P‐74 Evaluation of the in vivo effects of Tris‐EDTA and chlorhexidine digluconate 0.15% solution in chronic bacterial otitis externa: 11 cases
Identifieur interne : 001C79 ( Istex/Corpus ); précédent : 001C78; suivant : 001C80P‐74 Evaluation of the in vivo effects of Tris‐EDTA and chlorhexidine digluconate 0.15% solution in chronic bacterial otitis externa: 11 cases
Auteurs : G. Ghibaudo ; L. Cornegliani ; P. MartinoSource :
- Veterinary Dermatology [ 0959-4493 ] ; 2004-08.
Abstract
The objectives of this study were to evaluate in vivo tolerance, and antimicrobial and clinical activities of a topical otic preparation containing EDTA tromethamine (Tris) and chlorhexidine digluconate 0.15% solution (Otodine®) in dogs with chronic bacterial otitis externa. Eleven dogs were included. The affected ears were filled with the solution once daily during a 2‐week period. Dogs were evaluated on days 0, 14 and 28. Three clinical parameters (exudate, erythema, pain) and three cytologic parameters (Malassezia, cocci, rods) were scored (0–4 scale) by otoscopic and cytological examinations of otic exudate. Bacterial cultures were performed at each time point. If there were bacteria on cytological examination on day 14, the dogs were treated with the original product, with the addition of enrofloxacin (5%) applied 10 min after the original product, for a further 2 weeks. All 11 cases yielded isolates of resistant gram‐negative bacteria; gram‐positive bacteria were also isolated from six of 11 dogs. On day 14, six of 11 dogs were negative on culture examination; on day 28, 10 of 11 were negative and only one case had a positive culture. On day 14, clinical and microbial scores (cytology) were reduced by 54.6 and 71.1%, respectively, and by 85.7 and 94% on day 28. All cases reported good tolerance of the treatment. The results show that this ear solution was helpful in the management of chronic bacterial otitis externa in dogs and was well tolerated. There seems to be a synergistic effect of the combination of Tris‐EDTA/chlorhexidine digluconate 0.15% solution, and an antimicrobial agent (enrofloxacin) against resistant gram‐positive and gram‐negative bacteria. Funding: Self‐funded.
Url:
DOI: 10.1111/j.1365-3164.2004.00414_74.x
Links to Exploration step
ISTEX:3EC2FB89D7D040C56ADD942A27C23D367319F1DALe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">P‐74 Evaluation of the in vivo effects of Tris‐EDTA and chlorhexidine digluconate 0.15% solution in chronic bacterial otitis externa: 11 cases</title><author><name sortKey="Ghibaudo, G" sort="Ghibaudo, G" uniqKey="Ghibaudo G" first="G." last="Ghibaudo">G. Ghibaudo</name><affiliation><mods:affiliation>Clinica Veterinaria Malpensa, Samarate (Varese), Italy; Ambulatorio Veterinario Associato, Torino, Italy; Facoltà di Medicina Veterinaria, Università Degli Studi di Milano, Milano, Italy</mods:affiliation></affiliation></author><author><name sortKey="Cornegliani, L" sort="Cornegliani, L" uniqKey="Cornegliani L" first="L." last="Cornegliani">L. Cornegliani</name><affiliation><mods:affiliation>Clinica Veterinaria Malpensa, Samarate (Varese), Italy; Ambulatorio Veterinario Associato, Torino, Italy; Facoltà di Medicina Veterinaria, Università Degli Studi di Milano, Milano, Italy</mods:affiliation></affiliation></author><author><name sortKey="Martino, P" sort="Martino, P" uniqKey="Martino P" first="P." last="Martino">P. Martino</name><affiliation><mods:affiliation>Clinica Veterinaria Malpensa, Samarate (Varese), Italy; Ambulatorio Veterinario Associato, Torino, Italy; Facoltà di Medicina Veterinaria, Università Degli Studi di Milano, Milano, Italy</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:3EC2FB89D7D040C56ADD942A27C23D367319F1DA</idno><date when="2004" year="2004">2004</date><idno type="doi">10.1111/j.1365-3164.2004.00414_74.x</idno><idno type="url">https://api.istex.fr/document/3EC2FB89D7D040C56ADD942A27C23D367319F1DA/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001C79</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001C79</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">P‐74
Evaluation of the <hi rend="italic">in vivo</hi> effects of Tris‐EDTA and chlorhexidine digluconate 0.15% solution in chronic bacterial otitis externa: 11 cases</title><author><name sortKey="Ghibaudo, G" sort="Ghibaudo, G" uniqKey="Ghibaudo G" first="G." last="Ghibaudo">G. Ghibaudo</name><affiliation><mods:affiliation>Clinica Veterinaria Malpensa, Samarate (Varese), Italy; Ambulatorio Veterinario Associato, Torino, Italy; Facoltà di Medicina Veterinaria, Università Degli Studi di Milano, Milano, Italy</mods:affiliation></affiliation></author><author><name sortKey="Cornegliani, L" sort="Cornegliani, L" uniqKey="Cornegliani L" first="L." last="Cornegliani">L. Cornegliani</name><affiliation><mods:affiliation>Clinica Veterinaria Malpensa, Samarate (Varese), Italy; Ambulatorio Veterinario Associato, Torino, Italy; Facoltà di Medicina Veterinaria, Università Degli Studi di Milano, Milano, Italy</mods:affiliation></affiliation></author><author><name sortKey="Martino, P" sort="Martino, P" uniqKey="Martino P" first="P." last="Martino">P. Martino</name><affiliation><mods:affiliation>Clinica Veterinaria Malpensa, Samarate (Varese), Italy; Ambulatorio Veterinario Associato, Torino, Italy; Facoltà di Medicina Veterinaria, Università Degli Studi di Milano, Milano, Italy</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Veterinary Dermatology</title><title level="j" type="alt">VETERINARY DERMATOLOGY</title><idno type="ISSN">0959-4493</idno><idno type="eISSN">1365-3164</idno><imprint><biblScope unit="vol">15</biblScope><biblScope unit="page" from="65">65</biblScope><biblScope unit="page" to="65">65</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2004-08">2004-08</date></imprint><idno type="ISSN">0959-4493</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0959-4493</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The objectives of this study were to evaluate in vivo tolerance, and antimicrobial and clinical activities of a topical otic preparation containing EDTA tromethamine (Tris) and chlorhexidine digluconate 0.15% solution (Otodine®) in dogs with chronic bacterial otitis externa. Eleven dogs were included. The affected ears were filled with the solution once daily during a 2‐week period. Dogs were evaluated on days 0, 14 and 28. Three clinical parameters (exudate, erythema, pain) and three cytologic parameters (Malassezia, cocci, rods) were scored (0–4 scale) by otoscopic and cytological examinations of otic exudate. Bacterial cultures were performed at each time point. If there were bacteria on cytological examination on day 14, the dogs were treated with the original product, with the addition of enrofloxacin (5%) applied 10 min after the original product, for a further 2 weeks. All 11 cases yielded isolates of resistant gram‐negative bacteria; gram‐positive bacteria were also isolated from six of 11 dogs. On day 14, six of 11 dogs were negative on culture examination; on day 28, 10 of 11 were negative and only one case had a positive culture. On day 14, clinical and microbial scores (cytology) were reduced by 54.6 and 71.1%, respectively, and by 85.7 and 94% on day 28. All cases reported good tolerance of the treatment. The results show that this ear solution was helpful in the management of chronic bacterial otitis externa in dogs and was well tolerated. There seems to be a synergistic effect of the combination of Tris‐EDTA/chlorhexidine digluconate 0.15% solution, and an antimicrobial agent (enrofloxacin) against resistant gram‐positive and gram‐negative bacteria. 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Ghibaudo</name><affiliations><json:string>Clinica Veterinaria Malpensa, Samarate (Varese), Italy; Ambulatorio Veterinario Associato, Torino, Italy; Facoltà di Medicina Veterinaria, Università Degli Studi di Milano, Milano, Italy</json:string></affiliations></json:item><json:item><name>L. Cornegliani</name><affiliations><json:string>Clinica Veterinaria Malpensa, Samarate (Varese), Italy; Ambulatorio Veterinario Associato, Torino, Italy; Facoltà di Medicina Veterinaria, Università Degli Studi di Milano, Milano, Italy</json:string></affiliations></json:item><json:item><name>P. Martino</name><affiliations><json:string>Clinica Veterinaria Malpensa, Samarate (Varese), Italy; Ambulatorio Veterinario Associato, Torino, Italy; Facoltà di Medicina Veterinaria, Università Degli Studi di Milano, Milano, Italy</json:string></affiliations></json:item></author><articleId><json:string>VDE414_74_74</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>abstract</json:string></originalGenre><abstract>The objectives of this study were to evaluate in vivo tolerance, and antimicrobial and clinical activities of a topical otic preparation containing EDTA tromethamine (Tris) and chlorhexidine digluconate 0.15% solution (Otodine®) in dogs with chronic bacterial otitis externa. Eleven dogs were included. The affected ears were filled with the solution once daily during a 2‐week period. Dogs were evaluated on days 0, 14 and 28. Three clinical parameters (exudate, erythema, pain) and three cytologic parameters (Malassezia, cocci, rods) were scored (0–4 scale) by otoscopic and cytological examinations of otic exudate. Bacterial cultures were performed at each time point. If there were bacteria on cytological examination on day 14, the dogs were treated with the original product, with the addition of enrofloxacin (5%) applied 10 min after the original product, for a further 2 weeks. All 11 cases yielded isolates of resistant gram‐negative bacteria; gram‐positive bacteria were also isolated from six of 11 dogs. On day 14, six of 11 dogs were negative on culture examination; on day 28, 10 of 11 were negative and only one case had a positive culture. On day 14, clinical and microbial scores (cytology) were reduced by 54.6 and 71.1%, respectively, and by 85.7 and 94% on day 28. All cases reported good tolerance of the treatment. The results show that this ear solution was helpful in the management of chronic bacterial otitis externa in dogs and was well tolerated. There seems to be a synergistic effect of the combination of Tris‐EDTA/chlorhexidine digluconate 0.15% solution, and an antimicrobial agent (enrofloxacin) against resistant gram‐positive and gram‐negative bacteria. Funding: Self‐funded.</abstract><qualityIndicators><score>8.5</score><pdfVersion>1.4</pdfVersion><pdfPageSize>595 x 842 pts (A4)</pdfPageSize><refBibsNative>false</refBibsNative><abstractCharCount>1714</abstractCharCount><pdfWordCount>20170</pdfWordCount><pdfCharCount>133096</pdfCharCount><pdfPageCount>29</pdfPageCount><abstractWordCount>261</abstractWordCount></qualityIndicators><title>P‐74 Evaluation of the in vivo effects of Tris‐EDTA and chlorhexidine digluconate 0.15% solution in chronic bacterial otitis externa: 11 cases</title><genre><json:string>abstract</json:string></genre><host><title>Veterinary Dermatology</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1365-3164</json:string></doi><issn><json:string>0959-4493</json:string></issn><eissn><json:string>1365-3164</json:string></eissn><publisherId><json:string>VDE</json:string></publisherId><volume>15</volume><pages><first>65</first><last>65</last></pages><genre><json:string>journal</json:string></genre></host><categories><wos><json:string>science</json:string><json:string>veterinary sciences</json:string><json:string>dermatology</json:string></wos><scienceMetrix><json:string>applied sciences</json:string><json:string>agriculture, fisheries & forestry</json:string><json:string>veterinary sciences</json:string></scienceMetrix><inist><json:string>sciences appliquees, technologies et medecines</json:string><json:string>sciences biologiques et medicales</json:string><json:string>sciences medicales</json:string><json:string>pathologie infectieuse</json:string></inist></categories><publicationDate>2004</publicationDate><copyrightDate>2004</copyrightDate><doi><json:string>10.1111/j.1365-3164.2004.00414_74.x</json:string></doi><id>3EC2FB89D7D040C56ADD942A27C23D367319F1DA</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/3EC2FB89D7D040C56ADD942A27C23D367319F1DA/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/3EC2FB89D7D040C56ADD942A27C23D367319F1DA/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/3EC2FB89D7D040C56ADD942A27C23D367319F1DA/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">P‐74
Evaluation of the <hi rend="italic">in vivo</hi> effects of Tris‐EDTA and chlorhexidine digluconate 0.15% solution in chronic bacterial otitis externa: 11 cases</title></titleStmt><publicationStmt><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2004-08"></date></publicationStmt><notesStmt><note type="content-type" subtype="abstract" source="abstract" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-HPN7T1Q2-R">abstract</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="abstract"><analytic><title level="a" type="main">P‐74
Evaluation of the <hi rend="italic">in vivo</hi> effects of Tris‐EDTA and chlorhexidine digluconate 0.15% solution in chronic bacterial otitis externa: 11 cases</title><title level="a" type="short">Poster Abstracts</title><author xml:id="author-0000"><persName><forename type="first">G.</forename><surname>Ghibaudo</surname></persName><affiliation>Clinica Veterinaria Malpensa, Samarate (Varese), Italy; Ambulatorio Veterinario Associato, Torino, Italy; Facoltà di Medicina Veterinaria, Università Degli Studi di Milano, Milano, Italy<address><country key="IT"></country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">L.</forename><surname>Cornegliani</surname></persName><affiliation>Clinica Veterinaria Malpensa, Samarate (Varese), Italy; Ambulatorio Veterinario Associato, Torino, Italy; Facoltà di Medicina Veterinaria, Università Degli Studi di Milano, Milano, Italy<address><country key="IT"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">P.</forename><surname>Martino</surname></persName><affiliation>Clinica Veterinaria Malpensa, Samarate (Varese), Italy; Ambulatorio Veterinario Associato, Torino, Italy; Facoltà di Medicina Veterinaria, Università Degli Studi di Milano, Milano, Italy<address><country key="IT"></country></address></affiliation></author><idno type="istex">3EC2FB89D7D040C56ADD942A27C23D367319F1DA</idno><idno type="DOI">10.1111/j.1365-3164.2004.00414_74.x</idno><idno type="unit">VDE414_74_74</idno><idno type="toTypesetVersion">file:VDE.VDE414_74_74.pdf</idno></analytic><monogr><title level="j" type="main">Veterinary Dermatology</title><title level="j" type="alt">VETERINARY DERMATOLOGY</title><idno type="pISSN">0959-4493</idno><idno type="eISSN">1365-3164</idno><idno type="book-DOI">10.1111/(ISSN)1365-3164</idno><idno type="book-part-DOI">10.1111/vde.2004.15.issue-s1</idno><idno type="product">VDE</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">15</biblScope><biblScope unit="page" from="65">65</biblScope><biblScope unit="page" to="65">65</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2004-08"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><p>The objectives of this study were to evaluate <hi rend="italic">in vivo</hi> tolerance, and antimicrobial and clinical activities of a topical otic preparation containing EDTA tromethamine (Tris) and chlorhexidine digluconate 0.15% solution (Otodine<hi rend="superscript">®</hi>) in dogs with chronic bacterial otitis externa. Eleven dogs were included. The affected ears were filled with the solution once daily during a 2‐week period. Dogs were evaluated on days 0, 14 and 28. Three clinical parameters (exudate, erythema, pain) and three cytologic parameters (<hi rend="italic">Malassezia</hi>, cocci, rods) were scored (0–4 scale) by otoscopic and cytological examinations of otic exudate. Bacterial cultures were performed at each time point. If there were bacteria on cytological examination on day 14, the dogs were treated with the original product, with the addition of enrofloxacin (5%) applied 10 min after the original product, for a further 2 weeks. All 11 cases yielded isolates of resistant gram‐negative bacteria; gram‐positive bacteria were also isolated from six of 11 dogs. On day 14, six of 11 dogs were negative on culture examination; on day 28, 10 of 11 were negative and only one case had a positive culture. On day 14, clinical and microbial scores (cytology) were reduced by 54.6 and 71.1%, respectively, and by 85.7 and 94% on day 28. All cases reported good tolerance of the treatment. The results show that this ear solution was helpful in the management of chronic bacterial otitis externa in dogs and was well tolerated. There seems to be a synergistic effect of the combination of Tris‐EDTA/chlorhexidine digluconate 0.15% solution, and an antimicrobial agent (enrofloxacin) against resistant gram‐positive and gram‐negative bacteria.</p><p>
<hi rend="italic">Funding: Self‐funded.</hi>
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Evaluation of the <i>in vivo</i> effects of Tris‐EDTA and chlorhexidine digluconate 0.15% solution in chronic bacterial otitis externa: 11 cases</title><title type="short">Poster Abstracts</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#aff-1-1"><personName><givenNames>G.</givenNames><familyName>Ghibaudo</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#aff-1-1"><personName><givenNames>L.</givenNames><familyName>Cornegliani</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#aff-1-1"><personName><givenNames>P.</givenNames><familyName>Martino</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="aff-1-1" countryCode="IT"><unparsedAffiliation>Clinica Veterinaria Malpensa, Samarate (Varese), Italy; Ambulatorio Veterinario Associato, Torino, Italy; Facoltà di Medicina Veterinaria, Università Degli Studi di Milano, Milano, Italy</unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><p>The objectives of this study were to evaluate <i>in vivo</i> tolerance, and antimicrobial and clinical activities of a topical otic preparation containing EDTA tromethamine (Tris) and chlorhexidine digluconate 0.15% solution (Otodine<sup>®</sup>) in dogs with chronic bacterial otitis externa. Eleven dogs were included. The affected ears were filled with the solution once daily during a 2‐week period. Dogs were evaluated on days 0, 14 and 28. Three clinical parameters (exudate, erythema, pain) and three cytologic parameters (<i>Malassezia</i>, cocci, rods) were scored (0–4 scale) by otoscopic and cytological examinations of otic exudate. Bacterial cultures were performed at each time point. If there were bacteria on cytological examination on day 14, the dogs were treated with the original product, with the addition of enrofloxacin (5%) applied 10 min after the original product, for a further 2 weeks. All 11 cases yielded isolates of resistant gram‐negative bacteria; gram‐positive bacteria were also isolated from six of 11 dogs. On day 14, six of 11 dogs were negative on culture examination; on day 28, 10 of 11 were negative and only one case had a positive culture. On day 14, clinical and microbial scores (cytology) were reduced by 54.6 and 71.1%, respectively, and by 85.7 and 94% on day 28. All cases reported good tolerance of the treatment. The results show that this ear solution was helpful in the management of chronic bacterial otitis externa in dogs and was well tolerated. There seems to be a synergistic effect of the combination of Tris‐EDTA/chlorhexidine digluconate 0.15% solution, and an antimicrobial agent (enrofloxacin) against resistant gram‐positive and gram‐negative bacteria.</p><p> <i>Funding: Self‐funded.</i> </p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>P‐74 Evaluation of the in vivo effects of Tris‐EDTA and chlorhexidine digluconate 0.15% solution in chronic bacterial otitis externa: 11 cases</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Poster Abstracts</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>P‐74
Evaluation of the in vivo effects of Tris‐EDTA and chlorhexidine digluconate 0.15% solution in chronic bacterial otitis externa: 11 cases</title></titleInfo><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Ghibaudo</namePart><affiliation>Clinica Veterinaria Malpensa, Samarate (Varese), Italy; Ambulatorio Veterinario Associato, Torino, Italy; Facoltà di Medicina Veterinaria, Università Degli Studi di Milano, Milano, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Cornegliani</namePart><affiliation>Clinica Veterinaria Malpensa, Samarate (Varese), Italy; Ambulatorio Veterinario Associato, Torino, Italy; Facoltà di Medicina Veterinaria, Università Degli Studi di Milano, Milano, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Martino</namePart><affiliation>Clinica Veterinaria Malpensa, Samarate (Varese), Italy; Ambulatorio Veterinario Associato, Torino, Italy; Facoltà di Medicina Veterinaria, Università Degli Studi di Milano, Milano, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="abstract" displayLabel="abstract"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2004-08</dateIssued><copyrightDate encoding="w3cdtf">2004</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">The objectives of this study were to evaluate in vivo tolerance, and antimicrobial and clinical activities of a topical otic preparation containing EDTA tromethamine (Tris) and chlorhexidine digluconate 0.15% solution (Otodine®) in dogs with chronic bacterial otitis externa. Eleven dogs were included. The affected ears were filled with the solution once daily during a 2‐week period. Dogs were evaluated on days 0, 14 and 28. Three clinical parameters (exudate, erythema, pain) and three cytologic parameters (Malassezia, cocci, rods) were scored (0–4 scale) by otoscopic and cytological examinations of otic exudate. Bacterial cultures were performed at each time point. If there were bacteria on cytological examination on day 14, the dogs were treated with the original product, with the addition of enrofloxacin (5%) applied 10 min after the original product, for a further 2 weeks. All 11 cases yielded isolates of resistant gram‐negative bacteria; gram‐positive bacteria were also isolated from six of 11 dogs. On day 14, six of 11 dogs were negative on culture examination; on day 28, 10 of 11 were negative and only one case had a positive culture. On day 14, clinical and microbial scores (cytology) were reduced by 54.6 and 71.1%, respectively, and by 85.7 and 94% on day 28. All cases reported good tolerance of the treatment. The results show that this ear solution was helpful in the management of chronic bacterial otitis externa in dogs and was well tolerated. There seems to be a synergistic effect of the combination of Tris‐EDTA/chlorhexidine digluconate 0.15% solution, and an antimicrobial agent (enrofloxacin) against resistant gram‐positive and gram‐negative bacteria. Funding: Self‐funded.</abstract><relatedItem type="host"><titleInfo><title>Veterinary Dermatology</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0959-4493</identifier><identifier type="eISSN">1365-3164</identifier><identifier type="DOI">10.1111/(ISSN)1365-3164</identifier><identifier type="PublisherID">VDE</identifier><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><detail type="supplement"><caption>Suppl. no.</caption><number>s1</number></detail><extent unit="pages"><start>65</start><end>65</end></extent></part></relatedItem><identifier type="istex">3EC2FB89D7D040C56ADD942A27C23D367319F1DA</identifier><identifier type="DOI">10.1111/j.1365-3164.2004.00414_74.x</identifier><identifier type="ArticleID">VDE414_74_74</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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