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Infection with Chlamydia trachomatis Lymphogranuloma Venereum Serovar LI in Homosexual Men with Proctitis: Molecular Analysis of an Unusual Case Cluster

Identifieur interne : 002785 ( Istex/Corpus ); précédent : 002784; suivant : 002786

Infection with Chlamydia trachomatis Lymphogranuloma Venereum Serovar LI in Homosexual Men with Proctitis: Molecular Analysis of an Unusual Case Cluster

Auteurs : J. Eric Bauwens ; Mary F. Lampe ; Robert J. Suchland ; Kim Wong ; Walter E. Stamm

Source :

RBID : ISTEX:5639AE90C68015884E6D2E91917F311F7D5D8239

Abstract

Among 767 rectal isolates of Chlamydia trachomatis obtained from men over the period 1981–1991, 7 were found to be a rare lymphogranuloma venereum serovar, L1. These isolates were from rectal specimens taken from five male patients in 1982–1983. Six of the seven isolates were available for DNA sequencing studies. All six of these isolates shared the same DNA sequence in the major outer membrane protein (MOMP) gene variable domains and had different MOMP sequences than did the prototype L1, L2, and L3 strains, suggesting a point source outbreak. All five patients infected with serovar L-1 were homosexual men who had symptomatic proctitis characterized by rectal pain, discharge, tenesmus, abnormalities seen on anoscopy, and leukocytes seen on gram stains of rectal specimens. We conclude that an unrecognized point source outbreak of the rare chlamydial L1 serovar occurred among homosexual men in Seattle in 1982–1983, and that the clinical manifestations of L1 infection may be less severe than those of L2 infections.

Url:
DOI: 10.1093/clinids/20.3.576

Links to Exploration step

ISTEX:5639AE90C68015884E6D2E91917F311F7D5D8239

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<abstract>Among 767 rectal isolates of Chlamydia trachomatis obtained from men over the period 1981–1991, 7 were found to be a rare lymphogranuloma venereum serovar, L1. These isolates were from rectal specimens taken from five male patients in 1982–1983. Six of the seven isolates were available for DNA sequencing studies. All six of these isolates shared the same DNA sequence in the major outer membrane protein (MOMP) gene variable domains and had different MOMP sequences than did the prototype L1, L2, and L3 strains, suggesting a point source outbreak. All five patients infected with serovar L-1 were homosexual men who had symptomatic proctitis characterized by rectal pain, discharge, tenesmus, abnormalities seen on anoscopy, and leukocytes seen on gram stains of rectal specimens. We conclude that an unrecognized point source outbreak of the rare chlamydial L1 serovar occurred among homosexual men in Seattle in 1982–1983, and that the clinical manifestations of L1 infection may be less severe than those of L2 infections.</abstract>
<note type="author-notes">Reprints or correspondence: Dr. Walter E. Stamm, Harborview Medical Center, 325 Ninth Avenue, ZA-89, Seattle, Washington 98104.</note>
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<identifier type="ISSN">1058-4838</identifier>
<identifier type="eISSN">1537-6591</identifier>
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<date>1995</date>
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<caption>vol.</caption>
<number>20</number>
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<caption>no.</caption>
<number>3</number>
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<start>576</start>
<end>581</end>
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<identifier type="DOI">10.1093/clinids/20.3.576</identifier>
<accessCondition type="use and reproduction" contentType="copyright">© 1995 by The University of Chicago</accessCondition>
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