LymphedemaV1, France, Analysis, bibRecord, 000336

Guidance molecules in lung cancer

Identifieur interne : 000336 ( France/Analysis ); précédent : 000335; suivant : 000337

Guidance molecules in lung cancer

Auteurs : Patrick Nasarre [États-Unis] ; Vincent Potiron [États-Unis] ; Harry Drabkin [États-Unis] ; Joëlle Roche [États-Unis, France]

Source :

Cell Adhesion & Migration [ 1933-6918 ] ; 2010.

RBID : PMC:2852570

Abstract

Guidance molecules were first described in the nervous system to control axon outgrowth direction. They are also widely expressed outside the nervous system where they control cell migration, tissue development and establishment of the vascular network. In addition, they are involved in cancer development, tumor angiogenesis and metastasis. This review is primarily focused on their functions in lung cancer and their involvement in lung development is also presented. Five guidance molecule families and their corresponding receptors are described, including the semaphorins/neuropilins/plexins, ephrins and Eph receptors, netrin/DCC/UNC5, Slit/Robo and Notch/Delta. In addition, the possibility to target these molecules as a therapeutic approach in cancer is discussed.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852570

PubMed: 20139699
PubMed Central: 2852570

Affiliations:

Links to Exploration step

PMC:2852570

Le document en format XML

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Serveur d'exploration sur le lymphœdème

Guidance molecules in lung cancer

Guidance molecules in lung cancer

Source :

Abstract

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Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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