Anti-filarial activity of novel formulations of albendazole against experimental brugian filariasis
Identifieur interne : 001508 ( Istex/Corpus ); précédent : 001507; suivant : 001509Anti-filarial activity of novel formulations of albendazole against experimental brugian filariasis
Auteurs : R. L. Gaur ; S. Dixit ; M. K. Sahoo ; M. Khanna ; S. Singh ; P. K. MurthySource :
- Parasitology [ 0031-1820 ] ; 2007-04.
Abstract
The study was aimed at developing better orally active albendazole (ALB) formulations. Six formulations (ALB-1 to ALB-6) were prepared and tested against Brugia malayi in Mastomys coucha and jird (Meriones unguiculatus) at 200 mg/kg, orally, for 5 consecutive days. The anti-filarial efficacy was assessed against microfilariae (mf), adult worms and female reproductive potential. Three of the 6 ALB formulations showed greatly improved female worm sterilizing potential (ALB-1: 90%; ALB-3: 63%; ALB-4: 77% of untreated control) in B. malayi – M. coucha model. Sterilization efficacy of ALB-1 was also better than that shown by pure-ALB (P<0·001) or its marketed tablet formulation, Zentel (P<0·01), while that of ALB-4 was better than pure-ALB (P<0·05). The activity of ALB-3, pure-ALB and Zentel was, however, comparable. ALB-1 also showed late microfilaricidal activity with a maximum of 78% fall in microfilarial count. In contrast, neither the pure ALB nor Zentel showed any microfilaricidal activity. In the jird – B. malayi model, ALB-1 and ALB-4 showed marginal sterilizing efficacy whereas pure ALB or Zentel were ineffective. In conclusion the anti-filarial efficacy of ALB-1 was found to be superior to pure-ALB or Zentel.
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DOI: 10.1017/S0031182006001612
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Sahoo</name><affiliation><mods:affiliation>Division of Parasitology, Central Drug Research Institute, Lucknow, 226001, India</mods:affiliation></affiliation></author><author><name sortKey="Khanna, M" sort="Khanna, M" uniqKey="Khanna M" first="M." last="Khanna">M. Khanna</name><affiliation><mods:affiliation>Division of Pharmaceutics, Central Drug Research Institute, Lucknow, 226001, India</mods:affiliation></affiliation></author><author><name sortKey="Singh, S" sort="Singh, S" uniqKey="Singh S" first="S." last="Singh">S. Singh</name><affiliation><mods:affiliation>Division of Pharmaceutics, Central Drug Research Institute, Lucknow, 226001, India</mods:affiliation></affiliation></author><author><name sortKey="Murthy, P K" sort="Murthy, P K" uniqKey="Murthy P" first="P. K." last="Murthy">P. K. 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Gaur</name><affiliation><mods:affiliation>Division of Parasitology, Central Drug Research Institute, Lucknow, 226001, India</mods:affiliation></affiliation></author><author><name sortKey="Dixit, S" sort="Dixit, S" uniqKey="Dixit S" first="S." last="Dixit">S. Dixit</name><affiliation><mods:affiliation>Division of Parasitology, Central Drug Research Institute, Lucknow, 226001, India</mods:affiliation></affiliation></author><author><name sortKey="Sahoo, M K" sort="Sahoo, M K" uniqKey="Sahoo M" first="M. K." last="Sahoo">M. K. Sahoo</name><affiliation><mods:affiliation>Division of Parasitology, Central Drug Research Institute, Lucknow, 226001, India</mods:affiliation></affiliation></author><author><name sortKey="Khanna, M" sort="Khanna, M" uniqKey="Khanna M" first="M." last="Khanna">M. Khanna</name><affiliation><mods:affiliation>Division of Pharmaceutics, Central Drug Research Institute, Lucknow, 226001, India</mods:affiliation></affiliation></author><author><name sortKey="Singh, S" sort="Singh, S" uniqKey="Singh S" first="S." last="Singh">S. Singh</name><affiliation><mods:affiliation>Division of Pharmaceutics, Central Drug Research Institute, Lucknow, 226001, India</mods:affiliation></affiliation></author><author><name sortKey="Murthy, P K" sort="Murthy, P K" uniqKey="Murthy P" first="P. K." last="Murthy">P. K. Murthy</name><affiliation><mods:affiliation>Division of Parasitology, Central Drug Research Institute, Lucknow, 226001, India</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Parasitology</title><idno type="ISSN">0031-1820</idno><idno type="eISSN">1469-8161</idno><imprint><publisher>Cambridge University Press</publisher><pubPlace>Cambridge, UK</pubPlace><date type="published" when="2007-04">2007-04</date><biblScope unit="volume">134</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="537">537</biblScope><biblScope unit="page" to="544">544</biblScope></imprint><idno type="ISSN">0031-1820</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0031-1820</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">The study was aimed at developing better orally active albendazole (ALB) formulations. Six formulations (ALB-1 to ALB-6) were prepared and tested against Brugia malayi in Mastomys coucha and jird (Meriones unguiculatus) at 200 mg/kg, orally, for 5 consecutive days. The anti-filarial efficacy was assessed against microfilariae (mf), adult worms and female reproductive potential. Three of the 6 ALB formulations showed greatly improved female worm sterilizing potential (ALB-1: 90%; ALB-3: 63%; ALB-4: 77% of untreated control) in B. malayi – M. coucha model. Sterilization efficacy of ALB-1 was also better than that shown by pure-ALB (P<0·001) or its marketed tablet formulation, Zentel (P<0·01), while that of ALB-4 was better than pure-ALB (P<0·05). The activity of ALB-3, pure-ALB and Zentel was, however, comparable. ALB-1 also showed late microfilaricidal activity with a maximum of 78% fall in microfilarial count. In contrast, neither the pure ALB nor Zentel showed any microfilaricidal activity. In the jird – B. malayi model, ALB-1 and ALB-4 showed marginal sterilizing efficacy whereas pure ALB or Zentel were ineffective. In conclusion the anti-filarial efficacy of ALB-1 was found to be superior to pure-ALB or Zentel.</div></front></TEI><istex><corpusName>cambridge</corpusName><author><json:item><name>R. L. GAUR</name><affiliations><json:string>Division of Parasitology, Central Drug Research Institute, Lucknow, 226001, India</json:string></affiliations></json:item><json:item><name>S. DIXIT</name><affiliations><json:string>Division of Parasitology, Central Drug Research Institute, Lucknow, 226001, India</json:string></affiliations></json:item><json:item><name>M. K. SAHOO</name><affiliations><json:string>Division of Parasitology, Central Drug Research Institute, Lucknow, 226001, India</json:string></affiliations></json:item><json:item><name>M. KHANNA</name><affiliations><json:string>Division of Pharmaceutics, Central Drug Research Institute, Lucknow, 226001, India</json:string></affiliations></json:item><json:item><name>S. SINGH</name><affiliations><json:string>Division of Pharmaceutics, Central Drug Research Institute, Lucknow, 226001, India</json:string></affiliations></json:item><json:item><name>P. K. MURTHY</name><affiliations><json:string>Division of Parasitology, Central Drug Research Institute, Lucknow, 226001, India</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>albendazole</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>formulation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>filariasis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Brugia malayi</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Meriones unguiculatus</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Mastomys coucha</value></json:item></subject><arkIstex>ark:/67375/6GQ-SZB488XB-Q</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>research-article</json:string></originalGenre><abstract>The study was aimed at developing better orally active albendazole (ALB) formulations. Six formulations (ALB-1 to ALB-6) were prepared and tested against Brugia malayi in Mastomys coucha and jird (Meriones unguiculatus) at 200 mg/kg, orally, for 5 consecutive days. The anti-filarial efficacy was assessed against microfilariae (mf), adult worms and female reproductive potential. Three of the 6 ALB formulations showed greatly improved female worm sterilizing potential (ALB-1: 90%; ALB-3: 63%; ALB-4: 77% of untreated control) in B. malayi – M. coucha model. Sterilization efficacy of ALB-1 was also better than that shown by pure-ALB (P>0·001) or its marketed tablet formulation, Zentel (P>0·01), while that of ALB-4 was better than pure-ALB (P>0·05). The activity of ALB-3, pure-ALB and Zentel was, however, comparable. ALB-1 also showed late microfilaricidal activity with a maximum of 78% fall in microfilarial count. In contrast, neither the pure ALB nor Zentel showed any microfilaricidal activity. In the jird – B. malayi model, ALB-1 and ALB-4 showed marginal sterilizing efficacy whereas pure ALB or Zentel were ineffective. 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L.</forename><surname>GAUR</surname></persName><affiliation>Division of Parasitology, Central Drug Research Institute, Lucknow, 226001, India</affiliation></author><author xml:id="author-0001"><persName><forename type="first">S.</forename><surname>DIXIT</surname></persName><affiliation>Division of Parasitology, Central Drug Research Institute, Lucknow, 226001, India</affiliation></author><author xml:id="author-0002"><persName><forename type="first">M. K.</forename><surname>SAHOO</surname></persName><affiliation>Division of Parasitology, Central Drug Research Institute, Lucknow, 226001, India</affiliation></author><author xml:id="author-0003"><persName><forename type="first">M.</forename><surname>KHANNA</surname></persName><affiliation>Division of Pharmaceutics, Central Drug Research Institute, Lucknow, 226001, India</affiliation></author><author xml:id="author-0004"><persName><forename type="first">S.</forename><surname>SINGH</surname></persName><affiliation>Division of Pharmaceutics, Central Drug Research Institute, Lucknow, 226001, India</affiliation></author><author xml:id="author-0005"><persName><forename type="first">P. K.</forename><surname>MURTHY</surname></persName><affiliation>Division of Parasitology, Central Drug Research Institute, Lucknow, 226001, India</affiliation></author><idno type="istex">2DAAB185C3A67EBDE8249801F078556D38F461D9</idno><idno type="ark">ark:/67375/6GQ-SZB488XB-Q</idno><idno type="DOI">10.1017/S0031182006001612</idno><idno type="PII">S0031182006001612</idno><idno type="PMID">17078904</idno></analytic><monogr><title level="j">Parasitology</title><idno type="pISSN">0031-1820</idno><idno type="eISSN">1469-8161</idno><idno type="publisher-id">PAR</idno><imprint><publisher>Cambridge University Press</publisher><pubPlace>Cambridge, UK</pubPlace><date type="published" when="2007-04"></date><biblScope unit="volume">134</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="537">537</biblScope><biblScope unit="page" to="544">544</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2006-11-02</date></creation><langUsage><language ident="en">en</language></langUsage><abstract style="normal"><p>The study was aimed at developing better orally active albendazole (ALB) formulations. Six formulations (ALB-1 to ALB-6) were prepared and tested against Brugia malayi in Mastomys coucha and jird (Meriones unguiculatus) at 200 mg/kg, orally, for 5 consecutive days. The anti-filarial efficacy was assessed against microfilariae (mf), adult worms and female reproductive potential. Three of the 6 ALB formulations showed greatly improved female worm sterilizing potential (ALB-1: 90%; ALB-3: 63%; ALB-4: 77% of untreated control) in B. malayi – M. coucha model. Sterilization efficacy of ALB-1 was also better than that shown by pure-ALB (P<0·001) or its marketed tablet formulation, Zentel (P<0·01), while that of ALB-4 was better than pure-ALB (P<0·05). The activity of ALB-3, pure-ALB and Zentel was, however, comparable. ALB-1 also showed late microfilaricidal activity with a maximum of 78% fall in microfilarial count. In contrast, neither the pure ALB nor Zentel showed any microfilaricidal activity. In the jird – B. malayi model, ALB-1 and ALB-4 showed marginal sterilizing efficacy whereas pure ALB or Zentel were ineffective. In conclusion the anti-filarial efficacy of ALB-1 was found to be superior to pure-ALB or Zentel.</p></abstract><textClass><keywords scheme="keyword"><list><head>keywords</head><item><term>albendazole</term></item><item><term>formulation</term></item><item><term>filariasis</term></item><item><term>Brugia malayi</term></item><item><term>Meriones unguiculatus</term></item><item><term>Mastomys coucha</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2006-11-02">Created</change><change when="2007-04">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2017-09-5">References added</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="corpus cambridge not found" wicri:toSee="no header"><istex:xmlDeclaration>version='1.0' encoding='UTF-8'</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.0 20120330//EN" URI="JATS-journalpublishing1.dtd" name="istex:docType"></istex:docType><istex:document><article dtd-version="1.0" article-type="research-article"><front><journal-meta><journal-id journal-id-type="publisher-id">PAR</journal-id><journal-title-group><journal-title>Parasitology</journal-title><abbrev-journal-title>Parasitology</abbrev-journal-title></journal-title-group><issn pub-type="epub">1469-8161</issn><issn pub-type="ppub">0031-1820</issn><publisher><publisher-name>Cambridge University Press</publisher-name><publisher-loc>Cambridge, UK</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pii">S0031182006001612</article-id><article-id pub-id-type="pmid">17078904</article-id><article-id pub-id-type="doi">10.1017/S0031182006001612</article-id><title-group><article-title>Anti-filarial activity of novel formulations of albendazole against experimental brugian filariasis</article-title></title-group><contrib-group><contrib><name><surname>GAUR</surname><given-names>R. L.</given-names></name><aff>Division of Parasitology, <institution>Central Drug Research Institute</institution>, Lucknow, 226001, <country>India</country></aff></contrib><contrib><name><surname>DIXIT</surname><given-names>S.</given-names></name><aff>Division of Parasitology, <institution>Central Drug Research Institute</institution>, Lucknow, 226001, <country>India</country></aff></contrib><contrib><name><surname>SAHOO</surname><given-names>M. K.</given-names></name><aff>Division of Parasitology, <institution>Central Drug Research Institute</institution>, Lucknow, 226001, <country>India</country></aff></contrib><contrib><name><surname>KHANNA</surname><given-names>M.</given-names></name><aff>Division of Pharmaceutics, <institution>Central Drug Research Institute</institution>, Lucknow, 226001, <country>India</country></aff></contrib><contrib><name><surname>SINGH</surname><given-names>S.</given-names></name><aff>Division of Pharmaceutics, <institution>Central Drug Research Institute</institution>, Lucknow, 226001, <country>India</country></aff></contrib><contrib><name><surname>MURTHY</surname><given-names>P. K.</given-names></name><aff>Division of Parasitology, <institution>Central Drug Research Institute</institution>, Lucknow, 226001, <country>India</country></aff></contrib></contrib-group><pub-date pub-type="epub"><day>2</day><month>11</month><year>2006</year></pub-date><pub-date pub-type="ppub"><month>4</month><year>2007</year></pub-date><volume>134</volume><issue>4</issue><fpage>537</fpage><lpage>544</lpage><history><date date-type="accepted"><day>3</day><month>10</month><year>2006</year></date><date date-type="received"><day>5</day><month>5</month><year>2006</year></date><date date-type="rev-recd"><day>28</day><month>9</month><year>2006</year></date></history><permissions><copyright-statement>© 2006 Cambridge University Press</copyright-statement></permissions><abstract abstract-type="normal"><p>The study was aimed at developing better orally active albendazole (ALB) formulations. Six formulations (ALB-1 to ALB-6) were prepared and tested against <italic>Brugia malayi</italic> in <italic>Mastomys coucha</italic> and jird (<italic>Meriones unguiculatus</italic>) at 200 mg/kg, orally, for 5 consecutive days. The anti-filarial efficacy was assessed against microfilariae (mf), adult worms and female reproductive potential. Three of the 6 ALB formulations showed greatly improved female worm sterilizing potential (ALB-1: 90%; ALB-3: 63%; ALB-4: 77% of untreated control) in <italic>B. malayi</italic> – <italic>M. coucha</italic> model. Sterilization efficacy of ALB-1 was also better than that shown by pure-ALB (<italic>P</italic><0·001) or its marketed tablet formulation, Zentel (<italic>P</italic><0·01), while that of ALB-4 was better than pure-ALB (<italic>P</italic><0·05). The activity of ALB-3, pure-ALB and Zentel was, however, comparable. ALB-1 also showed late microfilaricidal activity with a maximum of 78% fall in microfilarial count. In contrast, neither the pure ALB nor Zentel showed any microfilaricidal activity. In the jird – <italic>B. malayi</italic> model, ALB-1 and ALB-4 showed marginal sterilizing efficacy whereas pure ALB or Zentel were ineffective. In conclusion the anti-filarial efficacy of ALB-1 was found to be superior to pure-ALB or Zentel.</p></abstract><kwd-group><kwd>albendazole</kwd><kwd>formulation</kwd><kwd>filariasis</kwd><kwd><italic>Brugia malayi</italic></kwd><kwd><italic>Meriones unguiculatus</italic></kwd><kwd><italic>Mastomys coucha</italic></kwd></kwd-group><counts><page-count count="8"></page-count></counts><custom-meta-group><custom-meta><meta-name>pdf</meta-name><meta-value>S0031182006001612a.pdf</meta-value></custom-meta></custom-meta-group></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Anti-filarial activity of novel formulations of albendazole against experimental brugian filariasis</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Anti-filarial activity of novel formulations of albendazole against experimental brugian filariasis</title></titleInfo><name type="personal"><namePart type="given">R. L.</namePart><namePart type="family">GAUR</namePart><affiliation>Division of Parasitology, Central Drug Research Institute, Lucknow, 226001, India</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">DIXIT</namePart><affiliation>Division of Parasitology, Central Drug Research Institute, Lucknow, 226001, India</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. K.</namePart><namePart type="family">SAHOO</namePart><affiliation>Division of Parasitology, Central Drug Research Institute, Lucknow, 226001, India</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">KHANNA</namePart><affiliation>Division of Pharmaceutics, Central Drug Research Institute, Lucknow, 226001, India</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">SINGH</namePart><affiliation>Division of Pharmaceutics, Central Drug Research Institute, Lucknow, 226001, India</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. K.</namePart><namePart type="family">MURTHY</namePart><affiliation>Division of Parasitology, Central Drug Research Institute, Lucknow, 226001, India</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Cambridge University Press</publisher><place><placeTerm type="text">Cambridge, UK</placeTerm></place><dateIssued encoding="w3cdtf">2007-04</dateIssued><dateCreated encoding="w3cdtf">2006-11-02</dateCreated><copyrightDate encoding="w3cdtf">2006</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract type="normal">The study was aimed at developing better orally active albendazole (ALB) formulations. Six formulations (ALB-1 to ALB-6) were prepared and tested against Brugia malayi in Mastomys coucha and jird (Meriones unguiculatus) at 200 mg/kg, orally, for 5 consecutive days. The anti-filarial efficacy was assessed against microfilariae (mf), adult worms and female reproductive potential. Three of the 6 ALB formulations showed greatly improved female worm sterilizing potential (ALB-1: 90%; ALB-3: 63%; ALB-4: 77% of untreated control) in B. malayi – M. coucha model. Sterilization efficacy of ALB-1 was also better than that shown by pure-ALB (P<0·001) or its marketed tablet formulation, Zentel (P<0·01), while that of ALB-4 was better than pure-ALB (P<0·05). The activity of ALB-3, pure-ALB and Zentel was, however, comparable. ALB-1 also showed late microfilaricidal activity with a maximum of 78% fall in microfilarial count. In contrast, neither the pure ALB nor Zentel showed any microfilaricidal activity. In the jird – B. malayi model, ALB-1 and ALB-4 showed marginal sterilizing efficacy whereas pure ALB or Zentel were ineffective. In conclusion the anti-filarial efficacy of ALB-1 was found to be superior to pure-ALB or Zentel.</abstract><subject><genre>keywords</genre><topic>albendazole</topic><topic>formulation</topic><topic>filariasis</topic><topic>Brugia malayi</topic><topic>Meriones unguiculatus</topic><topic>Mastomys coucha</topic></subject><relatedItem type="host"><titleInfo><title>Parasitology</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0031-1820</identifier><identifier type="eISSN">1469-8161</identifier><identifier type="PublisherID">PAR</identifier><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>134</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>537</start><end>544</end><total>8</total></extent></part></relatedItem><identifier type="istex">2DAAB185C3A67EBDE8249801F078556D38F461D9</identifier><identifier type="ark">ark:/67375/6GQ-SZB488XB-Q</identifier><identifier type="DOI">10.1017/S0031182006001612</identifier><identifier type="PII">S0031182006001612</identifier><identifier type="PMID">17078904</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2006 Cambridge University Press</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-G3RCRD03-V">cambridge</recordContentSource><recordOrigin>© 2006 Cambridge University Press</recordOrigin></recordInfo></mods></metadata><annexes><json:item><extension>gif</extension><original>true</original><mimetype>image/gif</mimetype><uri>https://api.istex.fr/document/2DAAB185C3A67EBDE8249801F078556D38F461D9/annexes/gif</uri></json:item></annexes><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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