Nephrogenic Fibrosing Dermopathy: A Review of the Massachusetts General Hospital Experience
Identifieur interne : 001719 ( Istex/Corpus ); précédent : 001718; suivant : 001720Nephrogenic Fibrosing Dermopathy: A Review of the Massachusetts General Hospital Experience
Auteurs : D. Goddard ; P. Lio ; J. Kay ; V. LiuSource :
- Journal of Cutaneous Pathology [ 0303-6987 ] ; 2005-01.
Abstract
We have undertaken a review of the Massachusetts General Hospital experience of nephrogenic fibrosing dermopathy (NFD). Twelve cases were identified, and the dermatopathologic features of lesional skin biopsies were examined. We looked systematically at nine parameters and graded each on a scale of 0 (minimal or none) to 3 (highest or most): 1) extent of fibrocytic proliferation, 2) extent of collagen thickening, 3) extent of vascularity, 4) extent of pannicular involvement, 5) extent of elastolysis, 6) presence of mucin, 7) presence of calcification, 8) presence of giant cells, and 9) presence of inflammation. Results demonstrate that fibrocytic proliferation, collagen thickening, inflammation, and vascularity most commonly were classified as grade 1–2; mucin deposition and elastolysis varied from 0–2; pannicular involvement ranged from 1–3; nearly all had calcification grade of 0, and there were no giant cells detected in any of the twelve cases. Comparing our results to published reports suggests that there are some interesting observations. Our cases tended to be less fibrocellular, have less mucin, and have more vascularity than the initial 14 cases described by Cowper et al (2001). The implications of the dermatopathologic findings for clinical course and prognosis are currently being evaluated.
Url:
DOI: 10.1111/j.0303-6987.2005.320ce.x
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Kay</name><affiliation><mods:affiliation>Departments of Dermatopathology, Dermatology and Rheumatology, Massachusetts General Hospital, Boston, MA, USA</mods:affiliation></affiliation></author><author><name sortKey="Liu, V" sort="Liu, V" uniqKey="Liu V" first="V." last="Liu">V. Liu</name><affiliation><mods:affiliation>Departments of Dermatopathology, Dermatology and Rheumatology, Massachusetts General Hospital, Boston, MA, USA</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:325C3171D0F17C3DB943B9502BF73815D1E2ABEA</idno><date when="2005" year="2005">2005</date><idno type="doi">10.1111/j.0303-6987.2005.320ce.x</idno><idno type="url">https://api.istex.fr/document/325C3171D0F17C3DB943B9502BF73815D1E2ABEA/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001719</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001719</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Nephrogenic Fibrosing Dermopathy: A Review of the Massachusetts General Hospital Experience</title><author><name sortKey="Goddard, D" sort="Goddard, D" uniqKey="Goddard D" first="D." last="Goddard">D. Goddard</name><affiliation><mods:affiliation>Departments of Dermatopathology, Dermatology and Rheumatology, Massachusetts General Hospital, Boston, MA, USA</mods:affiliation></affiliation></author><author><name sortKey="Lio, P" sort="Lio, P" uniqKey="Lio P" first="P." last="Lio">P. Lio</name><affiliation><mods:affiliation>Departments of Dermatopathology, Dermatology and Rheumatology, Massachusetts General Hospital, Boston, MA, USA</mods:affiliation></affiliation></author><author><name sortKey="Kay, J" sort="Kay, J" uniqKey="Kay J" first="J." last="Kay">J. Kay</name><affiliation><mods:affiliation>Departments of Dermatopathology, Dermatology and Rheumatology, Massachusetts General Hospital, Boston, MA, USA</mods:affiliation></affiliation></author><author><name sortKey="Liu, V" sort="Liu, V" uniqKey="Liu V" first="V." last="Liu">V. Liu</name><affiliation><mods:affiliation>Departments of Dermatopathology, Dermatology and Rheumatology, Massachusetts General Hospital, Boston, MA, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Cutaneous Pathology</title><title level="j" type="alt">JOURNAL OF CUTANEOUS PATHOLOGY</title><idno type="ISSN">0303-6987</idno><idno type="eISSN">1600-0560</idno><imprint><biblScope unit="vol">32</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="89">89</biblScope><biblScope unit="page" to="89">89</biblScope><biblScope unit="page-count">1</biblScope><publisher>Blackwell Publishing Ltd/Inc.</publisher><pubPlace>Oxford, UK; Malden, USA</pubPlace><date type="published" when="2005-01">2005-01</date></imprint><idno type="ISSN">0303-6987</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0303-6987</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have undertaken a review of the Massachusetts General Hospital experience of nephrogenic fibrosing dermopathy (NFD). Twelve cases were identified, and the dermatopathologic features of lesional skin biopsies were examined. We looked systematically at nine parameters and graded each on a scale of 0 (minimal or none) to 3 (highest or most): 1) extent of fibrocytic proliferation, 2) extent of collagen thickening, 3) extent of vascularity, 4) extent of pannicular involvement, 5) extent of elastolysis, 6) presence of mucin, 7) presence of calcification, 8) presence of giant cells, and 9) presence of inflammation. Results demonstrate that fibrocytic proliferation, collagen thickening, inflammation, and vascularity most commonly were classified as grade 1–2; mucin deposition and elastolysis varied from 0–2; pannicular involvement ranged from 1–3; nearly all had calcification grade of 0, and there were no giant cells detected in any of the twelve cases. Comparing our results to published reports suggests that there are some interesting observations. Our cases tended to be less fibrocellular, have less mucin, and have more vascularity than the initial 14 cases described by Cowper et al (2001). The implications of the dermatopathologic findings for clinical course and prognosis are currently being 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department</json:string><json:string>internal medicine2</json:string><json:string>fibrosing vasculitis</json:string><json:string>prognosis</json:string><json:string>clinic</json:string><json:string>diffuse</json:string><json:string>scalp</json:string><json:string>interface</json:string><json:string>cellular</json:string><json:string>edema</json:string><json:string>infection</json:string><json:string>deposition</json:string><json:string>recurrent</json:string><json:string>skin</json:string></teeft></keywords><author><json:item><name>D. Goddard</name><affiliations><json:string>Departments of Dermatopathology, Dermatology and Rheumatology, Massachusetts General Hospital, Boston, MA, USA</json:string></affiliations></json:item><json:item><name>P. Lio</name><affiliations><json:string>Departments of Dermatopathology, Dermatology and Rheumatology, Massachusetts General Hospital, Boston, MA, USA</json:string></affiliations></json:item><json:item><name>J. Kay</name><affiliations><json:string>Departments of Dermatopathology, Dermatology and Rheumatology, Massachusetts General Hospital, Boston, MA, USA</json:string></affiliations></json:item><json:item><name>V. Liu</name><affiliations><json:string>Departments of Dermatopathology, Dermatology and Rheumatology, Massachusetts General Hospital, Boston, MA, USA</json:string></affiliations></json:item></author><articleId><json:string>CUP320CE</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>abstract</json:string></originalGenre><abstract>We have undertaken a review of the Massachusetts General Hospital experience of nephrogenic fibrosing dermopathy (NFD). Twelve cases were identified, and the dermatopathologic features of lesional skin biopsies were examined. We looked systematically at nine parameters and graded each on a scale of 0 (minimal or none) to 3 (highest or most): 1) extent of fibrocytic proliferation, 2) extent of collagen thickening, 3) extent of vascularity, 4) extent of pannicular involvement, 5) extent of elastolysis, 6) presence of mucin, 7) presence of calcification, 8) presence of giant cells, and 9) presence of inflammation. Results demonstrate that fibrocytic proliferation, collagen thickening, inflammation, and vascularity most commonly were classified as grade 1–2; mucin deposition and elastolysis varied from 0–2; pannicular involvement ranged from 1–3; nearly all had calcification grade of 0, and there were no giant cells detected in any of the twelve cases. Comparing our results to published reports suggests that there are some interesting observations. Our cases tended to be less fibrocellular, have less mucin, and have more vascularity than the initial 14 cases described by Cowper et al (2001). The implications of the dermatopathologic findings for clinical course and prognosis are currently being evaluated.</abstract><qualityIndicators><score>7.328</score><pdfVersion>1.3</pdfVersion><pdfPageSize>595 x 782 pts</pdfPageSize><refBibsNative>false</refBibsNative><abstractCharCount>1322</abstractCharCount><pdfWordCount>46669</pdfWordCount><pdfCharCount>312307</pdfCharCount><pdfPageCount>53</pdfPageCount><abstractWordCount>194</abstractWordCount></qualityIndicators><title>Nephrogenic Fibrosing Dermopathy: A Review of the Massachusetts General Hospital Experience</title><genre><json:string>abstract</json:string></genre><host><title>Journal of Cutaneous Pathology</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1600-0560</json:string></doi><issn><json:string>0303-6987</json:string></issn><eissn><json:string>1600-0560</json:string></eissn><publisherId><json:string>CUP</json:string></publisherId><volume>32</volume><issue>1</issue><pages><first>89</first><last>89</last><total>1</total></pages><genre><json:string>journal</json:string></genre></host><categories><wos><json:string>science</json:string><json:string>pathology</json:string><json:string>dermatology</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>dermatology & venereal diseases</json:string></scienceMetrix><inist><json:string>sciences appliquees, technologies et medecines</json:string><json:string>sciences biologiques et medicales</json:string><json:string>sciences medicales</json:string><json:string>dermatologie</json:string></inist></categories><publicationDate>2005</publicationDate><copyrightDate>2005</copyrightDate><doi><json:string>10.1111/j.0303-6987.2005.320ce.x</json:string></doi><id>325C3171D0F17C3DB943B9502BF73815D1E2ABEA</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/325C3171D0F17C3DB943B9502BF73815D1E2ABEA/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/325C3171D0F17C3DB943B9502BF73815D1E2ABEA/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/325C3171D0F17C3DB943B9502BF73815D1E2ABEA/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Nephrogenic Fibrosing Dermopathy: A Review of the Massachusetts General Hospital Experience</title></titleStmt><publicationStmt><publisher>Blackwell Publishing Ltd/Inc.</publisher><pubPlace>Oxford, UK; 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Twelve cases were identified, and the dermatopathologic features of lesional skin biopsies were examined. We looked systematically at nine parameters and graded each on a scale of 0 (minimal or none) to 3 (highest or most): 1) extent of fibrocytic proliferation, 2) extent of collagen thickening, 3) extent of vascularity, 4) extent of pannicular involvement, 5) extent of elastolysis, 6) presence of mucin, 7) presence of calcification, 8) presence of giant cells, and 9) presence of inflammation. Results demonstrate that fibrocytic proliferation, collagen thickening, inflammation, and vascularity most commonly were classified as grade 1–2; mucin deposition and elastolysis varied from 0–2; pannicular involvement ranged from 1–3; nearly all had calcification grade of 0, and there were no giant cells detected in any of the twelve cases. Comparing our results to published reports suggests that there are some interesting observations. 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The implications of the dermatopathologic findings for clinical course and prognosis are currently being evaluated.</abstract><relatedItem type="host"><titleInfo><title>Journal of Cutaneous Pathology</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0303-6987</identifier><identifier type="eISSN">1600-0560</identifier><identifier type="DOI">10.1111/(ISSN)1600-0560</identifier><identifier type="PublisherID">CUP</identifier><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>89</start><end>89</end><total>1</total></extent></part></relatedItem><identifier type="istex">325C3171D0F17C3DB943B9502BF73815D1E2ABEA</identifier><identifier type="DOI">10.1111/j.0303-6987.2005.320ce.x</identifier><identifier type="ArticleID">CUP320CE</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd/Inc.</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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