Histogenesis of Kaposi's sarcoma in patients with and without acquired immune deficiency syndrome (AIDS).
Identifieur interne : 001F29 ( Istex/Corpus ); précédent : 001F28; suivant : 001F30Histogenesis of Kaposi's sarcoma in patients with and without acquired immune deficiency syndrome (AIDS).
Auteurs : R R Jones ; J. Spaull ; C. Spry ; E W JonesSource :
- Journal of Clinical Pathology [ 0021-9746 ] ; 1986-07.
Abstract
Immunohistochemical studies were performed in thirty skin biopsies from patients with Kaposi's sarcoma, who did and did not have the acquired immune deficiency syndrome (AIDS). Tumour histogenesis was rigorously tested using a battery of endothelial cell markers, which included two new monoclonal antibodies, EN4 and PAL E. These are both specific for endothelial cells and can be visualised in appropriately fixed paraffin embedded tissue. Whereas EN4 labels all endothelial cells, PAL E is negative in endothelium of lymphatic derivation. Lectin binding with Ulex europaeus agglutinin 1 (UEA-1) and the presence of factor VIII related antigen (FVIIIRA) and laminin were also examined. In nodular lesions of Kaposi's sarcoma the spindle cell areas were positive with EN4 and UEA-1, negative with PAL E, and showed focal staining for FVIIIRA and laminin. These results confirm that the tumour is of endothelial cell origin. Six patch stage lesions showed a network of angulated spaces, lined by cells that were positive with EN4 and UEA-1, negative with PAL E and anti-FVIIIRA, and showed only weak staining for laminin. This pattern was observed in both AIDS and non-AIDS related cases and strongly favours a lymphatic derivation for the tumour. This has important implications as it suggests that lymphatic endothelium may have special characteristics that lead to neoplastic transformation in patients with retrovirus infection.
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DOI: 10.1136/jcp.39.7.742
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Spry</name></author><author><name sortKey="Jones, E W" sort="Jones, E W" uniqKey="Jones E" first="E W" last="Jones">E W Jones</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:4432ED8328E6CE602481F796D9EF38EC799B895B</idno><date when="1986" year="1986">1986</date><idno type="doi">10.1136/jcp.39.7.742</idno><idno type="url">https://api.istex.fr/document/4432ED8328E6CE602481F796D9EF38EC799B895B/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001F29</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001F29</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Histogenesis of Kaposi's sarcoma in patients with and without acquired immune deficiency syndrome (AIDS).</title><author><name sortKey="Jones, R R" sort="Jones, R R" uniqKey="Jones R" first="R R" last="Jones">R R Jones</name></author><author><name sortKey="Spaull, J" sort="Spaull, J" uniqKey="Spaull J" first="J" last="Spaull">J. Spaull</name></author><author><name sortKey="Spry, C" sort="Spry, C" uniqKey="Spry C" first="C" last="Spry">C. Spry</name></author><author><name sortKey="Jones, E W" sort="Jones, E W" uniqKey="Jones E" first="E W" last="Jones">E W Jones</name></author></analytic><monogr></monogr><series><title level="j">Journal of Clinical Pathology</title><title level="j" type="abbrev">J Clin Pathol</title><idno type="ISSN">0021-9746</idno><idno type="eISSN">1472-4146</idno><imprint><publisher>BMJ Publishing Group Ltd and Association of Clinical Pathologists</publisher><date type="published" when="1986-07">1986-07</date><biblScope unit="volume">39</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="742">742</biblScope></imprint><idno type="ISSN">0021-9746</idno></series><idno type="istex">4432ED8328E6CE602481F796D9EF38EC799B895B</idno><idno type="DOI">10.1136/jcp.39.7.742</idno><idno type="href">jclinpath-39-742.pdf</idno><idno type="PMID">3090109</idno><idno type="local">jclinpath;39/7/742</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0021-9746</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Immunohistochemical studies were performed in thirty skin biopsies from patients with Kaposi's sarcoma, who did and did not have the acquired immune deficiency syndrome (AIDS). Tumour histogenesis was rigorously tested using a battery of endothelial cell markers, which included two new monoclonal antibodies, EN4 and PAL E. These are both specific for endothelial cells and can be visualised in appropriately fixed paraffin embedded tissue. Whereas EN4 labels all endothelial cells, PAL E is negative in endothelium of lymphatic derivation. Lectin binding with Ulex europaeus agglutinin 1 (UEA-1) and the presence of factor VIII related antigen (FVIIIRA) and laminin were also examined. In nodular lesions of Kaposi's sarcoma the spindle cell areas were positive with EN4 and UEA-1, negative with PAL E, and showed focal staining for FVIIIRA and laminin. These results confirm that the tumour is of endothelial cell origin. Six patch stage lesions showed a network of angulated spaces, lined by cells that were positive with EN4 and UEA-1, negative with PAL E and anti-FVIIIRA, and showed only weak staining for laminin. This pattern was observed in both AIDS and non-AIDS related cases and strongly favours a lymphatic derivation for the tumour. This has important implications as it suggests that lymphatic endothelium may have special characteristics that lead to neoplastic transformation in patients with retrovirus infection.</div></front></TEI><istex><corpusName>bmj</corpusName><keywords><teeft><json:string>sarcoma</json:string><json:string>tumour</json:string><json:string>lymphatic</json:string><json:string>endothelium</json:string><json:string>monoclonal</json:string><json:string>fviiira</json:string><json:string>laminin</json:string><json:string>pathol</json:string><json:string>immunostaining</json:string><json:string>polyclonal</json:string><json:string>lymphangiomatous</json:string><json:string>lectin</json:string><json:string>lymphatic endothelium</json:string><json:string>endothelial</json:string><json:string>histogenesis</json:string><json:string>fixation</json:string><json:string>clin</json:string><json:string>viii</json:string><json:string>nodular lesions</json:string><json:string>factor viii</json:string><json:string>lesion</json:string><json:string>monoclonal antibody</json:string><json:string>nodular</json:string><json:string>patch stage lesions</json:string><json:string>angulated spaces</json:string><json:string>monoclonal antibodies</json:string><json:string>wilson jones</json:string><json:string>polyclonal antisera</json:string><json:string>moderate reactivity</json:string><json:string>early lesions</json:string><json:string>endothelial cells</json:string><json:string>protease predigestion</json:string><json:string>endothelial cell origin</json:string><json:string>spindle cell areas</json:string><json:string>previous studies</json:string><json:string>spindle cells</json:string><json:string>vascular endothelium</json:string><json:string>biopsy specimens</json:string><json:string>plpfixed tissue</json:string><json:string>immune deficiency syndrome</json:string><json:string>lymphangiomatous changes</json:string><json:string>staining characteristics</json:string><json:string>vascular</json:string></teeft></keywords><author><json:item><name>R R Jones</name></json:item><json:item><name>J Spaull</name></json:item><json:item><name>C Spry</name></json:item><json:item><name>E W Jones</name></json:item></author><language><json:string>eng</json:string></language><originalGenre><json:string>research-article</json:string></originalGenre><abstract>Immunohistochemical studies were performed in thirty skin biopsies from patients with Kaposi's sarcoma, who did and did not have the acquired immune deficiency syndrome (AIDS). Tumour histogenesis was rigorously tested using a battery of endothelial cell markers, which included two new monoclonal antibodies, EN4 and PAL E. These are both specific for endothelial cells and can be visualised in appropriately fixed paraffin embedded tissue. Whereas EN4 labels all endothelial cells, PAL E is negative in endothelium of lymphatic derivation. Lectin binding with Ulex europaeus agglutinin 1 (UEA-1) and the presence of factor VIII related antigen (FVIIIRA) and laminin were also examined. In nodular lesions of Kaposi's sarcoma the spindle cell areas were positive with EN4 and UEA-1, negative with PAL E, and showed focal staining for FVIIIRA and laminin. These results confirm that the tumour is of endothelial cell origin. Six patch stage lesions showed a network of angulated spaces, lined by cells that were positive with EN4 and UEA-1, negative with PAL E and anti-FVIIIRA, and showed only weak staining for laminin. This pattern was observed in both AIDS and non-AIDS related cases and strongly favours a lymphatic derivation for the tumour. This has important implications as it suggests that lymphatic endothelium may have special characteristics that lead to neoplastic transformation in patients with retrovirus infection.</abstract><qualityIndicators><score>5.681</score><pdfVersion>1.3</pdfVersion><pdfPageSize>499.2 x 685.92 pts</pdfPageSize><refBibsNative>false</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>1432</abstractCharCount><pdfWordCount>3077</pdfWordCount><pdfCharCount>21064</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>217</abstractWordCount></qualityIndicators><title>Histogenesis of Kaposi's sarcoma in patients with and without acquired immune deficiency syndrome (AIDS).</title><pmid><json:string>3090109</json:string></pmid><genre><json:string>research-article</json:string></genre><host><title>Journal of Clinical Pathology</title><language><json:string>unknown</json:string></language><issn><json:string>0021-9746</json:string></issn><eissn><json:string>1472-4146</json:string></eissn><volume>39</volume><issue>7</issue><pages><first>742</first></pages><genre><json:string>journal</json:string></genre></host><categories><wos><json:string>science</json:string><json:string>pathology</json:string></wos><scienceMetrix></scienceMetrix><inist><json:string>sciences appliquees, technologies et medecines</json:string><json:string>sciences biologiques et medicales</json:string><json:string>sciences medicales</json:string></inist></categories><publicationDate>1986</publicationDate><copyrightDate>1986</copyrightDate><doi><json:string>10.1136/jcp.39.7.742</json:string></doi><id>4432ED8328E6CE602481F796D9EF38EC799B895B</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/4432ED8328E6CE602481F796D9EF38EC799B895B/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/4432ED8328E6CE602481F796D9EF38EC799B895B/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/4432ED8328E6CE602481F796D9EF38EC799B895B/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Histogenesis of Kaposi's sarcoma in patients with and without acquired immune deficiency syndrome (AIDS).</title><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>BMJ Publishing Group Ltd and Association of Clinical Pathologists</publisher><availability><p>BMJ</p></availability><date>1986-07-01</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Histogenesis of Kaposi's sarcoma in patients with and without acquired immune deficiency syndrome (AIDS).</title><author xml:id="author-1"><persName><forename type="first">R R</forename><surname>Jones</surname></persName></author><author xml:id="author-2"><persName><forename type="first">J</forename><surname>Spaull</surname></persName></author><author xml:id="author-3"><persName><forename type="first">C</forename><surname>Spry</surname></persName></author><author xml:id="author-4"><persName><forename type="first">E W</forename><surname>Jones</surname></persName></author></analytic><monogr><title level="j">Journal of Clinical Pathology</title><title level="j" type="abbrev">J Clin Pathol</title><idno type="pISSN">0021-9746</idno><idno type="eISSN">1472-4146</idno><imprint><publisher>BMJ Publishing Group Ltd and Association of Clinical Pathologists</publisher><date type="published" when="1986-07"></date><biblScope unit="volume">39</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="742">742</biblScope></imprint></monogr><idno type="istex">4432ED8328E6CE602481F796D9EF38EC799B895B</idno><idno type="DOI">10.1136/jcp.39.7.742</idno><idno type="href">jclinpath-39-742.pdf</idno><idno type="PMID">3090109</idno><idno type="local">jclinpath;39/7/742</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1986-07-01</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Immunohistochemical studies were performed in thirty skin biopsies from patients with Kaposi's sarcoma, who did and did not have the acquired immune deficiency syndrome (AIDS). Tumour histogenesis was rigorously tested using a battery of endothelial cell markers, which included two new monoclonal antibodies, EN4 and PAL E. These are both specific for endothelial cells and can be visualised in appropriately fixed paraffin embedded tissue. Whereas EN4 labels all endothelial cells, PAL E is negative in endothelium of lymphatic derivation. Lectin binding with Ulex europaeus agglutinin 1 (UEA-1) and the presence of factor VIII related antigen (FVIIIRA) and laminin were also examined. In nodular lesions of Kaposi's sarcoma the spindle cell areas were positive with EN4 and UEA-1, negative with PAL E, and showed focal staining for FVIIIRA and laminin. These results confirm that the tumour is of endothelial cell origin. Six patch stage lesions showed a network of angulated spaces, lined by cells that were positive with EN4 and UEA-1, negative with PAL E and anti-FVIIIRA, and showed only weak staining for laminin. This pattern was observed in both AIDS and non-AIDS related cases and strongly favours a lymphatic derivation for the tumour. This has important implications as it suggests that lymphatic endothelium may have special characteristics that lead to neoplastic transformation in patients with retrovirus infection.</p></abstract></profileDesc><revisionDesc><change when="1986-07-01">Created</change><change when="1986-07">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2017-01-19">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/4432ED8328E6CE602481F796D9EF38EC799B895B/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus bmj" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="no"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Archiving and Interchange DTD v2.3 20070202//EN" URI="archivearticle.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="research-article" xml:lang="EN"><front><journal-meta><journal-id journal-id-type="hwp">jclinpath</journal-id><journal-id journal-id-type="nlm-ta">J Clin Pathol</journal-id><journal-title>Journal of Clinical Pathology</journal-title><abbrev-journal-title abbrev-type="publisher">J Clin Pathol</abbrev-journal-title><issn pub-type="ppub">0021-9746</issn><issn pub-type="epub">1472-4146</issn><publisher><publisher-name>BMJ Publishing Group Ltd and Association of Clinical Pathologists</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">3090109</article-id><article-id pub-id-type="other">jclinpath;39/7/742</article-id><article-id pub-id-type="doi">10.1136/jcp.39.7.742</article-id><article-id pub-id-type="other">742</article-id><article-id pub-id-type="other">jcp.39.7.742</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Histogenesis of Kaposi's sarcoma in patients with and without acquired immune deficiency syndrome (AIDS).</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Jones</surname><given-names>R R</given-names></name></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Spaull</surname><given-names>J</given-names></name></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Spry</surname><given-names>C</given-names></name></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Jones</surname><given-names>E W</given-names></name></contrib></contrib-group><pub-date pub-type="ppub"><month>7</month><year>1986</year></pub-date><pub-date pub-type="epub"><day>1</day><month>7</month><year>1986</year></pub-date><volume>39</volume><volume-id pub-id-type="other">39</volume-id><volume-id pub-id-type="other">39</volume-id><issue>7</issue><issue-id pub-id-type="other">jclinpath;39/7</issue-id><issue-id pub-id-type="other">7</issue-id><issue-id pub-id-type="other">39/7</issue-id><fpage>742</fpage><self-uri content-type="pdf" xlink:role="full-text" xlink:href="jclinpath-39-742.pdf"></self-uri><abstract><p>Immunohistochemical studies were performed in thirty skin biopsies from patients with Kaposi's sarcoma, who did and did not have the acquired immune deficiency syndrome (AIDS). Tumour histogenesis was rigorously tested using a battery of endothelial cell markers, which included two new monoclonal antibodies, EN4 and PAL E. These are both specific for endothelial cells and can be visualised in appropriately fixed paraffin embedded tissue. Whereas EN4 labels all endothelial cells, PAL E is negative in endothelium of lymphatic derivation. Lectin binding with Ulex europaeus agglutinin 1 (UEA-1) and the presence of factor VIII related antigen (FVIIIRA) and laminin were also examined. In nodular lesions of Kaposi's sarcoma the spindle cell areas were positive with EN4 and UEA-1, negative with PAL E, and showed focal staining for FVIIIRA and laminin. These results confirm that the tumour is of endothelial cell origin. Six patch stage lesions showed a network of angulated spaces, lined by cells that were positive with EN4 and UEA-1, negative with PAL E and anti-FVIIIRA, and showed only weak staining for laminin. This pattern was observed in both AIDS and non-AIDS related cases and strongly favours a lymphatic derivation for the tumour. This has important implications as it suggests that lymphatic endothelium may have special characteristics that lead to neoplastic transformation in patients with retrovirus infection.</p></abstract></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Histogenesis of Kaposi's sarcoma in patients with and without acquired immune deficiency syndrome (AIDS).</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Histogenesis of Kaposi's sarcoma in patients with and without acquired immune deficiency syndrome (AIDS).</title></titleInfo><name type="personal"><namePart type="given">R R</namePart><namePart type="family">Jones</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Spaull</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Spry</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E W</namePart><namePart type="family">Jones</namePart><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article"></genre><originInfo><publisher>BMJ Publishing Group Ltd and Association of Clinical Pathologists</publisher><dateIssued encoding="w3cdtf">1986-07</dateIssued><dateCreated encoding="w3cdtf">1986-07-01</dateCreated><copyrightDate encoding="w3cdtf">1986</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Immunohistochemical studies were performed in thirty skin biopsies from patients with Kaposi's sarcoma, who did and did not have the acquired immune deficiency syndrome (AIDS). Tumour histogenesis was rigorously tested using a battery of endothelial cell markers, which included two new monoclonal antibodies, EN4 and PAL E. These are both specific for endothelial cells and can be visualised in appropriately fixed paraffin embedded tissue. Whereas EN4 labels all endothelial cells, PAL E is negative in endothelium of lymphatic derivation. Lectin binding with Ulex europaeus agglutinin 1 (UEA-1) and the presence of factor VIII related antigen (FVIIIRA) and laminin were also examined. In nodular lesions of Kaposi's sarcoma the spindle cell areas were positive with EN4 and UEA-1, negative with PAL E, and showed focal staining for FVIIIRA and laminin. These results confirm that the tumour is of endothelial cell origin. Six patch stage lesions showed a network of angulated spaces, lined by cells that were positive with EN4 and UEA-1, negative with PAL E and anti-FVIIIRA, and showed only weak staining for laminin. This pattern was observed in both AIDS and non-AIDS related cases and strongly favours a lymphatic derivation for the tumour. This has important implications as it suggests that lymphatic endothelium may have special characteristics that lead to neoplastic transformation in patients with retrovirus infection.</abstract><relatedItem type="host"><titleInfo><title>Journal of Clinical Pathology</title></titleInfo><titleInfo type="abbreviated"><title>J Clin Pathol</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0021-9746</identifier><identifier type="eISSN">1472-4146</identifier><identifier type="PublisherID-hwp">jclinpath</identifier><identifier type="PublisherID-nlm-ta">J Clin Pathol</identifier><part><date>1986</date><detail type="volume"><caption>vol.</caption><number>39</number></detail><detail type="issue"><caption>no.</caption><number>7</number></detail><extent unit="pages"><start>742</start></extent></part></relatedItem><identifier type="istex">4432ED8328E6CE602481F796D9EF38EC799B895B</identifier><identifier type="DOI">10.1136/jcp.39.7.742</identifier><identifier type="href">jclinpath-39-742.pdf</identifier><identifier type="PMID">3090109</identifier><identifier type="local">jclinpath;39/7/742</identifier><recordInfo><recordContentSource>BMJ</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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