Aluminum Is a Potential Environmental Factor for Crohn's Disease Induction
Identifieur interne : 000C00 ( Istex/Corpus ); précédent : 000B99; suivant : 000C01Aluminum Is a Potential Environmental Factor for Crohn's Disease Induction
Auteurs : Aaron LernerSource :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2007-06.
Abstract
Abstract: Aluminum (Al) is a common environmental compound with immune‐adjuvant activity and granulomatous inflammation inducer. Al exposure in food, additives, air, pharmaceuticals, and water pollution is ubiquitous in Western culture. Crohn's disease (CD) is a chronic relapsing intestinal inflammation in genetically susceptible individuals and is influenced by yet unidentified environmental factors. It is hypothesized, in the present review, that Al is a potential factor for induction or maintaining the inflammation in CD. Epidemiologically, CD incidence is higher in urban areas, where microparticle pollution is prevalent. Al immune activities share many characteristics with the immune pathology of CD: increased antigen presentation and APCs activation, many luminal bacterial or dietary compounds can be adsorbed to the metal and induce Th1 profile activity, promotion of humoral and cellular immune responses, proinflammatory, apoptotic, oxidative activity, and stress‐related molecule expression enhancement, affecting intestinal bacterial composition and virulence, granuloma formation, colitis induction in an animal model of CD, and terminal ileum uptake. The Al–bacterial interaction, the microparticles homing the intestine together with the extensive immune activity, put Al as a potential environmental candidate for CD induction and maintenance.
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DOI: 10.1196/annals.1381.035
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ISTEX:19AF300C25003EC66FEEE8E3F73DC82E0BB89E2DLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Aluminum Is a Potential Environmental Factor for Crohn's Disease Induction</title><author><name sortKey="Lerner, Aaron" sort="Lerner, Aaron" uniqKey="Lerner A" first="Aaron" last="Lerner">Aaron Lerner</name><affiliation><mods:affiliation>Pediatric Gastroenterology and Nutrition Unit, Carmel Medical Center, Pappaport School of Medicine, Technion‐Israel Institute of Technology, Haifa, Israel</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:19AF300C25003EC66FEEE8E3F73DC82E0BB89E2D</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1196/annals.1381.035</idno><idno type="url">https://api.istex.fr/document/19AF300C25003EC66FEEE8E3F73DC82E0BB89E2D/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000C00</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000C00</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Aluminum Is a Potential Environmental Factor for Crohn's Disease Induction</title><author><name sortKey="Lerner, Aaron" sort="Lerner, Aaron" uniqKey="Lerner A" first="Aaron" last="Lerner">Aaron Lerner</name><affiliation><mods:affiliation>Pediatric Gastroenterology and Nutrition Unit, Carmel Medical Center, Pappaport School of Medicine, Technion‐Israel Institute of Technology, Haifa, Israel</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Annals of the New York Academy of Sciences</title><title level="j" type="alt">ANNALS OF NEW YORK ACADEMY SCIENCES</title><idno type="ISSN">0077-8923</idno><idno type="eISSN">1749-6632</idno><imprint><biblScope unit="vol">1107</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="329">329</biblScope><biblScope unit="page" to="345">345</biblScope><biblScope unit="page-count">17</biblScope><publisher>Blackwell Publishing Inc</publisher><pubPlace>Malden, USA</pubPlace><date type="published" when="2007-06">2007-06</date></imprint><idno type="ISSN">0077-8923</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0077-8923</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Abstract: Aluminum (Al) is a common environmental compound with immune‐adjuvant activity and granulomatous inflammation inducer. Al exposure in food, additives, air, pharmaceuticals, and water pollution is ubiquitous in Western culture. Crohn's disease (CD) is a chronic relapsing intestinal inflammation in genetically susceptible individuals and is influenced by yet unidentified environmental factors. It is hypothesized, in the present review, that Al is a potential factor for induction or maintaining the inflammation in CD. Epidemiologically, CD incidence is higher in urban areas, where microparticle pollution is prevalent. Al immune activities share many characteristics with the immune pathology of CD: increased antigen presentation and APCs activation, many luminal bacterial or dietary compounds can be adsorbed to the metal and induce Th1 profile activity, promotion of humoral and cellular immune responses, proinflammatory, apoptotic, oxidative activity, and stress‐related molecule expression enhancement, affecting intestinal bacterial composition and virulence, granuloma formation, colitis induction in an animal model of CD, and terminal ileum uptake. The Al–bacterial interaction, the microparticles homing the intestine together with the extensive immune activity, put Al as a potential environmental candidate for CD induction and maintenance.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>immune</json:string><json:string>intestinal</json:string><json:string>adjuvant</json:string><json:string>microparticles</json:string><json:string>macrophage</json:string><json:string>receptor</json:string><json:string>luminal</json:string><json:string>dendritic</json:string><json:string>aluminium</json:string><json:string>bowel</json:string><json:string>hydroxide</json:string><json:string>colitis</json:string><json:string>transferrin</json:string><json:string>mucin</json:string><json:string>york academy</json:string><json:string>cytokine</json:string><json:string>inflammatory bowel 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transduction</json:string><json:string>immune activation</json:string><json:string>luminal mucins</json:string><json:string>aluminum hydroxide</json:string><json:string>potent enhancer</json:string><json:string>trace elem</json:string><json:string>inorganic microparticles</json:string><json:string>microparticle diet</json:string></teeft></keywords><author><json:item><name>AARON LERNER</name><affiliations><json:string>Pediatric Gastroenterology and Nutrition Unit, Carmel Medical Center, Pappaport School of Medicine, Technion‐Israel Institute of Technology, Haifa, Israel</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>aluminum</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Crohn's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>environmental factor</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>intestine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>mucosal immunology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>inflammation</value></json:item></subject><articleId><json:string>NYAS35</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Abstract: Aluminum (Al) is a common environmental compound with immune‐adjuvant activity and granulomatous inflammation inducer. Al exposure in food, additives, air, pharmaceuticals, and water pollution is ubiquitous in Western culture. Crohn's disease (CD) is a chronic relapsing intestinal inflammation in genetically susceptible individuals and is influenced by yet unidentified environmental factors. It is hypothesized, in the present review, that Al is a potential factor for induction or maintaining the inflammation in CD. Epidemiologically, CD incidence is higher in urban areas, where microparticle pollution is prevalent. Al immune activities share many characteristics with the immune pathology of CD: increased antigen presentation and APCs activation, many luminal bacterial or dietary compounds can be adsorbed to the metal and induce Th1 profile activity, promotion of humoral and cellular immune responses, proinflammatory, apoptotic, oxidative activity, and stress‐related molecule expression enhancement, affecting intestinal bacterial composition and virulence, granuloma formation, colitis induction in an animal model of CD, and terminal ileum uptake. 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<hi rend="bold">Aluminum (Al) is a common environmental compound with immune‐adjuvant activity and granulomatous inflammation inducer. Al exposure in food, additives, air, pharmaceuticals, and water pollution is ubiquitous in Western culture. Crohn's disease (CD) is a chronic relapsing intestinal inflammation in genetically susceptible individuals and is influenced by yet unidentified environmental factors. It is hypothesized, in the present review, that Al is a potential factor for induction or maintaining the inflammation in CD. Epidemiologically, CD incidence is higher in urban areas, where microparticle pollution is prevalent. Al immune activities share many characteristics with the immune pathology of CD: increased antigen presentation and APCs activation, many luminal bacterial or dietary compounds can be adsorbed to the metal and induce Th1 profile activity, promotion of humoral and cellular immune responses, proinflammatory, apoptotic, oxidative activity, and stress‐related molecule expression enhancement, affecting intestinal bacterial composition and virulence, granuloma formation, colitis induction in an animal model of CD, and terminal ileum uptake. The Al–bacterial interaction, the microparticles homing the intestine together with the extensive immune activity, put Al as a potential environmental candidate for CD induction and maintenance</hi>.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">aluminum</term><term xml:id="k2">Crohn's disease</term><term xml:id="k3">environmental factor</term><term xml:id="k4">intestine</term><term xml:id="k5">mucosal immunology</term><term xml:id="k6">inflammation</term></keywords><classCode scheme="tocHeading1">Part IV. Autoantibodies and the Gastrointestinal Tract</classCode></textClass><langUsage><language ident="EN"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/19AF300C25003EC66FEEE8E3F73DC82E0BB89E2D/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Inc</publisherName><publisherLoc>Malden, USA</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1749-6632</doi><issn type="print">0077-8923</issn><issn type="electronic">1749-6632</issn><idGroup><id type="product" value="NYAS"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="ANNALS OF NEW YORK ACADEMY SCIENCES">Annals of the New York Academy of Sciences</title></titleGroup></publicationMeta><publicationMeta level="part" position="06001"><doi origin="wiley">10.1111/nyas.2007.1107.issue-1</doi><titleGroup><title type="main">Autoimmunity, Part C The Mosaic of Autoimmunity</title></titleGroup><numberingGroup><numbering type="journalVolume" number="1107">1107</numbering><numbering type="journalIssue">1</numbering></numberingGroup><coverDate startDate="2007-06">June 2007</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="36" status="forIssue"><doi origin="wiley">10.1196/annals.1381.035</doi><idGroup><id type="unit" value="NYAS35"></id></idGroup><countGroup><count type="pageTotal" number="17"></count></countGroup><titleGroup><title type="tocHeading1">Part IV. Autoantibodies and the Gastrointestinal Tract</title></titleGroup><eventGroup><event type="firstOnline" date="2007-08-28"></event><event type="publishedOnlineFinalForm" date="2007-08-28"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.4 mode:FullText source:FullText result:FullText" date="2010-03-29"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-19"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-14"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="329">329</numbering><numbering type="pageLast" number="345">345</numbering></numberingGroup><correspondenceTo>Address for correspondence: Aaron Lerner, M.D., M.H.A., Pediatric Gastroenterology and Nutrition Unit, Carmel Medical Center, 7 Michal St, Haifa 34362, Israel. Voice: 972‐4‐8250‐527; fax: 972‐4‐8250‐919.
<email>lerner_aaron@clalit.org.il</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:NYAS.NYAS35.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="1"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="96"></count><count type="linksCrossRef" number="95"></count></countGroup><titleGroup><title type="main">Aluminum Is a Potential Environmental Factor for Crohn's Disease Induction</title><title type="subtitle">Extended Hypothesis</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>AARON</givenNames><familyName>LERNER</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="IL"><unparsedAffiliation>Pediatric Gastroenterology and Nutrition Unit, Carmel Medical Center, Pappaport School of Medicine, Technion‐Israel Institute of Technology, Haifa, Israel</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">aluminum</keyword><keyword xml:id="k2">Crohn's disease</keyword><keyword xml:id="k3">environmental factor</keyword><keyword xml:id="k4">intestine</keyword><keyword xml:id="k5">mucosal immunology</keyword><keyword xml:id="k6">inflammation</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b><sc>Abstract</sc>: </b> <b>Aluminum (Al) is a common environmental compound with immune‐adjuvant activity and granulomatous inflammation inducer. Al exposure in food, additives, air, pharmaceuticals, and water pollution is ubiquitous in Western culture. Crohn's disease (CD) is a chronic relapsing intestinal inflammation in genetically susceptible individuals and is influenced by yet unidentified environmental factors. It is hypothesized, in the present review, that Al is a potential factor for induction or maintaining the inflammation in CD. Epidemiologically, CD incidence is higher in urban areas, where microparticle pollution is prevalent. Al immune activities share many characteristics with the immune pathology of CD: increased antigen presentation and APCs activation, many luminal bacterial or dietary compounds can be adsorbed to the metal and induce Th1 profile activity, promotion of humoral and cellular immune responses, proinflammatory, apoptotic, oxidative activity, and stress‐related molecule expression enhancement, affecting intestinal bacterial composition and virulence, granuloma formation, colitis induction in an animal model of CD, and terminal ileum uptake. The Al–bacterial interaction, the microparticles homing the intestine together with the extensive immune activity, put Al as a potential environmental candidate for CD induction and maintenance</b>.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Aluminum Is a Potential Environmental Factor for Crohn's Disease Induction</title><subTitle>Extended Hypothesis</subTitle></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Aluminum Is a Potential Environmental Factor for Crohn's Disease Induction</title></titleInfo><name type="personal"><namePart type="given">AARON</namePart><namePart type="family">LERNER</namePart><affiliation>Pediatric Gastroenterology and Nutrition Unit, Carmel Medical Center, Pappaport School of Medicine, Technion‐Israel Institute of Technology, Haifa, Israel</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Inc</publisher><place><placeTerm type="text">Malden, USA</placeTerm></place><dateIssued encoding="w3cdtf">2007-06</dateIssued><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">1</extent><extent unit="references">96</extent></physicalDescription><abstract>Abstract: Aluminum (Al) is a common environmental compound with immune‐adjuvant activity and granulomatous inflammation inducer. Al exposure in food, additives, air, pharmaceuticals, and water pollution is ubiquitous in Western culture. Crohn's disease (CD) is a chronic relapsing intestinal inflammation in genetically susceptible individuals and is influenced by yet unidentified environmental factors. It is hypothesized, in the present review, that Al is a potential factor for induction or maintaining the inflammation in CD. Epidemiologically, CD incidence is higher in urban areas, where microparticle pollution is prevalent. Al immune activities share many characteristics with the immune pathology of CD: increased antigen presentation and APCs activation, many luminal bacterial or dietary compounds can be adsorbed to the metal and induce Th1 profile activity, promotion of humoral and cellular immune responses, proinflammatory, apoptotic, oxidative activity, and stress‐related molecule expression enhancement, affecting intestinal bacterial composition and virulence, granuloma formation, colitis induction in an animal model of CD, and terminal ileum uptake. The Al–bacterial interaction, the microparticles homing the intestine together with the extensive immune activity, put Al as a potential environmental candidate for CD induction and maintenance.</abstract><subject lang="en"><genre>keywords</genre><topic>aluminum</topic><topic>Crohn's disease</topic><topic>environmental factor</topic><topic>intestine</topic><topic>mucosal immunology</topic><topic>inflammation</topic></subject><relatedItem type="host"><titleInfo><title>Annals of the New York Academy of Sciences</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0077-8923</identifier><identifier type="eISSN">1749-6632</identifier><identifier type="DOI">10.1111/(ISSN)1749-6632</identifier><identifier type="PublisherID">NYAS</identifier><part><date>2007</date><detail type="title"><title>Autoimmunity, Part C The Mosaic of Autoimmunity</title></detail><detail type="volume"><caption>vol.</caption><number>1107</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>329</start><end>345</end><total>17</total></extent></part></relatedItem><identifier type="istex">19AF300C25003EC66FEEE8E3F73DC82E0BB89E2D</identifier><identifier type="DOI">10.1196/annals.1381.035</identifier><identifier type="ArticleID">NYAS35</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Inc</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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