Mass diethylcarbamazine chemotherapy for control of bancroftian filariasis: comparative efficacy of standard treatment and two semi-annual single-dose treatments
Identifieur interne : 001240 ( Istex/Corpus ); précédent : 001239; suivant : 001241Mass diethylcarbamazine chemotherapy for control of bancroftian filariasis: comparative efficacy of standard treatment and two semi-annual single-dose treatments
Auteurs : D. W. Meyrowitsch ; P. E. Simonsen ; W. H. MakundeSource :
- Transactions of the Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ] ; 1996.
Abstract
The efficacy of 2 strategies for control of bancroftian filariasis using mass diethylcarbamazine (DEC) chemotherapy was evaluated and compared in 2 endemic communities in Tanzania with pre-treatment microfilarial (mf) prevalences of 28·5% and 17·7%, and mf geometric mean intensities (GMI) of 588 mf/mL and 251 mf/mL, respectively. All individuals in the first community were offered DEC treatment with 6 mg/kg body weight given daily for 12 d (standard treatment). The second community was offered DEC treatment with 2 single doses of 6 mg/kg body weight given with an interval of 6 months (semi-annual single-dose treatment). Among those who were microfilaraemic before treatment, the mf clearance rates were 51·2% and 36·0%, and the mf GMIs were reduced by 98·6% and 92·2% one year after the start of the standard and the semi-annual regimens, respectively. At community level, the standard strategy and the semi-annual strategy reduced the mf prevalences to 15·1% and 11·6% (reductions of 47·0% and 34·5%) and the mf GMIs to 112 mf/mL and 102 mf/mL (reductions of 81·0% and 59·4%, respectively) one year after start of treatment. Both regimens resulted in remarkable improvements in small hydroceles among males presenting this condition before treatment. The lower efficacy of the semi-annual single-dose treatment in relation to the standard treatment in reducing microfilaraemias might be compensated for by continuing semi-annual treatments for a slightly longer period of time. Considering that the semi-annual treatment is easy to administer and more acceptable to the treated individuals, it may in the long run be a more feasible strategy for mass DEC chemotherapy than the standard treatment.
Url:
DOI: 10.1016/S0035-9203(96)90484-8
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Simonsen, Danish Bilharziasis Laboratory, Jaegersborg Alle 1D, 2920 Charlottenlund, Denmark.</mods:affiliation></affiliation><affiliation><mods:affiliation>Danish Bilharziasis Laboratory, Jaegersborg Alle 1D, 2920 Charlottenlund, Denmark</mods:affiliation></affiliation></author><author><name sortKey="Makunde, W H" sort="Makunde, W H" uniqKey="Makunde W" first="W. H." last="Makunde">W. H. Makunde</name><affiliation><mods:affiliation>Amani Medical Research Centre, P. O. 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Meyrowitsch</name><affiliation><mods:affiliation>Danish Bilharziasis Laboratory, Jaegersborg Alle 1D, 2920 Charlottenlund, Denmark</mods:affiliation></affiliation></author><author><name sortKey="Simonsen, P E" sort="Simonsen, P E" uniqKey="Simonsen P" first="P. E." last="Simonsen">P. E. Simonsen</name><affiliation><mods:affiliation>Address for correspondence: Dr Paul E. Simonsen, Danish Bilharziasis Laboratory, Jaegersborg Alle 1D, 2920 Charlottenlund, Denmark.</mods:affiliation></affiliation><affiliation><mods:affiliation>Danish Bilharziasis Laboratory, Jaegersborg Alle 1D, 2920 Charlottenlund, Denmark</mods:affiliation></affiliation></author><author><name sortKey="Makunde, W H" sort="Makunde, W H" uniqKey="Makunde W" first="W. H." last="Makunde">W. H. Makunde</name><affiliation><mods:affiliation>Amani Medical Research Centre, P. O. Box 4, Amani, Tanzania</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Transactions of the Royal Society of Tropical Medicine and Hygiene</title><title level="j" type="abbrev">TRSTMH</title><idno type="ISSN">0035-9203</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1996">1996</date><biblScope unit="volume">90</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="69">69</biblScope><biblScope unit="page" to="73">73</biblScope></imprint><idno type="ISSN">0035-9203</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0035-9203</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The efficacy of 2 strategies for control of bancroftian filariasis using mass diethylcarbamazine (DEC) chemotherapy was evaluated and compared in 2 endemic communities in Tanzania with pre-treatment microfilarial (mf) prevalences of 28·5% and 17·7%, and mf geometric mean intensities (GMI) of 588 mf/mL and 251 mf/mL, respectively. All individuals in the first community were offered DEC treatment with 6 mg/kg body weight given daily for 12 d (standard treatment). The second community was offered DEC treatment with 2 single doses of 6 mg/kg body weight given with an interval of 6 months (semi-annual single-dose treatment). Among those who were microfilaraemic before treatment, the mf clearance rates were 51·2% and 36·0%, and the mf GMIs were reduced by 98·6% and 92·2% one year after the start of the standard and the semi-annual regimens, respectively. At community level, the standard strategy and the semi-annual strategy reduced the mf prevalences to 15·1% and 11·6% (reductions of 47·0% and 34·5%) and the mf GMIs to 112 mf/mL and 102 mf/mL (reductions of 81·0% and 59·4%, respectively) one year after start of treatment. Both regimens resulted in remarkable improvements in small hydroceles among males presenting this condition before treatment. The lower efficacy of the semi-annual single-dose treatment in relation to the standard treatment in reducing microfilaraemias might be compensated for by continuing semi-annual treatments for a slightly longer period of time. Considering that the semi-annual treatment is easy to administer and more acceptable to the treated individuals, it may in the long run be a more feasible strategy for mass DEC chemotherapy than the standard treatment.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>filariasis</json:string><json:string>kwale</json:string><json:string>tawalani</json:string><json:string>microfilaraemic</json:string><json:string>microfilaraemia</json:string><json:string>bancroftian</json:string><json:string>hydrocele</json:string><json:string>chemotherapy</json:string><json:string>bancroftian filariasis</json:string><json:string>diethylcarbamazine</json:string><json:string>regimen</json:string><json:string>tanzania</json:string><json:string>tropical medicine</json:string><json:string>elephantiasis</json:string><json:string>standard treatment</json:string><json:string>amicrofilaraemic</json:string><json:string>present study</json:string><json:string>endemic</json:string><json:string>gmis</json:string><json:string>parasitological</json:string><json:string>microfilarial</json:string><json:string>simonsen</json:string><json:string>community level</json:string><json:string>clinical manifestations</json:string><json:string>microfilaraemic individuals</json:string><json:string>body weight</json:string><json:string>treatment regimens</json:string><json:string>american journal</json:string><json:string>mass treatment</json:string><json:string>parasitological survey</json:string><json:string>survey team</json:string><json:string>endemic communities</json:string><json:string>second dose</json:string><json:string>selective treatment</json:string><json:string>standard regimen</json:string><json:string>small hydroceles</json:string><json:string>study groups</json:string><json:string>standard dose treatment</json:string><json:string>clearance rate</json:string><json:string>clearance rates</json:string><json:string>research centre</json:string></teeft></keywords><author><json:item><name>D.W. Meyrowitsch</name><affiliations><json:string>Danish Bilharziasis Laboratory, Jaegersborg Alle 1D, 2920 Charlottenlund, Denmark</json:string></affiliations></json:item><json:item><name>P.E. Simonsen</name><affiliations><json:string>Address for correspondence: Dr Paul E. Simonsen, Danish Bilharziasis Laboratory, Jaegersborg Alle 1D, 2920 Charlottenlund, Denmark.</json:string><json:string>Danish Bilharziasis Laboratory, Jaegersborg Alle 1D, 2920 Charlottenlund, Denmark</json:string></affiliations></json:item><json:item><name>W.H. Makunde</name><affiliations><json:string>Amani Medical Research Centre, P. O. 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All individuals in the first community were offered DEC treatment with 6 mg/kg body weight given daily for 12 d (standard treatment). The second community was offered DEC treatment with 2 single doses of 6 mg/kg body weight given with an interval of 6 months (semi-annual single-dose treatment). Among those who were microfilaraemic before treatment, the mf clearance rates were 51·2% and 36·0%, and the mf GMIs were reduced by 98·6% and 92·2% one year after the start of the standard and the semi-annual regimens, respectively. At community level, the standard strategy and the semi-annual strategy reduced the mf prevalences to 15·1% and 11·6% (reductions of 47·0% and 34·5%) and the mf GMIs to 112 mf/mL and 102 mf/mL (reductions of 81·0% and 59·4%, respectively) one year after start of treatment. Both regimens resulted in remarkable improvements in small hydroceles among males presenting this condition before treatment. The lower efficacy of the semi-annual single-dose treatment in relation to the standard treatment in reducing microfilaraemias might be compensated for by continuing semi-annual treatments for a slightly longer period of time. Considering that the semi-annual treatment is easy to administer and more acceptable to the treated individuals, it may in the long run be a more feasible strategy for mass DEC chemotherapy than the standard treatment.</abstract><qualityIndicators><score>7.17</score><pdfVersion>1.3</pdfVersion><pdfPageSize>576 x 828 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>6</keywordCount><abstractCharCount>1705</abstractCharCount><pdfWordCount>4170</pdfWordCount><pdfCharCount>27359</pdfCharCount><pdfPageCount>5</pdfPageCount><abstractWordCount>261</abstractWordCount></qualityIndicators><title>Mass diethylcarbamazine chemotherapy for control of bancroftian filariasis: comparative efficacy of standard treatment and two semi-annual single-dose treatments</title><pii><json:string>S0035-9203(96)90484-8</json:string></pii><genre><json:string>research-article</json:string></genre><serie><title>Technical Report Series, no. 821</title><language><json:string>unknown</json:string></language></serie><host><title>Transactions of the Royal Society of Tropical Medicine and Hygiene</title><language><json:string>unknown</json:string></language><publicationDate>1996</publicationDate><issn><json:string>0035-9203</json:string></issn><pii><json:string>S0035-9203(00)X0175-7</json:string></pii><volume>90</volume><issue>1</issue><pages><first>69</first><last>73</last></pages><genre><json:string>journal</json:string></genre></host><categories><wos><json:string>social science</json:string><json:string>public, environmental & occupational health</json:string><json:string>science</json:string><json:string>tropical medicine</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>tropical medicine</json:string></scienceMetrix><inist><json:string>sciences appliquees, technologies et medecines</json:string><json:string>sciences biologiques et medicales</json:string><json:string>sciences medicales</json:string><json:string>pharmacologie. traitements medicamenteux</json:string></inist></categories><publicationDate>1996</publicationDate><copyrightDate>1996</copyrightDate><doi><json:string>10.1016/S0035-9203(96)90484-8</json:string></doi><id>27F22946F7A08DF7FB92E13B7898A43E1D1E91AD</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/27F22946F7A08DF7FB92E13B7898A43E1D1E91AD/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/27F22946F7A08DF7FB92E13B7898A43E1D1E91AD/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/27F22946F7A08DF7FB92E13B7898A43E1D1E91AD/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Mass diethylcarbamazine chemotherapy for control of bancroftian filariasis: comparative efficacy of standard treatment and two semi-annual single-dose treatments</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1996</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Mass diethylcarbamazine chemotherapy for control of bancroftian filariasis: comparative efficacy of standard treatment and two semi-annual single-dose treatments</title><author xml:id="author-0000"><persName><forename type="first">D.W.</forename><surname>Meyrowitsch</surname></persName><affiliation>Danish Bilharziasis Laboratory, Jaegersborg Alle 1D, 2920 Charlottenlund, Denmark</affiliation></author><author xml:id="author-0001"><persName><forename type="first">P.E.</forename><surname>Simonsen</surname></persName><affiliation>Address for correspondence: Dr Paul E. Simonsen, Danish Bilharziasis Laboratory, Jaegersborg Alle 1D, 2920 Charlottenlund, Denmark.</affiliation><affiliation>Danish Bilharziasis Laboratory, Jaegersborg Alle 1D, 2920 Charlottenlund, Denmark</affiliation></author><author xml:id="author-0002"><persName><forename type="first">W.H.</forename><surname>Makunde</surname></persName><affiliation>Amani Medical Research Centre, P. O. Box 4, Amani, Tanzania</affiliation></author><idno type="istex">27F22946F7A08DF7FB92E13B7898A43E1D1E91AD</idno><idno type="DOI">10.1016/S0035-9203(96)90484-8</idno><idno type="PII">S0035-9203(96)90484-8</idno></analytic><monogr><title level="j">Transactions of the Royal Society of Tropical Medicine and Hygiene</title><title level="j" type="abbrev">TRSTMH</title><idno type="pISSN">0035-9203</idno><idno type="PII">S0035-9203(00)X0175-7</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1996"></date><biblScope unit="volume">90</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="69">69</biblScope><biblScope unit="page" to="73">73</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1996</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>The efficacy of 2 strategies for control of bancroftian filariasis using mass diethylcarbamazine (DEC) chemotherapy was evaluated and compared in 2 endemic communities in Tanzania with pre-treatment microfilarial (mf) prevalences of 28·5% and 17·7%, and mf geometric mean intensities (GMI) of 588 mf/mL and 251 mf/mL, respectively. All individuals in the first community were offered DEC treatment with 6 mg/kg body weight given daily for 12 d (standard treatment). The second community was offered DEC treatment with 2 single doses of 6 mg/kg body weight given with an interval of 6 months (semi-annual single-dose treatment). Among those who were microfilaraemic before treatment, the mf clearance rates were 51·2% and 36·0%, and the mf GMIs were reduced by 98·6% and 92·2% one year after the start of the standard and the semi-annual regimens, respectively. At community level, the standard strategy and the semi-annual strategy reduced the mf prevalences to 15·1% and 11·6% (reductions of 47·0% and 34·5%) and the mf GMIs to 112 mf/mL and 102 mf/mL (reductions of 81·0% and 59·4%, respectively) one year after start of treatment. Both regimens resulted in remarkable improvements in small hydroceles among males presenting this condition before treatment. The lower efficacy of the semi-annual single-dose treatment in relation to the standard treatment in reducing microfilaraemias might be compensated for by continuing semi-annual treatments for a slightly longer period of time. Considering that the semi-annual treatment is easy to administer and more acceptable to the treated individuals, it may in the long run be a more feasible strategy for mass DEC chemotherapy than the standard treatment.</p></abstract><textClass><keywords scheme="keyword"><list><head>article-category</head><item><term>Chemotherapy and chemoprophylaxis</term></item></list></keywords></textClass><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Wuchereria bancrofti</term></item><item><term>filariasis</term></item><item><term>mass chemotherapy</term></item><item><term>diethylcarbamazine</term></item><item><term>comparison of regimens</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1995-08-18">Modified</change><change when="1996">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/27F22946F7A08DF7FB92E13B7898A43E1D1E91AD/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>TRSTMH</jid><aid>96904848</aid><ce:pii>S0035-9203(96)90484-8</ce:pii><ce:doi>10.1016/S0035-9203(96)90484-8</ce:doi><ce:copyright type="unknown" year="1996"></ce:copyright><ce:doctopics><ce:doctopic><ce:text>Chemotherapy and chemoprophylaxis</ce:text></ce:doctopic></ce:doctopics></item-info><head><ce:title>Mass diethylcarbamazine chemotherapy for control of bancroftian filariasis: comparative efficacy of standard treatment and two semi-annual single-dose treatments</ce:title><ce:author-group><ce:author><ce:given-name>D.W.</ce:given-name><ce:surname>Meyrowitsch</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>P.E.</ce:given-name><ce:surname>Simonsen</ce:surname><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>W.H.</ce:given-name><ce:surname>Makunde</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>2</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>1</ce:label><ce:textfn>Danish Bilharziasis Laboratory, Jaegersborg Alle 1D, 2920 Charlottenlund, Denmark</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>2</ce:label><ce:textfn>Amani Medical Research Centre, P. O. Box 4, Amani, Tanzania</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Address for correspondence: Dr Paul E. Simonsen, Danish Bilharziasis Laboratory, Jaegersborg Alle 1D, 2920 Charlottenlund, Denmark.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="22" month="6" year="1995"></ce:date-received><ce:date-revised day="18" month="8" year="1995"></ce:date-revised><ce:date-accepted day="22" month="8" year="1995"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>The efficacy of 2 strategies for control of bancroftian filariasis using mass diethylcarbamazine (DEC) chemotherapy was evaluated and compared in 2 endemic communities in Tanzania with pre-treatment microfilarial (mf) prevalences of 28·5% and 17·7%, and mf geometric mean intensities (GMI) of 588 mf/mL and 251 mf/mL, respectively. All individuals in the first community were offered DEC treatment with 6 mg/kg body weight given daily for 12 d (standard treatment). The second community was offered DEC treatment with 2 single doses of 6 mg/kg body weight given with an interval of 6 months (semi-annual single-dose treatment). Among those who were microfilaraemic before treatment, the mf clearance rates were 51·2% and 36·0%, and the mf GMIs were reduced by 98·6% and 92·2% one year after the start of the standard and the semi-annual regimens, respectively. At community level, the standard strategy and the semi-annual strategy reduced the mf prevalences to 15·1% and 11·6% (reductions of 47·0% and 34·5%) and the mf GMIs to 112 mf/mL and 102 mf/mL (reductions of 81·0% and 59·4%, respectively) one year after start of treatment. Both regimens resulted in remarkable improvements in small hydroceles among males presenting this condition before treatment. The lower efficacy of the semi-annual single-dose treatment in relation to the standard treatment in reducing microfilaraemias might be compensated for by continuing semi-annual treatments for a slightly longer period of time. Considering that the semi-annual treatment is easy to administer and more acceptable to the treated individuals, it may in the long run be a more feasible strategy for mass DEC chemotherapy than the standard treatment.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text><ce:italic>Wuchereria bancrofti</ce:italic></ce:text></ce:keyword><ce:keyword><ce:text>filariasis</ce:text></ce:keyword><ce:keyword><ce:text>mass chemotherapy</ce:text></ce:keyword><ce:keyword><ce:text>diethylcarbamazine</ce:text></ce:keyword><ce:keyword><ce:text>comparison of regimens</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Mass diethylcarbamazine chemotherapy for control of bancroftian filariasis: comparative efficacy of standard treatment and two semi-annual single-dose treatments</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Mass diethylcarbamazine chemotherapy for control of bancroftian filariasis: comparative efficacy of standard treatment and two semi-annual single-dose treatments</title></titleInfo><name type="personal"><namePart type="given">D.W.</namePart><namePart type="family">Meyrowitsch</namePart><affiliation>Danish Bilharziasis Laboratory, Jaegersborg Alle 1D, 2920 Charlottenlund, Denmark</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.E.</namePart><namePart type="family">Simonsen</namePart><affiliation>Address for correspondence: Dr Paul E. Simonsen, Danish Bilharziasis Laboratory, Jaegersborg Alle 1D, 2920 Charlottenlund, Denmark.</affiliation><affiliation>Danish Bilharziasis Laboratory, Jaegersborg Alle 1D, 2920 Charlottenlund, Denmark</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.H.</namePart><namePart type="family">Makunde</namePart><affiliation>Amani Medical Research Centre, P. O. Box 4, Amani, Tanzania</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1996</dateIssued><dateModified encoding="w3cdtf">1995-08-18</dateModified><copyrightDate encoding="w3cdtf">1996</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">The efficacy of 2 strategies for control of bancroftian filariasis using mass diethylcarbamazine (DEC) chemotherapy was evaluated and compared in 2 endemic communities in Tanzania with pre-treatment microfilarial (mf) prevalences of 28·5% and 17·7%, and mf geometric mean intensities (GMI) of 588 mf/mL and 251 mf/mL, respectively. All individuals in the first community were offered DEC treatment with 6 mg/kg body weight given daily for 12 d (standard treatment). The second community was offered DEC treatment with 2 single doses of 6 mg/kg body weight given with an interval of 6 months (semi-annual single-dose treatment). Among those who were microfilaraemic before treatment, the mf clearance rates were 51·2% and 36·0%, and the mf GMIs were reduced by 98·6% and 92·2% one year after the start of the standard and the semi-annual regimens, respectively. At community level, the standard strategy and the semi-annual strategy reduced the mf prevalences to 15·1% and 11·6% (reductions of 47·0% and 34·5%) and the mf GMIs to 112 mf/mL and 102 mf/mL (reductions of 81·0% and 59·4%, respectively) one year after start of treatment. Both regimens resulted in remarkable improvements in small hydroceles among males presenting this condition before treatment. The lower efficacy of the semi-annual single-dose treatment in relation to the standard treatment in reducing microfilaraemias might be compensated for by continuing semi-annual treatments for a slightly longer period of time. Considering that the semi-annual treatment is easy to administer and more acceptable to the treated individuals, it may in the long run be a more feasible strategy for mass DEC chemotherapy than the standard treatment.</abstract><subject><genre>article-category</genre><topic>Chemotherapy and chemoprophylaxis</topic></subject><subject><genre>Keywords</genre><topic>Wuchereria bancrofti</topic><topic>filariasis</topic><topic>mass chemotherapy</topic><topic>diethylcarbamazine</topic><topic>comparison of regimens</topic></subject><relatedItem type="host"><titleInfo><title>Transactions of the Royal Society of Tropical Medicine and Hygiene</title></titleInfo><titleInfo type="abbreviated"><title>TRSTMH</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">199601</dateIssued></originInfo><identifier type="ISSN">0035-9203</identifier><identifier type="PII">S0035-9203(00)X0175-7</identifier><part><date>199601</date><detail type="volume"><number>90</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue pages"><start>1</start><end>96</end></extent><extent unit="pages"><start>69</start><end>73</end></extent></part></relatedItem><identifier type="istex">27F22946F7A08DF7FB92E13B7898A43E1D1E91AD</identifier><identifier type="DOI">10.1016/S0035-9203(96)90484-8</identifier><identifier type="PII">S0035-9203(96)90484-8</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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