Differential humoral and cellular immunoreactivity to saline-and detergent-extracted filarial antigens
Identifieur interne : 001B03 ( Istex/Corpus ); précédent : 001B02; suivant : 001B04Differential humoral and cellular immunoreactivity to saline-and detergent-extracted filarial antigens
Auteurs : Patrick J. Lammie ; Mark L. Eberhard ; Robert C. Lowrie JrSource :
- Transactions of the Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ] ; 1990.
Abstract
The immunoreactivity to saline- and detergent-extracted filarial antigens of 31 Haitian subjects exposed to or infected with Wuchereria bancrofti was analysed. Cellular reactivity, monitored by blastogenesis in vitro, was significantly greater to a soluble extract of Brugia pahangi than to a detergent-extracted antigenic preparation. In contrast, serum antibody levels against the detergent extract were significantly higher. These differences were consistently observed in symptomatic, microfilaraemic, and asymptomatic/ amicrofilaraemic groups of patients. These patterns of immunoreactivity may reflect intrinsic differences between the 2 antigenic preparations in terms of composition or their mode of presentation to the host immune system.
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DOI: 10.1016/0035-9203(90)90339-G
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Lammie</name><affiliation><mods:affiliation>International Collaboration in Infectious Disease Research, Tulane University, New Orleans, LA 70112, USA</mods:affiliation></affiliation></author><author><name sortKey="Eberhard, Mark L" sort="Eberhard, Mark L" uniqKey="Eberhard M" first="Mark L." last="Eberhard">Mark L. Eberhard</name><affiliation><mods:affiliation>International Collaboration in Infectious Disease Research, Tulane University, New Orleans, LA 70112, USA</mods:affiliation></affiliation></author><author><name sortKey="Lowrie Jr, Robert C" sort="Lowrie Jr, Robert C" uniqKey="Lowrie Jr R" first="Robert C." last="Lowrie Jr">Robert C. 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Cellular reactivity, monitored by blastogenesis in vitro, was significantly greater to a soluble extract of Brugia pahangi than to a detergent-extracted antigenic preparation. In contrast, serum antibody levels against the detergent extract were significantly higher. These differences were consistently observed in symptomatic, microfilaraemic, and asymptomatic/ amicrofilaraemic groups of patients. 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Cellular reactivity, monitored by blastogenesis in vitro, was significantly greater to a soluble extract of Brugia pahangi than to a detergent-extracted antigenic preparation. In contrast, serum antibody levels against the detergent extract were significantly higher. These differences were consistently observed in symptomatic, microfilaraemic, and asymptomatic/ amicrofilaraemic groups of patients. 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Disease Research, Tulane University, New Orleans, LA 70112, USA</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Robert C.</forename><surname>Lowrie, Jr</surname></persName><affiliation>International Collaboration in Infectious Disease Research, Tulane University, New Orleans, LA 70112, USA</affiliation></author><idno type="istex">3B2E3AE4E192DB261A6B0F5D6597F5642401B9DD</idno><idno type="DOI">10.1016/0035-9203(90)90339-G</idno><idno type="PII">0035-9203(90)90339-G</idno></analytic><monogr><title level="j">Transactions of the Royal Society of Tropical Medicine and Hygiene</title><title level="j" type="abbrev">TRSTMH</title><idno type="pISSN">0035-9203</idno><idno type="PII">S0035-9203(00)X0173-3</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1990"></date><biblScope unit="volume">84</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="407">407</biblScope><biblScope unit="page" 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Cellular reactivity, monitored by blastogenesis in vitro, was significantly greater to a soluble extract of Brugia pahangi than to a detergent-extracted antigenic preparation. In contrast, serum antibody levels against the detergent extract were significantly higher. These differences were consistently observed in symptomatic, microfilaraemic, and asymptomatic/ amicrofilaraemic groups of patients. These patterns of immunoreactivity may reflect intrinsic differences between the 2 antigenic preparations in terms of composition or their mode of presentation to the host immune system.</p></abstract></profileDesc><revisionDesc><change when="1989-09-29">Modified</change><change when="1990">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/3B2E3AE4E192DB261A6B0F5D6597F5642401B9DD/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>TRSTMH</jid><aid>9090339G</aid><ce:pii>0035-9203(90)90339-G</ce:pii><ce:doi>10.1016/0035-9203(90)90339-G</ce:doi><ce:copyright type="unknown" year="1990"></ce:copyright></item-info><head><ce:title>Differential humoral and cellular immunoreactivity to saline-and detergent-extracted filarial antigens</ce:title><ce:author-group><ce:author><ce:given-name>Patrick J.</ce:given-name><ce:surname>Lammie</ce:surname><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>2</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Mark L.</ce:given-name><ce:surname>Eberhard</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF3"><ce:sup>3</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Robert C.</ce:given-name><ce:surname>Lowrie</ce:surname><ce:suffix>Jr</ce:suffix><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF4"><ce:sup>4</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>International Collaboration in Infectious Disease Research, Tulane University, New Orleans, LA 70112, USA</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Department of Microbiology, Immunology and Parasitology, LSU Medical Center, New Orleans, LA 70112, USA</ce:textfn></ce:affiliation><ce:affiliation id="AFF3"><ce:label>c</ce:label><ce:textfn>Parasitic Diseases Branch, Centers for Disease Control, Atlanta, GA 30333, USA</ce:textfn></ce:affiliation><ce:affiliation id="AFF4"><ce:label>d</ce:label><ce:textfn>Delta Regional Primate Research Center, Tulane University, Covington, LA 70433, USA</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Address correspondence to Dr Lammie at Parasitic Diseases Branch, Centers for Disease Control, 1600 Clifton Road, Atlanta, GA 30333, USA.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="19" month="6" year="1989"></ce:date-received><ce:date-revised day="29" month="9" year="1989"></ce:date-revised><ce:date-accepted day="3" month="10" year="1989"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>The immunoreactivity to saline- and detergent-extracted filarial antigens of 31 Haitian subjects exposed to or infected with <ce:italic>Wuchereria bancrofti</ce:italic> was analysed. Cellular reactivity, monitored by blastogenesis <ce:italic>in vitro</ce:italic>, was significantly greater to a soluble extract of <ce:italic>Brugia pahangi</ce:italic> than to a detergent-extracted antigenic preparation. In contrast, serum antibody levels against the detergent extract were significantly higher. These differences were consistently observed in symptomatic, microfilaraemic, and asymptomatic/ amicrofilaraemic groups of patients. These patterns of immunoreactivity may reflect intrinsic differences between the 2 antigenic preparations in terms of composition or their mode of presentation to the host immune system.</ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Differential humoral and cellular immunoreactivity to saline-and detergent-extracted filarial antigens</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Differential humoral and cellular immunoreactivity to saline-and detergent-extracted filarial antigens</title></titleInfo><name type="personal"><namePart type="given">Patrick J.</namePart><namePart type="family">Lammie</namePart><affiliation>International Collaboration in Infectious Disease Research, Tulane University, New Orleans, LA 70112, USA</affiliation><description>Address correspondence to Dr Lammie at Parasitic Diseases Branch, Centers for Disease Control, 1600 Clifton Road, Atlanta, GA 30333, USA.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mark L.</namePart><namePart type="family">Eberhard</namePart><affiliation>International Collaboration in Infectious Disease Research, Tulane University, New Orleans, LA 70112, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Robert C.</namePart><namePart type="family">Lowrie, Jr</namePart><affiliation>International Collaboration in Infectious Disease Research, Tulane University, New Orleans, LA 70112, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1990</dateIssued><dateModified encoding="w3cdtf">1989-09-29</dateModified><copyrightDate encoding="w3cdtf">1990</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">The immunoreactivity to saline- and detergent-extracted filarial antigens of 31 Haitian subjects exposed to or infected with Wuchereria bancrofti was analysed. Cellular reactivity, monitored by blastogenesis in vitro, was significantly greater to a soluble extract of Brugia pahangi than to a detergent-extracted antigenic preparation. In contrast, serum antibody levels against the detergent extract were significantly higher. These differences were consistently observed in symptomatic, microfilaraemic, and asymptomatic/ amicrofilaraemic groups of patients. 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