FIBRIN CUFF LYSIS IN CHRONIC VENOUS ULCERS TREATED WITH A HYDROCOLLOID DRESSING
Identifieur interne : 001B49 ( Istex/Corpus ); précédent : 001B48; suivant : 001B50FIBRIN CUFF LYSIS IN CHRONIC VENOUS ULCERS TREATED WITH A HYDROCOLLOID DRESSING
Auteurs : Gerit Mulder ; Richard Jones ; Stewart Cederholm-Williams ; George Cherry ; Terence RyanSource :
- International Journal of Dermatology [ 0011-9059 ] ; 1993-04.
Abstract
Background. Pericapillary fibrin cuffs (PFC) are a recognized part of the pathology of venous stasis ulcers. A hydrocolloid dressing capable of lysing wound surface fibrin was tested in venous ulcers for its capacity to lyse pericapillary fibrin below the wound surface. Methods. Tissue biopsies from the rims of 19 venous ulcers were evaluated for thickness of shallow and deep dermal PFCS before and after treatment with DuoDERM covered by Unna's boot and a compression bandage (DD+UB; n=9) versus the same treatment without the hydrocolloid dressing (UB; n=10). Frozen sections of all biopsies were stained with an immunofluorescent antibody to fibrin for rating of PFC thickness. Separate sections were stained with hematoxylin and eosin to assess capillary frequency, histopathology, and inflammation. All ratings and pathology assessments were performed blinded to treatment conditions. Results. Both deep and shallow PFCS were reduced in 89% of ulcers treated with DD+UB versus 40% of ulcers treated with UB (α < 0.04). No other significant differences in inflammation, histopathology, or capillary frequency were observed. Conclusions. Treatment with DD+UB reduced PFCS in twice the number of ulcers than UB alone in 1 week. This is the first scientific documentation that a topical wound dressing could reduce the pathophysiology associated with venous ulcers, beyond the known beneficial effect of graduated compression. Not all hydrocolloid dressings are fibrinolytic, so this effect may not generalize to other dressings.
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DOI: 10.1111/j.1365-4362.1993.tb04275.x
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">FIBRIN CUFF LYSIS IN CHRONIC VENOUS ULCERS TREATED WITH A HYDROCOLLOID DRESSING</title><author><name sortKey="Mulder, Gerit" sort="Mulder, Gerit" uniqKey="Mulder G" first="Gerit" last="Mulder">Gerit Mulder</name><affiliation><mods:affiliation>Wound Healing Institute, Denver, Colorado; the Department of Dermatology, Churchill Hospital, Oxford, England; and the Fibrinolysis Research Group, John Radcliffe Hospital, Oxford, England.</mods:affiliation></affiliation><affiliation><mods:affiliation>Address for correspondence: Gerit D. Mulder, D.P.M., Wound Healing Institute, 14991 E. Hampden, Suite 330, Aurora, CO 80014.</mods:affiliation></affiliation></author><author><name sortKey="Jones, Richard" sort="Jones, Richard" uniqKey="Jones R" first="Richard" last="Jones">Richard Jones</name><affiliation><mods:affiliation>Wound Healing Institute, Denver, Colorado; the Department of Dermatology, Churchill Hospital, Oxford, England; and the Fibrinolysis Research Group, John Radcliffe Hospital, Oxford, England.</mods:affiliation></affiliation></author><author><name sortKey="Cederholm Illiams, Stewart" sort="Cederholm Illiams, Stewart" uniqKey="Cederholm Illiams S" first="Stewart" last="Cederholm-Williams">Stewart Cederholm-Williams</name><affiliation><mods:affiliation>Wound Healing Institute, Denver, Colorado; the Department of Dermatology, Churchill Hospital, Oxford, England; and the Fibrinolysis Research Group, John Radcliffe Hospital, Oxford, England.</mods:affiliation></affiliation></author><author><name sortKey="Cherry, George" sort="Cherry, George" uniqKey="Cherry G" first="George" last="Cherry">George Cherry</name><affiliation><mods:affiliation>Wound Healing Institute, Denver, Colorado; the Department of Dermatology, Churchill Hospital, Oxford, England; and the Fibrinolysis Research Group, John Radcliffe Hospital, Oxford, England.</mods:affiliation></affiliation></author><author><name sortKey="Ryan, Terence" sort="Ryan, Terence" uniqKey="Ryan T" first="Terence" last="Ryan">Terence Ryan</name><affiliation><mods:affiliation>Wound Healing Institute, Denver, Colorado; the Department of Dermatology, Churchill Hospital, Oxford, England; and the Fibrinolysis Research Group, John Radcliffe Hospital, Oxford, England.</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:3C5694D53277C72078B13279359BC1C30893C4D4</idno><date when="1993" year="1993">1993</date><idno type="doi">10.1111/j.1365-4362.1993.tb04275.x</idno><idno type="url">https://api.istex.fr/document/3C5694D53277C72078B13279359BC1C30893C4D4/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001B49</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001B49</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">FIBRIN CUFF LYSIS IN CHRONIC VENOUS ULCERS TREATED WITH A HYDROCOLLOID DRESSING</title><author><name sortKey="Mulder, Gerit" sort="Mulder, Gerit" uniqKey="Mulder G" first="Gerit" last="Mulder">Gerit Mulder</name><affiliation><mods:affiliation>Wound Healing Institute, Denver, Colorado; the Department of Dermatology, Churchill Hospital, Oxford, England; and the Fibrinolysis Research Group, John Radcliffe Hospital, Oxford, England.</mods:affiliation></affiliation><affiliation><mods:affiliation>Address for correspondence: Gerit D. Mulder, D.P.M., Wound Healing Institute, 14991 E. Hampden, Suite 330, Aurora, CO 80014.</mods:affiliation></affiliation></author><author><name sortKey="Jones, Richard" sort="Jones, Richard" uniqKey="Jones R" first="Richard" last="Jones">Richard Jones</name><affiliation><mods:affiliation>Wound Healing Institute, Denver, Colorado; the Department of Dermatology, Churchill Hospital, Oxford, England; and the Fibrinolysis Research Group, John Radcliffe Hospital, Oxford, England.</mods:affiliation></affiliation></author><author><name sortKey="Cederholm Illiams, Stewart" sort="Cederholm Illiams, Stewart" uniqKey="Cederholm Illiams S" first="Stewart" last="Cederholm-Williams">Stewart Cederholm-Williams</name><affiliation><mods:affiliation>Wound Healing Institute, Denver, Colorado; the Department of Dermatology, Churchill Hospital, Oxford, England; and the Fibrinolysis Research Group, John Radcliffe Hospital, Oxford, England.</mods:affiliation></affiliation></author><author><name sortKey="Cherry, George" sort="Cherry, George" uniqKey="Cherry G" first="George" last="Cherry">George Cherry</name><affiliation><mods:affiliation>Wound Healing Institute, Denver, Colorado; the Department of Dermatology, Churchill Hospital, Oxford, England; and the Fibrinolysis Research Group, John Radcliffe Hospital, Oxford, England.</mods:affiliation></affiliation></author><author><name sortKey="Ryan, Terence" sort="Ryan, Terence" uniqKey="Ryan T" first="Terence" last="Ryan">Terence Ryan</name><affiliation><mods:affiliation>Wound Healing Institute, Denver, Colorado; the Department of Dermatology, Churchill Hospital, Oxford, England; and the Fibrinolysis Research Group, John Radcliffe Hospital, Oxford, England.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">International Journal of Dermatology</title><title level="j" type="alt">INTERNATIONAL JOURNAL OF DERMATOLOGY</title><idno type="ISSN">0011-9059</idno><idno type="eISSN">1365-4632</idno><imprint><biblScope unit="vol">32</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="304">304</biblScope><biblScope unit="page" to="306">306</biblScope><biblScope unit="page-count">3</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1993-04">1993-04</date></imprint><idno type="ISSN">0011-9059</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0011-9059</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background. Pericapillary fibrin cuffs (PFC) are a recognized part of the pathology of venous stasis ulcers. A hydrocolloid dressing capable of lysing wound surface fibrin was tested in venous ulcers for its capacity to lyse pericapillary fibrin below the wound surface. Methods. Tissue biopsies from the rims of 19 venous ulcers were evaluated for thickness of shallow and deep dermal PFCS before and after treatment with DuoDERM covered by Unna's boot and a compression bandage (DD+UB; n=9) versus the same treatment without the hydrocolloid dressing (UB; n=10). Frozen sections of all biopsies were stained with an immunofluorescent antibody to fibrin for rating of PFC thickness. Separate sections were stained with hematoxylin and eosin to assess capillary frequency, histopathology, and inflammation. All ratings and pathology assessments were performed blinded to treatment conditions. Results. Both deep and shallow PFCS were reduced in 89% of ulcers treated with DD+UB versus 40% of ulcers treated with UB (α < 0.04). No other significant differences in inflammation, histopathology, or capillary frequency were observed. Conclusions. Treatment with DD+UB reduced PFCS in twice the number of ulcers than UB alone in 1 week. This is the first scientific documentation that a topical wound dressing could reduce the pathophysiology associated with venous ulcers, beyond the known beneficial effect of graduated compression. Not all hydrocolloid dressings are fibrinolytic, so this effect may not generalize to other dressings.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>venous</json:string><json:string>pericapillary</json:string><json:string>hydrocolloid</json:string><json:string>cuff</json:string><json:string>ulceration</json:string><json:string>fibrin</json:string><json:string>hydrocolloid dressing</json:string><json:string>venous ulceration</json:string><json:string>duoderm</json:string><json:string>chronic venous ulcers</json:string><json:string>fibrin cuffs</json:string><json:string>venous ulcers</json:string><json:string>dermatol</json:string><json:string>burnand</json:string><json:string>pericapillary fibrin cuffs</json:string><json:string>control group</json:string><json:string>fibrinolytic</json:string><json:string>lysis</json:string><json:string>pericapillary fibrin</json:string><json:string>visible capillaries</json:string><json:string>fibrinolysis</json:string><json:string>venous disease</json:string><json:string>wound healing</json:string><json:string>ulcer</json:string><json:string>biopsy</json:string><json:string>hydrocolloid dressings</json:string><json:string>moderate cuffs</json:string><json:string>capillary frequency</json:string><json:string>wound healing institute</json:string><json:string>lyse fibrin</json:string><json:string>acad dermatol</json:string><json:string>compression bandages</json:string><json:string>venous return</json:string><json:string>compression bandage</json:string></teeft></keywords><author><json:item><name>GERIT MULDER D.P.M.</name><affiliations><json:string>Wound Healing Institute, Denver, Colorado; the Department of Dermatology, Churchill Hospital, Oxford, England; and the Fibrinolysis Research Group, John Radcliffe Hospital, Oxford, England.</json:string><json:string>Address for correspondence: Gerit D. Mulder, D.P.M., Wound Healing Institute, 14991 E. Hampden, Suite 330, Aurora, CO 80014.</json:string></affiliations></json:item><json:item><name>RICHARD JONES F.I.M.L.S.</name><affiliations><json:string>Wound Healing Institute, Denver, Colorado; the Department of Dermatology, Churchill Hospital, Oxford, England; and the Fibrinolysis Research Group, John Radcliffe Hospital, Oxford, England.</json:string></affiliations></json:item><json:item><name>STEWART CEDERHOLM‐WILLIAMS PH.D.</name><affiliations><json:string>Wound Healing Institute, Denver, Colorado; the Department of Dermatology, Churchill Hospital, Oxford, England; and the Fibrinolysis Research Group, John Radcliffe Hospital, Oxford, England.</json:string></affiliations></json:item><json:item><name>GEORGE CHERRY PH.D.</name><affiliations><json:string>Wound Healing Institute, Denver, Colorado; the Department of Dermatology, Churchill Hospital, Oxford, England; and the Fibrinolysis Research Group, John Radcliffe Hospital, Oxford, England.</json:string></affiliations></json:item><json:item><name>TERENCE RYAN M.D.</name><affiliations><json:string>Wound Healing Institute, Denver, Colorado; the Department of Dermatology, Churchill Hospital, Oxford, England; and the Fibrinolysis Research Group, John Radcliffe Hospital, Oxford, England.</json:string></affiliations></json:item></author><articleId><json:string>IJD304</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Background. Pericapillary fibrin cuffs (PFC) are a recognized part of the pathology of venous stasis ulcers. A hydrocolloid dressing capable of lysing wound surface fibrin was tested in venous ulcers for its capacity to lyse pericapillary fibrin below the wound surface. Methods. Tissue biopsies from the rims of 19 venous ulcers were evaluated for thickness of shallow and deep dermal PFCS before and after treatment with DuoDERM covered by Unna's boot and a compression bandage (DD+UB; n=9) versus the same treatment without the hydrocolloid dressing (UB; n=10). Frozen sections of all biopsies were stained with an immunofluorescent antibody to fibrin for rating of PFC thickness. Separate sections were stained with hematoxylin and eosin to assess capillary frequency, histopathology, and inflammation. All ratings and pathology assessments were performed blinded to treatment conditions. Results. Both deep and shallow PFCS were reduced in 89% of ulcers treated with DD+UB versus 40% of ulcers treated with UB (α > 0.04). No other significant differences in inflammation, histopathology, or capillary frequency were observed. Conclusions. Treatment with DD+UB reduced PFCS in twice the number of ulcers than UB alone in 1 week. This is the first scientific documentation that a topical wound dressing could reduce the pathophysiology associated with venous ulcers, beyond the known beneficial effect of graduated compression. Not all hydrocolloid dressings are fibrinolytic, so this effect may not generalize to other dressings.</abstract><qualityIndicators><score>6.212</score><pdfVersion>1.6</pdfVersion><pdfPageSize>527 x 769 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1533</abstractCharCount><pdfWordCount>1976</pdfWordCount><pdfCharCount>12335</pdfCharCount><pdfPageCount>4</pdfPageCount><abstractWordCount>228</abstractWordCount></qualityIndicators><title>FIBRIN CUFF LYSIS IN CHRONIC VENOUS ULCERS TREATED WITH A HYDROCOLLOID DRESSING</title><genre><json:string>article</json:string></genre><host><title>International Journal of Dermatology</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1365-4632</json:string></doi><issn><json:string>0011-9059</json:string></issn><eissn><json:string>1365-4632</json:string></eissn><publisherId><json:string>IJD</json:string></publisherId><volume>32</volume><issue>4</issue><pages><first>304</first><last>306</last><total>3</total></pages><genre><json:string>journal</json:string></genre></host><categories><wos><json:string>science</json:string><json:string>dermatology</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>dermatology & venereal diseases</json:string></scienceMetrix><inist><json:string>sciences appliquees, technologies et medecines</json:string><json:string>sciences biologiques et medicales</json:string><json:string>sciences medicales</json:string></inist></categories><publicationDate>1993</publicationDate><copyrightDate>1993</copyrightDate><doi><json:string>10.1111/j.1365-4362.1993.tb04275.x</json:string></doi><id>3C5694D53277C72078B13279359BC1C30893C4D4</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/3C5694D53277C72078B13279359BC1C30893C4D4/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/3C5694D53277C72078B13279359BC1C30893C4D4/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/3C5694D53277C72078B13279359BC1C30893C4D4/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">FIBRIN CUFF LYSIS IN CHRONIC VENOUS ULCERS TREATED WITH A HYDROCOLLOID DRESSING</title></titleStmt><publicationStmt><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1993-04"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">FIBRIN CUFF LYSIS IN CHRONIC VENOUS ULCERS TREATED WITH A HYDROCOLLOID DRESSING</title><author xml:id="author-0000" role="corresp"><persName><forename type="first">GERIT</forename><surname>MULDER</surname><roleName type="degree">D.P.M.</roleName></persName><affiliation>Wound Healing Institute, Denver, Colorado; the Department of Dermatology, Churchill Hospital, Oxford, England; and the Fibrinolysis Research Group, John Radcliffe Hospital, Oxford, England.<address><country key="US"></country></address></affiliation><affiliation>Address for correspondence: Gerit D. Mulder, D.P.M., Wound Healing Institute, 14991 E. Hampden, Suite 330, Aurora, CO 80014.</affiliation></author><author xml:id="author-0001"><persName><forename type="first">RICHARD</forename><surname>JONES</surname><roleName type="degree">F.I.M.L.S.</roleName></persName><affiliation>Wound Healing Institute, Denver, Colorado; the Department of Dermatology, Churchill Hospital, Oxford, England; and the Fibrinolysis Research Group, John Radcliffe Hospital, Oxford, England.<address><country key="US"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">STEWART</forename><surname>CEDERHOLM‐WILLIAMS</surname><roleName type="degree">PH.D.</roleName></persName><affiliation>Wound Healing Institute, Denver, Colorado; the Department of Dermatology, Churchill Hospital, Oxford, England; and the Fibrinolysis Research Group, John Radcliffe Hospital, Oxford, England.<address><country key="US"></country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">GEORGE</forename><surname>CHERRY</surname><roleName type="degree">PH.D.</roleName></persName><affiliation>Wound Healing Institute, Denver, Colorado; the Department of Dermatology, Churchill Hospital, Oxford, England; and the Fibrinolysis Research Group, John Radcliffe Hospital, Oxford, England.<address><country key="US"></country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">TERENCE</forename><surname>RYAN</surname><roleName type="degree">M.D.</roleName></persName><affiliation>Wound Healing Institute, Denver, Colorado; the Department of Dermatology, Churchill Hospital, Oxford, England; and the Fibrinolysis Research Group, John Radcliffe Hospital, Oxford, England.<address><country key="US"></country></address></affiliation></author><idno type="istex">3C5694D53277C72078B13279359BC1C30893C4D4</idno><idno type="DOI">10.1111/j.1365-4362.1993.tb04275.x</idno><idno type="unit">IJD304</idno><idno type="toTypesetVersion">file:IJD.IJD304.pdf</idno></analytic><monogr><title level="j" type="main">International Journal of Dermatology</title><title level="j" type="alt">INTERNATIONAL JOURNAL OF DERMATOLOGY</title><idno type="pISSN">0011-9059</idno><idno type="eISSN">1365-4632</idno><idno type="book-DOI">10.1111/(ISSN)1365-4632</idno><idno type="book-part-DOI">10.1111/ijd.1993.32.issue-4</idno><idno type="product">IJD</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">32</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="304">304</biblScope><biblScope unit="page" to="306">306</biblScope><biblScope unit="page-count">3</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1993-04"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><head>Abstract</head><p>
<hi rend="italic">Background.</hi> Pericapillary fibrin cuffs (PFC) are a recognized part of the pathology of venous stasis ulcers. A hydrocolloid dressing capable of lysing wound surface fibrin was tested in venous ulcers for its capacity to lyse pericapillary fibrin below the wound surface.</p><p>
<hi rend="italic">Methods.</hi> Tissue biopsies from the rims of 19 venous ulcers were evaluated for thickness of shallow and deep dermal PFCS before and after treatment with DuoDERM covered by Unna's boot and a compression bandage (DD+UB; n=9) versus the same treatment without the hydrocolloid dressing (UB; n=10). Frozen sections of all biopsies were stained with an immunofluorescent antibody to fibrin for rating of PFC thickness. Separate sections were stained with hematoxylin and eosin to assess capillary frequency, histopathology, and inflammation. All ratings and pathology assessments were performed blinded to treatment conditions.</p><p>
<hi rend="italic">Results.</hi> Both deep and shallow PFCS were reduced in 89% of ulcers treated with DD+UB versus 40% of ulcers treated with UB (α < 0.04). No other significant differences in inflammation, histopathology, or capillary frequency were observed.</p><p>
<hi rend="italic">Conclusions.</hi> Treatment with DD+UB reduced PFCS in twice the number of ulcers than UB alone in 1 week. This is the first scientific documentation that a topical wound dressing could reduce the pathophysiology associated with venous ulcers, beyond the known beneficial effect of graduated compression. Not all hydrocolloid dressings are fibrinolytic, so this effect may not generalize to other dressings.</p></abstract><textClass><classCode scheme="tocHeading1">PHARMACOLOGY AND THERAPEUTICS</classCode></textClass><langUsage><language ident="EN"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/3C5694D53277C72078B13279359BC1C30893C4D4/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1365-4632</doi><issn type="print">0011-9059</issn><issn type="electronic">1365-4632</issn><idGroup><id type="product" value="IJD"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="INTERNATIONAL JOURNAL OF DERMATOLOGY">International Journal of Dermatology</title></titleGroup></publicationMeta><publicationMeta level="part" position="04004"><doi origin="wiley">10.1111/ijd.1993.32.issue-4</doi><numberingGroup><numbering type="journalVolume" number="32">32</numbering><numbering type="journalIssue" number="4">4</numbering></numberingGroup><coverDate startDate="1993-04">April 1993</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="0030400" status="forIssue"><doi origin="wiley">10.1111/j.1365-4362.1993.tb04275.x</doi><idGroup><id type="unit" value="IJD304"></id></idGroup><countGroup><count type="pageTotal" number="3"></count></countGroup><titleGroup><title type="tocHeading1">PHARMACOLOGY AND THERAPEUTICS</title></titleGroup><eventGroup><event type="firstOnline" date="2007-05-31"></event><event type="publishedOnlineFinalForm" date="2007-05-31"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:HeaderRef result:HeaderRef" date="2010-03-04"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-13"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-24"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="304">304</numbering><numbering type="pageLast" number="306">306</numbering></numberingGroup><correspondenceTo>Address for correspondence: Gerit D. Mulder, D.P.M., Wound Healing Institute, 14991 E. Hampden, Suite 330, Aurora, CO 80014.</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:IJD.IJD304.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="referenceTotal" number="19"></count><count type="linksCrossRef" number="6"></count></countGroup><titleGroup><title type="main">FIBRIN CUFF LYSIS IN CHRONIC VENOUS ULCERS TREATED WITH A HYDROCOLLOID DRESSING</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1" corresponding="yes"><personName><givenNames>GERIT</givenNames><familyName>MULDER</familyName><degrees>D.P.M.</degrees></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>RICHARD</givenNames><familyName>JONES</familyName><degrees>F.I.M.L.S.</degrees></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>STEWART</givenNames><familyName>CEDERHOLM‐WILLIAMS</familyName><degrees>PH.D.</degrees></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>GEORGE</givenNames><familyName>CHERRY</familyName><degrees>PH.D.</degrees></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a1"><personName><givenNames>TERENCE</givenNames><familyName>RYAN</familyName><degrees>M.D.</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="US"><unparsedAffiliation>Wound Healing Institute, Denver, Colorado; the Department of Dermatology, Churchill Hospital, Oxford, England; and the Fibrinolysis Research Group, John Radcliffe Hospital, Oxford, England.</unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p> <i>Background.</i> Pericapillary fibrin cuffs (PFC) are a recognized part of the pathology of venous stasis ulcers. A hydrocolloid dressing capable of lysing wound surface fibrin was tested in venous ulcers for its capacity to lyse pericapillary fibrin below the wound surface.</p><p> <i>Methods.</i> Tissue biopsies from the rims of 19 venous ulcers were evaluated for thickness of shallow and deep dermal PFCS before and after treatment with DuoDERM covered by Unna's boot and a compression bandage (DD+UB; n=9) versus the same treatment without the hydrocolloid dressing (UB; n=10). Frozen sections of all biopsies were stained with an immunofluorescent antibody to fibrin for rating of PFC thickness. Separate sections were stained with hematoxylin and eosin to assess capillary frequency, histopathology, and inflammation. All ratings and pathology assessments were performed blinded to treatment conditions.</p><p> <i>Results.</i> Both deep and shallow PFCS were reduced in 89% of ulcers treated with DD+UB versus 40% of ulcers treated with UB (α < 0.04). No other significant differences in inflammation, histopathology, or capillary frequency were observed.</p><p> <i>Conclusions.</i> Treatment with DD+UB reduced PFCS in twice the number of ulcers than UB alone in 1 week. This is the first scientific documentation that a topical wound dressing could reduce the pathophysiology associated with venous ulcers, beyond the known beneficial effect of graduated compression. Not all hydrocolloid dressings are fibrinolytic, so this effect may not generalize to other dressings.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>FIBRIN CUFF LYSIS IN CHRONIC VENOUS ULCERS TREATED WITH A HYDROCOLLOID DRESSING</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>FIBRIN CUFF LYSIS IN CHRONIC VENOUS ULCERS TREATED WITH A HYDROCOLLOID DRESSING</title></titleInfo><name type="personal"><namePart type="given">GERIT</namePart><namePart type="family">MULDER</namePart><namePart type="termsOfAddress">D.P.M.</namePart><affiliation>Wound Healing Institute, Denver, Colorado; the Department of Dermatology, Churchill Hospital, Oxford, England; and the Fibrinolysis Research Group, John Radcliffe Hospital, Oxford, England.</affiliation><affiliation>Address for correspondence: Gerit D. Mulder, D.P.M., Wound Healing Institute, 14991 E. Hampden, Suite 330, Aurora, CO 80014.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RICHARD</namePart><namePart type="family">JONES</namePart><namePart type="termsOfAddress">F.I.M.L.S.</namePart><affiliation>Wound Healing Institute, Denver, Colorado; the Department of Dermatology, Churchill Hospital, Oxford, England; and the Fibrinolysis Research Group, John Radcliffe Hospital, Oxford, England.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">STEWART</namePart><namePart type="family">CEDERHOLM‐WILLIAMS</namePart><namePart type="termsOfAddress">PH.D.</namePart><affiliation>Wound Healing Institute, Denver, Colorado; the Department of Dermatology, Churchill Hospital, Oxford, England; and the Fibrinolysis Research Group, John Radcliffe Hospital, Oxford, England.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GEORGE</namePart><namePart type="family">CHERRY</namePart><namePart type="termsOfAddress">PH.D.</namePart><affiliation>Wound Healing Institute, Denver, Colorado; the Department of Dermatology, Churchill Hospital, Oxford, England; and the Fibrinolysis Research Group, John Radcliffe Hospital, Oxford, England.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TERENCE</namePart><namePart type="family">RYAN</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>Wound Healing Institute, Denver, Colorado; the Department of Dermatology, Churchill Hospital, Oxford, England; and the Fibrinolysis Research Group, John Radcliffe Hospital, Oxford, England.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">1993-04</dateIssued><copyrightDate encoding="w3cdtf">1993</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="references">19</extent></physicalDescription><abstract lang="en">Background. Pericapillary fibrin cuffs (PFC) are a recognized part of the pathology of venous stasis ulcers. A hydrocolloid dressing capable of lysing wound surface fibrin was tested in venous ulcers for its capacity to lyse pericapillary fibrin below the wound surface. Methods. Tissue biopsies from the rims of 19 venous ulcers were evaluated for thickness of shallow and deep dermal PFCS before and after treatment with DuoDERM covered by Unna's boot and a compression bandage (DD+UB; n=9) versus the same treatment without the hydrocolloid dressing (UB; n=10). Frozen sections of all biopsies were stained with an immunofluorescent antibody to fibrin for rating of PFC thickness. Separate sections were stained with hematoxylin and eosin to assess capillary frequency, histopathology, and inflammation. All ratings and pathology assessments were performed blinded to treatment conditions. Results. Both deep and shallow PFCS were reduced in 89% of ulcers treated with DD+UB versus 40% of ulcers treated with UB (α < 0.04). No other significant differences in inflammation, histopathology, or capillary frequency were observed. Conclusions. Treatment with DD+UB reduced PFCS in twice the number of ulcers than UB alone in 1 week. This is the first scientific documentation that a topical wound dressing could reduce the pathophysiology associated with venous ulcers, beyond the known beneficial effect of graduated compression. Not all hydrocolloid dressings are fibrinolytic, so this effect may not generalize to other dressings.</abstract><relatedItem type="host"><titleInfo><title>International Journal of Dermatology</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0011-9059</identifier><identifier type="eISSN">1365-4632</identifier><identifier type="DOI">10.1111/(ISSN)1365-4632</identifier><identifier type="PublisherID">IJD</identifier><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>304</start><end>306</end><total>3</total></extent></part></relatedItem><identifier type="istex">3C5694D53277C72078B13279359BC1C30893C4D4</identifier><identifier type="DOI">10.1111/j.1365-4362.1993.tb04275.x</identifier><identifier type="ArticleID">IJD304</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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