Prognostic Value of Quantitative Kaposi Sarcoma–Associated Herpesvirus Load in Posttransplantation Kaposi Sarcoma
Identifieur interne : 000652 ( France/Analysis ); précédent : 000651; suivant : 000653Prognostic Value of Quantitative Kaposi Sarcoma–Associated Herpesvirus Load in Posttransplantation Kaposi Sarcoma
Auteurs : Claire Pellet ; Sylvie Chevret ; Camille Francès ; Sylvie Euvrard ; Mylène Hurault ; Christophe Legendre ; Sophie Dalac ; Dominique Farge ; Corinne Antoine ; Christian Hiesse ; Marie-Noëlle Peraldi ; Philippe Lang ; Didier Samuel [France] ; Yvon Calmus ; Félix Agbalika ; Patrice Morel ; Fabien Calvo ; Céleste Lebbé [France]Source :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2002-07-01.
Abstract
Organ transplant recipients have a higher risk of Kaposi sarcoma (KS). A quantitative real-time polymerase chain reaction assay was developed to evaluate KS-associated herpesvirus (KSHV) as a prognostic tool in transplant recipients with KS. Forty-three patients who developed KS after transplantation were included in a cross-sectional study to correlate virus load with transplantation or KS parameters. Seventeen patients (40%) had KSHV viremia (>100 copies/μg of DNA; median, 6067 copies/μg of DNA). Factors associated with these levels of viremia by univariate analysis were progression of KS (P=.00002), time from KS diagnosis (P=.0007), actual stage of KS (P=.006), initial stage of KS (P=.22), graft loss (P=.013), and time from transplantation (P=.0246). Disease progression remained associated with KSHV viremia in a multivariate analysis (P=.01). Thus, quantification of KSHV load in peripheral blood mononuclear cells could represent a useful tool for monitoring transplant recipients with KS
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DOI: 10.1086/341088
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xml:lang="fr">France</country><wicri:regionArea>Department of Transplantation, Hôpital Paul Brousse, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Calmus, Yvon" sort="Calmus, Yvon" uniqKey="Calmus Y" first="Yvon" last="Calmus">Yvon Calmus</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Agbalika, Felix" sort="Agbalika, Felix" uniqKey="Agbalika F" first="Félix" last="Agbalika">Félix Agbalika</name><affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Morel, Patrice" sort="Morel, Patrice" uniqKey="Morel P" first="Patrice" last="Morel">Patrice Morel</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Calvo, Fabien" sort="Calvo, Fabien" uniqKey="Calvo F" first="Fabien" last="Calvo">Fabien Calvo</name><affiliation><wicri:noCountry code="no comma">Laboratory of Pharmacology and Departments of</wicri:noCountry></affiliation></author><author><name sortKey="Lebbe, Celeste" sort="Lebbe, Celeste" uniqKey="Lebbe C" first="Céleste" last="Lebbé">Céleste Lebbé</name><affiliation></affiliation><affiliation></affiliation><affiliation wicri:level="1"><country wicri:rule="url">France</country></affiliation></author></analytic><monogr></monogr><series><title level="j">The Journal of Infectious Diseases</title><title level="j" type="abbrev">The Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date type="published" when="2002-07-01">2002-07-01</date><biblScope unit="volume">186</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="110">110</biblScope><biblScope unit="page" to="113">113</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Organ transplant recipients have a higher risk of Kaposi sarcoma (KS). A quantitative real-time polymerase chain reaction assay was developed to evaluate KS-associated herpesvirus (KSHV) as a prognostic tool in transplant recipients with KS. Forty-three patients who developed KS after transplantation were included in a cross-sectional study to correlate virus load with transplantation or KS parameters. Seventeen patients (40%) had KSHV viremia (>100 copies/μg of DNA; median, 6067 copies/μg of DNA). Factors associated with these levels of viremia by univariate analysis were progression of KS (P=.00002), time from KS diagnosis (P=.0007), actual stage of KS (P=.006), initial stage of KS (P=.22), graft loss (P=.013), and time from transplantation (P=.0246). Disease progression remained associated with KSHV viremia in a multivariate analysis (P=.01). Thus, quantification of KSHV load in peripheral blood mononuclear cells could represent a useful tool for monitoring transplant recipients with KS</div></front></TEI><affiliations><list><country><li>France</li></country></list><tree><noCountry><name sortKey="Agbalika, Felix" sort="Agbalika, Felix" uniqKey="Agbalika F" first="Félix" last="Agbalika">Félix Agbalika</name><name sortKey="Antoine, Corinne" sort="Antoine, Corinne" uniqKey="Antoine C" first="Corinne" last="Antoine">Corinne Antoine</name><name sortKey="Calmus, Yvon" sort="Calmus, Yvon" uniqKey="Calmus Y" first="Yvon" last="Calmus">Yvon Calmus</name><name sortKey="Calvo, Fabien" sort="Calvo, Fabien" uniqKey="Calvo F" first="Fabien" last="Calvo">Fabien Calvo</name><name sortKey="Chevret, Sylvie" sort="Chevret, Sylvie" uniqKey="Chevret S" first="Sylvie" last="Chevret">Sylvie Chevret</name><name sortKey="Dalac, Sophie" sort="Dalac, Sophie" uniqKey="Dalac S" first="Sophie" last="Dalac">Sophie Dalac</name><name sortKey="Euvrard, Sylvie" sort="Euvrard, Sylvie" uniqKey="Euvrard S" first="Sylvie" last="Euvrard">Sylvie Euvrard</name><name sortKey="Farge, Dominique" sort="Farge, Dominique" uniqKey="Farge D" first="Dominique" last="Farge">Dominique Farge</name><name sortKey="Frances, Camille" sort="Frances, Camille" uniqKey="Frances C" first="Camille" last="Francès">Camille Francès</name><name sortKey="Hiesse, Christian" sort="Hiesse, Christian" uniqKey="Hiesse C" first="Christian" last="Hiesse">Christian Hiesse</name><name sortKey="Hurault, Mylene" sort="Hurault, Mylene" uniqKey="Hurault M" first="Mylène" last="Hurault">Mylène Hurault</name><name sortKey="Lang, Philippe" sort="Lang, Philippe" uniqKey="Lang P" first="Philippe" last="Lang">Philippe Lang</name><name sortKey="Legendre, Christophe" sort="Legendre, Christophe" uniqKey="Legendre C" first="Christophe" last="Legendre">Christophe Legendre</name><name sortKey="Morel, Patrice" sort="Morel, Patrice" uniqKey="Morel P" first="Patrice" last="Morel">Patrice Morel</name><name sortKey="Pellet, Claire" sort="Pellet, Claire" uniqKey="Pellet C" first="Claire" last="Pellet">Claire Pellet</name><name sortKey="Peraldi, Marie Noelle" sort="Peraldi, Marie Noelle" uniqKey="Peraldi M" first="Marie-Noëlle" last="Peraldi">Marie-Noëlle Peraldi</name></noCountry><country name="France"><noRegion><name sortKey="Samuel, Didier" sort="Samuel, Didier" uniqKey="Samuel D" first="Didier" last="Samuel">Didier Samuel</name></noRegion><name sortKey="Lebbe, Celeste" sort="Lebbe, Celeste" uniqKey="Lebbe C" first="Céleste" last="Lebbé">Céleste Lebbé</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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