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[Genetics of lymphedema: from Milroy's disease to cancer investigations].

Identifieur interne : 000644 ( France/Analysis ); précédent : 000643; suivant : 000645

[Genetics of lymphedema: from Milroy's disease to cancer investigations].

Auteurs : I. Quéré [France] ; M. Coupé ; V. Soulier-Sotto ; M. Evrard-Bras ; J P Laroche ; C. Janbon

Source :

RBID : pubmed:12162200

Descripteurs français

English descriptors

Abstract

New insight has recently been obtained into the molecular mechanisms regulating lymphatic development and function during embryogenesis. VEGF-C and D ligands have been shown to stimulate lymphangiogenesis and their lymphatic-specific receptor VEGFR-3 is linked to the human congenital and hereditary lymphedema in humans. Above all, new focus on lymphatic endothelial cells gives opportunities for developing innovative therapies for lymphedema and cancer metastasis.

PubMed: 12162200


Affiliations:


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pubmed:12162200

Le document en format XML

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<term>Ligands</term>
<term>Lymph</term>
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<div type="abstract" xml:lang="en">New insight has recently been obtained into the molecular mechanisms regulating lymphatic development and function during embryogenesis. VEGF-C and D ligands have been shown to stimulate lymphangiogenesis and their lymphatic-specific receptor VEGFR-3 is linked to the human congenital and hereditary lymphedema in humans. Above all, new focus on lymphatic endothelial cells gives opportunities for developing innovative therapies for lymphedema and cancer metastasis.</div>
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