Evidence for altered cell‐mediated immunity in postmastectomy lymphoedema
Identifieur interne : 004056 ( Istex/Checkpoint ); précédent : 004055; suivant : 004057Evidence for altered cell‐mediated immunity in postmastectomy lymphoedema
Auteurs : E. Mallon [Royaume-Uni] ; S. Powell [Royaume-Uni] ; Peter Mortimer (dermatologue) [Royaume-Uni] ; T. J. Ryan [Royaume-Uni]Source :
- British Journal of Dermatology [ 0007-0963 ] ; 1997-12.
Abstract
Patients with chronic lymphoedema are prone to develop chronic infections and various tumours in the lymphoedematous limb, suggesting that regional immune surveillance is impaired. To test the hypothesis that cutaneous cell‐mediated immunity is impaired. 35 women with postmastectomy lymphoedema were investigated using dinitrochlorobenzene to test the afferent and efferent loops of the allergic contact immune response. The results suppot the role of lymphatics as an important component of the immune response to allergens by the demonstration of impairment of both the afferent and efferent loops of the allergic contact dermatitis reaction, and confirm that there is suppression of immune competence in a lymphoedematous limb.
Url:
DOI: 10.1046/j.1365-2133.1997.19872068.x
Affiliations:
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<front><div type="abstract" xml:lang="en">Patients with chronic lymphoedema are prone to develop chronic infections and various tumours in the lymphoedematous limb, suggesting that regional immune surveillance is impaired. To test the hypothesis that cutaneous cell‐mediated immunity is impaired. 35 women with postmastectomy lymphoedema were investigated using dinitrochlorobenzene to test the afferent and efferent loops of the allergic contact immune response. The results suppot the role of lymphatics as an important component of the immune response to allergens by the demonstration of impairment of both the afferent and efferent loops of the allergic contact dermatitis reaction, and confirm that there is suppression of immune competence in a lymphoedematous limb.</div>
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