Pathologic Changes of Human Onchocerciasis: Implications for Future Research
Identifieur interne : 003410 ( Istex/Corpus ); précédent : 003409; suivant : 003411Pathologic Changes of Human Onchocerciasis: Implications for Future Research
Auteurs : Daniel H. Connor ; Gladys H. George ; Dean W. GibsonSource :
- Reviews of Infectious Diseases [ 1058-4838 ] ; 1985-11.
Abstract
Onchocerciasis — infection by Onchocerca volvulus — has four cardinal manifestations: dermatitis, subcutaneous nodules, sclerosing lymphadenitis, and eye disease. The first three are discussed here. The dermatitis begins when micro filariae degenerate in the dermis. This process is accompanied by inflammation, with degranulation of eosinophils and deposition of the major basic protein of the eosinophil granules on the cuticle of the microfilariae. So far as is known, the chronic effects of onchocerciasis are all a consequence of the degeneration of microfilariae. Subcutaneous nodules contain coiled adult worms and have an outer layer of fibrous scar and a central inflammatory cell exudate, which may cavitate. Perfusion of India ink reveals arborization of capillaries around adult worms, which derive nutrition from these networks. Onchocercal lymphadenitis is characterized initially by histiocytic hyperplasia and follicular atrophy and later by fibrosis and obstruction of lymph flow, a condition causing adenolymphocele (“hanging groin”) and elephantiasis of the genitalia. Some patients appear to have immune tolerance to degenerating microfilariae, perhaps as a result of exposure in utero to microfilarial antigens in the maternal circulation. In contrast, other patients (Yemenites, for example) have a localized but intense response to a few micro filariae; these patients are hypersensitive — perhaps because they were not exposed to microfilarial antigens in utero. Autopsy data on infection of deep organs are limited.
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DOI: 10.1093/clinids/7.6.809
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Gibson</name><affiliation><mods:affiliation>From the Department of Infectious and Parasitic Disease Pathology and the World Health Organization Collaborating Centre for the Histopathology of Filarial Diseases in Man, Armed Forces Institute of Pathology, Washington, D.C.</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:6F534AABD417C40F5D7C0DF69DD62011580CA0EC</idno><date when="1985" year="1985">1985</date><idno type="doi">10.1093/clinids/7.6.809</idno><idno type="url">https://api.istex.fr/document/6F534AABD417C40F5D7C0DF69DD62011580CA0EC/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">003410</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">003410</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Pathologic Changes of Human Onchocerciasis: Implications for Future Research</title><author><name sortKey="Connor, Daniel H" sort="Connor, Daniel H" uniqKey="Connor D" first="Daniel H." last="Connor">Daniel H. Connor</name><affiliation><mods:affiliation>From the Department of Infectious and Parasitic Disease Pathology and the World Health Organization Collaborating Centre for the Histopathology of Filarial Diseases in Man, Armed Forces Institute of Pathology, Washington, D.C.</mods:affiliation></affiliation></author><author><name sortKey="George, Gladys H" sort="George, Gladys H" uniqKey="George G" first="Gladys H." last="George">Gladys H. George</name><affiliation><mods:affiliation>From the Department of Infectious and Parasitic Disease Pathology and the World Health Organization Collaborating Centre for the Histopathology of Filarial Diseases in Man, Armed Forces Institute of Pathology, Washington, D.C.</mods:affiliation></affiliation></author><author><name sortKey="Gibson, Dean W" sort="Gibson, Dean W" uniqKey="Gibson D" first="Dean W." last="Gibson">Dean W. Gibson</name><affiliation><mods:affiliation>From the Department of Infectious and Parasitic Disease Pathology and the World Health Organization Collaborating Centre for the Histopathology of Filarial Diseases in Man, Armed Forces Institute of Pathology, Washington, D.C.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Reviews of Infectious Diseases</title><title level="j" type="abbrev">Reviews of Infectious Diseases</title><idno type="ISSN">1058-4838</idno><idno type="eISSN">1537-6591</idno><imprint><publisher>The University of Chicago Press</publisher><date type="published" when="1985-11">1985-11</date><biblScope unit="volume">7</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="809">809</biblScope><biblScope unit="page" to="819">819</biblScope></imprint><idno type="ISSN">1058-4838</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1058-4838</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Onchocerciasis — infection by Onchocerca volvulus — has four cardinal manifestations: dermatitis, subcutaneous nodules, sclerosing lymphadenitis, and eye disease. The first three are discussed here. The dermatitis begins when micro filariae degenerate in the dermis. This process is accompanied by inflammation, with degranulation of eosinophils and deposition of the major basic protein of the eosinophil granules on the cuticle of the microfilariae. So far as is known, the chronic effects of onchocerciasis are all a consequence of the degeneration of microfilariae. Subcutaneous nodules contain coiled adult worms and have an outer layer of fibrous scar and a central inflammatory cell exudate, which may cavitate. Perfusion of India ink reveals arborization of capillaries around adult worms, which derive nutrition from these networks. Onchocercal lymphadenitis is characterized initially by histiocytic hyperplasia and follicular atrophy and later by fibrosis and obstruction of lymph flow, a condition causing adenolymphocele (“hanging groin”) and elephantiasis of the genitalia. Some patients appear to have immune tolerance to degenerating microfilariae, perhaps as a result of exposure in utero to microfilarial antigens in the maternal circulation. In contrast, other patients (Yemenites, for example) have a localized but intense response to a few micro filariae; these patients are hypersensitive — perhaps because they were not exposed to microfilarial antigens in utero. Autopsy data on infection of deep organs are limited.</div></front></TEI><istex><corpusName>oup</corpusName><author><json:item><name>Daniel H. Connor</name><affiliations><json:string>From the Department of Infectious and Parasitic Disease Pathology and the World Health Organization Collaborating Centre for the Histopathology of Filarial Diseases in Man, Armed Forces Institute of Pathology, Washington, D.C.</json:string></affiliations></json:item><json:item><name>Gladys H. George</name><affiliations><json:string>From the Department of Infectious and Parasitic Disease Pathology and the World Health Organization Collaborating Centre for the Histopathology of Filarial Diseases in Man, Armed Forces Institute of Pathology, Washington, D.C.</json:string></affiliations></json:item><json:item><name>Dean W. Gibson</name><affiliations><json:string>From the Department of Infectious and Parasitic Disease Pathology and the World Health Organization Collaborating Centre for the Histopathology of Filarial Diseases in Man, Armed Forces Institute of Pathology, Washington, D.C.</json:string></affiliations></json:item></author><language><json:string>unknown</json:string></language><originalGenre><json:string>research-article</json:string></originalGenre><abstract>Onchocerciasis — infection by Onchocerca volvulus — has four cardinal manifestations: dermatitis, subcutaneous nodules, sclerosing lymphadenitis, and eye disease. The first three are discussed here. The dermatitis begins when micro filariae degenerate in the dermis. This process is accompanied by inflammation, with degranulation of eosinophils and deposition of the major basic protein of the eosinophil granules on the cuticle of the microfilariae. So far as is known, the chronic effects of onchocerciasis are all a consequence of the degeneration of microfilariae. Subcutaneous nodules contain coiled adult worms and have an outer layer of fibrous scar and a central inflammatory cell exudate, which may cavitate. Perfusion of India ink reveals arborization of capillaries around adult worms, which derive nutrition from these networks. Onchocercal lymphadenitis is characterized initially by histiocytic hyperplasia and follicular atrophy and later by fibrosis and obstruction of lymph flow, a condition causing adenolymphocele (“hanging groin”) and elephantiasis of the genitalia. Some patients appear to have immune tolerance to degenerating microfilariae, perhaps as a result of exposure in utero to microfilarial antigens in the maternal circulation. In contrast, other patients (Yemenites, for example) have a localized but intense response to a few micro filariae; these patients are hypersensitive — perhaps because they were not exposed to microfilarial antigens in utero. 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Connor, Department of Infectious and Parasitic Disease Pathology, Armed Forces Institute of Pathology, Washington, D.C. 20306.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Pathologic Changes of Human Onchocerciasis: Implications for Future Research</title><author xml:id="author-0000" corresp="yes"><persName><forename type="first">Daniel H.</forename><surname>Connor</surname></persName><affiliation>From the Department of Infectious and Parasitic Disease Pathology and the World Health Organization Collaborating Centre for the Histopathology of Filarial Diseases in Man, Armed Forces Institute of Pathology, Washington, D.C.</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Gladys H.</forename><surname>George</surname></persName><affiliation>From the Department of Infectious and Parasitic Disease Pathology and the World Health Organization Collaborating Centre for the Histopathology of Filarial Diseases in Man, Armed Forces Institute of Pathology, Washington, D.C.</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Dean W.</forename><surname>Gibson</surname></persName><affiliation>From the Department of Infectious and Parasitic Disease Pathology and the World Health Organization Collaborating Centre for the Histopathology of Filarial Diseases in Man, Armed Forces Institute of Pathology, Washington, D.C.</affiliation></author><idno type="istex">6F534AABD417C40F5D7C0DF69DD62011580CA0EC</idno><idno type="DOI">10.1093/clinids/7.6.809</idno></analytic><monogr><title level="j">Reviews of Infectious Diseases</title><title level="j" type="abbrev">Reviews of Infectious Diseases</title><idno type="pISSN">1058-4838</idno><idno type="eISSN">1537-6591</idno><idno type="PublisherID">cid</idno><idno type="PublisherID-hwp">cid</idno><imprint><publisher>The University of Chicago Press</publisher><date type="published" when="1985-11"></date><biblScope unit="volume">7</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="809">809</biblScope><biblScope unit="page" to="819">819</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1985</date></creation><abstract><p>Onchocerciasis — infection by Onchocerca volvulus — has four cardinal manifestations: dermatitis, subcutaneous nodules, sclerosing lymphadenitis, and eye disease. The first three are discussed here. The dermatitis begins when micro filariae degenerate in the dermis. This process is accompanied by inflammation, with degranulation of eosinophils and deposition of the major basic protein of the eosinophil granules on the cuticle of the microfilariae. So far as is known, the chronic effects of onchocerciasis are all a consequence of the degeneration of microfilariae. Subcutaneous nodules contain coiled adult worms and have an outer layer of fibrous scar and a central inflammatory cell exudate, which may cavitate. Perfusion of India ink reveals arborization of capillaries around adult worms, which derive nutrition from these networks. Onchocercal lymphadenitis is characterized initially by histiocytic hyperplasia and follicular atrophy and later by fibrosis and obstruction of lymph flow, a condition causing adenolymphocele (“hanging groin”) and elephantiasis of the genitalia. Some patients appear to have immune tolerance to degenerating microfilariae, perhaps as a result of exposure in utero to microfilarial antigens in the maternal circulation. In contrast, other patients (Yemenites, for example) have a localized but intense response to a few micro filariae; these patients are hypersensitive — perhaps because they were not exposed to microfilarial antigens in utero. 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<subject>Onchocerciasis</subject>
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<title-group>
<article-title>Pathologic Changes of Human Onchocerciasis: Implications for Future Research</article-title>
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<name><surname>Connor</surname><given-names>Daniel H.</given-names></name>
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<contrib contrib-type="author">
<name><surname>George</surname><given-names>Gladys H.</given-names></name>
</contrib>
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<name><surname>Gibson</surname><given-names>Dean W.</given-names></name>
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<aff><institution>From the Department of Infectious and Parasitic Disease Pathology and the World Health Organization Collaborating Centre for the Histopathology of Filarial Diseases in Man, Armed Forces Institute of Pathology</institution>, <addr-line>Washington, D.C.</addr-line></aff>
</contrib-group>
<author-notes>
<corresp id="cor1">Please address requests for reprints to Dr. Daniel H. Connor, Department of Infectious and Parasitic Disease Pathology, Armed Forces Institute of Pathology, Washington, D.C. 20306.</corresp>
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<pub-date pub-type="ppub">
<month>11</month>
<year>1985</year>
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<volume>7</volume>
<issue>6</issue>
<fpage>809</fpage>
<lpage>819</lpage>
<copyright-statement>© 1985 by The University of Chicago</copyright-statement>
<copyright-year>1985</copyright-year>
<abstract>
<p>Onchocerciasis — infection by <italic>Onchocerca volvulus</italic> — has four cardinal manifestations: dermatitis, subcutaneous nodules, sclerosing lymphadenitis, and eye disease. The first three are discussed here. The dermatitis begins when micro filariae degenerate in the dermis. This process is accompanied by inflammation, with degranulation of eosinophils and deposition of the major basic protein of the eosinophil granules on the cuticle of the microfilariae. So far as is known, the chronic effects of onchocerciasis are all a consequence of the degeneration of microfilariae. Subcutaneous nodules contain coiled adult worms and have an outer layer of fibrous scar and a central inflammatory cell exudate, which may cavitate. Perfusion of India ink reveals arborization of capillaries around adult worms, which derive nutrition from these networks. Onchocercal lymphadenitis is characterized initially by histiocytic hyperplasia and follicular atrophy and later by fibrosis and obstruction of lymph flow, a condition causing adenolymphocele (“hanging groin”) and elephantiasis of the genitalia. Some patients appear to have immune tolerance to degenerating microfilariae, perhaps as a result of exposure in utero to microfilarial antigens in the maternal circulation. In contrast, other patients (Yemenites, for example) have a localized but intense response to a few micro filariae; these patients are hypersensitive — perhaps because they were not exposed to microfilarial antigens in utero. Autopsy data on infection of deep organs are limited.</p>
</abstract>
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</front>
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The first three are discussed here. The dermatitis begins when micro filariae degenerate in the dermis. This process is accompanied by inflammation, with degranulation of eosinophils and deposition of the major basic protein of the eosinophil granules on the cuticle of the microfilariae. So far as is known, the chronic effects of onchocerciasis are all a consequence of the degeneration of microfilariae. Subcutaneous nodules contain coiled adult worms and have an outer layer of fibrous scar and a central inflammatory cell exudate, which may cavitate. Perfusion of India ink reveals arborization of capillaries around adult worms, which derive nutrition from these networks. Onchocercal lymphadenitis is characterized initially by histiocytic hyperplasia and follicular atrophy and later by fibrosis and obstruction of lymph flow, a condition causing adenolymphocele (“hanging groin”) and elephantiasis of the genitalia. Some patients appear to have immune tolerance to degenerating microfilariae, perhaps as a result of exposure in utero to microfilarial antigens in the maternal circulation. In contrast, other patients (Yemenites, for example) have a localized but intense response to a few micro filariae; these patients are hypersensitive — perhaps because they were not exposed to microfilarial antigens in utero. Autopsy data on infection of deep organs are limited.</abstract><note type="author-notes">Please address requests for reprints to Dr. Daniel H. Connor, Department of Infectious and Parasitic Disease Pathology, Armed Forces Institute of Pathology, Washington, D.C. 20306.</note><relatedItem type="host"><titleInfo><title>Reviews of Infectious Diseases</title></titleInfo><titleInfo type="abbreviated"><title>Reviews of Infectious Diseases</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">1058-4838</identifier><identifier type="eISSN">1537-6591</identifier><identifier type="PublisherID">cid</identifier><identifier type="PublisherID-hwp">cid</identifier><part><date>1985</date><detail type="volume"><caption>vol.</caption><number>7</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>809</start><end>819</end></extent></part></relatedItem><identifier type="istex">6F534AABD417C40F5D7C0DF69DD62011580CA0EC</identifier><identifier type="DOI">10.1093/clinids/7.6.809</identifier><accessCondition type="use and reproduction" contentType="copyright">© 1985 by The University of Chicago</accessCondition><recordInfo><recordContentSource>OUP</recordContentSource></recordInfo></mods></metadata><annexes><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/6F534AABD417C40F5D7C0DF69DD62011580CA0EC/annexes/pdf</uri></json:item></annexes><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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