LymphedemaV1, France, Analysis, bibRecord, 000175

Cell death and diseases related to oxidative stress:4-hydroxynonenal (HNE) in the balance

Identifieur interne : 000175 ( France/Analysis ); précédent : 000174; suivant : 000176

Cell death and diseases related to oxidative stress:4-hydroxynonenal (HNE) in the balance

Auteurs : S. Dalleau [France] ; M. Baradat [France] ; F. Guéraud [France] ; L. Huc [France]

Source :

Cell Death and Differentiation [ 1350-9047 ] ; 2013.

RBID : PMC:3824598

Abstract

During the last three decades, 4-hydroxy-2-nonenal (HNE), a major α,β-unsaturated aldehyde product of n-6 fatty acid oxidation, has been shown to be involved in a great number of pathologies such as metabolic diseases, neurodegenerative diseases and cancers. These multiple pathologies can be explained by the fact that HNE is a potent modulator of numerous cell processes such as oxidative stress signaling, cell proliferation, transformation or cell death. The main objective of this review is to focus on the different aspects of HNE-induced cell death, with a particular emphasis on apoptosis. HNE is a special apoptotic inducer because of its abilities to form protein adducts and to propagate oxidative stress. It can stimulate intrinsic and extrinsic apoptotic pathways and interact with typical actors such as tumor protein 53, JNK, Fas or mitochondrial regulators. At the same time, due to its oxidant status, it can also induce some cellular defense mechanisms against oxidative stress, thus being involved in its own detoxification. These processes in turn limit the apoptotic potential of HNE. These dualities can imbalance cell fate, either toward cell death or toward survival, depending on the cell type, the metabolic state and the ability to detoxify.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824598

DOI: 10.1038/cdd.2013.138
PubMed: 24096871
PubMed Central: 3824598

Affiliations:

France

Links to Exploration step

PMC:3824598

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cell death and diseases related to oxidative stress:4-hydroxynonenal (HNE) in the balance</title>
<author><name sortKey="Dalleau, S" sort="Dalleau, S" uniqKey="Dalleau S" first="S" last="Dalleau">S. Dalleau</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>INRA, TOXALIM (Research Centre in Food Toxicology)</institution>
, 180 chemin de Tournefeuille, F-31027 Toulouse,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Université de Toulouse III, INP, ENVT, UPS, TOXALIM</institution>
, F-31027 Toulouse,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Baradat, M" sort="Baradat, M" uniqKey="Baradat M" first="M" last="Baradat">M. Baradat</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>INRA, TOXALIM (Research Centre in Food Toxicology)</institution>
, 180 chemin de Tournefeuille, F-31027 Toulouse,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Université de Toulouse III, INP, ENVT, UPS, TOXALIM</institution>
, F-31027 Toulouse,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gueraud, F" sort="Gueraud, F" uniqKey="Gueraud F" first="F" last="Guéraud">F. Guéraud</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>INRA, TOXALIM (Research Centre in Food Toxicology)</institution>
, 180 chemin de Tournefeuille, F-31027 Toulouse,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Université de Toulouse III, INP, ENVT, UPS, TOXALIM</institution>
, F-31027 Toulouse,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Huc, L" sort="Huc, L" uniqKey="Huc L" first="L" last="Huc">L. Huc</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>INRA, TOXALIM (Research Centre in Food Toxicology)</institution>
, 180 chemin de Tournefeuille, F-31027 Toulouse,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Université de Toulouse III, INP, ENVT, UPS, TOXALIM</institution>
, F-31027 Toulouse,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24096871</idno>
<idno type="pmc">3824598</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824598</idno>
<idno type="RBID">PMC:3824598</idno>
<idno type="doi">10.1038/cdd.2013.138</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">000118</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000118</idno>
<idno type="wicri:Area/Pmc/Curation">000118</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000118</idno>
<idno type="wicri:Area/Pmc/Checkpoint">002457</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002457</idno>
<idno type="wicri:Area/Ncbi/Merge">005E09</idno>
<idno type="wicri:Area/Ncbi/Curation">005E09</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">005E09</idno>
<idno type="wicri:doubleKey">1350-9047:2013:Dalleau S:cell:death:and</idno>
<idno type="wicri:Area/Main/Merge">003830</idno>
<idno type="wicri:Area/Main/Curation">003822</idno>
<idno type="wicri:Area/Main/Exploration">003822</idno>
<idno type="wicri:Area/France/Extraction">000175</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cell death and diseases related to oxidative stress:4-hydroxynonenal (HNE) in the balance</title>
<author><name sortKey="Dalleau, S" sort="Dalleau, S" uniqKey="Dalleau S" first="S" last="Dalleau">S. Dalleau</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>INRA, TOXALIM (Research Centre in Food Toxicology)</institution>
, 180 chemin de Tournefeuille, F-31027 Toulouse,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Université de Toulouse III, INP, ENVT, UPS, TOXALIM</institution>
, F-31027 Toulouse,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Baradat, M" sort="Baradat, M" uniqKey="Baradat M" first="M" last="Baradat">M. Baradat</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>INRA, TOXALIM (Research Centre in Food Toxicology)</institution>
, 180 chemin de Tournefeuille, F-31027 Toulouse,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Université de Toulouse III, INP, ENVT, UPS, TOXALIM</institution>
, F-31027 Toulouse,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gueraud, F" sort="Gueraud, F" uniqKey="Gueraud F" first="F" last="Guéraud">F. Guéraud</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>INRA, TOXALIM (Research Centre in Food Toxicology)</institution>
, 180 chemin de Tournefeuille, F-31027 Toulouse,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Université de Toulouse III, INP, ENVT, UPS, TOXALIM</institution>
, F-31027 Toulouse,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Huc, L" sort="Huc, L" uniqKey="Huc L" first="L" last="Huc">L. Huc</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>INRA, TOXALIM (Research Centre in Food Toxicology)</institution>
, 180 chemin de Tournefeuille, F-31027 Toulouse,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Université de Toulouse III, INP, ENVT, UPS, TOXALIM</institution>
, F-31027 Toulouse,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Cell Death and Differentiation</title>
<idno type="ISSN">1350-9047</idno>
<idno type="eISSN">1476-5403</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>During the last three decades, 4-hydroxy-2-nonenal (HNE), a major <italic>α</italic>
,<italic>β-</italic>
unsaturated aldehyde product of n-6 fatty acid oxidation, has been shown to be involved in a great number of pathologies such as metabolic diseases, neurodegenerative diseases and cancers. These multiple pathologies can be explained by the fact that HNE is a potent modulator of numerous cell processes such as oxidative stress signaling, cell proliferation, transformation or cell death. The main objective of this review is to focus on the different aspects of HNE-induced cell death, with a particular emphasis on apoptosis. HNE is a special apoptotic inducer because of its abilities to form protein adducts and to propagate oxidative stress. It can stimulate intrinsic and extrinsic apoptotic pathways and interact with typical actors such as tumor protein 53, JNK, Fas or mitochondrial regulators. At the same time, due to its oxidant status, it can also induce some cellular defense mechanisms against oxidative stress, thus being involved in its own detoxification. These processes in turn limit the apoptotic potential of HNE. These dualities can imbalance cell fate, either toward cell death or toward survival, depending on the cell type, the metabolic state and the ability to detoxify.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
</list>
<tree><country name="France"><noRegion><name sortKey="Dalleau, S" sort="Dalleau, S" uniqKey="Dalleau S" first="S" last="Dalleau">S. Dalleau</name>
</noRegion>
<name sortKey="Baradat, M" sort="Baradat, M" uniqKey="Baradat M" first="M" last="Baradat">M. Baradat</name>
<name sortKey="Baradat, M" sort="Baradat, M" uniqKey="Baradat M" first="M" last="Baradat">M. Baradat</name>
<name sortKey="Dalleau, S" sort="Dalleau, S" uniqKey="Dalleau S" first="S" last="Dalleau">S. Dalleau</name>
<name sortKey="Gueraud, F" sort="Gueraud, F" uniqKey="Gueraud F" first="F" last="Guéraud">F. Guéraud</name>
<name sortKey="Gueraud, F" sort="Gueraud, F" uniqKey="Gueraud F" first="F" last="Guéraud">F. Guéraud</name>
<name sortKey="Huc, L" sort="Huc, L" uniqKey="Huc L" first="L" last="Huc">L. Huc</name>
<name sortKey="Huc, L" sort="Huc, L" uniqKey="Huc L" first="L" last="Huc">L. Huc</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/France/Analysis

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000175 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000175 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    LymphedemaV1
   |flux=    France
   |étape=   Analysis
   |type=    RBID
   |clé=     PMC:3824598
   |texte=   Cell death and diseases related to oxidative stress:4-hydroxynonenal (HNE) in the balance
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/France/Analysis/RBID.i   -Sk "pubmed:24096871" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/France/Analysis/biblio.hfd   \
       | NlmPubMed2Wicri -a LymphedemaV1

This area was generated with Dilib version V0.6.31.
Data generation: Sat Nov 4 17:40:35 2017. Site generation: Tue Feb 13 16:42:16 2024

Serveur d'exploration sur le lymphœdème

Cell death and diseases related to oxidative stress:4-hydroxynonenal (HNE) in the balance

Cell death and diseases related to oxidative stress:4-hydroxynonenal (HNE) in the balance

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.