Common toxicity criteria: version 2.0. an improved reference for grading the acute effects of cancer treatment: impact on radiotherapy
Identifieur interne : 000161 ( Istex/Corpus ); précédent : 000160; suivant : 000162Common toxicity criteria: version 2.0. an improved reference for grading the acute effects of cancer treatment: impact on radiotherapy
Auteurs : Andy Trotti ; Roger Byhardt ; Joanne Stetz ; Clement Gwede ; Benjamin Corn ; Karen Fu ; Leonard Gunderson ; Beryl Mccormick ; Mitchell Morris ; Tyvin Rich ; William Shipley ; Walter CurranSource :
- International Journal of Radiation Oncology, Biology, Physics [ 0360-3016 ] ; 2000.
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Abstract
In 1997, the National Cancer Institute (NCI) led an effort to revise and expand the Common Toxicity Criteria (CTC) with the goal of integrating systemic agent, radiation, and surgical criteria into a comprehensive and standardized system. Representatives from the Radiation Therapy Oncology Group (RTOG) participated in this process in an effort to improve acute radiation related criteria and to achieve better clarity and consistency among modalities. CTC v. 2.0 replaces the previous NCI CTC and the RTOG Acute Radiation Morbidity Scoring Criteria and includes more than 260 individual adverse events with more than 100 of these applicable to acute radiation effects. One of the advantages of the revised criteria for radiation oncology is the opportunity to grade acute radiation effects not adequately captured under the previous RTOG system. A pilot study conducted by the RTOG indicated the new criteria are indeed more comprehensive and were preferred by research associates. CTC v. 2.0 represents an improvement in the evaluation and grading of acute toxicity for all modalities.
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DOI: 10.1016/S0360-3016(99)00559-3
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ISTEX:036669930279CBD2A5ADDF9B4CF4F8CB7D9A7C21Le document en format XML
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Lee Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612-9497</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: trotti@moffitt.usf.edu</mods:affiliation></affiliation></author><author><name sortKey="Byhardt, Roger" sort="Byhardt, Roger" uniqKey="Byhardt R" first="Roger" last="Byhardt">Roger Byhardt</name><affiliation><mods:affiliation>Medical College of Wisconsin, Milwaukee, WI, USA</mods:affiliation></affiliation></author><author><name sortKey="Stetz, Joanne" sort="Stetz, Joanne" uniqKey="Stetz J" first="Joanne" last="Stetz">Joanne Stetz</name><affiliation><mods:affiliation>RTOG Headquarters, Philadelphia, PA, USA</mods:affiliation></affiliation></author><author><name sortKey="Gwede, Clement" sort="Gwede, Clement" uniqKey="Gwede C" first="Clement" last="Gwede">Clement Gwede</name><affiliation><mods:affiliation>H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL, USA</mods:affiliation></affiliation></author><author><name sortKey="Corn, Benjamin" sort="Corn, Benjamin" uniqKey="Corn B" first="Benjamin" last="Corn">Benjamin Corn</name><affiliation><mods:affiliation>Thomas Jefferson University Hospital/Bodine Cancer Treatment Center, Philadelphia, PA, USA</mods:affiliation></affiliation></author><author><name sortKey="Fu, Karen" sort="Fu, Karen" uniqKey="Fu K" first="Karen" last="Fu">Karen Fu</name><affiliation><mods:affiliation>University of California San Franciso, San Francisco, CA, USA</mods:affiliation></affiliation></author><author><name sortKey="Gunderson, Leonard" sort="Gunderson, Leonard" uniqKey="Gunderson L" first="Leonard" last="Gunderson">Leonard Gunderson</name><affiliation><mods:affiliation>Mayo Clinic, Medical School, Rochester, MN, USA</mods:affiliation></affiliation></author><author><name sortKey="Mccormick, Beryl" sort="Mccormick, Beryl" uniqKey="Mccormick B" first="Beryl" last="Mccormick">Beryl Mccormick</name><affiliation><mods:affiliation>Memorial Sloan-Kettering, Cornell Medical College, New York, NY, USA</mods:affiliation></affiliation></author><author><name sortKey="Morris, Mitchell" sort="Morris, Mitchell" uniqKey="Morris M" first="Mitchell" last="Morris">Mitchell Morris</name><affiliation><mods:affiliation>University of Texas M. D. Anderson Cancer Center, Houston, TX, USA</mods:affiliation></affiliation></author><author><name sortKey="Rich, Tyvin" sort="Rich, Tyvin" uniqKey="Rich T" first="Tyvin" last="Rich">Tyvin Rich</name><affiliation><mods:affiliation>University of Virginia Science Center, Charlottesville, VA, USA</mods:affiliation></affiliation></author><author><name sortKey="Shipley, William" sort="Shipley, William" uniqKey="Shipley W" first="William" last="Shipley">William Shipley</name><affiliation><mods:affiliation>Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA</mods:affiliation></affiliation></author><author><name sortKey="Curran, Walter" sort="Curran, Walter" uniqKey="Curran W" first="Walter" last="Curran">Walter Curran</name><affiliation><mods:affiliation>Thomas Jefferson University Hospital/Bodine Cancer Treatment Center, Philadelphia, PA, USA</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:036669930279CBD2A5ADDF9B4CF4F8CB7D9A7C21</idno><date when="2000" year="2000">2000</date><idno type="doi">10.1016/S0360-3016(99)00559-3</idno><idno type="url">https://api.istex.fr/document/036669930279CBD2A5ADDF9B4CF4F8CB7D9A7C21/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000161</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000161</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Common toxicity criteria: version 2.0. an improved reference for grading the acute effects of cancer treatment: impact on radiotherapy</title><author><name sortKey="Trotti, Andy" sort="Trotti, Andy" uniqKey="Trotti A" first="Andy" last="Trotti">Andy Trotti</name><affiliation><mods:affiliation>H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Reprint requests to: Dr. Andy Trotti, Division of Radiation Oncology, H. Lee Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612-9497</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: trotti@moffitt.usf.edu</mods:affiliation></affiliation></author><author><name sortKey="Byhardt, Roger" sort="Byhardt, Roger" uniqKey="Byhardt R" first="Roger" last="Byhardt">Roger Byhardt</name><affiliation><mods:affiliation>Medical College of Wisconsin, Milwaukee, WI, USA</mods:affiliation></affiliation></author><author><name sortKey="Stetz, Joanne" sort="Stetz, Joanne" uniqKey="Stetz J" first="Joanne" last="Stetz">Joanne Stetz</name><affiliation><mods:affiliation>RTOG Headquarters, Philadelphia, PA, USA</mods:affiliation></affiliation></author><author><name sortKey="Gwede, Clement" sort="Gwede, Clement" uniqKey="Gwede C" first="Clement" last="Gwede">Clement Gwede</name><affiliation><mods:affiliation>H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL, USA</mods:affiliation></affiliation></author><author><name sortKey="Corn, Benjamin" sort="Corn, Benjamin" uniqKey="Corn B" first="Benjamin" last="Corn">Benjamin Corn</name><affiliation><mods:affiliation>Thomas Jefferson University Hospital/Bodine Cancer Treatment Center, Philadelphia, PA, USA</mods:affiliation></affiliation></author><author><name sortKey="Fu, Karen" sort="Fu, Karen" uniqKey="Fu K" first="Karen" last="Fu">Karen Fu</name><affiliation><mods:affiliation>University of California San Franciso, San Francisco, CA, USA</mods:affiliation></affiliation></author><author><name sortKey="Gunderson, Leonard" sort="Gunderson, Leonard" uniqKey="Gunderson L" first="Leonard" last="Gunderson">Leonard Gunderson</name><affiliation><mods:affiliation>Mayo Clinic, Medical School, Rochester, MN, USA</mods:affiliation></affiliation></author><author><name sortKey="Mccormick, Beryl" sort="Mccormick, Beryl" uniqKey="Mccormick B" first="Beryl" last="Mccormick">Beryl Mccormick</name><affiliation><mods:affiliation>Memorial Sloan-Kettering, Cornell Medical College, New York, NY, USA</mods:affiliation></affiliation></author><author><name sortKey="Morris, Mitchell" sort="Morris, Mitchell" uniqKey="Morris M" first="Mitchell" last="Morris">Mitchell Morris</name><affiliation><mods:affiliation>University of Texas M. D. Anderson Cancer Center, Houston, TX, USA</mods:affiliation></affiliation></author><author><name sortKey="Rich, Tyvin" sort="Rich, Tyvin" uniqKey="Rich T" first="Tyvin" last="Rich">Tyvin Rich</name><affiliation><mods:affiliation>University of Virginia Science Center, Charlottesville, VA, USA</mods:affiliation></affiliation></author><author><name sortKey="Shipley, William" sort="Shipley, William" uniqKey="Shipley W" first="William" last="Shipley">William Shipley</name><affiliation><mods:affiliation>Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA</mods:affiliation></affiliation></author><author><name sortKey="Curran, Walter" sort="Curran, Walter" uniqKey="Curran W" first="Walter" last="Curran">Walter Curran</name><affiliation><mods:affiliation>Thomas Jefferson University Hospital/Bodine Cancer Treatment Center, Philadelphia, PA, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">International Journal of Radiation Oncology, Biology, Physics</title><title level="j" type="abbrev">ROB</title><idno type="ISSN">0360-3016</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2000">2000</date><biblScope unit="volume">47</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="13">13</biblScope><biblScope unit="page" to="47">47</biblScope></imprint><idno type="ISSN">0360-3016</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0360-3016</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute effects</term><term>Adverse events</term><term>Chemoradiation</term><term>Chemotherapy</term><term>Combined modality</term><term>Complications</term><term>Morbidity</term><term>Normal tissue effects</term><term>Radiation</term><term>Side effects</term><term>Toxicity</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In 1997, the National Cancer Institute (NCI) led an effort to revise and expand the Common Toxicity Criteria (CTC) with the goal of integrating systemic agent, radiation, and surgical criteria into a comprehensive and standardized system. Representatives from the Radiation Therapy Oncology Group (RTOG) participated in this process in an effort to improve acute radiation related criteria and to achieve better clarity and consistency among modalities. CTC v. 2.0 replaces the previous NCI CTC and the RTOG Acute Radiation Morbidity Scoring Criteria and includes more than 260 individual adverse events with more than 100 of these applicable to acute radiation effects. One of the advantages of the revised criteria for radiation oncology is the opportunity to grade acute radiation effects not adequately captured under the previous RTOG system. A pilot study conducted by the RTOG indicated the new criteria are indeed more comprehensive and were preferred by research associates. 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category</json:string><json:string>baseline value</json:string></teeft></keywords><author><json:item><name>Andy Trotti M.D.</name><affiliations><json:string>H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL, USA</json:string><json:string>Reprint requests to: Dr. Andy Trotti, Division of Radiation Oncology, H. Lee Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612-9497</json:string><json:string>E-mail: trotti@moffitt.usf.edu</json:string></affiliations></json:item><json:item><name>Roger Byhardt M.D.</name><affiliations><json:string>Medical College of Wisconsin, Milwaukee, WI, USA</json:string></affiliations></json:item><json:item><name>Joanne Stetz R.N.</name><affiliations><json:string>RTOG Headquarters, Philadelphia, PA, USA</json:string></affiliations></json:item><json:item><name>Clement Gwede R.N.</name><affiliations><json:string>H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL, USA</json:string></affiliations></json:item><json:item><name>Benjamin Corn M.D.</name><affiliations><json:string>Thomas Jefferson University Hospital/Bodine Cancer Treatment Center, Philadelphia, PA, USA</json:string></affiliations></json:item><json:item><name>Karen Fu M.D.</name><affiliations><json:string>University of California San Franciso, San Francisco, CA, USA</json:string></affiliations></json:item><json:item><name>Leonard Gunderson M.D.</name><affiliations><json:string>Mayo Clinic, Medical School, Rochester, MN, USA</json:string></affiliations></json:item><json:item><name>Beryl McCormick M.D.</name><affiliations><json:string>Memorial Sloan-Kettering, Cornell Medical College, New York, NY, USA</json:string></affiliations></json:item><json:item><name>Mitchell Morris∫</name><affiliations><json:string>University of Texas M. D. Anderson Cancer Center, Houston, TX, USA</json:string></affiliations></json:item><json:item><name>Tyvin Rich M.D.</name><affiliations><json:string>University of Virginia Science Center, Charlottesville, VA, USA</json:string></affiliations></json:item><json:item><name>William Shipley M.D.</name><affiliations><json:string>Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA</json:string></affiliations></json:item><json:item><name>Walter Curran M.D.</name><affiliations><json:string>Thomas Jefferson University Hospital/Bodine Cancer Treatment Center, Philadelphia, PA, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>CRITICAL REVIEW</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Toxicity</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Acute effects</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Side effects</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Adverse events</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Morbidity</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Complications</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Normal tissue effects</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Radiation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Chemotherapy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Chemoradiation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Combined modality</value></json:item></subject><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>In 1997, the National Cancer Institute (NCI) led an effort to revise and expand the Common Toxicity Criteria (CTC) with the goal of integrating systemic agent, radiation, and surgical criteria into a comprehensive and standardized system. Representatives from the Radiation Therapy Oncology Group (RTOG) participated in this process in an effort to improve acute radiation related criteria and to achieve better clarity and consistency among modalities. CTC v. 2.0 replaces the previous NCI CTC and the RTOG Acute Radiation Morbidity Scoring Criteria and includes more than 260 individual adverse events with more than 100 of these applicable to acute radiation effects. One of the advantages of the revised criteria for radiation oncology is the opportunity to grade acute radiation effects not adequately captured under the previous RTOG system. A pilot study conducted by the RTOG indicated the new criteria are indeed more comprehensive and were preferred by research associates. 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Lee Moffitt Cancer Center, University of South Florida, Tampa, FL, USA</affiliation><affiliation>Reprint requests to: Dr. Andy Trotti, Division of Radiation Oncology, H. Lee Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612-9497</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Roger</forename><surname>Byhardt</surname></persName><roleName type="degree">M.D.</roleName><affiliation>Medical College of Wisconsin, Milwaukee, WI, USA</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Joanne</forename><surname>Stetz</surname></persName><roleName type="degree">R.N.</roleName><affiliation>RTOG Headquarters, Philadelphia, PA, USA</affiliation></author><author xml:id="author-0003"><persName><forename type="first">Clement</forename><surname>Gwede</surname></persName><roleName type="degree">R.N.</roleName><note type="biography">M.P.H.</note><affiliation>M.P.H.</affiliation><affiliation>H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL, USA</affiliation></author><author xml:id="author-0004"><persName><forename type="first">Benjamin</forename><surname>Corn</surname></persName><roleName type="degree">M.D.</roleName><affiliation>Thomas Jefferson University Hospital/Bodine Cancer Treatment Center, Philadelphia, PA, USA</affiliation></author><author xml:id="author-0005"><persName><forename type="first">Karen</forename><surname>Fu</surname></persName><roleName type="degree">M.D.</roleName><affiliation>University of California San Franciso, San Francisco, CA, USA</affiliation></author><author xml:id="author-0006"><persName><forename type="first">Leonard</forename><surname>Gunderson</surname></persName><roleName type="degree">M.D.</roleName><affiliation>Mayo Clinic, Medical School, Rochester, MN, USA</affiliation></author><author xml:id="author-0007"><persName><forename type="first">Beryl</forename><surname>McCormick</surname></persName><roleName type="degree">M.D.</roleName><affiliation>Memorial Sloan-Kettering, Cornell Medical College, New York, NY, USA</affiliation></author><author xml:id="author-0008"><persName><forename type="first">Mitchell</forename><surname>Morris∫</surname></persName><affiliation>University of Texas M. D. Anderson Cancer Center, Houston, TX, USA</affiliation></author><author xml:id="author-0009"><persName><forename type="first">Tyvin</forename><surname>Rich</surname></persName><roleName type="degree">M.D.</roleName><note type="biography">∞</note><affiliation>∞</affiliation><affiliation>University of Virginia Science Center, Charlottesville, VA, USA</affiliation></author><author xml:id="author-0010"><persName><forename type="first">William</forename><surname>Shipley</surname></persName><roleName type="degree">M.D.</roleName><affiliation>Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA</affiliation></author><author xml:id="author-0011"><persName><forename type="first">Walter</forename><surname>Curran</surname></persName><roleName type="degree">M.D.</roleName><affiliation>Thomas Jefferson University Hospital/Bodine Cancer Treatment Center, Philadelphia, PA, USA</affiliation></author><idno type="istex">036669930279CBD2A5ADDF9B4CF4F8CB7D9A7C21</idno><idno type="DOI">10.1016/S0360-3016(99)00559-3</idno><idno type="PII">S0360-3016(99)00559-3</idno></analytic><monogr><title level="j">International Journal of Radiation Oncology, Biology, Physics</title><title level="j" type="abbrev">ROB</title><idno type="pISSN">0360-3016</idno><idno type="PII">S0360-3016(00)X0079-X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2000"></date><biblScope unit="volume">47</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="13">13</biblScope><biblScope unit="page" to="47">47</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2000</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>In 1997, the National Cancer Institute (NCI) led an effort to revise and expand the Common Toxicity Criteria (CTC) with the goal of integrating systemic agent, radiation, and surgical criteria into a comprehensive and standardized system. Representatives from the Radiation Therapy Oncology Group (RTOG) participated in this process in an effort to improve acute radiation related criteria and to achieve better clarity and consistency among modalities. CTC v. 2.0 replaces the previous NCI CTC and the RTOG Acute Radiation Morbidity Scoring Criteria and includes more than 260 individual adverse events with more than 100 of these applicable to acute radiation effects. One of the advantages of the revised criteria for radiation oncology is the opportunity to grade acute radiation effects not adequately captured under the previous RTOG system. A pilot study conducted by the RTOG indicated the new criteria are indeed more comprehensive and were preferred by research associates. CTC v. 2.0 represents an improvement in the evaluation and grading of acute toxicity for all modalities.</p></abstract><textClass><keywords scheme="keyword"><list><head>article-category</head><item><term>CRITICAL REVIEW</term></item></list></keywords></textClass><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Toxicity</term></item><item><term>Acute effects</term></item><item><term>Side effects</term></item><item><term>Adverse events</term></item><item><term>Morbidity</term></item><item><term>Complications</term></item><item><term>Normal tissue effects</term></item><item><term>Radiation</term></item><item><term>Chemotherapy</term></item><item><term>Chemoradiation</term></item><item><term>Combined modality</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2000">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/036669930279CBD2A5ADDF9B4CF4F8CB7D9A7C21/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: body; tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla" xml:lang="en"><item-info><jid>ROB</jid><aid>6876</aid><ce:pii>S0360-3016(99)00559-3</ce:pii><ce:doi>10.1016/S0360-3016(99)00559-3</ce:doi><ce:copyright type="full-transfer" year="2000">Elsevier Science Inc.</ce:copyright><ce:doctopics><ce:doctopic><ce:text>CRITICAL REVIEW</ce:text></ce:doctopic></ce:doctopics></item-info><head><ce:dochead><ce:textfn>CRITICAL REVIEW</ce:textfn></ce:dochead><ce:title>Common toxicity criteria: version 2.0. an improved reference for grading the acute effects of cancer treatment: impact on radiotherapy</ce:title><ce:author-group><ce:author><ce:given-name>Andy</ce:given-name><ce:surname>Trotti</ce:surname><ce:degrees>M.D.</ce:degrees><ce:cross-ref refid="AFF1">∗</ce:cross-ref><ce:cross-ref refid="CORR1">*</ce:cross-ref><ce:e-address>trotti@moffitt.usf.edu</ce:e-address></ce:author><ce:author><ce:given-name>Roger</ce:given-name><ce:surname>Byhardt</ce:surname><ce:degrees>M.D.</ce:degrees><ce:cross-ref refid="AFF2"><ce:sup>†</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Joanne</ce:given-name><ce:surname>Stetz</ce:surname><ce:degrees>R.N.</ce:degrees><ce:cross-ref refid="AFF3"><ce:sup>‡</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Clement</ce:given-name><ce:surname>Gwede</ce:surname><ce:degrees>R.N.</ce:degrees><ce:roles>M.P.H.</ce:roles><ce:cross-ref refid="AFF1">∗</ce:cross-ref></ce:author><ce:author><ce:given-name>Benjamin</ce:given-name><ce:surname>Corn</ce:surname><ce:degrees>M.D.</ce:degrees><ce:cross-ref refid="AFF4"><ce:sup>§</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Karen</ce:given-name><ce:surname>Fu</ce:surname><ce:degrees>M.D.</ce:degrees><ce:cross-ref refid="AFF5"><ce:sup>∥</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Leonard</ce:given-name><ce:surname>Gunderson</ce:surname><ce:degrees>M.D.</ce:degrees><ce:cross-ref refid="AFF6"><ce:sup>¶</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Beryl</ce:given-name><ce:surname>McCormick</ce:surname><ce:degrees>M.D.</ce:degrees><ce:cross-ref refid="AFF7"><ce:sup>#</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Mitchell</ce:given-name><ce:surname>Morris∫</ce:surname><ce:cross-ref refid="AFF8"><ce:sup>h</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Tyvin</ce:given-name><ce:surname>Rich</ce:surname><ce:degrees>M.D.</ce:degrees><ce:roles>∞</ce:roles><ce:cross-ref refid="AFF9"><ce:sup>i</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>William</ce:given-name><ce:surname>Shipley</ce:surname><ce:degrees>M.D.</ce:degrees><ce:cross-ref refid="AFF10">∗∗</ce:cross-ref></ce:author><ce:author><ce:given-name>Walter</ce:given-name><ce:surname>Curran</ce:surname><ce:degrees>M.D.</ce:degrees><ce:cross-ref refid="AFF4"><ce:sup>§</ce:sup></ce:cross-ref></ce:author><ce:collaboration><ce:text>Radiation Therapy Oncology Group</ce:text></ce:collaboration><ce:affiliation id="AFF1"><ce:label>∗</ce:label><ce:textfn>H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL, USA</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>†</ce:label><ce:textfn>Medical College of Wisconsin, Milwaukee, WI, USA</ce:textfn></ce:affiliation><ce:affiliation id="AFF3"><ce:label>‡</ce:label><ce:textfn>RTOG Headquarters, Philadelphia, PA, USA</ce:textfn></ce:affiliation><ce:affiliation id="AFF4"><ce:label>§</ce:label><ce:textfn>Thomas Jefferson University Hospital/Bodine Cancer Treatment Center, Philadelphia, PA, USA</ce:textfn></ce:affiliation><ce:affiliation id="AFF5"><ce:label>∥</ce:label><ce:textfn>University of California San Franciso, San Francisco, CA, USA</ce:textfn></ce:affiliation><ce:affiliation id="AFF6"><ce:label>¶</ce:label><ce:textfn>Mayo Clinic, Medical School, Rochester, MN, USA</ce:textfn></ce:affiliation><ce:affiliation id="AFF7"><ce:label>#</ce:label><ce:textfn>Memorial Sloan-Kettering, Cornell Medical College, New York, NY, USA</ce:textfn></ce:affiliation><ce:affiliation id="AFF8"><ce:label>∫</ce:label><ce:textfn>University of Texas M. D. Anderson Cancer Center, Houston, TX, USA</ce:textfn></ce:affiliation><ce:affiliation id="AFF9"><ce:label>∞</ce:label><ce:textfn>University of Virginia Science Center, Charlottesville, VA, USA</ce:textfn></ce:affiliation><ce:affiliation id="AFF10"><ce:label>∗∗</ce:label><ce:textfn>Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA</ce:textfn></ce:affiliation><ce:correspondence id="CORR1"><ce:label>*</ce:label><ce:text>Reprint requests to: Dr. Andy Trotti, Division of Radiation Oncology, H. Lee Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612-9497</ce:text></ce:correspondence></ce:author-group><ce:date-accepted day="9" month="12" year="1999"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>In 1997, the National Cancer Institute (NCI) led an effort to revise and expand the Common Toxicity Criteria (CTC) with the goal of integrating systemic agent, radiation, and surgical criteria into a comprehensive and standardized system. Representatives from the Radiation Therapy Oncology Group (RTOG) participated in this process in an effort to improve acute radiation related criteria and to achieve better clarity and consistency among modalities. CTC v. 2.0 replaces the previous NCI CTC and the RTOG Acute Radiation Morbidity Scoring Criteria and includes more than 260 individual adverse events with more than 100 of these applicable to acute radiation effects. One of the advantages of the revised criteria for radiation oncology is the opportunity to grade acute radiation effects not adequately captured under the previous RTOG system. A pilot study conducted by the RTOG indicated the new criteria are indeed more comprehensive and were preferred by research associates. CTC v. 2.0 represents an improvement in the evaluation and grading of acute toxicity for all modalities.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="keyword"><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Toxicity</ce:text></ce:keyword><ce:keyword><ce:text>Acute effects</ce:text></ce:keyword><ce:keyword><ce:text>Side effects</ce:text></ce:keyword><ce:keyword><ce:text>Adverse events</ce:text></ce:keyword><ce:keyword><ce:text>Morbidity</ce:text></ce:keyword><ce:keyword><ce:text>Complications</ce:text></ce:keyword><ce:keyword><ce:text>Normal tissue effects</ce:text></ce:keyword><ce:keyword><ce:text>Radiation</ce:text></ce:keyword><ce:keyword><ce:text>Chemotherapy</ce:text></ce:keyword><ce:keyword><ce:text>Chemoradiation</ce:text></ce:keyword><ce:keyword><ce:text>Combined modality</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Common toxicity criteria: version 2.0. an improved reference for grading the acute effects of cancer treatment: impact on radiotherapy</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Common toxicity criteria: version 2.0. an improved reference for grading the acute effects of cancer treatment: impact on radiotherapy</title></titleInfo><name type="corporate"><namePart>Radiation Therapy Oncology Group</namePart></name><name type="personal"><namePart type="given">Andy</namePart><namePart type="family">Trotti</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL, USA</affiliation><affiliation>Reprint requests to: Dr. Andy Trotti, Division of Radiation Oncology, H. Lee Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612-9497</affiliation><affiliation>E-mail: trotti@moffitt.usf.edu</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Roger</namePart><namePart type="family">Byhardt</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>Medical College of Wisconsin, Milwaukee, WI, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Joanne</namePart><namePart type="family">Stetz</namePart><namePart type="termsOfAddress">R.N.</namePart><affiliation>RTOG Headquarters, Philadelphia, PA, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Clement</namePart><namePart type="family">Gwede</namePart><namePart type="termsOfAddress">R.N.</namePart><affiliation>H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL, USA</affiliation><description>M.P.H.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Benjamin</namePart><namePart type="family">Corn</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>Thomas Jefferson University Hospital/Bodine Cancer Treatment Center, Philadelphia, PA, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Karen</namePart><namePart type="family">Fu</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>University of California San Franciso, San Francisco, CA, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Leonard</namePart><namePart type="family">Gunderson</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>Mayo Clinic, Medical School, Rochester, MN, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Beryl</namePart><namePart type="family">McCormick</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>Memorial Sloan-Kettering, Cornell Medical College, New York, NY, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mitchell</namePart><namePart type="family">Morris∫</namePart><affiliation>University of Texas M. D. Anderson Cancer Center, Houston, TX, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Tyvin</namePart><namePart type="family">Rich</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>University of Virginia Science Center, Charlottesville, VA, USA</affiliation><description>∞</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">William</namePart><namePart type="family">Shipley</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Walter</namePart><namePart type="family">Curran</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>Thomas Jefferson University Hospital/Bodine Cancer Treatment Center, Philadelphia, PA, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">2000</dateIssued><copyrightDate encoding="w3cdtf">2000</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">In 1997, the National Cancer Institute (NCI) led an effort to revise and expand the Common Toxicity Criteria (CTC) with the goal of integrating systemic agent, radiation, and surgical criteria into a comprehensive and standardized system. Representatives from the Radiation Therapy Oncology Group (RTOG) participated in this process in an effort to improve acute radiation related criteria and to achieve better clarity and consistency among modalities. CTC v. 2.0 replaces the previous NCI CTC and the RTOG Acute Radiation Morbidity Scoring Criteria and includes more than 260 individual adverse events with more than 100 of these applicable to acute radiation effects. One of the advantages of the revised criteria for radiation oncology is the opportunity to grade acute radiation effects not adequately captured under the previous RTOG system. A pilot study conducted by the RTOG indicated the new criteria are indeed more comprehensive and were preferred by research associates. CTC v. 2.0 represents an improvement in the evaluation and grading of acute toxicity for all modalities.</abstract><note type="content">Section title: CRITICAL REVIEW</note><subject><genre>article-category</genre><topic>CRITICAL REVIEW</topic></subject><subject lang="en"><genre>Keywords</genre><topic>Toxicity</topic><topic>Acute effects</topic><topic>Side effects</topic><topic>Adverse events</topic><topic>Morbidity</topic><topic>Complications</topic><topic>Normal tissue effects</topic><topic>Radiation</topic><topic>Chemotherapy</topic><topic>Chemoradiation</topic><topic>Combined modality</topic></subject><relatedItem type="host"><titleInfo><title>International Journal of Radiation Oncology, Biology, Physics</title></titleInfo><titleInfo type="abbreviated"><title>ROB</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">20000401</dateIssued></originInfo><identifier type="ISSN">0360-3016</identifier><identifier type="PII">S0360-3016(00)X0079-X</identifier><part><date>20000401</date><detail type="volume"><number>47</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue pages"><start>1</start><end>268</end></extent><extent unit="pages"><start>13</start><end>47</end></extent></part></relatedItem><identifier type="istex">036669930279CBD2A5ADDF9B4CF4F8CB7D9A7C21</identifier><identifier type="DOI">10.1016/S0360-3016(99)00559-3</identifier><identifier type="PII">S0360-3016(99)00559-3</identifier><accessCondition type="use and reproduction" contentType="copyright">©2000 Elsevier Science Inc.</accessCondition><recordInfo><recordContentSource>ELSEVIER</recordContentSource><recordOrigin>Elsevier Science Inc., ©2000</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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