Combination of fluconazole and alpha-tocopherol in the treatment of yellow nail syndrome.
Identifieur interne : 000388 ( France/Analysis ); précédent : 000387; suivant : 000389Combination of fluconazole and alpha-tocopherol in the treatment of yellow nail syndrome.
Auteurs : Robert Baran [France] ; Luc ThomasSource :
- Journal of drugs in dermatology : JDD [ 1545-9616 ] ; 2009.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Antifongiques (administration et posologie), Association de médicaments, Femelle, Fluconazole (administration et posologie), Humains, Mâle, Onychopathies (anatomopathologie), Onychopathies (traitement médicamenteux), Sujet âgé, Syndrome, Vitamines (administration et posologie), alpha-Tocophérol (administration et posologie).
- MESH :
- administration et posologie : Antifongiques, Fluconazole, Vitamines, alpha-Tocophérol.
- anatomopathologie : Onychopathies.
- traitement médicamenteux : Onychopathies.
- Adulte d'âge moyen, Association de médicaments, Femelle, Humains, Mâle, Sujet âgé, Syndrome.
English descriptors
- KwdEn :
- MESH :
- chemical , administration & dosage : Antifungal Agents, Fluconazole, Vitamins, alpha-Tocopherol.
- drug therapy : Nail Diseases.
- pathology : Nail Diseases.
- Aged, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Syndrome.
Abstract
Yellow nail syndrome (YNS) is an uncommon disorder that is characterized by the slow nail growth, marked thickening, and yellow to yellow-green discoloration of the fingernails or toenails. Although the etiology of YNS is unknown, a diagnosis is indicated by the concurrent presentation of the nail changes, with lymphedema and respiratory manifestations. Although lymphedema and respiratory manifestations are sometimes manageable with regimens of medical and surgical treatments, YNS treatment options are limited and often unsuccessful. For the patient, YNS can also be cosmetically unacceptable and concealment with nail polish may not always be possible. However, it is now widely accepted that the azole class of antifungals can stimulate linear nail growth. In addition, vitamin E has also been reported in the treatment of YNS with positive results. Herein, the authors report on a promising combination treatment of oral fluconazole pulse therapy and oral alpha-tocopherol (vitamin E) in 13 patients with YNS with clinical successes observed in 2 individuals and clinical cures observed in 11 subjects.
PubMed: 19271377
Affiliations:
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pubmed:19271377Le document en format XML
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sortKey="Baran, Robert" sort="Baran, Robert" uniqKey="Baran R" first="Robert" last="Baran">Robert Baran</name><affiliation wicri:level="1"><nlm:affiliation>Nail Disease Centre, Cannes, France. baran.r@club-internet.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Nail Disease Centre, Cannes</wicri:regionArea><wicri:noRegion>Cannes</wicri:noRegion><wicri:noRegion>Cannes</wicri:noRegion></affiliation></author><author><name sortKey="Thomas, Luc" sort="Thomas, Luc" uniqKey="Thomas L" first="Luc" last="Thomas">Luc Thomas</name></author></analytic><series><title level="j">Journal of drugs in dermatology : JDD</title><idno type="ISSN">1545-9616</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Antifungal Agents (administration & dosage)</term><term>Drug Therapy, Combination</term><term>Female</term><term>Fluconazole (administration & dosage)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Nail Diseases (drug therapy)</term><term>Nail Diseases (pathology)</term><term>Syndrome</term><term>Vitamins (administration & dosage)</term><term>alpha-Tocopherol (administration & dosage)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Antifongiques (administration et posologie)</term><term>Association de médicaments</term><term>Femelle</term><term>Fluconazole (administration et posologie)</term><term>Humains</term><term>Mâle</term><term>Onychopathies (anatomopathologie)</term><term>Onychopathies (traitement médicamenteux)</term><term>Sujet âgé</term><term>Syndrome</term><term>Vitamines (administration et posologie)</term><term>alpha-Tocophérol (administration et posologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antifungal Agents</term><term>Fluconazole</term><term>Vitamins</term><term>alpha-Tocopherol</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antifongiques</term><term>Fluconazole</term><term>Vitamines</term><term>alpha-Tocophérol</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Onychopathies</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Nail Diseases</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Nail Diseases</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Onychopathies</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Drug Therapy, Combination</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Syndrome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge 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Although the etiology of YNS is unknown, a diagnosis is indicated by the concurrent presentation of the nail changes, with lymphedema and respiratory manifestations. Although lymphedema and respiratory manifestations are sometimes manageable with regimens of medical and surgical treatments, YNS treatment options are limited and often unsuccessful. For the patient, YNS can also be cosmetically unacceptable and concealment with nail polish may not always be possible. However, it is now widely accepted that the azole class of antifungals can stimulate linear nail growth. In addition, vitamin E has also been reported in the treatment of YNS with positive results. Herein, the authors report on a promising combination treatment of oral fluconazole pulse therapy and oral alpha-tocopherol (vitamin E) in 13 patients with YNS with clinical successes observed in 2 individuals and clinical cures observed in 11 subjects.</div></front></TEI><affiliations><list><country><li>France</li></country></list><tree><noCountry><name sortKey="Thomas, Luc" sort="Thomas, Luc" uniqKey="Thomas L" first="Luc" last="Thomas">Luc Thomas</name></noCountry><country name="France"><noRegion><name sortKey="Baran, Robert" sort="Baran, Robert" uniqKey="Baran R" first="Robert" last="Baran">Robert Baran</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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