Role of hypoxia and vascular endothelial growth factors in lymphangiogenesis
Identifieur interne : 000067 ( France/Analysis ); précédent : 000066; suivant : 000068Role of hypoxia and vascular endothelial growth factors in lymphangiogenesis
Auteurs : Florent Morfoisse [France] ; Edith Renaud [France] ; Fransky Hantelys [France] ; Anne-Catherine Prats [France] ; Barbara Garmy-Susini [France]Source :
- Molecular & Cellular Oncology [ 2372-3556 ] ; 2015.
Abstract
Hypoxia is a major condition for the induction of angiogenesis during tumor development but its role in lymphangiogenesis remains unclear. Blood and lymphatic vasculatures are stimulated by growth factors from the vascular endothelial family: the VEGFs. In this review, we investigate the role of hypoxia in the molecular regulation of synthesis of lymphangiogenic growth factors VEGF-A, VEGF-C, and VEGF-D. Gene expression can be regulated at transcriptional and translational levels by hypoxia. Despite strong regulation of DNA transcription induced by hypoxia-inducible factors (HIFs), the majority of cellular stresses such as hypoxia lead to inhibition of cap-dependent translation of the mRNA, resulting in downregulation of protein synthesis. Here, we describe how translation initiation of VEGF mRNAs is induced by hypoxia through an internal ribosome entry site (IRES)-dependent mechanism. Considering the implication of the lymphatic vasculature in metastatic dissemination, it seems crucial to understand the hypoxia-induced molecular regulation of lymphangiogenic growth factors to obtain new insights for cancer therapy.
Url:
DOI: 10.1080/23723556.2015.1024821
PubMed: 27308508
PubMed Central: 4905355
Affiliations:
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strict</wicri:regionArea></affiliation></author><author><name sortKey="Prats, Anne Catherine" sort="Prats, Anne Catherine" uniqKey="Prats A" first="Anne-Catherine" last="Prats">Anne-Catherine Prats</name><affiliation wicri:level="1"><nlm:aff id="af0002"><institution>TRADGENE, UPS (EA4554)</institution>,<addr-line>F-31432</addr-line>, Toulouse,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Garmy Susini, Barbara" sort="Garmy Susini, Barbara" uniqKey="Garmy Susini B" first="Barbara" last="Garmy-Susini">Barbara Garmy-Susini</name><affiliation wicri:level="1"><nlm:aff id="af0001"><institution>UMR 1048-I2MC, INSERM, UPS</institution>,<addr-line>F-31432</addr-line>, Toulouse,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Molecular & Cellular Oncology</title><idno type="eISSN">2372-3556</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Hypoxia is a major condition for the induction of angiogenesis during tumor development but its role in lymphangiogenesis remains unclear. Blood and lymphatic vasculatures are stimulated by growth factors from the vascular endothelial family: the VEGFs. In this review, we investigate the role of hypoxia in the molecular regulation of synthesis of lymphangiogenic growth factors VEGF-A, VEGF-C, and VEGF-D. Gene expression can be regulated at transcriptional and translational levels by hypoxia. Despite strong regulation of DNA transcription induced by hypoxia-inducible factors (HIFs), the majority of cellular stresses such as hypoxia lead to inhibition of cap-dependent translation of the mRNA, resulting in downregulation of protein synthesis. Here, we describe how translation initiation of VEGF mRNAs is induced by hypoxia through an internal ribosome entry site (IRES)-dependent mechanism. 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uniqKey="Ohgi S">S Ohgi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tzao, C" uniqKey="Tzao C">C Tzao</name></author><author><name sortKey="Lee, Sc" uniqKey="Lee S">SC Lee</name></author><author><name sortKey="Tung, Hj" uniqKey="Tung H">HJ Tung</name></author><author><name sortKey="Hsu, Hs" uniqKey="Hsu H">HS Hsu</name></author><author><name sortKey="Hsu, Wh" uniqKey="Hsu W">WH Hsu</name></author><author><name sortKey="Sun, Gh" uniqKey="Sun G">GH Sun</name></author><author><name sortKey="Yu, Cp" uniqKey="Yu C">CP Yu</name></author><author><name sortKey="Jin, Js" uniqKey="Jin J">JS Jin</name></author><author><name sortKey="Cheng, Yl" uniqKey="Cheng Y">YL Cheng</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li></country></list><tree><country name="France"><noRegion><name sortKey="Morfoisse, Florent" sort="Morfoisse, Florent" uniqKey="Morfoisse F" first="Florent" last="Morfoisse">Florent Morfoisse</name></noRegion><name sortKey="Garmy Susini, Barbara" sort="Garmy Susini, Barbara" uniqKey="Garmy Susini B" first="Barbara" last="Garmy-Susini">Barbara Garmy-Susini</name><name sortKey="Hantelys, Fransky" sort="Hantelys, Fransky" uniqKey="Hantelys F" first="Fransky" last="Hantelys">Fransky Hantelys</name><name sortKey="Prats, Anne Catherine" sort="Prats, Anne Catherine" uniqKey="Prats A" first="Anne-Catherine" last="Prats">Anne-Catherine Prats</name><name sortKey="Renaud, Edith" sort="Renaud, Edith" uniqKey="Renaud E" first="Edith" last="Renaud">Edith Renaud</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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