Radical wide excision and selective inguinal node dissection for squamous cell carcinoma of the vulva
Identifieur interne : 003365 ( Istex/Corpus ); précédent : 003364; suivant : 003366Radical wide excision and selective inguinal node dissection for squamous cell carcinoma of the vulva
Auteurs : Thomas W. Burke ; C. Allen Stringer ; David M. Gershenson ; Creighton L. Edwards ; Mitchell Morris ; J. Taylor WhartonSource :
- Gynecologic Oncology [ 0090-8258 ] ; 1990.
Abstract
Limited resection of some vulvar cancers may provide cure rates equivalent to those obtained with radical vulvectomy and bilateral inguinal node dissection. Rapid recovery, fewer complications, and better functional result have been described as advantages to less extensive procedures. Since 1978, 32 patients with invasive squamous cell cancer of the vulva (depth > 1 mm) and clinically negative inguinal lymph nodes underwent radical wide excisions as primary therapy. Mean age at diagnosis was 61 years. Seventeen patients had T1 and 15 had T2 tumors. Resection of the primary lesion was tailored to lesion location and size, and dissection was carried to the deep perineal fascia. Twenty-two patients had unilateral superficial inguinal lymph node dissections, five with midline lesions had bilateral superficial dissections, and five had node samplings which included deep inguinal nodes. Depth of invasion ranged from 1.5 to 13.0 mm. Mean largest lesion dimension was 23 mm. Five-year lifetable survival for the entire group was 84%. Univariate analysis of potential prognostic variables showed no significant recurrence or survival differences for patient age (P = 0.56), symptom duration (P = 0.57), FIGO stage (P = 0.67), tumor grade (P = 0.20), tumor location (P = 0.26), depth of invasion (P = 0.56), or resection margin status (P = 0.63). Thirty-one percent of patients had perioperative complications, and 16% developed delayed complications. Mean hospital stay was 10 days. Three patients (10%) developed new or recurrent vulvar disease and underwent additional therapy. None have died of disease, although one is alive with persistent tumor. Radical wide excision and selective inguinal lymphadenectomy constitute a reasonable alternative to radical vulvectomy with bilateral inguinal node dissections for squamous tumors clinically limited to the vulva. Outcome may not be strongly influenced by lesion size or depth of invasion.
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DOI: 10.1016/0090-8258(90)90067-U
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Gershenson</name><affiliation><mods:affiliation>Department of Gynecology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030 USA</mods:affiliation></affiliation></author><author><name sortKey="Edwards, Creighton L" sort="Edwards, Creighton L" uniqKey="Edwards C" first="Creighton L." last="Edwards">Creighton L. Edwards</name><affiliation><mods:affiliation>Department of Gynecology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030 USA</mods:affiliation></affiliation></author><author><name sortKey="Morris, Mitchell" sort="Morris, Mitchell" uniqKey="Morris M" first="Mitchell" last="Morris">Mitchell Morris</name><affiliation><mods:affiliation>Department of Gynecology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030 USA</mods:affiliation></affiliation></author><author><name sortKey="Wharton, J Taylor" sort="Wharton, J Taylor" uniqKey="Wharton J" first="J. Taylor" last="Wharton">J. Taylor Wharton</name><affiliation><mods:affiliation>Department of Gynecology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030 USA</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:6E31F98F3BB3D3C09C95364E4378AA73C0C941CD</idno><date when="1990" year="1990">1990</date><idno type="doi">10.1016/0090-8258(90)90067-U</idno><idno type="url">https://api.istex.fr/document/6E31F98F3BB3D3C09C95364E4378AA73C0C941CD/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">003365</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">003365</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Radical wide excision and selective inguinal node dissection for squamous cell carcinoma of the vulva</title><author><name sortKey="Burke, Thomas W" sort="Burke, Thomas W" uniqKey="Burke T" first="Thomas W." last="Burke">Thomas W. Burke</name><affiliation><mods:affiliation>Department of Gynecology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030 USA</mods:affiliation></affiliation></author><author><name sortKey="Stringer, C Allen" sort="Stringer, C Allen" uniqKey="Stringer C" first="C. Allen" last="Stringer">C. Allen Stringer</name><affiliation><mods:affiliation>Department of Gynecology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030 USA</mods:affiliation></affiliation></author><author><name sortKey="Gershenson, David M" sort="Gershenson, David M" uniqKey="Gershenson D" first="David M." last="Gershenson">David M. Gershenson</name><affiliation><mods:affiliation>Department of Gynecology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030 USA</mods:affiliation></affiliation></author><author><name sortKey="Edwards, Creighton L" sort="Edwards, Creighton L" uniqKey="Edwards C" first="Creighton L." last="Edwards">Creighton L. Edwards</name><affiliation><mods:affiliation>Department of Gynecology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030 USA</mods:affiliation></affiliation></author><author><name sortKey="Morris, Mitchell" sort="Morris, Mitchell" uniqKey="Morris M" first="Mitchell" last="Morris">Mitchell Morris</name><affiliation><mods:affiliation>Department of Gynecology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030 USA</mods:affiliation></affiliation></author><author><name sortKey="Wharton, J Taylor" sort="Wharton, J Taylor" uniqKey="Wharton J" first="J. Taylor" last="Wharton">J. Taylor Wharton</name><affiliation><mods:affiliation>Department of Gynecology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030 USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Gynecologic Oncology</title><title level="j" type="abbrev">YGYNO</title><idno type="ISSN">0090-8258</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1990">1990</date><biblScope unit="volume">38</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="328">328</biblScope><biblScope unit="page" to="332">332</biblScope></imprint><idno type="ISSN">0090-8258</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0090-8258</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Limited resection of some vulvar cancers may provide cure rates equivalent to those obtained with radical vulvectomy and bilateral inguinal node dissection. Rapid recovery, fewer complications, and better functional result have been described as advantages to less extensive procedures. Since 1978, 32 patients with invasive squamous cell cancer of the vulva (depth > 1 mm) and clinically negative inguinal lymph nodes underwent radical wide excisions as primary therapy. Mean age at diagnosis was 61 years. Seventeen patients had T1 and 15 had T2 tumors. Resection of the primary lesion was tailored to lesion location and size, and dissection was carried to the deep perineal fascia. Twenty-two patients had unilateral superficial inguinal lymph node dissections, five with midline lesions had bilateral superficial dissections, and five had node samplings which included deep inguinal nodes. Depth of invasion ranged from 1.5 to 13.0 mm. Mean largest lesion dimension was 23 mm. Five-year lifetable survival for the entire group was 84%. Univariate analysis of potential prognostic variables showed no significant recurrence or survival differences for patient age (P = 0.56), symptom duration (P = 0.57), FIGO stage (P = 0.67), tumor grade (P = 0.20), tumor location (P = 0.26), depth of invasion (P = 0.56), or resection margin status (P = 0.63). Thirty-one percent of patients had perioperative complications, and 16% developed delayed complications. Mean hospital stay was 10 days. Three patients (10%) developed new or recurrent vulvar disease and underwent additional therapy. None have died of disease, although one is alive with persistent tumor. Radical wide excision and selective inguinal lymphadenectomy constitute a reasonable alternative to radical vulvectomy with bilateral inguinal node dissections for squamous tumors clinically limited to the vulva. 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Burke M.D.</name><affiliations><json:string>Department of Gynecology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030 USA</json:string></affiliations></json:item><json:item><name>C.Allen Stringer M.D.</name><affiliations><json:string>Department of Gynecology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030 USA</json:string></affiliations></json:item><json:item><name>David M. Gershenson M.D.</name><affiliations><json:string>Department of Gynecology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030 USA</json:string></affiliations></json:item><json:item><name>Creighton L. Edwards M.D.</name><affiliations><json:string>Department of Gynecology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030 USA</json:string></affiliations></json:item><json:item><name>Mitchell Morris M.D.</name><affiliations><json:string>Department of Gynecology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030 USA</json:string></affiliations></json:item><json:item><name>J.Taylor Wharton M.D.</name><affiliations><json:string>Department of Gynecology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030 USA</json:string></affiliations></json:item></author><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Limited resection of some vulvar cancers may provide cure rates equivalent to those obtained with radical vulvectomy and bilateral inguinal node dissection. Rapid recovery, fewer complications, and better functional result have been described as advantages to less extensive procedures. Since 1978, 32 patients with invasive squamous cell cancer of the vulva (depth > 1 mm) and clinically negative inguinal lymph nodes underwent radical wide excisions as primary therapy. Mean age at diagnosis was 61 years. Seventeen patients had T1 and 15 had T2 tumors. Resection of the primary lesion was tailored to lesion location and size, and dissection was carried to the deep perineal fascia. Twenty-two patients had unilateral superficial inguinal lymph node dissections, five with midline lesions had bilateral superficial dissections, and five had node samplings which included deep inguinal nodes. Depth of invasion ranged from 1.5 to 13.0 mm. Mean largest lesion dimension was 23 mm. Five-year lifetable survival for the entire group was 84%. Univariate analysis of potential prognostic variables showed no significant recurrence or survival differences for patient age (P = 0.56), symptom duration (P = 0.57), FIGO stage (P = 0.67), tumor grade (P = 0.20), tumor location (P = 0.26), depth of invasion (P = 0.56), or resection margin status (P = 0.63). Thirty-one percent of patients had perioperative complications, and 16% developed delayed complications. Mean hospital stay was 10 days. Three patients (10%) developed new or recurrent vulvar disease and underwent additional therapy. None have died of disease, although one is alive with persistent tumor. Radical wide excision and selective inguinal lymphadenectomy constitute a reasonable alternative to radical vulvectomy with bilateral inguinal node dissections for squamous tumors clinically limited to the vulva. 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D. Anderson Cancer Center, Houston, Texas 77030 USA</affiliation></author><author xml:id="author-0001"><persName><forename type="first">C.Allen</forename><surname>Stringer</surname></persName><roleName type="degree">M.D.</roleName><affiliation>Department of Gynecology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030 USA</affiliation></author><author xml:id="author-0002"><persName><forename type="first">David M.</forename><surname>Gershenson</surname></persName><roleName type="degree">M.D.</roleName><affiliation>Department of Gynecology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030 USA</affiliation></author><author xml:id="author-0003"><persName><forename type="first">Creighton L.</forename><surname>Edwards</surname></persName><roleName type="degree">M.D.</roleName><affiliation>Department of Gynecology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030 USA</affiliation></author><author xml:id="author-0004"><persName><forename type="first">Mitchell</forename><surname>Morris</surname></persName><roleName type="degree">M.D.</roleName><affiliation>Department of Gynecology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030 USA</affiliation></author><author xml:id="author-0005"><persName><forename type="first">J.Taylor</forename><surname>Wharton</surname></persName><roleName type="degree">M.D.</roleName><affiliation>Department of Gynecology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030 USA</affiliation></author><idno type="istex">6E31F98F3BB3D3C09C95364E4378AA73C0C941CD</idno><idno type="DOI">10.1016/0090-8258(90)90067-U</idno><idno type="PII">0090-8258(90)90067-U</idno></analytic><monogr><title level="j">Gynecologic Oncology</title><title level="j" type="abbrev">YGYNO</title><idno type="pISSN">0090-8258</idno><idno type="PII">S0090-8258(00)X0172-2</idno><meeting><addName>Proceedings of the 21st Annual Meeting of the Society of Gynecologic Oncologists, San Francisco, California</addName><date>199002</date></meeting><imprint><publisher>ELSEVIER</publisher><date type="published" when="1990"></date><biblScope unit="volume">38</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="328">328</biblScope><biblScope unit="page" to="332">332</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1990</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Limited resection of some vulvar cancers may provide cure rates equivalent to those obtained with radical vulvectomy and bilateral inguinal node dissection. Rapid recovery, fewer complications, and better functional result have been described as advantages to less extensive procedures. Since 1978, 32 patients with invasive squamous cell cancer of the vulva (depth > 1 mm) and clinically negative inguinal lymph nodes underwent radical wide excisions as primary therapy. Mean age at diagnosis was 61 years. Seventeen patients had T1 and 15 had T2 tumors. Resection of the primary lesion was tailored to lesion location and size, and dissection was carried to the deep perineal fascia. Twenty-two patients had unilateral superficial inguinal lymph node dissections, five with midline lesions had bilateral superficial dissections, and five had node samplings which included deep inguinal nodes. Depth of invasion ranged from 1.5 to 13.0 mm. Mean largest lesion dimension was 23 mm. Five-year lifetable survival for the entire group was 84%. Univariate analysis of potential prognostic variables showed no significant recurrence or survival differences for patient age (P = 0.56), symptom duration (P = 0.57), FIGO stage (P = 0.67), tumor grade (P = 0.20), tumor location (P = 0.26), depth of invasion (P = 0.56), or resection margin status (P = 0.63). Thirty-one percent of patients had perioperative complications, and 16% developed delayed complications. Mean hospital stay was 10 days. Three patients (10%) developed new or recurrent vulvar disease and underwent additional therapy. None have died of disease, although one is alive with persistent tumor. Radical wide excision and selective inguinal lymphadenectomy constitute a reasonable alternative to radical vulvectomy with bilateral inguinal node dissections for squamous tumors clinically limited to the vulva. Outcome may not be strongly influenced by lesion size or depth of invasion.</p></abstract></profileDesc><revisionDesc><change when="1990">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/6E31F98F3BB3D3C09C95364E4378AA73C0C941CD/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>YGYNO</jid><aid>9090067U</aid><ce:pii>0090-8258(90)90067-U</ce:pii><ce:doi>10.1016/0090-8258(90)90067-U</ce:doi><ce:copyright type="unknown" year="1990"></ce:copyright></item-info><head><ce:article-footnote><ce:label>☆</ce:label><ce:note-para>Presented at the annual meeting of the Society of Gynecologic Oncologists, San Francisco, CA, February 4–7, 1990.</ce:note-para></ce:article-footnote><ce:title>Radical wide excision and selective inguinal node dissection for squamous cell carcinoma of the vulva</ce:title><ce:author-group><ce:author><ce:given-name>Thomas W.</ce:given-name><ce:surname>Burke</ce:surname><ce:degrees>M.D.</ce:degrees><ce:cross-ref refid="COR1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>C.Allen</ce:given-name><ce:surname>Stringer</ce:surname><ce:degrees>M.D.</ce:degrees></ce:author><ce:author><ce:given-name>David M.</ce:given-name><ce:surname>Gershenson</ce:surname><ce:degrees>M.D.</ce:degrees></ce:author><ce:author><ce:given-name>Creighton L.</ce:given-name><ce:surname>Edwards</ce:surname><ce:degrees>M.D.</ce:degrees></ce:author><ce:author><ce:given-name>Mitchell</ce:given-name><ce:surname>Morris</ce:surname><ce:degrees>M.D.</ce:degrees></ce:author><ce:author><ce:given-name>J.Taylor</ce:given-name><ce:surname>Wharton</ce:surname><ce:degrees>M.D.</ce:degrees></ce:author><ce:affiliation><ce:textfn>Department of Gynecology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030 USA</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>1</ce:label><ce:text>To whom requests for reprints should be addressed.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="22" month="1" year="1990"></ce:date-received><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Limited resection of some vulvar cancers may provide cure rates equivalent to those obtained with radical vulvectomy and bilateral inguinal node dissection. Rapid recovery, fewer complications, and better functional result have been described as advantages to less extensive procedures. Since 1978, 32 patients with invasive squamous cell cancer of the vulva (depth > 1 mm) and clinically negative inguinal lymph nodes underwent radical wide excisions as primary therapy. Mean age at diagnosis was 61 years. Seventeen patients had T1 and 15 had T2 tumors. Resection of the primary lesion was tailored to lesion location and size, and dissection was carried to the deep perineal fascia. Twenty-two patients had unilateral superficial inguinal lymph node dissections, five with midline lesions had bilateral superficial dissections, and five had node samplings which included deep inguinal nodes. Depth of invasion ranged from 1.5 to 13.0 mm. Mean largest lesion dimension was 23 mm. Five-year lifetable survival for the entire group was 84%. Univariate analysis of potential prognostic variables showed no significant recurrence or survival differences for patient age (<ce:italic>P</ce:italic> = 0.56), symptom duration (<ce:italic>P</ce:italic> = 0.57), FIGO stage (<ce:italic>P</ce:italic> = 0.67), tumor grade (<ce:italic>P</ce:italic> = 0.20), tumor location (<ce:italic>P</ce:italic> = 0.26), depth of invasion (<ce:italic>P</ce:italic> = 0.56), or resection margin status (<ce:italic>P</ce:italic> = 0.63). Thirty-one percent of patients had perioperative complications, and 16% developed delayed complications. Mean hospital stay was 10 days. Three patients (10%) developed new or recurrent vulvar disease and underwent additional therapy. None have died of disease, although one is alive with persistent tumor. Radical wide excision and selective inguinal lymphadenectomy constitute a reasonable alternative to radical vulvectomy with bilateral inguinal node dissections for squamous tumors clinically limited to the vulva. Outcome may not be strongly influenced by lesion size or depth of invasion.</ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Radical wide excision and selective inguinal node dissection for squamous cell carcinoma of the vulva</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Radical wide excision and selective inguinal node dissection for squamous cell carcinoma of the vulva</title></titleInfo><name type="personal"><namePart type="given">Thomas W.</namePart><namePart type="family">Burke</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>Department of Gynecology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030 USA</affiliation><description>To whom requests for reprints should be addressed.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.Allen</namePart><namePart type="family">Stringer</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>Department of Gynecology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030 USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">David M.</namePart><namePart type="family">Gershenson</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>Department of Gynecology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030 USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Creighton L.</namePart><namePart type="family">Edwards</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>Department of Gynecology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030 USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mitchell</namePart><namePart type="family">Morris</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>Department of Gynecology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030 USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.Taylor</namePart><namePart type="family">Wharton</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>Department of Gynecology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030 USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1990</dateIssued><copyrightDate encoding="w3cdtf">1990</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Limited resection of some vulvar cancers may provide cure rates equivalent to those obtained with radical vulvectomy and bilateral inguinal node dissection. Rapid recovery, fewer complications, and better functional result have been described as advantages to less extensive procedures. Since 1978, 32 patients with invasive squamous cell cancer of the vulva (depth > 1 mm) and clinically negative inguinal lymph nodes underwent radical wide excisions as primary therapy. Mean age at diagnosis was 61 years. Seventeen patients had T1 and 15 had T2 tumors. Resection of the primary lesion was tailored to lesion location and size, and dissection was carried to the deep perineal fascia. Twenty-two patients had unilateral superficial inguinal lymph node dissections, five with midline lesions had bilateral superficial dissections, and five had node samplings which included deep inguinal nodes. Depth of invasion ranged from 1.5 to 13.0 mm. Mean largest lesion dimension was 23 mm. Five-year lifetable survival for the entire group was 84%. Univariate analysis of potential prognostic variables showed no significant recurrence or survival differences for patient age (P = 0.56), symptom duration (P = 0.57), FIGO stage (P = 0.67), tumor grade (P = 0.20), tumor location (P = 0.26), depth of invasion (P = 0.56), or resection margin status (P = 0.63). Thirty-one percent of patients had perioperative complications, and 16% developed delayed complications. Mean hospital stay was 10 days. Three patients (10%) developed new or recurrent vulvar disease and underwent additional therapy. None have died of disease, although one is alive with persistent tumor. Radical wide excision and selective inguinal lymphadenectomy constitute a reasonable alternative to radical vulvectomy with bilateral inguinal node dissections for squamous tumors clinically limited to the vulva. Outcome may not be strongly influenced by lesion size or depth of invasion.</abstract><note>Presented at the annual meeting of the Society of Gynecologic Oncologists, San Francisco, CA, February 4–7, 1990.</note><relatedItem type="host"><titleInfo><title>Gynecologic Oncology</title></titleInfo><titleInfo type="abbreviated"><title>YGYNO</title></titleInfo><name type="conference"><namePart>Proceedings of the 21st Annual Meeting of the Society of Gynecologic Oncologists, San Francisco, California</namePart><namePart type="date">199002</namePart></name><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">199009</dateIssued></originInfo><identifier type="ISSN">0090-8258</identifier><identifier type="PII">S0090-8258(00)X0172-2</identifier><part><date>199009</date><detail type="issue"><title>Proceedings of the 21st Annual Meeting of the Society of Gynecologic Oncologists, San Francisco, California</title></detail><detail type="volume"><number>38</number><caption>vol.</caption></detail><detail type="issue"><number>3</number><caption>no.</caption></detail><extent unit="issue pages"><start>297</start><end>497</end></extent><extent unit="pages"><start>328</start><end>332</end></extent></part></relatedItem><identifier type="istex">6E31F98F3BB3D3C09C95364E4378AA73C0C941CD</identifier><identifier type="DOI">10.1016/0090-8258(90)90067-U</identifier><identifier type="PII">0090-8258(90)90067-U</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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