Role of hypoxia and vascular endothelial growth factors in lymphangiogenesis
Identifieur interne : 000109 ( France/Analysis ); précédent : 000108; suivant : 000110Role of hypoxia and vascular endothelial growth factors in lymphangiogenesis
Auteurs : Florent Morfoisse [France] ; Edith Renaud [France] ; Fransky Hantelys [France] ; Anne-Catherine Prats [France] ; Barbara Garmy-Susini [France]Source :
- Molecular & Cellular Oncology [ 2372-3548 ] ; 2014.
Abstract
Hypoxia is known to be a major factor in the induction of angiogenesis during tumor development but its role in lymphangiogenesis remains unclear. Blood and lymphatic vasculatures are stimulated by the vascular endothelial family of growth factors – the VEGFs. In this review, we investigate the role of hypoxia in the molecular regulation of synthesis of the lymphangiogenic growth factors VEGF-A, VEGF-C, and VEGF-D. Gene expression can be regulated by hypoxia at either transcriptional or translational levels. In contrast to strong induction of DNA transcription by hypoxia-inducible factors (HIFs), the majority of cellular stresses such as hypoxia lead to inhibition of cap-dependent translation of mRNA and downregulation of protein synthesis. Here, we describe how initiation of translation of
Url:
DOI: 10.4161/mco.29907
PubMed: 27308316
PubMed Central: 4905169
Affiliations:
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UPS; Toulouse, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université de Toulouse; UPS; Toulouse</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">UPS; TRADGENE; EA4554; Toulouse, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UPS; TRADGENE; EA4554; Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Renaud, Edith" sort="Renaud, Edith" uniqKey="Renaud E" first="Edith" last="Renaud">Edith Renaud</name><affiliation wicri:level="1"><nlm:aff id="A1">Université de Toulouse; UPS; Toulouse, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université de Toulouse; UPS; Toulouse</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">UPS; TRADGENE; EA4554; Toulouse, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UPS; TRADGENE; EA4554; Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Hantelys, Fransky" sort="Hantelys, Fransky" uniqKey="Hantelys F" first="Fransky" last="Hantelys">Fransky Hantelys</name><affiliation wicri:level="1"><nlm:aff id="A1">Université de Toulouse; UPS; Toulouse, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université de Toulouse; UPS; Toulouse</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">UPS; TRADGENE; EA4554; Toulouse, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UPS; TRADGENE; EA4554; Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Prats, Anne Catherine" sort="Prats, Anne Catherine" uniqKey="Prats A" first="Anne-Catherine" last="Prats">Anne-Catherine Prats</name><affiliation wicri:level="1"><nlm:aff id="A1">Université de Toulouse; UPS; Toulouse, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université de Toulouse; UPS; Toulouse</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">UPS; TRADGENE; EA4554; Toulouse, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UPS; TRADGENE; EA4554; Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Garmy Susini, Barbara" sort="Garmy Susini, Barbara" uniqKey="Garmy Susini B" first="Barbara" last="Garmy-Susini">Barbara Garmy-Susini</name><affiliation wicri:level="1"><nlm:aff id="A3">INSERM U1048; Toulouse, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1048; Toulouse</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A1">Université de Toulouse; UPS; Toulouse, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université de Toulouse; UPS; Toulouse</wicri:regionArea></affiliation></author></analytic><series><title level="j">Molecular & Cellular Oncology</title><idno type="ISSN">2372-3548</idno><idno type="eISSN">2372-3556</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Hypoxia is known to be a major factor in the induction of angiogenesis during tumor development but its role in lymphangiogenesis remains unclear. Blood and lymphatic vasculatures are stimulated by the vascular endothelial family of growth factors – the VEGFs. In this review, we investigate the role of hypoxia in the molecular regulation of synthesis of the lymphangiogenic growth factors VEGF-A, VEGF-C, and VEGF-D. Gene expression can be regulated by hypoxia at either transcriptional or translational levels. In contrast to strong induction of DNA transcription by hypoxia-inducible factors (HIFs), the majority of cellular stresses such as hypoxia lead to inhibition of cap-dependent translation of mRNA and downregulation of protein synthesis. Here, we describe how initiation of translation of <italic>VEGF</italic> mRNA is induced by hypoxia through an internal ribosome entry site (IRES)-dependent mechanism. Considering the implications of the lymphatic vasculature for metastatic dissemination, it is crucial to understand the molecular regulation of lymphangiogenic growth factors by hypoxia to obtain new insights into cancer therapy.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Jeltsch, M" uniqKey="Jeltsch M">M Jeltsch</name></author><author><name sortKey="Tammela, T" uniqKey="Tammela T">T Tammela</name></author><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author><author><name sortKey="Wilting, J" uniqKey="Wilting J">J Wilting</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baluk, P" uniqKey="Baluk P">P Baluk</name></author><author><name sortKey="Tammela, T" uniqKey="Tammela T">T Tammela</name></author><author><name sortKey="Ator, E" uniqKey="Ator E">E Ator</name></author><author><name sortKey="Lyubynska, N" uniqKey="Lyubynska N">N 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Lee</name></author><author><name sortKey="Tung, Hj" uniqKey="Tung H">HJ Tung</name></author><author><name sortKey="Hsu, Hs" uniqKey="Hsu H">HS Hsu</name></author><author><name sortKey="Hsu, Wh" uniqKey="Hsu W">WH Hsu</name></author><author><name sortKey="Sun, Gh" uniqKey="Sun G">GH Sun</name></author><author><name sortKey="Yu, Cp" uniqKey="Yu C">CP Yu</name></author><author><name sortKey="Jin, Js" uniqKey="Jin J">JS Jin</name></author><author><name sortKey="Cheng, Yl" uniqKey="Cheng Y">YL Cheng</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li></country></list><tree><country name="France"><noRegion><name sortKey="Morfoisse, Florent" sort="Morfoisse, Florent" uniqKey="Morfoisse F" first="Florent" last="Morfoisse">Florent Morfoisse</name></noRegion><name sortKey="Garmy Susini, Barbara" sort="Garmy Susini, Barbara" uniqKey="Garmy Susini B" first="Barbara" last="Garmy-Susini">Barbara Garmy-Susini</name><name sortKey="Garmy Susini, Barbara" sort="Garmy Susini, Barbara" uniqKey="Garmy Susini B" first="Barbara" last="Garmy-Susini">Barbara Garmy-Susini</name><name sortKey="Hantelys, Fransky" sort="Hantelys, Fransky" uniqKey="Hantelys F" first="Fransky" last="Hantelys">Fransky Hantelys</name><name sortKey="Hantelys, Fransky" sort="Hantelys, Fransky" uniqKey="Hantelys F" first="Fransky" last="Hantelys">Fransky Hantelys</name><name sortKey="Morfoisse, Florent" sort="Morfoisse, Florent" uniqKey="Morfoisse F" first="Florent" last="Morfoisse">Florent Morfoisse</name><name sortKey="Prats, Anne Catherine" sort="Prats, Anne Catherine" uniqKey="Prats A" first="Anne-Catherine" last="Prats">Anne-Catherine Prats</name><name sortKey="Prats, Anne Catherine" sort="Prats, Anne Catherine" uniqKey="Prats A" first="Anne-Catherine" last="Prats">Anne-Catherine Prats</name><name sortKey="Renaud, Edith" sort="Renaud, Edith" uniqKey="Renaud E" first="Edith" last="Renaud">Edith Renaud</name><name sortKey="Renaud, Edith" sort="Renaud, Edith" uniqKey="Renaud E" first="Edith" last="Renaud">Edith Renaud</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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