Is podoplanin expression associated with the proliferative activity of ameloblastomas?
Identifieur interne : 000A37 ( Istex/Corpus ); précédent : 000A36; suivant : 000A38Is podoplanin expression associated with the proliferative activity of ameloblastomas?
Auteurs : Kc Tjioe ; Dt Oliveira ; Ct Soares ; Jrp Lauris ; Jh DamanteSource :
- Oral Diseases [ 1354-523X ] ; 2012-10.
Abstract
Oral Diseases (2012) 18, 673–679
Url:
DOI: 10.1111/j.1601-0825.2012.01924.x
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ISTEX:1634391F1D69B729D26983A8B1312791680051D1Le document en format XML
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Soares</name><affiliation><mods:affiliation>Department of Pathology, Lauro de Souza Lima Institute, Bauru, São Paulo</mods:affiliation></affiliation></author><author><name sortKey="Lauris, Jrp" sort="Lauris, Jrp" uniqKey="Lauris J" first="Jrp" last="Lauris">Jrp Lauris</name><affiliation><mods:affiliation>Department of Community Dentistry, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Damante, Jh" sort="Damante, Jh" uniqKey="Damante J" first="Jh" last="Damante">Jh Damante</name><affiliation><mods:affiliation>Department of Stomatology, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Oral Diseases</title><title level="j" type="alt">ORAL DISEASES</title><idno type="ISSN">1354-523X</idno><idno type="eISSN">1601-0825</idno><imprint><biblScope 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expression</json:string><json:string>cytoplasmic</json:string><json:string>epithelium</json:string><json:string>zustin</json:string><json:string>proliferative</json:string><json:string>ameloblastoma</json:string><json:string>follicle</json:string><json:string>sawa</json:string><json:string>bauru</json:string><json:string>immunohistochemical</json:string><json:string>odontogenic epithelium</json:string><json:string>paulo</json:string><json:string>immunostaining</json:string><json:string>proliferative activity</json:string><json:string>ameloblast</json:string><json:string>tjioe</json:string><json:string>imaizumi</json:string><json:string>unerupted</json:string><json:string>lamina</json:string><json:string>cytoplasmic expression</json:string><json:string>odontogenic epithelial cells</json:string><json:string>unerupted teeth</json:string><json:string>membranous expression</json:string><json:string>dental lamina</json:string><json:string>epithelial odontogenic cells</json:string><json:string>dental follicle</json:string><json:string>epithelial islands</json:string><json:string>positive cells</json:string><json:string>bauru school</json:string><json:string>mitotic activity</json:string><json:string>odontogenic tumors</json:string><json:string>dental follicles</json:string><json:string>central cells</json:string><json:string>peripheral cells</json:string><json:string>membranous podoplanin expression</json:string><json:string>enamel epithelium</json:string><json:string>remnant</json:string><json:string>odontogenic cells</json:string><json:string>granular cells</json:string><json:string>epithelial cells</json:string><json:string>oral pathol</json:string><json:string>immunohistochemical reactivity</json:string><json:string>wilcoxon test</json:string><json:string>local invasion</json:string></teeft></keywords><author><json:item><name>KC Tjioe</name><affiliations><json:string>Department of Stomatology, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo</json:string></affiliations></json:item><json:item><name>DT Oliveira</name><affiliations><json:string>Department of Stomatology, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo</json:string></affiliations></json:item><json:item><name>CT Soares</name><affiliations><json:string>Department of Pathology, Lauro de Souza Lima Institute, Bauru, São Paulo</json:string></affiliations></json:item><json:item><name>JRP Lauris</name><affiliations><json:string>Department of Community Dentistry, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil</json:string></affiliations></json:item><json:item><name>JH Damante</name><affiliations><json:string>Department of Stomatology, Bauru School of Dentistry, University of São Paulo, Bauru, São 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type="short">Podoplanin expression in ameloblastomas</title><author xml:id="author-0000"><persName><forename type="first">KC</forename><surname>Tjioe</surname></persName><affiliation>Department of Stomatology, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo</affiliation></author><author xml:id="author-0001"><persName><forename type="first">DT</forename><surname>Oliveira</surname></persName><affiliation>Department of Stomatology, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo</affiliation></author><author xml:id="author-0002"><persName><forename type="first">CT</forename><surname>Soares</surname></persName><affiliation>Department of Pathology, Lauro de Souza Lima Institute, Bauru, São Paulo</affiliation></author><author xml:id="author-0003"><persName><forename type="first">JRP</forename><surname>Lauris</surname></persName><affiliation>Department of Community Dentistry, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil<address><country key="BR"></country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">JH</forename><surname>Damante</surname></persName><affiliation>Department of Stomatology, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo</affiliation></author><idno type="istex">1634391F1D69B729D26983A8B1312791680051D1</idno><idno type="DOI">10.1111/j.1601-0825.2012.01924.x</idno><idno type="unit">ODI1924</idno><idno type="toTypesetVersion">file:ODI.ODI1924.pdf</idno></analytic><monogr><title level="j" type="main">Oral Diseases</title><title level="j" type="alt">ORAL DISEASES</title><idno type="pISSN">1354-523X</idno><idno type="eISSN">1601-0825</idno><idno type="book-DOI">10.1111/(ISSN)1601-0825</idno><idno type="book-part-DOI">10.1111/odi.2012.18.issue-7</idno><idno type="product">ODI</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">18</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="673">673</biblScope><biblScope unit="page" to="679">679</biblScope><biblScope unit="page-count">7</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2012-10"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><p><hi rend="italic">Oral Diseases</hi> (2012) <hi rend="bold">18</hi>, 673–679</p><p><hi rend="bold">Objectives: </hi> The aim of this study was to investigate the relationship between podoplanin expression and proliferative activity of ameloblastomas and remnants of the odontogenic epithelium from dental follicles (DF) of unerupted teeth.</p><p><hi rend="bold">Subjects and methods: </hi> Thirty‐three paraffin‐embedded ameloblastomas and thirty‐two DF obtained of unerupted teeth were analyzed by immunohistochemistry using anti‐human podoplanin and anti‐Ki‐67 antibodies. Podoplanin expression in odontogenic epithelial cells was evaluated using a scoring method, and the Ki‐67 labeling index was determined by the percentage of positive odontogenic cells.</p><p><hi rend="bold">Results: </hi> All ameloblastomas displayed podoplanin expression in ameloblast‐like cells of the epithelial islands. Membranous expression of podoplanin in ameloblastomas was stronger than in the remnants of odontogenic epithelium (<hi rend="italic">P</hi> = 0.001). Statistically significant difference was observed between the cytoplasmic and membranous expression of podoplanin in the remnants of odontogenic epithelium (<hi rend="italic">P</hi> = 0.001). The index of epithelial odontogenic proliferative activity, verified by Ki‐67 expression, was higher in ameloblastomas <hi rend="italic">vs</hi> remnants of odontogenic epithelium (<hi rend="italic">P</hi> < 0.001). No statistically significant correlation was identified between podoplanin and the cellular odontogenic proliferative activity in ameloblastomas and DF (<hi rend="italic">P</hi> > 0.05).</p><p><hi rend="bold">Conclusions: </hi> These results provide evidence that there is no connection between podoplanin immunostaining and odontogenic cellular proliferative activity and suggest a role for membranous podoplanin expression in the local invasion of ameloblastomas.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">ameloblastoma</term><term xml:id="k2">podoplanin</term><term xml:id="k3">dental follicle</term><term xml:id="k4">odontogenic tumor</term><term xml:id="k5">Ki‐67</term></keywords><classCode scheme="tocHeading1">Original Articles</classCode><classCode scheme="articleCategory">ORIGINAL ARTICLE</classCode></textClass><langUsage><language ident="EN"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/1634391F1D69B729D26983A8B1312791680051D1/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1601-0825</doi><issn type="print">1354-523X</issn><issn type="electronic">1601-0825</issn><idGroup><id type="product" value="ODI"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="ORAL DISEASES">Oral Diseases</title></titleGroup></publicationMeta><publicationMeta level="part" position="10107"><doi origin="wiley">10.1111/odi.2012.18.issue-7</doi><numberingGroup><numbering type="journalVolume" number="18">18</numbering><numbering type="journalIssue" number="7">7</numbering></numberingGroup><coverDate startDate="2012-10">October 2012</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="8" status="forIssue"><doi origin="wiley">10.1111/j.1601-0825.2012.01924.x</doi><idGroup><id type="unit" value="ODI1924"></id></idGroup><countGroup><count type="pageTotal" number="7"></count></countGroup><titleGroup><title type="tocHeading1">Original Articles</title><title type="articleCategory">ORIGINAL ARTICLE</title></titleGroup><copyright>© 2012 John Wiley & Sons A/S</copyright><eventGroup><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:3.1.6 mode:FullText" date="2012-09-11"></event><event type="publishedOnlineAccepted" date="2012-02-28"></event><event type="publishedOnlineEarlyUnpaginated" date="2012-03-23"></event><event type="firstOnline" date="2012-03-23"></event><event type="publishedOnlineFinalForm" date="2012-09-11"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-06"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.3.4 mode:FullText" date="2015-02-25"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="673">673</numbering><numbering type="pageLast" number="679">679</numbering></numberingGroup><correspondenceTo>Kellen Cristine Tjioe, DDS, MSc, PhD Student, Department of Stomatology, Area of Pathology, Bauru School of Dentistry, Alameda Octávio Pinheiro Brisolla, 9‐75 CEP 17012‐901, Bauru, São Paulo, Brazil. Tel: 00 55 21 14 32358251, Fax: 00 55 21 14 32234679, E‐mail: <email>kellentjioe@yahoo.com.br</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:ODI.ODI1924.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received 4 December 2011; revised 8 February 2012; accepted 20 February 2012</unparsedEditorialHistory><countGroup><count type="figureTotal" number="3"></count><count type="tableTotal" number="4"></count></countGroup><titleGroup><title type="main">Is podoplanin expression associated with the proliferative activity of ameloblastomas?</title><title type="shortAuthors">KC Tjioe <i>et al</i></title><title type="short"><b>Podoplanin expression in ameloblastomas</b></title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>KC</givenNames><familyName>Tjioe</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>DT</givenNames><familyName>Oliveira</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a2"><personName><givenNames>CT</givenNames><familyName>Soares</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a3"><personName><givenNames>JRP</givenNames><familyName>Lauris</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a1"><personName><givenNames>JH</givenNames><familyName>Damante</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>Department of Stomatology, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo</unparsedAffiliation></affiliation><affiliation xml:id="a2"><unparsedAffiliation>Department of Pathology, Lauro de Souza Lima Institute, Bauru, São Paulo</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="BR"><unparsedAffiliation>Department of Community Dentistry, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">ameloblastoma</keyword><keyword xml:id="k2">podoplanin</keyword><keyword xml:id="k3">dental follicle</keyword><keyword xml:id="k4">odontogenic tumor</keyword><keyword xml:id="k5">Ki‐67</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p><i>Oral Diseases</i> (2012) <b>18</b>, 673–679</p><p><b>Objectives: </b> The aim of this study was to investigate the relationship between podoplanin expression and proliferative activity of ameloblastomas and remnants of the odontogenic epithelium from dental follicles (DF) of unerupted teeth.</p><p><b>Subjects and methods: </b> Thirty‐three paraffin‐embedded ameloblastomas and thirty‐two DF obtained of unerupted teeth were analyzed by immunohistochemistry using anti‐human podoplanin and anti‐Ki‐67 antibodies. Podoplanin expression in odontogenic epithelial cells was evaluated using a scoring method, and the Ki‐67 labeling index was determined by the percentage of positive odontogenic cells.</p><p><b>Results: </b> All ameloblastomas displayed podoplanin expression in ameloblast‐like cells of the epithelial islands. Membranous expression of podoplanin in ameloblastomas was stronger than in the remnants of odontogenic epithelium (<i>P</i> = 0.001). Statistically significant difference was observed between the cytoplasmic and membranous expression of podoplanin in the remnants of odontogenic epithelium (<i>P</i> = 0.001). The index of epithelial odontogenic proliferative activity, verified by Ki‐67 expression, was higher in ameloblastomas <i>vs</i> remnants of odontogenic epithelium (<i>P</i> < 0.001). No statistically significant correlation was identified between podoplanin and the cellular odontogenic proliferative activity in ameloblastomas and DF (<i>P</i> > 0.05).</p><p><b>Conclusions: </b> These results provide evidence that there is no connection between podoplanin immunostaining and odontogenic cellular proliferative activity and suggest a role for membranous podoplanin expression in the local invasion of ameloblastomas.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Is podoplanin expression associated with the proliferative activity of ameloblastomas?</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Podoplanin expression in ameloblastomas</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Is podoplanin expression associated with the proliferative activity of ameloblastomas?</title></titleInfo><name type="personal"><namePart type="given">KC</namePart><namePart type="family">Tjioe</namePart><affiliation>Department of Stomatology, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DT</namePart><namePart type="family">Oliveira</namePart><affiliation>Department of Stomatology, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CT</namePart><namePart type="family">Soares</namePart><affiliation>Department of Pathology, Lauro de Souza Lima Institute, Bauru, São Paulo</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JRP</namePart><namePart type="family">Lauris</namePart><affiliation>Department of Community Dentistry, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JH</namePart><namePart type="family">Damante</namePart><affiliation>Department of Stomatology, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2012-10</dateIssued><edition>Received 4 December 2011; revised 8 February 2012; accepted 20 February 2012</edition><copyrightDate encoding="w3cdtf">2012</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">4</extent></physicalDescription><abstract>Oral Diseases (2012) 18, 673–679</abstract><abstract>Objectives: The aim of this study was to investigate the relationship between podoplanin expression and proliferative activity of ameloblastomas and remnants of the odontogenic epithelium from dental follicles (DF) of unerupted teeth.</abstract><abstract>Subjects and methods: Thirty‐three paraffin‐embedded ameloblastomas and thirty‐two DF obtained of unerupted teeth were analyzed by immunohistochemistry using anti‐human podoplanin and anti‐Ki‐67 antibodies. Podoplanin expression in odontogenic epithelial cells was evaluated using a scoring method, and the Ki‐67 labeling index was determined by the percentage of positive odontogenic cells.</abstract><abstract>Results: All ameloblastomas displayed podoplanin expression in ameloblast‐like cells of the epithelial islands. Membranous expression of podoplanin in ameloblastomas was stronger than in the remnants of odontogenic epithelium (P = 0.001). Statistically significant difference was observed between the cytoplasmic and membranous expression of podoplanin in the remnants of odontogenic epithelium (P = 0.001). The index of epithelial odontogenic proliferative activity, verified by Ki‐67 expression, was higher in ameloblastomas vs remnants of odontogenic epithelium (P < 0.001). No statistically significant correlation was identified between podoplanin and the cellular odontogenic proliferative activity in ameloblastomas and DF (P > 0.05).</abstract><abstract>Conclusions: These results provide evidence that there is no connection between podoplanin immunostaining and odontogenic cellular proliferative activity and suggest a role for membranous podoplanin expression in the local invasion of ameloblastomas.</abstract><subject lang="en"><genre>keywords</genre><topic>ameloblastoma</topic><topic>podoplanin</topic><topic>dental follicle</topic><topic>odontogenic tumor</topic><topic>Ki‐67</topic></subject><relatedItem type="host"><titleInfo><title>Oral Diseases</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>ORIGINAL ARTICLE</topic></subject><identifier type="ISSN">1354-523X</identifier><identifier type="eISSN">1601-0825</identifier><identifier type="DOI">10.1111/(ISSN)1601-0825</identifier><identifier type="PublisherID">ODI</identifier><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>18</number></detail><detail type="issue"><caption>no.</caption><number>7</number></detail><extent unit="pages"><start>673</start><end>679</end><total>7</total></extent></part></relatedItem><identifier type="istex">1634391F1D69B729D26983A8B1312791680051D1</identifier><identifier type="DOI">10.1111/j.1601-0825.2012.01924.x</identifier><identifier type="ArticleID">ODI1924</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2012 John Wiley & Sons A/S</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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