Tumor Lymphangiogenesis Predicts Melanoma Metastasis to Sentinel Lymph Nodes
Identifieur interne : 000B92 ( Istex/Corpus ); précédent : 000B91; suivant : 000B93Tumor Lymphangiogenesis Predicts Melanoma Metastasis to Sentinel Lymph Nodes
Auteurs : Sam S. Dadras ; Bernhard Lange-Asschenfeldt ; Alona Muzikansky ; Martin C. Mihm ; Michael DetmarSource :
- Journal of Cutaneous Pathology [ 0303-6987 ] ; 2005-01.
Abstract
Cutaneous melanoma is a common and frequently lethal melanocytic neoplasm that can quickly metastasize to regional lymph nodes. Currently, prognosis is determined by measuring tumor thickness but more reliable markers for metastatic spread are urgently needed. We investigated whether the extent of tumor lymphangiogenesis can predict melanoma metastasis to sentinel lymph nodes (SLN). We quantified the extent of tumor lymphangiogenesis, as well as other factors, in excised primary tumors and in SLN biopsy samples from 45 patients with primary cutaneous melanoma. Primary melanomas from patients whose tumors had metastasized to the SLN, along with their metastastic foci, contained prominent hotspots of increased lymphatic vessel density, compared to non‐metastatic tumors. Multivariate risk analysis revealed that the lymphatic vascular area (LVA) of primary melanomas, an index of tumor lymphangiogenesis, was the most sensitive prognostic marker for SLN metastasis, and was even able to more accurately predict which tumors would become metastatic to SLN than measuring tumor thickness. The extent of tumor lymphangiogenesis is a highly sensitive (83%) and specific (89%) prognostic marker of lymph node metastasis. Assessment of lymphangiogenesis in primary melanomas may be a more effective approach than measuring tumor thickness in selecting patients with early metastatic disease for aggressive therapy.
Url:
DOI: 10.1111/j.0303-6987.2005.320bd.x
Links to Exploration step
ISTEX:1992B8650B68A71FB1F9952549225CFAEBE68181Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Tumor Lymphangiogenesis Predicts Melanoma Metastasis to Sentinel Lymph Nodes</title><author><name sortKey="Dadras, Sam S" sort="Dadras, Sam S" uniqKey="Dadras S" first="Sam S." last="Dadras">Sam S. Dadras</name><affiliation><mods:affiliation>Departments of Pathology and Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA</mods:affiliation></affiliation></author><author><name sortKey="Lange Sschenfeldt, Bernhard" sort="Lange Sschenfeldt, Bernhard" uniqKey="Lange Sschenfeldt B" first="Bernhard" last="Lange-Asschenfeldt">Bernhard Lange-Asschenfeldt</name><affiliation><mods:affiliation>Departments of Pathology and Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA</mods:affiliation></affiliation></author><author><name sortKey="Muzikansky, Alona" sort="Muzikansky, Alona" uniqKey="Muzikansky A" first="Alona" last="Muzikansky">Alona Muzikansky</name><affiliation><mods:affiliation>Departments of Pathology and Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA</mods:affiliation></affiliation></author><author><name sortKey="Mihm, Martin C" sort="Mihm, Martin C" uniqKey="Mihm M" first="Martin C." last="Mihm">Martin C. Mihm</name><affiliation><mods:affiliation>Departments of Pathology and Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA</mods:affiliation></affiliation></author><author><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name><affiliation><mods:affiliation>Departments of Pathology and Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:1992B8650B68A71FB1F9952549225CFAEBE68181</idno><date when="2005" year="2005">2005</date><idno type="doi">10.1111/j.0303-6987.2005.320bd.x</idno><idno type="url">https://api.istex.fr/document/1992B8650B68A71FB1F9952549225CFAEBE68181/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000B92</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000B92</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Tumor Lymphangiogenesis Predicts Melanoma Metastasis to Sentinel Lymph Nodes</title><author><name sortKey="Dadras, Sam S" sort="Dadras, Sam S" uniqKey="Dadras S" first="Sam S." last="Dadras">Sam S. Dadras</name><affiliation><mods:affiliation>Departments of Pathology and Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA</mods:affiliation></affiliation></author><author><name sortKey="Lange Sschenfeldt, Bernhard" sort="Lange Sschenfeldt, Bernhard" uniqKey="Lange Sschenfeldt B" first="Bernhard" last="Lange-Asschenfeldt">Bernhard Lange-Asschenfeldt</name><affiliation><mods:affiliation>Departments of Pathology and Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA</mods:affiliation></affiliation></author><author><name sortKey="Muzikansky, Alona" sort="Muzikansky, Alona" uniqKey="Muzikansky A" first="Alona" last="Muzikansky">Alona Muzikansky</name><affiliation><mods:affiliation>Departments of Pathology and Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA</mods:affiliation></affiliation></author><author><name sortKey="Mihm, Martin C" sort="Mihm, Martin C" uniqKey="Mihm M" first="Martin C." last="Mihm">Martin C. Mihm</name><affiliation><mods:affiliation>Departments of Pathology and Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA</mods:affiliation></affiliation></author><author><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name><affiliation><mods:affiliation>Departments of Pathology and Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Cutaneous Pathology</title><title level="j" type="alt">JOURNAL OF CUTANEOUS PATHOLOGY</title><idno type="ISSN">0303-6987</idno><idno type="eISSN">1600-0560</idno><imprint><biblScope unit="vol">32</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="84">84</biblScope><biblScope unit="page" to="84">84</biblScope><biblScope unit="page-count">1</biblScope><publisher>Blackwell Publishing Ltd/Inc.</publisher><pubPlace>Oxford, UK; Malden, USA</pubPlace><date type="published" when="2005-01">2005-01</date></imprint><idno type="ISSN">0303-6987</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0303-6987</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cutaneous melanoma is a common and frequently lethal melanocytic neoplasm that can quickly metastasize to regional lymph nodes. Currently, prognosis is determined by measuring tumor thickness but more reliable markers for metastatic spread are urgently needed. We investigated whether the extent of tumor lymphangiogenesis can predict melanoma metastasis to sentinel lymph nodes (SLN). We quantified the extent of tumor lymphangiogenesis, as well as other factors, in excised primary tumors and in SLN biopsy samples from 45 patients with primary cutaneous melanoma. Primary melanomas from patients whose tumors had metastasized to the SLN, along with their metastastic foci, contained prominent hotspots of increased lymphatic vessel density, compared to non‐metastatic tumors. Multivariate risk analysis revealed that the lymphatic vascular area (LVA) of primary melanomas, an index of tumor lymphangiogenesis, was the most sensitive prognostic marker for SLN metastasis, and was even able to more accurately predict which tumors would become metastatic to SLN than measuring tumor thickness. The extent of tumor lymphangiogenesis is a highly sensitive (83%) and specific (89%) prognostic marker of lymph node metastasis. Assessment of lymphangiogenesis in primary melanomas may be a more effective approach than measuring tumor thickness in selecting patients with early metastatic disease for aggressive therapy.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>cutaneous</json:string><json:string>dermatology</json:string><json:string>melanoma</json:string><json:string>nevus</json:string><json:string>nodule</json:string><json:string>neoplasm</json:string><json:string>melanocytic</json:string><json:string>histologic</json:string><json:string>dermis</json:string><json:string>malignant</json:string><json:string>carcinoma</json:string><json:string>node</json:string><json:string>immunohistochemical</json:string><json:string>metastatic</json:string><json:string>dermal</json:string><json:string>epidermal</json:string><json:string>lesion</json:string><json:string>metastasis</json:string><json:string>biopsy</json:string><json:string>dermatopathology</json:string><json:string>eccrine</json:string><json:string>lymphocyte</json:string><json:string>papule</json:string><json:string>subcutaneous</json:string><json:string>cyst</json:string><json:string>histological</json:string><json:string>vasculitis</json:string><json:string>squamous</json:string><json:string>lymphoma</json:string><json:string>basal</json:string><json:string>histologically</json:string><json:string>sarcoma</json:string><json:string>granulomatous</json:string><json:string>granuloma</json:string><json:string>atypia</json:string><json:string>kinase</json:string><json:string>histopathologic</json:string><json:string>perivascular</json:string><json:string>atypical</json:string><json:string>differential diagnosis</json:string><json:string>dermatitis</json:string><json:string>epithelial</json:string><json:string>immunohistochemistry</json:string><json:string>erythematous</json:string><json:string>excision</json:string><json:string>benign</json:string><json:string>dysplastic</json:string><json:string>positivity</json:string><json:string>mitotic</json:string><json:string>sebaceous</json:string><json:string>erythema</json:string><json:string>receptor</json:string><json:string>keratoses</json:string><json:string>eosinophil</json:string><json:string>stroma</json:string><json:string>histiocyte</json:string><json:string>tumor cells</json:string><json:string>adnexal</json:string><json:string>squamous cell carcinoma</json:string><json:string>neoplastic</json:string><json:string>keratinocytes</json:string><json:string>mucin</json:string><json:string>mutation</json:string><json:string>spitz</json:string><json:string>mycosis</json:string><json:string>adenocarcinoma</json:string><json:string>fibrosing</json:string><json:string>epithelioid</json:string><json:string>fungoides</json:string><json:string>basal cell carcinoma</json:string><json:string>lichen</json:string><json:string>actin</json:string><json:string>lymphadenopathy</json:string><json:string>epithelium</json:string><json:string>cell lymphoma</json:string><json:string>malignant melanoma</json:string><json:string>skin biopsy</json:string><json:string>skin lesions</json:string><json:string>follicular</json:string><json:string>cutis</json:string><json:string>mycosis fungoides</json:string><json:string>neurofibroma</json:string><json:string>medical center</json:string><json:string>panniculitis</json:string><json:string>infiltrates</json:string><json:string>dermatomyositis</json:string><json:string>vimentin</json:string><json:string>invasive</json:string><json:string>basaloid</json:string><json:string>etiology</json:string><json:string>pleomorphic</json:string><json:string>cytokeratin</json:string><json:string>anaplastic</json:string><json:string>asymptomatic</json:string><json:string>braf</json:string><json:string>actinic</json:string><json:string>melanocyte</json:string><json:string>lupus</json:string><json:string>tumour</json:string><json:string>junctional</json:string><json:string>punch biopsy</json:string><json:string>melanin</json:string><json:string>follicle</json:string><json:string>myoepithelial</json:string><json:string>alopecia</json:string><json:string>melanocytic lesions</json:string><json:string>malignancy</json:string><json:string>inflammation</json:string><json:string>gvhd</json:string><json:string>subcutis</json:string><json:string>mucinous</json:string><json:string>neutrophil</json:string><json:string>histopathological</json:string><json:string>hypha</json:string><json:string>neutrophilic</json:string><json:string>lymphoid</json:string><json:string>chemotherapy</json:string><json:string>nephrogenic</json:string><json:string>cytologic</json:string><json:string>dermopathy</json:string><json:string>rearrangement</json:string><json:string>intraepidermal</json:string><json:string>immunoreactivity</json:string><json:string>nephrogenic fibrosing dermopathy</json:string><json:string>verrucous</json:string><json:string>case report</json:string><json:string>spitz nevi</json:string><json:string>pathway</json:string><json:string>apocrine</json:string><json:string>desmin</json:string><json:string>nucleolus</json:string><json:string>elastosis</json:string><json:string>mitoses</json:string><json:string>exam</json:string><json:string>syndrome</json:string><json:string>lymph</json:string><json:string>nodular</json:string><json:string>histopathology</json:string><json:string>hyperkeratosis</json:string><json:string>lower extremities</json:string><json:string>dysplastic nevi</json:string><json:string>granule</json:string><json:string>skin biopsies</json:string><json:string>desmoplastic</json:string><json:string>hemangioma</json:string><json:string>palisading</json:string><json:string>bullous</json:string><json:string>srcasm</json:string><json:string>physical examination</json:string><json:string>planus</json:string><json:string>multinucleated</json:string><json:string>erythematosus</json:string><json:string>inflammatory</json:string><json:string>epidermis</json:string><json:string>plaque</json:string><json:string>factor xiiia</json:string><json:string>saitama</json:string><json:string>cockerell</json:string><json:string>pathology1</json:string><json:string>clinical impression</json:string><json:string>myxoid</json:string><json:string>xiiia</json:string><json:string>hyperpigmentation</json:string><json:string>lymphoproliferative</json:string><json:string>cystic</json:string><json:string>spindle cells</json:string><json:string>histology</json:string><json:string>necrotizing</json:string><json:string>zygomycosis</json:string><json:string>neurofibromatosis</json:string><json:string>atab</json:string><json:string>monoclonal</json:string><json:string>histologic findings</json:string><json:string>primary melanomas</json:string><json:string>lymphatic</json:string><json:string>lesional</json:string><json:string>folliculitis</json:string><json:string>clinical presentation</json:string><json:string>hidradenoma</json:string><json:string>subungal</json:string><json:string>keratosis</json:string><json:string>androgen</json:string><json:string>fibroma</json:string><json:string>cytoplasmic</json:string><json:string>year history</json:string><json:string>immune</json:string><json:string>sptcl</json:string><json:string>hamartoma</json:string><json:string>voriconazole</json:string><json:string>intradermal</json:string><json:string>herpes</json:string><json:string>eruption</json:string><json:string>hyperplasia</json:string><json:string>chromogranin</json:string><json:string>perifollicular</json:string><json:string>cytologic atypia</json:string><json:string>neuroendocrine</json:string><json:string>seborrheic</json:string><json:string>merkel</json:string><json:string>ulceration</json:string><json:string>histiocytic</json:string><json:string>eosinophilia</json:string><json:string>dermatosis</json:string><json:string>laboratory medicine</json:string><json:string>subset</json:string><json:string>intravascular</json:string><json:string>neoplastic cells</json:string><json:string>larva</json:string><json:string>plasmacytoid</json:string><json:string>cell carcinoma</json:string><json:string>primary cutaneous</json:string><json:string>reticular</json:string><json:string>parakeratosis</json:string><json:string>immunocompromised</json:string><json:string>fibromatosis</json:string><json:string>junb</json:string><json:string>dendritic</json:string><json:string>dfsp</json:string><json:string>plasma cells</json:string><json:string>phat</json:string><json:string>vellus</json:string><json:string>cytometry</json:string><json:string>keratin</json:string><json:string>shimizu</json:string><json:string>mediastinal</json:string><json:string>lipedematous</json:string><json:string>lymph nodes</json:string><json:string>common melanocytic nevi</json:string><json:string>calponin</json:string><json:string>mitotic activity</json:string><json:string>leukaemia</json:string><json:string>melanocytic nevi</json:string><json:string>scleromyxedema</json:string><json:string>keratinocyte</json:string><json:string>durham</json:string><json:string>eosinophilic</json:string><json:string>recurrence</json:string><json:string>lipomembranous</json:string><json:string>actinic keratoses</json:string><json:string>reactive</json:string><json:string>trichoepithelioma</json:string><json:string>mesenchymal</json:string><json:string>compound nevi</json:string><json:string>leukemia cutis</json:string><json:string>lichenoid</json:string><json:string>chordoma</json:string><json:string>immunoperoxidase</json:string><json:string>hematologic</json:string><json:string>dermatopathologists</json:string><json:string>vacuolar</json:string><json:string>dyskeratosis</json:string><json:string>hybridization</json:string><json:string>cyclin</json:string><json:string>leiomyosarcoma</json:string><json:string>apoptosis</json:string><json:string>clinical history</json:string><json:string>chondroid</json:string><json:string>immunohistochemical staining</json:string><json:string>histopathologic findings</json:string><json:string>positive staining</json:string><json:string>extramammary</json:string><json:string>immunohistochemical stains</json:string><json:string>histologic features</json:string><json:string>clinicopathological</json:string><json:string>herpetic</json:string><json:string>annulare</json:string><json:string>metaplasia</json:string><json:string>violaceous</json:string><json:string>nuclear staining</json:string><json:string>immunohistochemically</json:string><json:string>glomus</json:string><json:string>histiocytoma</json:string><json:string>pleomorphism</json:string><json:string>breast carcinoma</json:string><json:string>langerhans</json:string><json:string>special stains</json:string><json:string>clark level</json:string><json:string>meningothelial</json:string><json:string>metastatic melanoma</json:string><json:string>globule</json:string><json:string>macule</json:string><json:string>myofibroblastic</json:string><json:string>pruritic</json:string><json:string>polyclonal</json:string><json:string>smooth muscle actin</json:string><json:string>overlying</json:string><json:string>congenital</json:string><json:string>fungal</json:string><json:string>tumor</json:string><json:string>proliferation</json:string><json:string>residual</json:string><json:string>rash</json:string><json:string>lichen planus</json:string><json:string>tumor thickness</json:string><json:string>actinic keratosis</json:string><json:string>electron microscopy</json:string><json:string>merkel cell carcinoma</json:string><json:string>paget cells</json:string><json:string>prominent nucleoli</json:string><json:string>erythema vasculitis</json:string><json:string>physical exam</json:string><json:string>shadow cells</json:string><json:string>epithelioid cells</json:string><json:string>family history</json:string><json:string>desmoplastic melanoma</json:string><json:string>duke university</json:string><json:string>androgen receptor expression</json:string><json:string>benign neoplasm</json:string><json:string>unusual case</json:string><json:string>atypical lymphocytes</json:string><json:string>histological features</json:string><json:string>stain</json:string><json:string>diagnosis</json:string><json:string>eyelid</json:string><json:string>trauma</json:string><json:string>papillary</json:string><json:string>histologic examination</json:string><json:string>mayo clinic</json:string><json:string>dermal mucin</json:string><json:string>epidermal effacement</json:string><json:string>basal cell carcinomas</json:string><json:string>seborrheic keratoses</json:string><json:string>medical sciences</json:string><json:string>histological examination</json:string><json:string>epidermal nevus</json:string><json:string>deep dermis</json:string><json:string>intravascular lymphoma</json:string><json:string>indiana university school</json:string><json:string>medical history</json:string><json:string>focal areas</json:string><json:string>eccrine poroma</json:string><json:string>flow cytometry</json:string><json:string>topical steroids</json:string><json:string>clinical appearance</json:string><json:string>sebaceous carcinoma</json:string><json:string>elderly patients</json:string><json:string>cockerell department</json:string><json:string>tissue cultures</json:string><json:string>bone marrow</json:string><json:string>extramammary disease</json:string><json:string>tumor lymphangiogenesis</json:string><json:string>elastic fibers</json:string><json:string>cutaneous disease</json:string><json:string>endothelial cells</json:string><json:string>blue nevi</json:string><json:string>metastatic melanomas</json:string><json:string>systemic involvement</json:string><json:string>incontinentia pigmenti</json:string><json:string>lipedematous alopecia</json:string><json:string>squamous islands</json:string><json:string>correct diagnosis</json:string><json:string>clinical diagnosis</json:string><json:string>vesicular nuclei</json:string><json:string>marker</json:string><json:string>extremity</json:string><json:string>ulcerated</json:string><json:string>endothelial</json:string><json:string>surgical</json:string><json:string>necrosis</json:string><json:string>interstitial</json:string><json:string>steroid</json:string><json:string>stanford</json:string><json:string>paget</json:string><json:string>matrix</json:string><json:string>mayo</json:string><json:string>variant</json:string><json:string>immunohistochemical analysis</json:string><json:string>cutaneous lesions</json:string><json:string>chronic gvhd</json:string><json:string>first case</json:string><json:string>biopsy specimens</json:string><json:string>epithelial membrane antigen</json:string><json:string>immunohistochemical study</json:string><json:string>multinucleated giant cells</json:string><json:string>stanford university</json:string><json:string>cutaneous sparganosis</json:string><json:string>lymph node</json:string><json:string>chapel hill</json:string><json:string>reticular dermis</json:string><json:string>local recurrence</json:string><json:string>melanocytic neoplasms</json:string><json:string>similar lesions</json:string><json:string>precocious puberty</json:string><json:string>lichen sclerosus</json:string><json:string>columbia university college</json:string><json:string>polymerase chain reaction</json:string><json:string>braf mutations</json:string><json:string>monoclonal antibody</json:string><json:string>lobular panniculitis</json:string><json:string>hair follicles</json:string><json:string>large cell transformation</json:string><json:string>glomus coccygeum</json:string><json:string>mast cell disorders</json:string><json:string>boston university</json:string><json:string>hair matrix differentiation</json:string><json:string>cleveland clinic foundation</json:string><json:string>invasive melanoma</json:string><json:string>pustular drug eruption</json:string><json:string>rheumatoid arthritis</json:string><json:string>medical university</json:string><json:string>normal skin</json:string><json:string>ohio state university</json:string><json:string>cutaneous manifestations</json:string><json:string>clinical features</json:string><json:string>intradermal nevi</json:string><json:string>constitutional symptoms</json:string><json:string>lymph node metastasis</json:string><json:string>medical college</json:string><json:string>histologic sections</json:string><json:string>discoid lupus erythematosus</json:string><json:string>subcutaneous tissue</json:string><json:string>lupus erythematosus</json:string><json:string>genetic identity analysis</json:string><json:string>oklahoma health sciences center</json:string><json:string>eosinophilic cytoplasm</json:string><json:string>granuloma annulare</json:string><json:string>cutaneous leiomyosarcoma</json:string><json:string>diagnostic challenge</json:string><json:string>histologic criteria</json:string><json:string>drug eruption</json:string><json:string>multicentric reticulohistiocytosis</json:string><json:string>weight loss</json:string><json:string>billings departments</json:string><json:string>shimizu departments</json:string><json:string>overlying epidermis</json:string><json:string>previous studies</json:string><json:string>clear cell hidradenoma</json:string><json:string>cutaneous larva migrans</json:string><json:string>histological findings</json:string><json:string>recurrent nevi</json:string><json:string>sentinel lymph nodes</json:string><json:string>atypical neurofibroma</json:string><json:string>papillary dermis</json:string><json:string>matrical differentiation</json:string><json:string>quest diagnostics</json:string><json:string>male patient</json:string><json:string>control group</json:string><json:string>metastatic disease</json:string><json:string>cocaine</json:string><json:string>vesicular</json:string><json:string>pathogenesis</json:string><json:string>simplex</json:string><json:string>disorder</json:string><json:string>systemic</json:string><json:string>cell</json:string><json:string>progression</json:string><json:string>collagen</json:string><json:string>transplant</json:string><json:string>nra</json:string><json:string>unremarkable</json:string><json:string>dysplasia</json:string><json:string>caucasian</json:string><json:string>circumscribed</json:string><json:string>renal</json:string><json:string>necrotic</json:string><json:string>differentiation</json:string><json:string>cytoplasm</json:string><json:string>leukemia</json:string><json:string>sentinel</json:string><json:string>little rock</json:string><json:string>basement membrane</json:string><json:string>nodular vasculitis</json:string><json:string>peripheral lymphoma</json:string><json:string>interface dermatitis</json:string><json:string>leukocytoclastic vasculitis</json:string><json:string>skeletal muscle</json:string><json:string>subcutaneous nodule</json:string><json:string>complete digeorge syndrome</json:string><json:string>extensive involvement</json:string><json:string>surgical excision</json:string><json:string>hematologic malignancies</json:string><json:string>african american woman</json:string><json:string>tattoo pigment</json:string><json:string>histopathologic diagnosis</json:string><json:string>pacinian corpuscles</json:string><json:string>progressive mucinous histiocytosis</json:string><json:string>texas health science center</json:string><json:string>transplant patient</json:string><json:string>rare tumor</json:string><json:string>intraepidermal variant</json:string><json:string>lower legs</json:string><json:string>eccrine poromas</json:string><json:string>elastosis perforans serpiginosa</json:string><json:string>several years</json:string><json:string>melanin pigment uptake</json:string><json:string>eosinophilic panniculitis</json:string><json:string>primary mucinous adenocarcinoma</json:string><json:string>ileostomy site</json:string><json:string>factor viii</json:string><json:string>herpetic folliculitis</json:string><json:string>pagets disease</json:string><json:string>case reports</json:string><json:string>adnexal structures</json:string><json:string>follicular mucinosis</json:string><json:string>multiple lesions</json:string><json:string>skin biopsy specimen</json:string><json:string>collagen bundles</json:string><json:string>entire dermis</json:string><json:string>spitzoid melanomas</json:string><json:string>granulomatous inflammation</json:string><json:string>spitz nevus</json:string><json:string>clinical course</json:string><json:string>follicular eruption</json:string><json:string>significant difference</json:string><json:string>syringocystadenocarcinoma papilliferum</json:string><json:string>melanoma progression</json:string><json:string>university hospital</json:string><json:string>dermatofibrosarcoma protuberans</json:string><json:string>sentinel lymph node biopsy</json:string><json:string>borderline melanocytic proliferations</json:string><json:string>radiation therapy</json:string><json:string>diagnostic criteria</json:string><json:string>myoepithelial cells</json:string><json:string>metcalf department</json:string><json:string>louisiana state university health sciences center</json:string><json:string>blood cultures</json:string><json:string>infectious etiology</json:string><json:string>joseph mercy hospital</json:string><json:string>acute gvhd</json:string><json:string>wayne state university</json:string><json:string>rare entity</json:string><json:string>nonablative hsct</json:string><json:string>clinical practice</json:string><json:string>histopathologic examination</json:string><json:string>dermoid cyst</json:string><json:string>dermal edema</json:string><json:string>vellus hairs</json:string><json:string>cladophialophora bantiana</json:string><json:string>crowson departments</json:string><json:string>dermatology university</json:string><json:string>tissue eosinophilia</json:string><json:string>medical laboratories</json:string><json:string>dermal tumor</json:string><json:string>baylor college</json:string><json:string>anderson cancer center</json:string><json:string>histological patterns</json:string><json:string>rare mitotic figures</json:string><json:string>lichen simplex chronicus</json:string><json:string>upper dermis</json:string><json:string>immunohistochemical profile</json:string><json:string>benign trichoblastic neoplasms</json:string><json:string>cutaneous melanoma</json:string><json:string>lesional cells</json:string><json:string>results show</json:string><json:string>granular layer</json:string><json:string>mammary disease</json:string><json:string>primary cutaneous melanoma</json:string><json:string>skin tumors</json:string><json:string>basaloid neoplasm</json:string><json:string>keratinocyte differentiation</json:string><json:string>ductal differentiation</json:string><json:string>malignant lesions</json:string><json:string>nodular hidradenoma</json:string><json:string>lymphoid cells</json:string><json:string>pediatric population</json:string><json:string>initial biopsies</json:string><json:string>binder department</json:string><json:string>male infant</json:string><json:string>rare case</json:string><json:string>nerve sheath tumor</json:string><json:string>negative staining</json:string><json:string>interstitial granulomatous dermatitis</json:string><json:string>first report</json:string><json:string>wide excision</json:string><json:string>blood vessels</json:string><json:string>mast cells</json:string><json:string>definitive diagnosis</json:string><json:string>high index</json:string><json:string>month history</json:string><json:string>poor prognosis</json:string><json:string>systemic symptoms</json:string><json:string>such lesions</json:string><json:string>subcutaneous lymphoma</json:string><json:string>systemic plasmacytosis</json:string><json:string>peripheral blood</json:string><json:string>internal medicine</json:string><json:string>cutaneous lymphoma</json:string><json:string>complete resolution</json:string><json:string>mayo foundation</json:string><json:string>atypical fibroxanthoma</json:string><json:string>cellular atypia</json:string><json:string>primary cutaneous anaplastic</json:string><json:string>malignant lymphoma</json:string><json:string>osteoid metaplasia</json:string><json:string>literature review</json:string><json:string>nail unit</json:string><json:string>follicular differentiation</json:string><json:string>lymphatic endothelium</json:string><json:string>muscle weakness</json:string><json:string>barrett department</json:string><json:string>johns hopkins</json:string><json:string>ring finger</json:string><json:string>meningothelial elements</json:string><json:string>thrombogenic vasculopathy</json:string><json:string>dermoid cysts</json:string><json:string>growth pattern</json:string><json:string>incisional biopsy</json:string><json:string>granulomatous lymphangiitis</json:string><json:string>giant cells</json:string><json:string>karyorrhectic debris</json:string><json:string>further studies</json:string><json:string>rosalie elenitsas</json:string><json:string>cutaneous manifestation</json:string><json:string>sacral area</json:string><json:string>basaloid cells</json:string><json:string>erythema nodosum</json:string><json:string>klinefelter syndrome</json:string><json:string>peripheral palisading</json:string><json:string>mucin deposition</json:string><json:string>cutaneous mast cell disorders</json:string><json:string>chordoma cutis</json:string><json:string>rete ridges</json:string><json:string>recent studies</json:string><json:string>magro1 department</json:string><json:string>internal medicine2</json:string><json:string>fibrosing vasculitis</json:string><json:string>prognosis</json:string><json:string>clinic</json:string><json:string>diffuse</json:string><json:string>scalp</json:string><json:string>interface</json:string><json:string>cellular</json:string><json:string>edema</json:string><json:string>infection</json:string><json:string>deposition</json:string><json:string>recurrent</json:string><json:string>skin</json:string></teeft></keywords><author><json:item><name>Sam S. Dadras</name><affiliations><json:string>Departments of Pathology and Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA</json:string></affiliations></json:item><json:item><name>Bernhard Lange‐Asschenfeldt</name><affiliations><json:string>Departments of Pathology and Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA</json:string></affiliations></json:item><json:item><name>Alona Muzikansky</name><affiliations><json:string>Departments of Pathology and Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA</json:string></affiliations></json:item><json:item><name>Martin C. Mihm</name><affiliations><json:string>Departments of Pathology and Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA</json:string></affiliations></json:item><json:item><name>Michael Detmar</name><affiliations><json:string>Departments of Pathology and Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA</json:string></affiliations></json:item></author><articleId><json:string>CUP320BD</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>abstract</json:string></originalGenre><abstract>Cutaneous melanoma is a common and frequently lethal melanocytic neoplasm that can quickly metastasize to regional lymph nodes. Currently, prognosis is determined by measuring tumor thickness but more reliable markers for metastatic spread are urgently needed. We investigated whether the extent of tumor lymphangiogenesis can predict melanoma metastasis to sentinel lymph nodes (SLN). We quantified the extent of tumor lymphangiogenesis, as well as other factors, in excised primary tumors and in SLN biopsy samples from 45 patients with primary cutaneous melanoma. Primary melanomas from patients whose tumors had metastasized to the SLN, along with their metastastic foci, contained prominent hotspots of increased lymphatic vessel density, compared to non‐metastatic tumors. Multivariate risk analysis revealed that the lymphatic vascular area (LVA) of primary melanomas, an index of tumor lymphangiogenesis, was the most sensitive prognostic marker for SLN metastasis, and was even able to more accurately predict which tumors would become metastatic to SLN than measuring tumor thickness. The extent of tumor lymphangiogenesis is a highly sensitive (83%) and specific (89%) prognostic marker of lymph node metastasis. Assessment of lymphangiogenesis in primary melanomas may be a more effective approach than measuring tumor thickness in selecting patients with early metastatic disease for aggressive therapy.</abstract><qualityIndicators><score>7.4</score><pdfVersion>1.3</pdfVersion><pdfPageSize>595 x 782 pts</pdfPageSize><refBibsNative>false</refBibsNative><abstractCharCount>1416</abstractCharCount><pdfWordCount>46669</pdfWordCount><pdfCharCount>312307</pdfCharCount><pdfPageCount>53</pdfPageCount><abstractWordCount>200</abstractWordCount></qualityIndicators><title>Tumor Lymphangiogenesis Predicts Melanoma Metastasis to Sentinel Lymph Nodes</title><genre><json:string>abstract</json:string></genre><host><title>Journal of Cutaneous Pathology</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1600-0560</json:string></doi><issn><json:string>0303-6987</json:string></issn><eissn><json:string>1600-0560</json:string></eissn><publisherId><json:string>CUP</json:string></publisherId><volume>32</volume><issue>1</issue><pages><first>84</first><last>84</last><total>1</total></pages><genre><json:string>journal</json:string></genre></host><categories><wos><json:string>science</json:string><json:string>pathology</json:string><json:string>dermatology</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>dermatology & venereal diseases</json:string></scienceMetrix><inist><json:string>sciences appliquees, technologies et medecines</json:string><json:string>sciences biologiques et medicales</json:string><json:string>sciences medicales</json:string></inist></categories><publicationDate>2005</publicationDate><copyrightDate>2005</copyrightDate><doi><json:string>10.1111/j.0303-6987.2005.320bd.x</json:string></doi><id>1992B8650B68A71FB1F9952549225CFAEBE68181</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/1992B8650B68A71FB1F9952549225CFAEBE68181/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/1992B8650B68A71FB1F9952549225CFAEBE68181/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/1992B8650B68A71FB1F9952549225CFAEBE68181/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Tumor Lymphangiogenesis Predicts Melanoma Metastasis to Sentinel Lymph Nodes</title></titleStmt><publicationStmt><publisher>Blackwell Publishing Ltd/Inc.</publisher><pubPlace>Oxford, UK; Malden, USA</pubPlace><date type="published" when="2005-01"></date></publicationStmt><notesStmt><note type="content-type" subtype="abstract" source="abstract" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-HPN7T1Q2-R">abstract</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="abstract"><analytic><title level="a" type="main">Tumor Lymphangiogenesis Predicts Melanoma Metastasis to Sentinel Lymph Nodes</title><title level="a" type="short">Abstracts</title><author xml:id="author-0000"><persName><forename type="first">Sam S.</forename><surname>Dadras</surname></persName><affiliation>Departments of Pathology and Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA<address><country key="US"></country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Bernhard</forename><surname>Lange‐Asschenfeldt</surname></persName><affiliation>Departments of Pathology and Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA<address><country key="US"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Alona</forename><surname>Muzikansky</surname></persName><affiliation>Departments of Pathology and Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA<address><country key="US"></country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Martin C.</forename><surname>Mihm</surname></persName><affiliation>Departments of Pathology and Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA<address><country key="US"></country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Michael</forename><surname>Detmar</surname></persName><affiliation>Departments of Pathology and Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA<address><country key="US"></country></address></affiliation></author><idno type="istex">1992B8650B68A71FB1F9952549225CFAEBE68181</idno><idno type="DOI">10.1111/j.0303-6987.2005.320bd.x</idno><idno type="unit">CUP320BD</idno><idno type="toTypesetVersion">file:CUP.CUP320bd.pdf</idno></analytic><monogr><title level="j" type="main">Journal of Cutaneous Pathology</title><title level="j" type="alt">JOURNAL OF CUTANEOUS PATHOLOGY</title><idno type="pISSN">0303-6987</idno><idno type="eISSN">1600-0560</idno><idno type="book-DOI">10.1111/(ISSN)1600-0560</idno><idno type="book-part-DOI">10.1111/cup.2005.32.issue-1</idno><idno type="product">CUP</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">32</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="84">84</biblScope><biblScope unit="page" to="84">84</biblScope><biblScope unit="page-count">1</biblScope><publisher>Blackwell Publishing Ltd/Inc.</publisher><pubPlace>Oxford, UK; Malden, USA</pubPlace><date type="published" when="2005-01"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><p>Cutaneous melanoma is a common and frequently lethal melanocytic neoplasm that can quickly metastasize to regional lymph nodes. Currently, prognosis is determined by measuring tumor thickness but more reliable markers for metastatic spread are urgently needed. We investigated whether the extent of tumor lymphangiogenesis can predict melanoma metastasis to sentinel lymph nodes (SLN). We quantified the extent of tumor lymphangiogenesis, as well as other factors, in excised primary tumors and in SLN biopsy samples from 45 patients with primary cutaneous melanoma. Primary melanomas from patients whose tumors had metastasized to the SLN, along with their metastastic foci, contained prominent hotspots of increased lymphatic vessel density, compared to non‐metastatic tumors. Multivariate risk analysis revealed that the lymphatic vascular area (LVA) of primary melanomas, an index of tumor lymphangiogenesis, was the most sensitive prognostic marker for SLN metastasis, and was even able to more accurately predict which tumors would become metastatic to SLN than measuring tumor thickness. The extent of tumor lymphangiogenesis is a highly sensitive (83%) and specific (89%) prognostic marker of lymph node metastasis. Assessment of lymphangiogenesis in primary melanomas may be a more effective approach than measuring tumor thickness in selecting patients with early metastatic disease for aggressive therapy.</p></abstract><textClass><classCode scheme="tocHeading1">ASOD 41st meeting Abstracts</classCode></textClass><langUsage><language ident="EN"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/1992B8650B68A71FB1F9952549225CFAEBE68181/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley component found"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd/Inc.</publisherName><publisherLoc>Oxford, UK; Malden, USA</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-0560</doi><issn type="print">0303-6987</issn><issn type="electronic">1600-0560</issn><idGroup><id type="product" value="CUP"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="JOURNAL OF CUTANEOUS PATHOLOGY">Journal of Cutaneous Pathology</title></titleGroup></publicationMeta><publicationMeta level="part" position="01001"><doi origin="wiley">10.1111/cup.2005.32.issue-1</doi><numberingGroup><numbering type="journalVolume" number="32">32</numbering><numbering type="journalIssue" number="1">1</numbering></numberingGroup><coverDate startDate="2005-01">January 2005</coverDate></publicationMeta><publicationMeta level="unit" type="abstract" position="0008400" status="forIssue"><doi origin="wiley">10.1111/j.0303-6987.2005.320bd.x</doi><idGroup><id type="unit" value="CUP320BD"></id></idGroup><countGroup><count type="pageTotal" number="1"></count></countGroup><titleGroup><title type="tocHeading1">ASOD 41st meeting Abstracts</title></titleGroup><eventGroup><event type="firstOnline" date="2008-06-28"></event><event type="publishedOnlineFinalForm" date="2008-06-28"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.15 mode:FullText source:Header result:Header" date="2010-07-19"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-16"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-30"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="84">84</numbering><numbering type="pageLast" number="84">84</numbering></numberingGroup><linkGroup><link type="toTypesetVersion" href="file:CUP.CUP320bd.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="0"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="0"></count><count type="wordTotal" number="1835"></count><count type="linksPubMed" number="0"></count><count type="linksCrossRef" number="0"></count></countGroup><titleGroup><title type="main">Tumor Lymphangiogenesis Predicts Melanoma Metastasis to Sentinel Lymph Nodes</title><title type="shortAuthors"><b>Abstracts</b></title><title type="short"><b>Abstracts</b></title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>Sam S.</givenNames><familyName>Dadras</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>Bernhard</givenNames><familyName>Lange‐Asschenfeldt</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>Alona</givenNames><familyName>Muzikansky</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>Martin C.</givenNames><familyName>Mihm</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a1"><personName><givenNames>Michael</givenNames><familyName>Detmar</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="US"><unparsedAffiliation>Departments of Pathology and Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA</unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><p>Cutaneous melanoma is a common and frequently lethal melanocytic neoplasm that can quickly metastasize to regional lymph nodes. Currently, prognosis is determined by measuring tumor thickness but more reliable markers for metastatic spread are urgently needed. We investigated whether the extent of tumor lymphangiogenesis can predict melanoma metastasis to sentinel lymph nodes (SLN). We quantified the extent of tumor lymphangiogenesis, as well as other factors, in excised primary tumors and in SLN biopsy samples from 45 patients with primary cutaneous melanoma. Primary melanomas from patients whose tumors had metastasized to the SLN, along with their metastastic foci, contained prominent hotspots of increased lymphatic vessel density, compared to non‐metastatic tumors. Multivariate risk analysis revealed that the lymphatic vascular area (LVA) of primary melanomas, an index of tumor lymphangiogenesis, was the most sensitive prognostic marker for SLN metastasis, and was even able to more accurately predict which tumors would become metastatic to SLN than measuring tumor thickness. The extent of tumor lymphangiogenesis is a highly sensitive (83%) and specific (89%) prognostic marker of lymph node metastasis. Assessment of lymphangiogenesis in primary melanomas may be a more effective approach than measuring tumor thickness in selecting patients with early metastatic disease for aggressive therapy.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Tumor Lymphangiogenesis Predicts Melanoma Metastasis to Sentinel Lymph Nodes</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Abstracts</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Tumor Lymphangiogenesis Predicts Melanoma Metastasis to Sentinel Lymph Nodes</title></titleInfo><name type="personal"><namePart type="given">Sam S.</namePart><namePart type="family">Dadras</namePart><affiliation>Departments of Pathology and Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bernhard</namePart><namePart type="family">Lange‐Asschenfeldt</namePart><affiliation>Departments of Pathology and Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alona</namePart><namePart type="family">Muzikansky</namePart><affiliation>Departments of Pathology and Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Martin C.</namePart><namePart type="family">Mihm</namePart><affiliation>Departments of Pathology and Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michael</namePart><namePart type="family">Detmar</namePart><affiliation>Departments of Pathology and Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="abstract" displayLabel="abstract"></genre><originInfo><publisher>Blackwell Publishing Ltd/Inc.</publisher><place><placeTerm type="text">Oxford, UK; Malden, USA</placeTerm></place><dateIssued encoding="w3cdtf">2005-01</dateIssued><copyrightDate encoding="w3cdtf">2005</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="words">1835</extent></physicalDescription><abstract lang="en">Cutaneous melanoma is a common and frequently lethal melanocytic neoplasm that can quickly metastasize to regional lymph nodes. Currently, prognosis is determined by measuring tumor thickness but more reliable markers for metastatic spread are urgently needed. We investigated whether the extent of tumor lymphangiogenesis can predict melanoma metastasis to sentinel lymph nodes (SLN). We quantified the extent of tumor lymphangiogenesis, as well as other factors, in excised primary tumors and in SLN biopsy samples from 45 patients with primary cutaneous melanoma. Primary melanomas from patients whose tumors had metastasized to the SLN, along with their metastastic foci, contained prominent hotspots of increased lymphatic vessel density, compared to non‐metastatic tumors. Multivariate risk analysis revealed that the lymphatic vascular area (LVA) of primary melanomas, an index of tumor lymphangiogenesis, was the most sensitive prognostic marker for SLN metastasis, and was even able to more accurately predict which tumors would become metastatic to SLN than measuring tumor thickness. The extent of tumor lymphangiogenesis is a highly sensitive (83%) and specific (89%) prognostic marker of lymph node metastasis. Assessment of lymphangiogenesis in primary melanomas may be a more effective approach than measuring tumor thickness in selecting patients with early metastatic disease for aggressive therapy.</abstract><relatedItem type="host"><titleInfo><title>Journal of Cutaneous Pathology</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0303-6987</identifier><identifier type="eISSN">1600-0560</identifier><identifier type="DOI">10.1111/(ISSN)1600-0560</identifier><identifier type="PublisherID">CUP</identifier><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>84</start><end>84</end><total>1</total></extent></part></relatedItem><identifier type="istex">1992B8650B68A71FB1F9952549225CFAEBE68181</identifier><identifier type="DOI">10.1111/j.0303-6987.2005.320bd.x</identifier><identifier type="ArticleID">CUP320BD</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd/Inc.</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B92 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 000B92 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:1992B8650B68A71FB1F9952549225CFAEBE68181
|texte= Tumor Lymphangiogenesis Predicts Melanoma Metastasis to Sentinel Lymph Nodes
}}
| This area was generated with Dilib version V0.6.31. |  |