LockdownV1, Main, Exploration, bibRecord, 002890

Nanobody-triggered lockdown of VSRs reveals ligand reloading in the Golgi.

Identifieur interne : 002890 ( Main/Exploration ); précédent : 002889; suivant : 002891

Nanobody-triggered lockdown of VSRs reveals ligand reloading in the Golgi.

Auteurs : Simone Früholz [Allemagne] ; Florian F Ler [Allemagne] ; Üner Kolukisaoglu [Allemagne] ; Peter Pimpl [Allemagne, République populaire de Chine]

Source :

Nature communications [ 2041-1723 ] ; 2018.

RBID : pubmed:29440677

Descripteurs français

KwdFr :
- Appareil de Golgi (génétique), Appareil de Golgi (métabolisme), Arabidopsis (génétique), Arabidopsis (métabolisme), Endocytose (MeSH), Endosomes (génétique), Endosomes (métabolisme), Ligands (MeSH), Pois (génétique), Pois (métabolisme), Protéines végétales (génétique), Protéines végétales (métabolisme), Réseau trans-golgien (génétique), Réseau trans-golgien (métabolisme), Tabac (génétique), Tabac (métabolisme), Transport des protéines (MeSH), Vacuoles (génétique), Vacuoles (métabolisme).
MESH :
- génétique : Appareil de Golgi, Arabidopsis, Endosomes, Pois, Protéines végétales, Réseau trans-golgien, Tabac, Vacuoles.
- métabolisme : Appareil de Golgi, Arabidopsis, Endosomes, Pois, Protéines végétales, Réseau trans-golgien, Tabac, Vacuoles.
- Endocytose, Ligands, Transport des protéines.

English descriptors

KwdEn :
- Arabidopsis (genetics), Arabidopsis (metabolism), Endocytosis (MeSH), Endosomes (genetics), Endosomes (metabolism), Golgi Apparatus (genetics), Golgi Apparatus (metabolism), Ligands (MeSH), Peas (genetics), Peas (metabolism), Plant Proteins (genetics), Plant Proteins (metabolism), Protein Transport (MeSH), Tobacco (genetics), Tobacco (metabolism), Vacuoles (genetics), Vacuoles (metabolism), trans-Golgi Network (genetics), trans-Golgi Network (metabolism).
MESH :
- chemical , genetics : Plant Proteins.
- chemical , metabolism : Plant Proteins.
- chemical : Ligands.
- genetics : Arabidopsis, Endosomes, Golgi Apparatus, Peas, Tobacco, Vacuoles, trans-Golgi Network.
- metabolism : Arabidopsis, Endosomes, Golgi Apparatus, Peas, Tobacco, Vacuoles, trans-Golgi Network.
- Endocytosis, Protein Transport.

Abstract

Protein degradation in lytic compartments is crucial for eukaryotic cells. At the heart of this process, vacuolar sorting receptors (VSRs) bind soluble hydrolases in the secretory pathway and release them into the vacuolar route. Sorting efficiency is suggested to result from receptor recycling. However, how and to where plant VSRs recycle remains controversial. Here we present a nanobody-epitope interaction-based protein labeling and tracking approach to dissect their anterograde and retrograde transport routes in vivo. We simultaneously employ two different nanobody-epitope pairs: one for the location-specific post-translational fluorescence labeling of receptors and the other pair to trigger their compartment-specific lockdown via an endocytosed dual-epitope linker protein. We demonstrate VSR recycling from the TGN/EE, thereby identifying the cis-Golgi as the recycling target and show that recycled VSRs reload ligands. This is evidence that bidirectional VSR-mediated sorting of vacuolar proteins exists and occurs between the Golgi and the TGN/EE.

DOI: 10.1038/s41467-018-02909-6
PubMed: 29440677
PubMed Central: PMC5811495

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 002892
to stream Main, to step Curation: 002892

Le document en format XML

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<term>Tabac (génétique)</term>
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<front><div type="abstract" xml:lang="en">Protein degradation in lytic compartments is crucial for eukaryotic cells. At the heart of this process, vacuolar sorting receptors (VSRs) bind soluble hydrolases in the secretory pathway and release them into the vacuolar route. Sorting efficiency is suggested to result from receptor recycling. However, how and to where plant VSRs recycle remains controversial. Here we present a nanobody-epitope interaction-based protein labeling and tracking approach to dissect their anterograde and retrograde transport routes in vivo. We simultaneously employ two different nanobody-epitope pairs: one for the location-specific post-translational fluorescence labeling of receptors and the other pair to trigger their compartment-specific lockdown via an endocytosed dual-epitope linker protein. We demonstrate VSR recycling from the TGN/EE, thereby identifying the cis-Golgi as the recycling target and show that recycled VSRs reload ligands. This is evidence that bidirectional VSR-mediated sorting of vacuolar proteins exists and occurs between the Golgi and the TGN/EE.</div>
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<Abstract><AbstractText>Protein degradation in lytic compartments is crucial for eukaryotic cells. At the heart of this process, vacuolar sorting receptors (VSRs) bind soluble hydrolases in the secretory pathway and release them into the vacuolar route. Sorting efficiency is suggested to result from receptor recycling. However, how and to where plant VSRs recycle remains controversial. Here we present a nanobody-epitope interaction-based protein labeling and tracking approach to dissect their anterograde and retrograde transport routes in vivo. We simultaneously employ two different nanobody-epitope pairs: one for the location-specific post-translational fluorescence labeling of receptors and the other pair to trigger their compartment-specific lockdown via an endocytosed dual-epitope linker protein. We demonstrate VSR recycling from the TGN/EE, thereby identifying the cis-Golgi as the recycling target and show that recycled VSRs reload ligands. This is evidence that bidirectional VSR-mediated sorting of vacuolar proteins exists and occurs between the Golgi and the TGN/EE.</AbstractText>
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<ReferenceList><Reference><Citation>J Cell Biol. 1988 Mar;106(3):617-28</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2964450</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1985 Mar 25;260(6):3731-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3871776</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Plant Cell. 2011 Sep;23(9):3463-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21934143</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Protein Sci. 2010 Dec;19(12):2389-401</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20945358</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2016 Feb 19;291(8):3767-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26677230</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Plant Physiol. 1997 May;114(1):325-36</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9159954</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Plant Cell Physiol. 2004 Jan;45(1):9-17</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14749481</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Plant Cell Physiol. 2002 Jul;43(7):726-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12154135</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Plant J. 2010 Jan;61(1):107-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19796370</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Plant Cell. 2004 Mar;16(3):672-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14973159</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Annu Rev Plant Biol. 2016 Apr 29;67:309-35</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27128466</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Plants. 2015 Jul 06;1:15094</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27250258</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Plant Cell. 2007 Jan;19(1):296-319</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17209124</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Plant Cell. 2002 Jan;14(1):237-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11826310</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Plant. 2011 Sep;4(5):854-68</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21493745</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Plant Cell. 2013 Sep;25(9):3434-49</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24014545</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1985 Oct 5;260(22):12008-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2931431</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMC Plant Biol. 2012 Sep 12;12:164</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22970698</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Plant J. 2004 Mar;37(5):678-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14871308</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Plant Cell. 2000 Apr;12(4):493-506</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10760239</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Annu Rev Biochem. 1986;55:663-700</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2874766</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Plant. 2013 Sep;6(5):1419-37</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23702593</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Drug Discov Today. 2016 Jul;21(7):1076-113</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27080147</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Essays Biochem. 2016 Oct 15;60(2):173-180</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27744333</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3403-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8159760</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Biol. 2014 Jun 16;24(12 ):1383-1389</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24881875</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1979 May;76(5):2331-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">287076</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Bot. 2016 Aug;67(15):4435-49</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27262127</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Plant Cell. 2006 Jun;18(6):1477-97</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16714388</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Plant Cell. 2014 Mar;26(3):1308-29</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24642936</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Protoplasma. 2014 Jan;251(1):247-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24019013</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Plant Cell. 2014 Sep;26(9):3693-708</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25271241</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Methods. 2006 Nov;3(11):887-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17060912</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Plant Cell. 2013 Oct;25(10):4028-43</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24104564</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Mol Biol. 2013 Jul 24;425(14):2397-411</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23557833</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Cell Biol. 1980 Jun;85(3):839-52</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7190150</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1983 Jun 10;258(11):7121-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6304079</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cold Spring Harb Symp Quant Biol. 1982;46 Pt 2:713-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6286220</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Plant Cell. 2006 Mar;18(3):715-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16461582</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Plant J. 2010 May 1;62(4):601-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20149141</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 1993 Jun 3;363(6428):446-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8502296</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Plant Physiol. 1997 Sep;115(1):29-39</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9306690</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1974 Aug 25;249(16):5153-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">4368448</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Ageing Res Rev. 2016 Dec;32:51-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27143694</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Plant J. 2014 Dec;80(6):977-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25293377</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Plant Cell. 2010 Aug;22(8):2825-37</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20807880</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Plant Cell. 2006 Sep;18(9):2275-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16935987</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Ageing Res Rev. 2016 Dec;32:2-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27125853</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Plants. 2016 Mar 07;2:16017</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27249560</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
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Nanobody-triggered lockdown of VSRs reveals ligand reloading in the Golgi.

Nanobody-triggered lockdown of VSRs reveals ligand reloading in the Golgi.

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