Immunization with L. sigmodontis Microfilariae Reduces Peripheral Microfilaraemia after Challenge Infection by Inhibition of Filarial Embryogenesis
Identifieur interne : 000224 ( France/Analysis ); précédent : 000223; suivant : 000225Immunization with L. sigmodontis Microfilariae Reduces Peripheral Microfilaraemia after Challenge Infection by Inhibition of Filarial Embryogenesis
Auteurs : Sebastian Ziewer [Allemagne] ; Marc P. Hübner [Allemagne] ; Bettina Dubben [Allemagne] ; Wolfgang H. Hoffmann [Allemagne] ; Odile Bain [France] ; Coralie Martin [France] ; Achim Hoerauf [Allemagne] ; Sabine Specht [Allemagne]Source :
- PLoS Neglected Tropical Diseases [ 1935-2727 ] ; 2012.
Abstract
Lymphatic filariasis and onchocerciasis are two chronic diseases mediated by parasitic filarial worms causing long term disability and massive socioeconomic problems. Filariae are transmitted by blood-feeding mosquitoes that take up the first stage larvae from an infected host and deliver it after maturation into infective stage to a new host. After closure of vector control programs, disease control relies mainly on mass drug administration with drugs that are primarily effective against first stage larvae and require many years of annual/biannual administration. Therefore, there is an urgent need for alternative treatment ways, i.e. other effective drugs or vaccines.
Using the
Our results present a tool to understand the immunological basis of vaccine induced protection in order to develop a microfilariae-based vaccine that reduces adult worm burden and prevents microfilaraemia, a powerful weapon to stop transmission of filariasis.
Url:
DOI: 10.1371/journal.pntd.0001558
PubMed: 22413031
PubMed Central: 3295809
Affiliations:
- Allemagne, France
- Bade-Wurtemberg, District de Cologne, District de Tübingen, Rhénanie-du-Nord-Westphalie, Île-de-France
- Bonn, Paris, Tübingen
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PMC:3295809Le document en format XML
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Hübner</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Dubben, Bettina" sort="Dubben, Bettina" uniqKey="Dubben B" first="Bettina" last="Dubben">Bettina Dubben</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Hoffmann, Wolfgang H" sort="Hoffmann, Wolfgang H" uniqKey="Hoffmann W" first="Wolfgang H." last="Hoffmann">Wolfgang H. Hoffmann</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Institute of Tropical Medicine, University Hospital Tuebingen, Tuebingen, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Tropical Medicine, University Hospital Tuebingen, Tuebingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Bain, Odile" sort="Bain, Odile" uniqKey="Bain O" first="Odile" last="Bain">Odile Bain</name><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>UMR 7245 MCAM MNHN CNRS, Muséum National d'Histoire Naturelle, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR 7245 MCAM MNHN CNRS, Muséum National d'Histoire Naturelle, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Martin, Coralie" sort="Martin, Coralie" uniqKey="Martin C" first="Coralie" last="Martin">Coralie Martin</name><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>UMR 7245 MCAM MNHN CNRS, Muséum National d'Histoire Naturelle, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR 7245 MCAM MNHN CNRS, Muséum National d'Histoire Naturelle, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Hoerauf, Achim" sort="Hoerauf, Achim" uniqKey="Hoerauf A" first="Achim" last="Hoerauf">Achim Hoerauf</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Specht, Sabine" sort="Specht, Sabine" uniqKey="Specht S" first="Sabine" last="Specht">Sabine Specht</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author></analytic><series><title level="j">PLoS Neglected Tropical Diseases</title><idno type="ISSN">1935-2727</idno><idno type="eISSN">1935-2735</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Lymphatic filariasis and onchocerciasis are two chronic diseases mediated by parasitic filarial worms causing long term disability and massive socioeconomic problems. Filariae are transmitted by blood-feeding mosquitoes that take up the first stage larvae from an infected host and deliver it after maturation into infective stage to a new host. After closure of vector control programs, disease control relies mainly on mass drug administration with drugs that are primarily effective against first stage larvae and require many years of annual/biannual administration. Therefore, there is an urgent need for alternative treatment ways, i.e. other effective drugs or vaccines.</p></sec><sec><title>Methodology/Principal Findings</title><p>Using the <italic>Litomosoides sigmodontis</italic> murine model of filariasis we demonstrate that immunization with microfilariae together with the adjuvant alum prevents mice from developing high microfilaraemia after challenge infection. Immunization achieved 70% to 100% protection in the peripheral blood and in the pleural space and furthermore strongly reduced the microfilarial load in mice that remained microfilaraemic. Protection was associated with the impairment of intrauterine filarial embryogenesis and with local and systemic microfilarial-specific host IgG, as well as IFN-γ secretion by host cells from the site of infection. Furthermore immunization significantly reduced adult worm burden.</p></sec><sec><title>Conclusions/Significance</title><p>Our results present a tool to understand the immunological basis of vaccine induced protection in order to develop a microfilariae-based vaccine that reduces adult worm burden and prevents microfilaraemia, a powerful weapon to stop transmission of filariasis.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Taylor, Mj" uniqKey="Taylor M">MJ Taylor</name></author><author><name sortKey="Hoerauf, A" uniqKey="Hoerauf A">A Hoerauf</name></author><author><name sortKey="Bockarie, M" uniqKey="Bockarie M">M Bockarie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoerauf, A" uniqKey="Hoerauf A">A Hoerauf</name></author><author><name sortKey="Pfarr, K" uniqKey="Pfarr K">K Pfarr</name></author><author><name sortKey="Mand, S" uniqKey="Mand S">S Mand</name></author><author><name 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Saeftel</name></author><author><name sortKey="Specht, S" uniqKey="Specht S">S Specht</name></author><author><name sortKey="Fischer, K" uniqKey="Fischer K">K Fischer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bockarie, Mj" uniqKey="Bockarie M">MJ Bockarie</name></author><author><name sortKey="Taylor, Mj" uniqKey="Taylor M">MJ Taylor</name></author><author><name sortKey="Gyapong, Jo" uniqKey="Gyapong J">JO Gyapong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brindley, Pj" uniqKey="Brindley P">PJ Brindley</name></author><author><name sortKey="Mitreva, M" uniqKey="Mitreva M">M Mitreva</name></author><author><name sortKey="Ghedin, E" uniqKey="Ghedin E">E Ghedin</name></author><author><name sortKey="Lustigman, S" uniqKey="Lustigman S">S Lustigman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Babayan, Sa" uniqKey="Babayan S">SA Babayan</name></author><author><name sortKey="Allen, Je" uniqKey="Allen J">JE Allen</name></author><author><name sortKey="Taylor, Dw" uniqKey="Taylor D">DW Taylor</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>France</li></country><region><li>Bade-Wurtemberg</li><li>District de Cologne</li><li>District de Tübingen</li><li>Rhénanie-du-Nord-Westphalie</li><li>Île-de-France</li></region><settlement><li>Bonn</li><li>Paris</li><li>Tübingen</li></settlement></list><tree><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Ziewer, Sebastian" sort="Ziewer, Sebastian" uniqKey="Ziewer S" first="Sebastian" last="Ziewer">Sebastian Ziewer</name></region><name sortKey="Dubben, Bettina" sort="Dubben, Bettina" uniqKey="Dubben B" first="Bettina" last="Dubben">Bettina Dubben</name><name sortKey="Hoerauf, Achim" sort="Hoerauf, Achim" uniqKey="Hoerauf A" first="Achim" last="Hoerauf">Achim Hoerauf</name><name sortKey="Hoffmann, Wolfgang H" sort="Hoffmann, Wolfgang H" uniqKey="Hoffmann W" first="Wolfgang H." last="Hoffmann">Wolfgang H. Hoffmann</name><name sortKey="Hubner, Marc P" sort="Hubner, Marc P" uniqKey="Hubner M" first="Marc P." last="Hübner">Marc P. Hübner</name><name sortKey="Specht, Sabine" sort="Specht, Sabine" uniqKey="Specht S" first="Sabine" last="Specht">Sabine Specht</name></country><country name="France"><region name="Île-de-France"><name sortKey="Bain, Odile" sort="Bain, Odile" uniqKey="Bain O" first="Odile" last="Bain">Odile Bain</name></region><name sortKey="Martin, Coralie" sort="Martin, Coralie" uniqKey="Martin C" first="Coralie" last="Martin">Coralie Martin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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