sup>, with five other wound dressings including impregnated gauzes and some other modern wound dressings.</p><p><b>Method: </b> Cultures in monolayer were used to study the morphology and growth of fibroblasts. The Bell model of cultured dermis equivalents was used to investigate myofibroblast differentiation. These cultures were labelled α‐SM actin and F‐actin.</p><p><b>Results: </b> Two of the tested dressings induced cytotoxic effects on the fibroblasts. They were found to inhibit cell growth (greater than 60%) and to disturb cell shape and cytoskeletal differentiation. Urgotul<sup>®</sup> and the remaining three dressings showed no effect on proliferation. However some of them modified fibroblast morphology and affected F‐actin distribution.</p><p><b>Conclusion: </b> Depending on their nature and components, wound dressings may respect or affect in vitro fibroblast behaviour (proliferation, morphology, and α‐SM actin and F‐actin distribution). The observed in vitro findings require further investigations.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Comparison of Different Wound Dressings on Cultured Human Fibroblasts and Collagen Lattices</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Comparison of Different Wound Dressings on Cultured Human Fibroblasts and Collagen Lattices</title></titleInfo><name type="personal"><namePart type="given">P</namePart><namePart type="family">Humbert</namePart><affiliation>Engineering and Cutaneous Biology Laboratory, Besançon, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Viennet</namePart><affiliation>Engineering and Cutaneous Biology Laboratory, Besançon, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Bride</namePart><affiliation>Engineering and Cutaneous Biology Laboratory, Besançon, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AC</namePart><namePart type="family">Gabiot</namePart><affiliation>Engineering and Cutaneous Biology Laboratory, Besançon, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="abstract" displayLabel="abstract"></genre><originInfo><publisher>Blackwell Science Inc</publisher><place><placeTerm type="text">Oxford, UK; Malden, USA</placeTerm></place><dateIssued encoding="w3cdtf">2005-01</dateIssued><copyrightDate encoding="w3cdtf">2005</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="words">4249</extent></physicalDescription><abstract>Introduction: The cellular phases (granulation, reepithelialization, and dermal remodelling) of the healing process involve many cell types. Fibroblasts and myofibroblasts are the key cells in granulation tissue formation and wound contraction.</abstract><abstract>Objective: To compare the effects on cultured human fibroblasts of a new nonadhesive lipidocolloid wound dressing, Urgotul®, with five other wound dressings including impregnated gauzes and some other modern wound dressings.</abstract><abstract>Method: Cultures in monolayer were used to study the morphology and growth of fibroblasts. The Bell model of cultured dermis equivalents was used to investigate myofibroblast differentiation. These cultures were labelled α‐SM actin and F‐actin.</abstract><abstract>Results: Two of the tested dressings induced cytotoxic effects on the fibroblasts. They were found to inhibit cell growth (greater than 60%) and to disturb cell shape and cytoskeletal differentiation. Urgotul® and the remaining three dressings showed no effect on proliferation. However some of them modified fibroblast morphology and affected F‐actin distribution.</abstract><abstract>Conclusion: Depending on their nature and components, wound dressings may respect or affect in vitro fibroblast behaviour (proliferation, morphology, and α‐SM actin and F‐actin distribution). The observed in vitro findings require further investigations.</abstract><relatedItem type="host"><titleInfo><title>Wound Repair and Regeneration</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">1067-1927</identifier><identifier type="eISSN">1524-475X</identifier><identifier type="DOI">10.1111/(ISSN)1524-475X</identifier><identifier type="PublisherID">WRR</identifier><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>A21</start><end>A21</end><total>1</total></extent></part></relatedItem><identifier type="istex">6F6CE84C905C965D7B17E37A0C94471277445685</identifier><identifier type="DOI">10.1111/j.1067-1927.2005.130117o.x</identifier><identifier type="ArticleID">WRR130117O</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Science Inc</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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