Dipeptide Absorption in Cystinuria
Identifieur interne : 003030 ( Istex/Corpus ); précédent : 003029; suivant : 003031Dipeptide Absorption in Cystinuria
Auteurs : M. D. Hellier ; D. Perrett ; C. D. HoldsworthSource :
- British Medical Journal [ 0007-1447 ] ; 1970-12-26.
Abstract
Absorption of a dipeptide and its constituent amino-acids has been studied by a perfusion technique in a patient with cystinuria and in a normal subject. Though the cystinuric patient was unable to absorb the dibasic amino-acid lysine in its free form, the dipeptide glycyl-L-lysine was well absorbed. Both free lysine and glycyl-L-lysine were well absorbed in the normal subject. This finding suggests that the reason that clinical malnutrition does not occur in cystinuria, despite defective intestinal absorption and heavy renal loss of dibasic amino-acids and cystine, is that these amino-acids can be absorbed in the form of oligopeptides.
Url:
DOI: 10.1136/bmj.4.5738.782
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ISTEX:674B0824963956CC35E4432E57682258888F0D21Le document en format XML
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Holdsworth</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:674B0824963956CC35E4432E57682258888F0D21</idno><date when="1970" year="1970">1970</date><idno type="doi">10.1136/bmj.4.5738.782</idno><idno type="url">https://api.istex.fr/document/674B0824963956CC35E4432E57682258888F0D21/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">003030</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">003030</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Dipeptide Absorption in Cystinuria</title><author><name sortKey="Hellier, M D" sort="Hellier, M D" uniqKey="Hellier M" first="M. D." last="Hellier">M. D. Hellier</name></author><author><name sortKey="Perrett, D" sort="Perrett, D" uniqKey="Perrett D" first="D." last="Perrett">D. Perrett</name></author><author><name sortKey="Holdsworth, C D" sort="Holdsworth, C D" uniqKey="Holdsworth C" first="C. D." last="Holdsworth">C. D. Holdsworth</name></author></analytic><monogr></monogr><series><title level="j">British Medical Journal</title><title level="j" type="abbrev">Br Med J</title><idno type="ISSN">0007-1447</idno><idno type="eISSN">1468-5833</idno><imprint><publisher>British Medical Journal Publishing Group</publisher><date type="published" when="1970-12-26">1970-12-26</date><biblScope unit="volume">4</biblScope><biblScope unit="issue">5738</biblScope><biblScope unit="page" from="782">782</biblScope></imprint><idno type="ISSN">0007-1447</idno></series><idno type="istex">674B0824963956CC35E4432E57682258888F0D21</idno><idno type="DOI">10.1136/bmj.4.5738.782</idno><idno type="href">bmj-4-782.pdf</idno><idno type="PMID">5497408</idno><idno type="local">bmj;4/5738/782</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0007-1447</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Absorption of a dipeptide and its constituent amino-acids has been studied by a perfusion technique in a patient with cystinuria and in a normal subject. 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Though the cystinuric patient was unable to absorb the dibasic amino-acid lysine in its free form, the dipeptide glycyl-L-lysine was well absorbed. Both free lysine and glycyl-L-lysine were well absorbed in the normal subject. This finding suggests that the reason that clinical malnutrition does not occur in cystinuria, despite defective intestinal absorption and heavy renal loss of dibasic amino-acids and cystine, is that these amino-acids can be absorbed in the form of oligopeptides.</p></abstract><textClass><keywords scheme="keyword"><list><head>hwp-journal-coll</head><item><term>Urology</term></item></list></keywords></textClass><textClass><keywords scheme="keyword"><list><head>hwp-journal-coll</head><item><term>Urological surgery</term></item></list></keywords></textClass><textClass><keywords scheme="keyword"><list><head>hwp-journal-coll</head><item><term>Metabolic disorders</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1970-12-26">Created</change><change when="1970-12-26">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2017-01-19">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/674B0824963956CC35E4432E57682258888F0D21/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus bmj" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="no"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Archiving and Interchange DTD v2.3 20070202//EN" URI="archivearticle.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="letter" xml:lang="EN"><front><journal-meta><journal-id journal-id-type="hwp">bmj</journal-id><journal-id journal-id-type="nlm-ta">BMJ</journal-id><journal-title>British Medical Journal</journal-title><abbrev-journal-title abbrev-type="publisher">Br Med J</abbrev-journal-title><issn pub-type="ppub">0007-1447</issn><issn pub-type="epub">1468-5833</issn><publisher><publisher-name>British Medical Journal Publishing Group</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">5497408</article-id><article-id pub-id-type="other">bmj;4/5738/782</article-id><article-id pub-id-type="doi">10.1136/bmj.4.5738.782</article-id><article-id pub-id-type="other">782</article-id><article-id pub-id-type="other">bmj.4.5738.782</article-id><article-categories><subj-group subj-group-type="heading"><subject>Preliminary Communications</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>Urology</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>Urological surgery</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>Metabolic disorders</subject></subj-group></article-categories><title-group><article-title>Dipeptide Absorption in Cystinuria</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Hellier</surname><given-names>M. 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D.</given-names></name></contrib></contrib-group><pub-date pub-type="ppub"><day>26</day><month>12</month><year>1970</year></pub-date><pub-date pub-type="epub"><day>26</day><month>12</month><year>1970</year></pub-date><volume>4</volume><volume-id pub-id-type="other">4</volume-id><volume-id pub-id-type="other">4</volume-id><issue>5738</issue><issue-id pub-id-type="other">bmj;4/5738</issue-id><issue-id pub-id-type="other">5738</issue-id><issue-id pub-id-type="other">4/5738</issue-id><fpage>782</fpage><self-uri content-type="pdf" xlink:role="full-text" xlink:href="bmj-4-782.pdf"></self-uri><abstract><p>Absorption of a dipeptide and its constituent amino-acids has been studied by a perfusion technique in a patient with cystinuria and in a normal subject. Though the cystinuric patient was unable to absorb the dibasic amino-acid lysine in its free form, the dipeptide glycyl-L-lysine was well absorbed. Both free lysine and glycyl-L-lysine were well absorbed in the normal subject.</p><p>This finding suggests that the reason that clinical malnutrition does not occur in cystinuria, despite defective intestinal absorption and heavy renal loss of dibasic amino-acids and cystine, is that these amino-acids can be absorbed in the form of oligopeptides.</p></abstract></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Dipeptide Absorption in Cystinuria</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Dipeptide Absorption in Cystinuria</title></titleInfo><name type="personal"><namePart type="given">M. 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Though the cystinuric patient was unable to absorb the dibasic amino-acid lysine in its free form, the dipeptide glycyl-L-lysine was well absorbed. Both free lysine and glycyl-L-lysine were well absorbed in the normal subject. This finding suggests that the reason that clinical malnutrition does not occur in cystinuria, despite defective intestinal absorption and heavy renal loss of dibasic amino-acids and cystine, is that these amino-acids can be absorbed in the form of oligopeptides.</abstract><relatedItem type="host"><titleInfo><title>British Medical Journal</title></titleInfo><titleInfo type="abbreviated"><title>Br Med J</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0007-1447</identifier><identifier type="eISSN">1468-5833</identifier><identifier type="PublisherID-hwp">bmj</identifier><identifier type="PublisherID-nlm-ta">BMJ</identifier><part><date>1970</date><detail type="volume"><caption>vol.</caption><number>4</number></detail><detail type="issue"><caption>no.</caption><number>5738</number></detail><extent unit="pages"><start>782</start></extent></part></relatedItem><identifier type="istex">674B0824963956CC35E4432E57682258888F0D21</identifier><identifier type="DOI">10.1136/bmj.4.5738.782</identifier><identifier type="href">bmj-4-782.pdf</identifier><identifier type="PMID">5497408</identifier><identifier type="local">bmj;4/5738/782</identifier><recordInfo><recordContentSource>BMJ</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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