Decongestion improves cell‐mediated immunity in postmastectomy arm lymphoedema: a pilot study
Identifieur interne : 002827 ( Istex/Corpus ); précédent : 002826; suivant : 002828Decongestion improves cell‐mediated immunity in postmastectomy arm lymphoedema: a pilot study
Auteurs : G. Szolnoky ; A. Dobozy ; L. KeménySource :
- Journal of the European Academy of Dermatology and Venereology [ 0926-9959 ] ; 2013-12.
Abstract
Background Chronic lymphoedematous limbs have an increased propensity for infections and primary or secondary malignant tumours. It has been attributed to suppressed delayed‐type hypersensitivity measured in lymphoedemas related to Stewart–Treves syndrome, Kaposi’s sarcoma or breast cancer treatment. Cell‐mediated immunity is an effective defence mechanism against bacteria, fungi, viruses and tumour cells.
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DOI: 10.1111/j.1468-3083.2012.04647.x
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Kemény</name><affiliation><mods:affiliation>Department of Dermatology and Allergology, Szeged University, Szeged, Hungary, and Dermatological Research Group, Hungarian Academy of Sciences, Szeged, Hungary</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of the European Academy of Dermatology and Venereology</title><title level="j" type="alt">JOURNAL OF EUROPEAN ACADEMY DERMATOLOGY VENEREOLOGY</title><idno type="ISSN">0926-9959</idno><idno type="eISSN">1468-3083</idno><imprint><biblScope unit="vol">27</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1579">1579</biblScope><biblScope unit="page" to="1582">1582</biblScope><biblScope unit="page-count">4</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2013-12">2013-12</date></imprint><idno type="ISSN">0926-9959</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0926-9959</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Background Chronic lymphoedematous limbs have an increased propensity for infections and primary or secondary malignant tumours. It has been attributed to suppressed delayed‐type hypersensitivity measured in lymphoedemas related to Stewart–Treves syndrome, Kaposi’s sarcoma or breast cancer treatment. Cell‐mediated immunity is an effective defence mechanism against bacteria, fungi, viruses and tumour cells.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>lymphoedema</json:string><json:string>tuberculin</json:string><json:string>decongestion</json:string><json:string>lymphoedematous</json:string><json:string>immune</json:string><json:string>dermatology</json:string><json:string>oedema</json:string><json:string>venereology</json:string><json:string>ruocco</json:string><json:string>european academy</json:string><json:string>dermatol</json:string><json:string>decongestive</json:string><json:string>lymphatic</json:string><json:string>bcrl</json:string><json:string>lymphoedematous limbs</json:string><json:string>szolnoky</json:string><json:string>sarcoma</json:string><json:string>jeadv</json:string><json:string>lymphology</json:string><json:string>oedema volume</json:string><json:string>immune response</json:string><json:string>hypersensitivity</json:string><json:string>szeged</json:string><json:string>mallon</json:string><json:string>authors journal</json:string><json:string>tuberculin skin test</json:string><json:string>healthy arms</json:string><json:string>tuberculin units</json:string><json:string>lymph stasis</json:string><json:string>baseline</json:string><json:string>independent examiners</json:string><json:string>tuberculin solutions</json:string><json:string>decongestive lymphatic therapy</json:string><json:string>venereology szolnoky</json:string><json:string>limb volumes</json:string><json:string>consecutive injections</json:string><json:string>volume difference</json:string><json:string>breast cancer</json:string><json:string>healthy limbs</json:string><json:string>volar surfaces</json:string><json:string>immune cells</json:string><json:string>defence mechanism</json:string><json:string>decongestive lymphoedema therapy</json:string><json:string>dermatol venereol</json:string><json:string>international society</json:string></teeft></keywords><author><json:item><name>G. 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Journal of the European Academy of Dermatology and Venereology © 2012 European Academy of Dermatology and Venereology</licence></availability><date type="published" when="2013-12"></date></publicationStmt><notesStmt><note type="content-type" subtype="brief-communication" source="shortCommunication" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-S9SX2MFS-0">brief-communication</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="brief-communication"><analytic><title level="a" type="main">Decongestion improves cell‐mediated immunity in postmastectomy arm lymphoedema: a pilot study</title><title level="a" type="short">Decongestion improves cellular immunity in lymphoedema</title><author xml:id="author-0000" role="corresp"><persName><forename type="first">G.</forename><surname>Szolnoky</surname></persName><affiliation>G. Szolnoky. E‐mail:szolnoky@dermall.hu</affiliation></author><author xml:id="author-0001"><persName><forename type="first">A.</forename><surname>Dobozy</surname></persName><affiliation>Department of Dermatology and Allergology, Szeged University, Szeged, Hungary, and Dermatological Research Group, Hungarian Academy of Sciences, Szeged, Hungary<address><country key="HU"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">L.</forename><surname>Kemény</surname></persName><affiliation>Department of Dermatology and Allergology, Szeged University, Szeged, Hungary, and Dermatological Research Group, Hungarian Academy of Sciences, Szeged, Hungary<address><country key="HU"></country></address></affiliation></author><idno type="istex">570797D4EAEA489FFFE3A87B432F346A0B9DA193</idno><idno type="DOI">10.1111/j.1468-3083.2012.04647.x</idno><idno type="unit">JDV4647</idno><idno type="toTypesetVersion">file:JDV.JDV4647.pdf</idno></analytic><monogr><title level="j" type="main">Journal of the European Academy of Dermatology and Venereology</title><title level="j" type="alt">JOURNAL OF EUROPEAN ACADEMY DERMATOLOGY VENEREOLOGY</title><idno type="pISSN">0926-9959</idno><idno type="eISSN">1468-3083</idno><idno type="book-DOI">10.1111/(ISSN)1468-3083</idno><idno type="book-part-DOI">10.1111/jdv.2013.27.issue-12</idno><idno type="product">JDV</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">27</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1579">1579</biblScope><biblScope unit="page" to="1582">1582</biblScope><biblScope unit="page-count">4</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2013-12"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><head>Abstract</head><p><hi rend="bold">Background </hi> Chronic lymphoedematous limbs have an increased propensity for infections and primary or secondary malignant tumours. It has been attributed to suppressed delayed‐type hypersensitivity measured in lymphoedemas related to Stewart–Treves syndrome, Kaposi’s sarcoma or breast cancer treatment. Cell‐mediated immunity is an effective defence mechanism against bacteria, fungi, viruses and tumour cells.</p><p><hi rend="bold">Objective </hi> We aimed to examine whether decongestive lymphoedema therapy could improve cell‐mediated immunity in breast cancer treatment‐related lymphoedema (BCRL).</p><p><hi rend="bold">Methods </hi> Eight women with unilateral BCRL were included in this study. At baseline, tuberculin skin test (TST) was performed on the volar surfaces of the forearms of the affected and non‐affected sides using 0.5, 1 and 5 tuberculin units in the form of three consecutive injections with 3‐cm spaces in‐between, and arm volumes were measured using the Kuhnke’s disc model. Decongestive lymphatic therapy was given to swollen arms in 10 consecutive working days. At the end of intensive decongestion, TST on affected side and bilateral volumetry were repeated.</p><p><hi rend="bold">Results </hi> Baseline test using undiluted (5 units) and fivefold diluted (1 unit) tuberculin solutions has shown significant differences (<hi rend="italic">P </hi>< 0.05) between the mean sizes (11.81 ± 2.32 and 7.75 ± 1.92; 7.12 ± 1.12 and 5.12 ± 0.91 respectively) in favour to healthy arms. Post therapeutically, the mean sizes were significantly increased (<hi rend="italic">P</hi> < 0.05) in the dilutions of 1 : 1 and 1 : 5 (7.75 ± 1.92 and 10.56 ± 1.23 mm, 5.12 ± 0.91 and 5.93 ± 1.74 mm respectively).</p><p><hi rend="bold">Conclusion </hi> Significant increase in TST sizes suggests that decongestive lymphatic therapy is able to partially restore impaired cellular immune function in BCRL.</p></abstract><textClass><classCode scheme="tocHeading1">SHORT REPORTS</classCode><classCode scheme="articleCategory">SHORT REPORT</classCode></textClass><langUsage><language ident="EN"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/570797D4EAEA489FFFE3A87B432F346A0B9DA193/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1468-3083</doi><issn type="print">0926-9959</issn><issn type="electronic">1468-3083</issn><idGroup><id type="product" value="JDV"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="JOURNAL OF EUROPEAN ACADEMY DERMATOLOGY VENEREOLOGY">Journal of the European Academy of Dermatology and Venereology</title></titleGroup></publicationMeta><publicationMeta level="part" position="12112"><doi origin="wiley">10.1111/jdv.2013.27.issue-12</doi><numberingGroup><numbering type="journalVolume" number="27">27</numbering><numbering type="journalIssue" number="12">12</numbering></numberingGroup><coverDate startDate="2013-12">December 2013</coverDate></publicationMeta><publicationMeta level="unit" type="shortCommunication" position="17" status="forIssue"><doi origin="wiley">10.1111/j.1468-3083.2012.04647.x</doi><idGroup><id type="unit" value="JDV4647"></id></idGroup><countGroup><count type="pageTotal" number="4"></count></countGroup><titleGroup><title type="tocHeading1">SHORT REPORTS</title><title type="articleCategory">SHORT REPORT</title></titleGroup><copyright>© 2012 The Authors. Journal of the European Academy of Dermatology and Venereology © 2012 European Academy of Dermatology and Venereology</copyright><eventGroup><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:3.2.6 mode:FullText" date="2013-11-15"></event><event agent="SPS" date="2013-11-15" type="xmlCorrected"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.2.6 mode:FullText" date="2013-11-21"></event><event type="publishedOnlineEarlyUnpaginated" date="2012-07-23"></event><event type="firstOnline" date="2012-07-23"></event><event type="publishedOnlineFinalForm" date="2013-11-21"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-01"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="1579">1579</numbering><numbering type="pageLast" number="1582">1582</numbering></numberingGroup><correspondenceTo> G. Szolnoky. <b>E‐mail:</b><email>szolnoky@dermall.hu</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JDV.JDV4647.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received: 16 March 2012; Accepted: 15 June 2012</unparsedEditorialHistory><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="2"></count></countGroup><titleGroup><title type="main">Decongestion improves cell‐mediated immunity in postmastectomy arm lymphoedema: a pilot study</title><title type="shortAuthors">Szolnoky <i>et al.</i></title><title type="short">Decongestion improves cellular immunity in lymphoedema</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" corresponding="yes"><personName><givenNames>G.</givenNames><familyName>Szolnoky</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#aff-1-1"><personName><givenNames>A.</givenNames><familyName>Dobozy</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#aff-1-1"><personName><givenNames>L.</givenNames><familyName>Kemény</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="aff-1-1" countryCode="HU"><unparsedAffiliation>Department of Dermatology and Allergology, Szeged University, Szeged, Hungary, and Dermatological Research Group, Hungarian Academy of Sciences, Szeged, Hungary</unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p><b>Background </b> Chronic lymphoedematous limbs have an increased propensity for infections and primary or secondary malignant tumours. It has been attributed to suppressed delayed‐type hypersensitivity measured in lymphoedemas related to Stewart–Treves syndrome, Kaposi’s sarcoma or breast cancer treatment. Cell‐mediated immunity is an effective defence mechanism against bacteria, fungi, viruses and tumour cells.</p><p><b>Objective </b> We aimed to examine whether decongestive lymphoedema therapy could improve cell‐mediated immunity in breast cancer treatment‐related lymphoedema (BCRL).</p><p><b>Methods </b> Eight women with unilateral BCRL were included in this study. At baseline, tuberculin skin test (TST) was performed on the volar surfaces of the forearms of the affected and non‐affected sides using 0.5, 1 and 5 tuberculin units in the form of three consecutive injections with 3‐cm spaces in‐between, and arm volumes were measured using the Kuhnke’s disc model. Decongestive lymphatic therapy was given to swollen arms in 10 consecutive working days. At the end of intensive decongestion, TST on affected side and bilateral volumetry were repeated.</p><p><b>Results </b> Baseline test using undiluted (5 units) and fivefold diluted (1 unit) tuberculin solutions has shown significant differences (<i>P </i>< 0.05) between the mean sizes (11.81 ± 2.32 and 7.75 ± 1.92; 7.12 ± 1.12 and 5.12 ± 0.91 respectively) in favour to healthy arms. Post therapeutically, the mean sizes were significantly increased (<i>P</i> < 0.05) in the dilutions of 1 : 1 and 1 : 5 (7.75 ± 1.92 and 10.56 ± 1.23 mm, 5.12 ± 0.91 and 5.93 ± 1.74 mm respectively).</p><p><b>Conclusion </b> Significant increase in TST sizes suggests that decongestive lymphatic therapy is able to partially restore impaired cellular immune function in BCRL.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p><b>Conflict of Interest</b>
None</p></note><note xml:id="fn2"><p><b>Funding sources</b>
None</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Decongestion improves cell‐mediated immunity in postmastectomy arm lymphoedema: a pilot study</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Decongestion improves cellular immunity in lymphoedema</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Decongestion improves cell‐mediated immunity in postmastectomy arm lymphoedema: a pilot study</title></titleInfo><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Szolnoky</namePart><affiliation>E-mail: szolnoky@dermall.hu</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Dobozy</namePart><affiliation>Department of Dermatology and Allergology, Szeged University, Szeged, Hungary, and Dermatological Research Group, Hungarian Academy of Sciences, Szeged, Hungary</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Kemény</namePart><affiliation>Department of Dermatology and Allergology, Szeged University, Szeged, Hungary, and Dermatological Research Group, Hungarian Academy of Sciences, Szeged, Hungary</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="brief-communication" displayLabel="shortCommunication"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2013-12</dateIssued><edition>Received: 16 March 2012; Accepted: 15 June 2012</edition><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">2</extent></physicalDescription><abstract>Background Chronic lymphoedematous limbs have an increased propensity for infections and primary or secondary malignant tumours. It has been attributed to suppressed delayed‐type hypersensitivity measured in lymphoedemas related to Stewart–Treves syndrome, Kaposi’s sarcoma or breast cancer treatment. Cell‐mediated immunity is an effective defence mechanism against bacteria, fungi, viruses and tumour cells.</abstract><abstract>Objective We aimed to examine whether decongestive lymphoedema therapy could improve cell‐mediated immunity in breast cancer treatment‐related lymphoedema (BCRL).</abstract><abstract>Methods Eight women with unilateral BCRL were included in this study. At baseline, tuberculin skin test (TST) was performed on the volar surfaces of the forearms of the affected and non‐affected sides using 0.5, 1 and 5 tuberculin units in the form of three consecutive injections with 3‐cm spaces in‐between, and arm volumes were measured using the Kuhnke’s disc model. Decongestive lymphatic therapy was given to swollen arms in 10 consecutive working days. At the end of intensive decongestion, TST on affected side and bilateral volumetry were repeated.</abstract><abstract>Results Baseline test using undiluted (5 units) and fivefold diluted (1 unit) tuberculin solutions has shown significant differences (P < 0.05) between the mean sizes (11.81 ± 2.32 and 7.75 ± 1.92; 7.12 ± 1.12 and 5.12 ± 0.91 respectively) in favour to healthy arms. Post therapeutically, the mean sizes were significantly increased (P < 0.05) in the dilutions of 1 : 1 and 1 : 5 (7.75 ± 1.92 and 10.56 ± 1.23 mm, 5.12 ± 0.91 and 5.93 ± 1.74 mm respectively).</abstract><abstract>Conclusion Significant increase in TST sizes suggests that decongestive lymphatic therapy is able to partially restore impaired cellular immune function in BCRL.</abstract><relatedItem type="host"><titleInfo><title>Journal of the European Academy of Dermatology and Venereology</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>SHORT REPORT</topic></subject><identifier type="ISSN">0926-9959</identifier><identifier type="eISSN">1468-3083</identifier><identifier type="DOI">10.1111/(ISSN)1468-3083</identifier><identifier type="PublisherID">JDV</identifier><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>27</number></detail><detail type="issue"><caption>no.</caption><number>12</number></detail><extent unit="pages"><start>1579</start><end>1582</end><total>4</total></extent></part></relatedItem><identifier type="istex">570797D4EAEA489FFFE3A87B432F346A0B9DA193</identifier><identifier type="DOI">10.1111/j.1468-3083.2012.04647.x</identifier><identifier type="ArticleID">JDV4647</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2012 The Authors. Journal of the European Academy of Dermatology and Venereology © 2012 European Academy of Dermatology and Venereology</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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|type= RBID
|clé= ISTEX:570797D4EAEA489FFFE3A87B432F346A0B9DA193
|texte= Decongestion improves cell‐mediated immunity in postmastectomy arm lymphoedema: a pilot study
}}
| This area was generated with Dilib version V0.6.31. |  |