Species differences in the hepatotoxicity of coumarin: A comparison of rat and Mongolian gerbil
Identifieur interne : 000A88 ( Istex/Corpus ); précédent : 000A87; suivant : 000A89Species differences in the hepatotoxicity of coumarin: A comparison of rat and Mongolian gerbil
Auteurs : Julia H. Fentem ; Jeffrey R. Fry ; Norman W. ThomasSource :
- Toxicology [ 0300-483X ] ; 1992.
Abstract
The acute hepatic effects of coumarin (2H-1-benzopyran-2-one) in male Wistar rats and Mongolian gerbils has been compared. A single dose of coumarin (125 mg/kg, intraperitoneally (i.p.)) was hepatotoxic to rats within 24 h as assessed by its effects on a variety of hepatic parameters. Coumarin-induced hepatotoxicity was associated with significant increases in relative liver weight, plasma alanine and aspartate aminotransferase activities and hepatic non-protein sulphydryl groups. Cytochrome P-450 content and 7-ethoxycoumarin O-deethylase and glucose 6-phosphatase activities were significantly lower in coumarin-treated compared with control rats. Centrilobular necrosis was only observed in two out of six rats at this dose, but was present in all four coumarin-treated rats when the dose was increased to 150 mg/kg. In contrast to the effects observed in the rat, no evidence was found for coumarin-induced hepatotoxicity in gerbils following a single i.p. dose of 125 mg/kg. These data indicate that the gerbil is less sensitive to the hepatotoxic effects of coumarin than the rat.
Url:
DOI: 10.1016/0300-483X(92)90059-N
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Fentem</name><affiliation><mods:affiliation>Departments of Physiology and Pharmacology, Medical School Queen's Medical Centre, Nottingham NG7 2UH U.K.</mods:affiliation></affiliation></author><author><name sortKey="Fry, Jeffrey R" sort="Fry, Jeffrey R" uniqKey="Fry J" first="Jeffrey R." last="Fry">Jeffrey R. Fry</name><affiliation><mods:affiliation>Correspondence to: Jeffrey R. Fry.</mods:affiliation></affiliation><affiliation><mods:affiliation>Departments of Physiology and Pharmacology, Medical School Queen's Medical Centre, Nottingham NG7 2UH U.K.</mods:affiliation></affiliation></author><author><name sortKey="Thomas, Norman W" sort="Thomas, Norman W" uniqKey="Thomas N" first="Norman W." last="Thomas">Norman W. Thomas</name><affiliation><mods:affiliation>Human Morphology, Medical School, Queen's Medical Centre, Nottingham NG7 2UH U.K.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Toxicology</title><title level="j" type="abbrev">TOX</title><idno type="ISSN">0300-483X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1992">1992</date><biblScope unit="volume">71</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="129">129</biblScope><biblScope unit="page" to="136">136</biblScope></imprint><idno type="ISSN">0300-483X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0300-483X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The acute hepatic effects of coumarin (2H-1-benzopyran-2-one) in male Wistar rats and Mongolian gerbils has been compared. A single dose of coumarin (125 mg/kg, intraperitoneally (i.p.)) was hepatotoxic to rats within 24 h as assessed by its effects on a variety of hepatic parameters. Coumarin-induced hepatotoxicity was associated with significant increases in relative liver weight, plasma alanine and aspartate aminotransferase activities and hepatic non-protein sulphydryl groups. Cytochrome P-450 content and 7-ethoxycoumarin O-deethylase and glucose 6-phosphatase activities were significantly lower in coumarin-treated compared with control rats. Centrilobular necrosis was only observed in two out of six rats at this dose, but was present in all four coumarin-treated rats when the dose was increased to 150 mg/kg. In contrast to the effects observed in the rat, no evidence was found for coumarin-induced hepatotoxicity in gerbils following a single i.p. dose of 125 mg/kg. These data indicate that the gerbil is less sensitive to the hepatotoxic effects of coumarin than the rat.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>coumarin</json:string><json:string>gerbil</json:string><json:string>hepatic</json:string><json:string>hepatotoxicity</json:string><json:string>toxicity</json:string><json:string>centrilobular</json:string><json:string>mongolian</json:string><json:string>hepatotoxic</json:string><json:string>sulphydryl</json:string><json:string>relative liver weight</json:string><json:string>coumarin metabolism</json:string><json:string>centrilobular necrosis</json:string><json:string>single dose</json:string><json:string>control rats</json:string><json:string>hepatic parameters</json:string><json:string>liver microsomes</json:string><json:string>central vein</json:string><json:string>coumarin dose</json:string><json:string>mongolian gerbil</json:string><json:string>mongolian gerbils</json:string><json:string>pilot study</json:string><json:string>liver toxicity</json:string><json:string>coumarin hepatotoxicity</json:string><json:string>cellular infiltration</json:string><json:string>hepatic necrosis</json:string><json:string>histopathological changes</json:string><json:string>metabolism</json:string><json:string>necrosis</json:string><json:string>rat</json:string><json:string>biochemical investigations</json:string><json:string>publishers ireland</json:string><json:string>male wistar rats</json:string><json:string>hepatic sulphydryl groups</json:string><json:string>cytochrome content</json:string><json:string>small arrows</json:string><json:string>portal triad</json:string><json:string>histological examination</json:string><json:string>liver sections</json:string><json:string>glucose activities</json:string><json:string>centrilobular hepatic necrosis</json:string><json:string>single injection</json:string><json:string>present study</json:string><json:string>other rats</json:string><json:string>liver homogenates</json:string><json:string>alanine aminotransferase</json:string><json:string>food cosmet</json:string><json:string>aspartate aminotransferase</json:string><json:string>monooxygenase activities</json:string></teeft></keywords><author><json:item><name>Julia H. Fentem</name><affiliations><json:string>Departments of Physiology and Pharmacology, Medical School Queen's Medical Centre, Nottingham NG7 2UH U.K.</json:string></affiliations></json:item><json:item><name>Jeffrey R. Fry</name><affiliations><json:string>Correspondence to: Jeffrey R. Fry.</json:string><json:string>Departments of Physiology and Pharmacology, Medical School Queen's Medical Centre, Nottingham NG7 2UH U.K.</json:string></affiliations></json:item><json:item><name>Norman W. Thomas</name><affiliations><json:string>Human Morphology, Medical School, Queen's Medical Centre, Nottingham NG7 2UH U.K.</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Coumarin</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Gerbil</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Hepatotoxicity</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Rat</value></json:item></subject><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>The acute hepatic effects of coumarin (2H-1-benzopyran-2-one) in male Wistar rats and Mongolian gerbils has been compared. A single dose of coumarin (125 mg/kg, intraperitoneally (i.p.)) was hepatotoxic to rats within 24 h as assessed by its effects on a variety of hepatic parameters. Coumarin-induced hepatotoxicity was associated with significant increases in relative liver weight, plasma alanine and aspartate aminotransferase activities and hepatic non-protein sulphydryl groups. Cytochrome P-450 content and 7-ethoxycoumarin O-deethylase and glucose 6-phosphatase activities were significantly lower in coumarin-treated compared with control rats. Centrilobular necrosis was only observed in two out of six rats at this dose, but was present in all four coumarin-treated rats when the dose was increased to 150 mg/kg. In contrast to the effects observed in the rat, no evidence was found for coumarin-induced hepatotoxicity in gerbils following a single i.p. dose of 125 mg/kg. 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Fry.</affiliation><affiliation>Departments of Physiology and Pharmacology, Medical School Queen's Medical Centre, Nottingham NG7 2UH U.K.</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Norman W.</forename><surname>Thomas</surname></persName><affiliation>Human Morphology, Medical School, Queen's Medical Centre, Nottingham NG7 2UH U.K.</affiliation></author><idno type="istex">1771BC0BD3736467873EDCFDBC49373C274823F4</idno><idno type="DOI">10.1016/0300-483X(92)90059-N</idno><idno type="PII">0300-483X(92)90059-N</idno></analytic><monogr><title level="j">Toxicology</title><title level="j" type="abbrev">TOX</title><idno type="pISSN">0300-483X</idno><idno type="PII">S0300-483X(00)X0193-X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1992"></date><biblScope unit="volume">71</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="129">129</biblScope><biblScope unit="page" to="136">136</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1992</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>The acute hepatic effects of coumarin (2H-1-benzopyran-2-one) in male Wistar rats and Mongolian gerbils has been compared. A single dose of coumarin (125 mg/kg, intraperitoneally (i.p.)) was hepatotoxic to rats within 24 h as assessed by its effects on a variety of hepatic parameters. Coumarin-induced hepatotoxicity was associated with significant increases in relative liver weight, plasma alanine and aspartate aminotransferase activities and hepatic non-protein sulphydryl groups. Cytochrome P-450 content and 7-ethoxycoumarin O-deethylase and glucose 6-phosphatase activities were significantly lower in coumarin-treated compared with control rats. Centrilobular necrosis was only observed in two out of six rats at this dose, but was present in all four coumarin-treated rats when the dose was increased to 150 mg/kg. In contrast to the effects observed in the rat, no evidence was found for coumarin-induced hepatotoxicity in gerbils following a single i.p. dose of 125 mg/kg. These data indicate that the gerbil is less sensitive to the hepatotoxic effects of coumarin than the rat.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Coumarin</term></item><item><term>Gerbil</term></item><item><term>Hepatotoxicity</term></item><item><term>Rat</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1992">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/1771BC0BD3736467873EDCFDBC49373C274823F4/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>TOX</jid><aid>9290059N</aid><ce:pii>0300-483X(92)90059-N</ce:pii><ce:doi>10.1016/0300-483X(92)90059-N</ce:doi><ce:copyright type="unknown" year="1992"></ce:copyright></item-info><head><ce:dochead><ce:textfn>Short communication</ce:textfn></ce:dochead><ce:title>Species differences in the hepatotoxicity of coumarin: A comparison of rat and Mongolian gerbil</ce:title><ce:author-group><ce:author><ce:given-name>Julia H.</ce:given-name><ce:surname>Fentem</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Jeffrey R.</ce:given-name><ce:surname>Fry</ce:surname><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Norman W.</ce:given-name><ce:surname>Thomas</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Departments of Physiology and Pharmacology, Medical School Queen's Medical Centre, Nottingham NG7 2UH U.K.</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Human Morphology, Medical School, Queen's Medical Centre, Nottingham NG7 2UH U.K.</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Correspondence to: Jeffrey R. Fry.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="3" month="7" year="1991"></ce:date-received><ce:date-accepted day="23" month="10" year="1991"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>The acute hepatic effects of coumarin (2<ce:italic>H</ce:italic>-1-benzopyran-2-one) in male Wistar rats and Mongolian gerbils has been compared. A single dose of coumarin (125 mg/kg, intraperitoneally (i.p.)) was hepatotoxic to rats within 24 h as assessed by its effects on a variety of hepatic parameters. Coumarin-induced hepatotoxicity was associated with significant increases in relative liver weight, plasma alanine and aspartate aminotransferase activities and hepatic non-protein sulphydryl groups. Cytochrome <ce:italic>P</ce:italic>-450 content and 7-ethoxycoumarin <ce:italic>O</ce:italic>-deethylase and glucose 6-phosphatase activities were significantly lower in coumarin-treated compared with control rats. Centrilobular necrosis was only observed in two out of six rats at this dose, but was present in all four coumarin-treated rats when the dose was increased to 150 mg/kg. In contrast to the effects observed in the rat, no evidence was found for coumarin-induced hepatotoxicity in gerbils following a single i.p. dose of 125 mg/kg. These data indicate that the gerbil is less sensitive to the hepatotoxic effects of coumarin than the rat.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Coumarin</ce:text></ce:keyword><ce:keyword><ce:text>Gerbil</ce:text></ce:keyword><ce:keyword><ce:text>Hepatotoxicity</ce:text></ce:keyword><ce:keyword><ce:text>Rat</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Species differences in the hepatotoxicity of coumarin: A comparison of rat and Mongolian gerbil</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Species differences in the hepatotoxicity of coumarin: A comparison of rat and Mongolian gerbil</title></titleInfo><name type="personal"><namePart type="given">Julia H.</namePart><namePart type="family">Fentem</namePart><affiliation>Departments of Physiology and Pharmacology, Medical School Queen's Medical Centre, Nottingham NG7 2UH U.K.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jeffrey R.</namePart><namePart type="family">Fry</namePart><affiliation>Correspondence to: Jeffrey R. Fry.</affiliation><affiliation>Departments of Physiology and Pharmacology, Medical School Queen's Medical Centre, Nottingham NG7 2UH U.K.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Norman W.</namePart><namePart type="family">Thomas</namePart><affiliation>Human Morphology, Medical School, Queen's Medical Centre, Nottingham NG7 2UH U.K.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1992</dateIssued><copyrightDate encoding="w3cdtf">1992</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">The acute hepatic effects of coumarin (2H-1-benzopyran-2-one) in male Wistar rats and Mongolian gerbils has been compared. A single dose of coumarin (125 mg/kg, intraperitoneally (i.p.)) was hepatotoxic to rats within 24 h as assessed by its effects on a variety of hepatic parameters. Coumarin-induced hepatotoxicity was associated with significant increases in relative liver weight, plasma alanine and aspartate aminotransferase activities and hepatic non-protein sulphydryl groups. Cytochrome P-450 content and 7-ethoxycoumarin O-deethylase and glucose 6-phosphatase activities were significantly lower in coumarin-treated compared with control rats. Centrilobular necrosis was only observed in two out of six rats at this dose, but was present in all four coumarin-treated rats when the dose was increased to 150 mg/kg. In contrast to the effects observed in the rat, no evidence was found for coumarin-induced hepatotoxicity in gerbils following a single i.p. dose of 125 mg/kg. These data indicate that the gerbil is less sensitive to the hepatotoxic effects of coumarin than the rat.</abstract><note type="content">Section title: Short communication</note><subject><genre>Keywords</genre><topic>Coumarin</topic><topic>Gerbil</topic><topic>Hepatotoxicity</topic><topic>Rat</topic></subject><relatedItem type="host"><titleInfo><title>Toxicology</title></titleInfo><titleInfo type="abbreviated"><title>TOX</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">1992</dateIssued></originInfo><identifier type="ISSN">0300-483X</identifier><identifier type="PII">S0300-483X(00)X0193-X</identifier><part><date>1992</date><detail type="volume"><number>71</number><caption>vol.</caption></detail><detail type="issue"><number>1–2</number><caption>no.</caption></detail><extent unit="issue pages"><start>1</start><end>192</end></extent><extent unit="pages"><start>129</start><end>136</end></extent></part></relatedItem><identifier type="istex">1771BC0BD3736467873EDCFDBC49373C274823F4</identifier><identifier type="DOI">10.1016/0300-483X(92)90059-N</identifier><identifier type="PII">0300-483X(92)90059-N</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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