The Oxford Royal College of General Practitioners Clinical Informatics Digital Hub: Protocol to Develop Extended COVID-19 Surveillance and Trial Platforms.
Identifieur interne : 002541 ( Main/Corpus ); précédent : 002540; suivant : 002542The Oxford Royal College of General Practitioners Clinical Informatics Digital Hub: Protocol to Develop Extended COVID-19 Surveillance and Trial Platforms.
Auteurs : Simon De Lusignan ; Nicholas Jones ; Jienchi Dorward ; Rachel Byford ; Harshana Liyanage ; John Briggs ; Filipa Ferreira ; Oluwafunmi Akinyemi ; Gayatri Amirthalingam ; Chris Bates ; Jamie Lopez Bernal ; Gavin Dabrera ; Alex Eavis ; Alex J. Elliot ; Michael Feher ; Else Krajenbrink ; Uy Hoang ; Gary Howsam ; Jonathan Leach ; Cecilia Okusi ; Brian Nicholson ; Philip Nieri ; Julian Sherlock ; Gillian Smith ; Mark Thomas ; Nicholas Thomas ; Manasa Tripathy ; William Victor ; John Williams ; Ian Wood ; Maria Zambon ; John Parry ; Shaun O'Hanlon ; Mark Joy ; Chris Butler ; Martin Marshall ; F D Richard HobbsSource :
- JMIR public health and surveillance [ 2369-2960 ] ; 2020.
English descriptors
- KwdEn :
- COVID-19 (MeSH), Clinical Trials as Topic (MeSH), Coronavirus Infections (epidemiology), General Practice (organization & administration), Humans (MeSH), Medical Records Systems, Computerized (MeSH), Pandemics (MeSH), Pneumonia, Viral (epidemiology), Primary Health Care (organization & administration), Public Health Surveillance (MeSH), Societies, Medical (MeSH), United Kingdom (epidemiology).
- MESH :
- geographic , epidemiology : United Kingdom.
- epidemiology : Coronavirus Infections, Pneumonia, Viral.
- organization & administration : General Practice, Primary Health Care.
- COVID-19, Clinical Trials as Topic, Humans, Medical Records Systems, Computerized, Pandemics, Public Health Surveillance, Societies, Medical.
Abstract
BACKGROUND
Routinely recorded primary care data have been used for many years by sentinel networks for surveillance. More recently, real world data have been used for a wider range of research projects to support rapid, inexpensive clinical trials. Because the partial national lockdown in the United Kingdom due to the coronavirus disease (COVID-19) pandemic has resulted in decreasing community disease incidence, much larger numbers of general practices are needed to deliver effective COVID-19 surveillance and contribute to in-pandemic clinical trials.
OBJECTIVE
The aim of this protocol is to describe the rapid design and development of the Oxford Royal College of General Practitioners Clinical Informatics Digital Hub (ORCHID) and its first two platforms. The Surveillance Platform will provide extended primary care surveillance, while the Trials Platform is a streamlined clinical trials platform that will be integrated into routine primary care practice.
METHODS
We will apply the FAIR (Findable, Accessible, Interoperable, and Reusable) metadata principles to a new, integrated digital health hub that will extract routinely collected general practice electronic health data for use in clinical trials and provide enhanced communicable disease surveillance. The hub will be findable through membership in Health Data Research UK and European metadata repositories. Accessibility through an online application system will provide access to study-ready data sets or developed custom data sets. Interoperability will be facilitated by fixed linkage to other key sources such as Hospital Episodes Statistics and the Office of National Statistics using pseudonymized data. All semantic descriptors (ie, ontologies) and code used for analysis will be made available to accelerate analyses. We will also make data available using common data models, starting with the US Food and Drug Administration Sentinel and Observational Medical Outcomes Partnership approaches, to facilitate international studies. The Surveillance Platform will provide access to data for health protection and promotion work as authorized through agreements between Oxford, the Royal College of General Practitioners, and Public Health England. All studies using the Trials Platform will go through appropriate ethical and other regulatory approval processes.
RESULTS
The hub will be a bottom-up, professionally led network that will provide benefits for member practices, our health service, and the population served. Data will only be used for SQUIRE (surveillance, quality improvement, research, and education) purposes. We have already received positive responses from practices, and the number of practices in the network has doubled to over 1150 since February 2020. COVID-19 surveillance has resulted in tripling of the number of virology sites to 293 (target 300), which has aided the collection of the largest ever weekly total of surveillance swabs in the United Kingdom as well as over 3000 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serology samples. Practices are recruiting to the PRINCIPLE (Platform Randomised trial of INterventions against COVID-19 In older PeopLE) trial, and these participants will be followed up through ORCHID. These initial outputs demonstrate the feasibility of ORCHID to provide an extended national digital health hub.
CONCLUSIONS
ORCHID will provide equitable and innovative use of big data through a professionally led national primary care network and the application of FAIR principles. The secure data hub will host routinely collected general practice data linked to other key health care repositories for clinical trials and support enhanced in situ surveillance without always requiring large volume data extracts. ORCHID will support rapid data extraction, analysis, and dissemination with the aim of improving future research and development in general practice to positively impact patient care.
INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID)
DERR1-10.2196/19773.
DOI: 10.2196/19773
PubMed: 32484782
PubMed Central: PMC7333793
Links to Exploration step
pubmed:32484782Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Oxford Royal College of General Practitioners Clinical Informatics Digital Hub: Protocol to Develop Extended COVID-19 Surveillance and Trial Platforms.</title><author><name sortKey="De Lusignan, Simon" sort="De Lusignan, Simon" uniqKey="De Lusignan S" first="Simon" last="De Lusignan">Simon De Lusignan</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Royal College of General Practitioners, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Jones, Nicholas" sort="Jones, Nicholas" uniqKey="Jones N" first="Nicholas" last="Jones">Nicholas Jones</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Dorward, Jienchi" sort="Dorward, Jienchi" uniqKey="Dorward J" first="Jienchi" last="Dorward">Jienchi Dorward</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Byford, Rachel" sort="Byford, Rachel" uniqKey="Byford R" first="Rachel" last="Byford">Rachel Byford</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Liyanage, Harshana" sort="Liyanage, Harshana" uniqKey="Liyanage H" first="Harshana" last="Liyanage">Harshana Liyanage</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Briggs, John" sort="Briggs, John" uniqKey="Briggs J" first="John" last="Briggs">John Briggs</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Ferreira, Filipa" sort="Ferreira, Filipa" uniqKey="Ferreira F" first="Filipa" last="Ferreira">Filipa Ferreira</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Akinyemi, Oluwafunmi" sort="Akinyemi, Oluwafunmi" uniqKey="Akinyemi O" first="Oluwafunmi" last="Akinyemi">Oluwafunmi Akinyemi</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Amirthalingam, Gayatri" sort="Amirthalingam, Gayatri" uniqKey="Amirthalingam G" first="Gayatri" last="Amirthalingam">Gayatri Amirthalingam</name><affiliation><nlm:affiliation>Public Health England, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Bates, Chris" sort="Bates, Chris" uniqKey="Bates C" first="Chris" last="Bates">Chris Bates</name><affiliation><nlm:affiliation>TPP SystmOne, Leeds, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Lopez Bernal, Jamie" sort="Lopez Bernal, Jamie" uniqKey="Lopez Bernal J" first="Jamie" last="Lopez Bernal">Jamie Lopez Bernal</name><affiliation><nlm:affiliation>Public Health England, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Dabrera, Gavin" sort="Dabrera, Gavin" uniqKey="Dabrera G" first="Gavin" last="Dabrera">Gavin Dabrera</name><affiliation><nlm:affiliation>Public Health England, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Eavis, Alex" sort="Eavis, Alex" uniqKey="Eavis A" first="Alex" last="Eavis">Alex Eavis</name><affiliation><nlm:affiliation>EMIS Group, Leeds, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Elliot, Alex J" sort="Elliot, Alex J" uniqKey="Elliot A" first="Alex J" last="Elliot">Alex J. Elliot</name><affiliation><nlm:affiliation>Real-time Syndromic Surveillance Team, Field Service, Public Health England, Birmingham, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Feher, Michael" sort="Feher, Michael" uniqKey="Feher M" first="Michael" last="Feher">Michael Feher</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Krajenbrink, Else" sort="Krajenbrink, Else" uniqKey="Krajenbrink E" first="Else" last="Krajenbrink">Else Krajenbrink</name><affiliation><nlm:affiliation>Royal College of General Practitioners, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Hoang, Uy" sort="Hoang, Uy" uniqKey="Hoang U" first="Uy" last="Hoang">Uy Hoang</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Howsam, Gary" sort="Howsam, Gary" uniqKey="Howsam G" first="Gary" last="Howsam">Gary Howsam</name><affiliation><nlm:affiliation>Royal College of General Practitioners, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Leach, Jonathan" sort="Leach, Jonathan" uniqKey="Leach J" first="Jonathan" last="Leach">Jonathan Leach</name><affiliation><nlm:affiliation>Royal College of General Practitioners, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Okusi, Cecilia" sort="Okusi, Cecilia" uniqKey="Okusi C" first="Cecilia" last="Okusi">Cecilia Okusi</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Nicholson, Brian" sort="Nicholson, Brian" uniqKey="Nicholson B" first="Brian" last="Nicholson">Brian Nicholson</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Nieri, Philip" sort="Nieri, Philip" uniqKey="Nieri P" first="Philip" last="Nieri">Philip Nieri</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Sherlock, Julian" sort="Sherlock, Julian" uniqKey="Sherlock J" first="Julian" last="Sherlock">Julian Sherlock</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Smith, Gillian" sort="Smith, Gillian" uniqKey="Smith G" first="Gillian" last="Smith">Gillian Smith</name><affiliation><nlm:affiliation>Real-time Syndromic Surveillance Team, Field Service, Public Health England, Birmingham, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Thomas, Mark" sort="Thomas, Mark" uniqKey="Thomas M" first="Mark" last="Thomas">Mark Thomas</name><affiliation><nlm:affiliation>Royal College of General Practitioners, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Thomas, Nicholas" sort="Thomas, Nicholas" uniqKey="Thomas N" first="Nicholas" last="Thomas">Nicholas Thomas</name><affiliation><nlm:affiliation>Royal College of General Practitioners, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Tripathy, Manasa" sort="Tripathy, Manasa" uniqKey="Tripathy M" first="Manasa" last="Tripathy">Manasa Tripathy</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Victor, William" sort="Victor, William" uniqKey="Victor W" first="William" last="Victor">William Victor</name><affiliation><nlm:affiliation>Royal College of General Practitioners, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Williams, John" sort="Williams, John" uniqKey="Williams J" first="John" last="Williams">John Williams</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Wood, Ian" sort="Wood, Ian" uniqKey="Wood I" first="Ian" last="Wood">Ian Wood</name><affiliation><nlm:affiliation>Royal College of General Practitioners, London, United Kingdom.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>EMIS Group, Leeds, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Zambon, Maria" sort="Zambon, Maria" uniqKey="Zambon M" first="Maria" last="Zambon">Maria Zambon</name><affiliation><nlm:affiliation>Public Health England, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Parry, John" sort="Parry, John" uniqKey="Parry J" first="John" last="Parry">John Parry</name><affiliation><nlm:affiliation>TPP SystmOne, Leeds, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="O Hanlon, Shaun" sort="O Hanlon, Shaun" uniqKey="O Hanlon S" first="Shaun" last="O'Hanlon">Shaun O'Hanlon</name><affiliation><nlm:affiliation>EMIS Group, Leeds, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Joy, Mark" sort="Joy, Mark" uniqKey="Joy M" first="Mark" last="Joy">Mark Joy</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Butler, Chris" sort="Butler, Chris" uniqKey="Butler C" first="Chris" last="Butler">Chris Butler</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Marshall, Martin" sort="Marshall, Martin" uniqKey="Marshall M" first="Martin" last="Marshall">Martin Marshall</name><affiliation><nlm:affiliation>Royal College of General Practitioners, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Hobbs, F D Richard" sort="Hobbs, F D Richard" uniqKey="Hobbs F" first="F D Richard" last="Hobbs">F D Richard Hobbs</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32484782</idno><idno type="pmid">32484782</idno><idno type="doi">10.2196/19773</idno><idno type="pmc">PMC7333793</idno><idno type="wicri:Area/Main/Corpus">002541</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">002541</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The Oxford Royal College of General Practitioners Clinical Informatics Digital Hub: Protocol to Develop Extended COVID-19 Surveillance and Trial Platforms.</title><author><name sortKey="De Lusignan, Simon" sort="De Lusignan, Simon" uniqKey="De Lusignan S" first="Simon" last="De Lusignan">Simon De Lusignan</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Royal College of General Practitioners, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Jones, Nicholas" sort="Jones, Nicholas" uniqKey="Jones N" first="Nicholas" last="Jones">Nicholas Jones</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Dorward, Jienchi" sort="Dorward, Jienchi" uniqKey="Dorward J" first="Jienchi" last="Dorward">Jienchi Dorward</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Byford, Rachel" sort="Byford, Rachel" uniqKey="Byford R" first="Rachel" last="Byford">Rachel Byford</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Liyanage, Harshana" sort="Liyanage, Harshana" uniqKey="Liyanage H" first="Harshana" last="Liyanage">Harshana Liyanage</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Briggs, John" sort="Briggs, John" uniqKey="Briggs J" first="John" last="Briggs">John Briggs</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Ferreira, Filipa" sort="Ferreira, Filipa" uniqKey="Ferreira F" first="Filipa" last="Ferreira">Filipa Ferreira</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Akinyemi, Oluwafunmi" sort="Akinyemi, Oluwafunmi" uniqKey="Akinyemi O" first="Oluwafunmi" last="Akinyemi">Oluwafunmi Akinyemi</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Amirthalingam, Gayatri" sort="Amirthalingam, Gayatri" uniqKey="Amirthalingam G" first="Gayatri" last="Amirthalingam">Gayatri Amirthalingam</name><affiliation><nlm:affiliation>Public Health England, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Bates, Chris" sort="Bates, Chris" uniqKey="Bates C" first="Chris" last="Bates">Chris Bates</name><affiliation><nlm:affiliation>TPP SystmOne, Leeds, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Lopez Bernal, Jamie" sort="Lopez Bernal, Jamie" uniqKey="Lopez Bernal J" first="Jamie" last="Lopez Bernal">Jamie Lopez Bernal</name><affiliation><nlm:affiliation>Public Health England, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Dabrera, Gavin" sort="Dabrera, Gavin" uniqKey="Dabrera G" first="Gavin" last="Dabrera">Gavin Dabrera</name><affiliation><nlm:affiliation>Public Health England, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Eavis, Alex" sort="Eavis, Alex" uniqKey="Eavis A" first="Alex" last="Eavis">Alex Eavis</name><affiliation><nlm:affiliation>EMIS Group, Leeds, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Elliot, Alex J" sort="Elliot, Alex J" uniqKey="Elliot A" first="Alex J" last="Elliot">Alex J. Elliot</name><affiliation><nlm:affiliation>Real-time Syndromic Surveillance Team, Field Service, Public Health England, Birmingham, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Feher, Michael" sort="Feher, Michael" uniqKey="Feher M" first="Michael" last="Feher">Michael Feher</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Krajenbrink, Else" sort="Krajenbrink, Else" uniqKey="Krajenbrink E" first="Else" last="Krajenbrink">Else Krajenbrink</name><affiliation><nlm:affiliation>Royal College of General Practitioners, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Hoang, Uy" sort="Hoang, Uy" uniqKey="Hoang U" first="Uy" last="Hoang">Uy Hoang</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Howsam, Gary" sort="Howsam, Gary" uniqKey="Howsam G" first="Gary" last="Howsam">Gary Howsam</name><affiliation><nlm:affiliation>Royal College of General Practitioners, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Leach, Jonathan" sort="Leach, Jonathan" uniqKey="Leach J" first="Jonathan" last="Leach">Jonathan Leach</name><affiliation><nlm:affiliation>Royal College of General Practitioners, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Okusi, Cecilia" sort="Okusi, Cecilia" uniqKey="Okusi C" first="Cecilia" last="Okusi">Cecilia Okusi</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Nicholson, Brian" sort="Nicholson, Brian" uniqKey="Nicholson B" first="Brian" last="Nicholson">Brian Nicholson</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Nieri, Philip" sort="Nieri, Philip" uniqKey="Nieri P" first="Philip" last="Nieri">Philip Nieri</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Sherlock, Julian" sort="Sherlock, Julian" uniqKey="Sherlock J" first="Julian" last="Sherlock">Julian Sherlock</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Smith, Gillian" sort="Smith, Gillian" uniqKey="Smith G" first="Gillian" last="Smith">Gillian Smith</name><affiliation><nlm:affiliation>Real-time Syndromic Surveillance Team, Field Service, Public Health England, Birmingham, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Thomas, Mark" sort="Thomas, Mark" uniqKey="Thomas M" first="Mark" last="Thomas">Mark Thomas</name><affiliation><nlm:affiliation>Royal College of General Practitioners, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Thomas, Nicholas" sort="Thomas, Nicholas" uniqKey="Thomas N" first="Nicholas" last="Thomas">Nicholas Thomas</name><affiliation><nlm:affiliation>Royal College of General Practitioners, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Tripathy, Manasa" sort="Tripathy, Manasa" uniqKey="Tripathy M" first="Manasa" last="Tripathy">Manasa Tripathy</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Victor, William" sort="Victor, William" uniqKey="Victor W" first="William" last="Victor">William Victor</name><affiliation><nlm:affiliation>Royal College of General Practitioners, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Williams, John" sort="Williams, John" uniqKey="Williams J" first="John" last="Williams">John Williams</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Wood, Ian" sort="Wood, Ian" uniqKey="Wood I" first="Ian" last="Wood">Ian Wood</name><affiliation><nlm:affiliation>Royal College of General Practitioners, London, United Kingdom.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>EMIS Group, Leeds, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Zambon, Maria" sort="Zambon, Maria" uniqKey="Zambon M" first="Maria" last="Zambon">Maria Zambon</name><affiliation><nlm:affiliation>Public Health England, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Parry, John" sort="Parry, John" uniqKey="Parry J" first="John" last="Parry">John Parry</name><affiliation><nlm:affiliation>TPP SystmOne, Leeds, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="O Hanlon, Shaun" sort="O Hanlon, Shaun" uniqKey="O Hanlon S" first="Shaun" last="O'Hanlon">Shaun O'Hanlon</name><affiliation><nlm:affiliation>EMIS Group, Leeds, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Joy, Mark" sort="Joy, Mark" uniqKey="Joy M" first="Mark" last="Joy">Mark Joy</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Butler, Chris" sort="Butler, Chris" uniqKey="Butler C" first="Chris" last="Butler">Chris Butler</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Marshall, Martin" sort="Marshall, Martin" uniqKey="Marshall M" first="Martin" last="Marshall">Martin Marshall</name><affiliation><nlm:affiliation>Royal College of General Practitioners, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Hobbs, F D Richard" sort="Hobbs, F D Richard" uniqKey="Hobbs F" first="F D Richard" last="Hobbs">F D Richard Hobbs</name><affiliation><nlm:affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author></analytic><series><title level="j">JMIR public health and surveillance</title><idno type="eISSN">2369-2960</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>COVID-19 (MeSH)</term><term>Clinical Trials as Topic (MeSH)</term><term>Coronavirus Infections (epidemiology)</term><term>General Practice (organization & administration)</term><term>Humans (MeSH)</term><term>Medical Records Systems, Computerized (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (epidemiology)</term><term>Primary Health Care (organization & administration)</term><term>Public Health Surveillance (MeSH)</term><term>Societies, Medical (MeSH)</term><term>United Kingdom (epidemiology)</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>United Kingdom</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="organization & administration" xml:lang="en"><term>General Practice</term><term>Primary Health Care</term></keywords><keywords scheme="MESH" xml:lang="en"><term>COVID-19</term><term>Clinical Trials as Topic</term><term>Humans</term><term>Medical Records Systems, Computerized</term><term>Pandemics</term><term>Public Health Surveillance</term><term>Societies, Medical</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Routinely recorded primary care data have been used for many years by sentinel networks for surveillance. More recently, real world data have been used for a wider range of research projects to support rapid, inexpensive clinical trials. Because the partial national lockdown in the United Kingdom due to the coronavirus disease (COVID-19) pandemic has resulted in decreasing community disease incidence, much larger numbers of general practices are needed to deliver effective COVID-19 surveillance and contribute to in-pandemic clinical trials.</p></div><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>The aim of this protocol is to describe the rapid design and development of the Oxford Royal College of General Practitioners Clinical Informatics Digital Hub (ORCHID) and its first two platforms. The Surveillance Platform will provide extended primary care surveillance, while the Trials Platform is a streamlined clinical trials platform that will be integrated into routine primary care practice.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>We will apply the FAIR (Findable, Accessible, Interoperable, and Reusable) metadata principles to a new, integrated digital health hub that will extract routinely collected general practice electronic health data for use in clinical trials and provide enhanced communicable disease surveillance. The hub will be findable through membership in Health Data Research UK and European metadata repositories. Accessibility through an online application system will provide access to study-ready data sets or developed custom data sets. Interoperability will be facilitated by fixed linkage to other key sources such as Hospital Episodes Statistics and the Office of National Statistics using pseudonymized data. All semantic descriptors (ie, ontologies) and code used for analysis will be made available to accelerate analyses. We will also make data available using common data models, starting with the US Food and Drug Administration Sentinel and Observational Medical Outcomes Partnership approaches, to facilitate international studies. The Surveillance Platform will provide access to data for health protection and promotion work as authorized through agreements between Oxford, the Royal College of General Practitioners, and Public Health England. All studies using the Trials Platform will go through appropriate ethical and other regulatory approval processes.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>The hub will be a bottom-up, professionally led network that will provide benefits for member practices, our health service, and the population served. Data will only be used for SQUIRE (surveillance, quality improvement, research, and education) purposes. We have already received positive responses from practices, and the number of practices in the network has doubled to over 1150 since February 2020. COVID-19 surveillance has resulted in tripling of the number of virology sites to 293 (target 300), which has aided the collection of the largest ever weekly total of surveillance swabs in the United Kingdom as well as over 3000 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serology samples. Practices are recruiting to the PRINCIPLE (Platform Randomised trial of INterventions against COVID-19 In older PeopLE) trial, and these participants will be followed up through ORCHID. These initial outputs demonstrate the feasibility of ORCHID to provide an extended national digital health hub.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>ORCHID will provide equitable and innovative use of big data through a professionally led national primary care network and the application of FAIR principles. The secure data hub will host routinely collected general practice data linked to other key health care repositories for clinical trials and support enhanced in situ surveillance without always requiring large volume data extracts. ORCHID will support rapid data extraction, analysis, and dissemination with the aim of improving future research and development in general practice to positively impact patient care.</p></div><div type="abstract" xml:lang="en"><p><b>INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID)</b></p><p>DERR1-10.2196/19773.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32484782</PMID><DateCompleted><Year>2020</Year><Month>07</Month><Day>07</Day></DateCompleted><DateRevised><Year>2020</Year><Month>12</Month><Day>18</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2369-2960</ISSN><JournalIssue CitedMedium="Internet"><Volume>6</Volume><Issue>3</Issue><PubDate><Year>2020</Year><Month>07</Month><Day>02</Day></PubDate></JournalIssue><Title>JMIR public health and surveillance</Title><ISOAbbreviation>JMIR Public Health Surveill</ISOAbbreviation></Journal><ArticleTitle>The Oxford Royal College of General Practitioners Clinical Informatics Digital Hub: Protocol to Develop Extended COVID-19 Surveillance and Trial Platforms.</ArticleTitle><Pagination><MedlinePgn>e19773</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.2196/19773</ELocationID><Abstract><AbstractText Label="BACKGROUND">Routinely recorded primary care data have been used for many years by sentinel networks for surveillance. More recently, real world data have been used for a wider range of research projects to support rapid, inexpensive clinical trials. Because the partial national lockdown in the United Kingdom due to the coronavirus disease (COVID-19) pandemic has resulted in decreasing community disease incidence, much larger numbers of general practices are needed to deliver effective COVID-19 surveillance and contribute to in-pandemic clinical trials.</AbstractText><AbstractText Label="OBJECTIVE">The aim of this protocol is to describe the rapid design and development of the Oxford Royal College of General Practitioners Clinical Informatics Digital Hub (ORCHID) and its first two platforms. The Surveillance Platform will provide extended primary care surveillance, while the Trials Platform is a streamlined clinical trials platform that will be integrated into routine primary care practice.</AbstractText><AbstractText Label="METHODS">We will apply the FAIR (Findable, Accessible, Interoperable, and Reusable) metadata principles to a new, integrated digital health hub that will extract routinely collected general practice electronic health data for use in clinical trials and provide enhanced communicable disease surveillance. The hub will be findable through membership in Health Data Research UK and European metadata repositories. Accessibility through an online application system will provide access to study-ready data sets or developed custom data sets. Interoperability will be facilitated by fixed linkage to other key sources such as Hospital Episodes Statistics and the Office of National Statistics using pseudonymized data. All semantic descriptors (ie, ontologies) and code used for analysis will be made available to accelerate analyses. We will also make data available using common data models, starting with the US Food and Drug Administration Sentinel and Observational Medical Outcomes Partnership approaches, to facilitate international studies. The Surveillance Platform will provide access to data for health protection and promotion work as authorized through agreements between Oxford, the Royal College of General Practitioners, and Public Health England. All studies using the Trials Platform will go through appropriate ethical and other regulatory approval processes.</AbstractText><AbstractText Label="RESULTS">The hub will be a bottom-up, professionally led network that will provide benefits for member practices, our health service, and the population served. Data will only be used for SQUIRE (surveillance, quality improvement, research, and education) purposes. We have already received positive responses from practices, and the number of practices in the network has doubled to over 1150 since February 2020. COVID-19 surveillance has resulted in tripling of the number of virology sites to 293 (target 300), which has aided the collection of the largest ever weekly total of surveillance swabs in the United Kingdom as well as over 3000 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serology samples. Practices are recruiting to the PRINCIPLE (Platform Randomised trial of INterventions against COVID-19 In older PeopLE) trial, and these participants will be followed up through ORCHID. These initial outputs demonstrate the feasibility of ORCHID to provide an extended national digital health hub.</AbstractText><AbstractText Label="CONCLUSIONS">ORCHID will provide equitable and innovative use of big data through a professionally led national primary care network and the application of FAIR principles. The secure data hub will host routinely collected general practice data linked to other key health care repositories for clinical trials and support enhanced in situ surveillance without always requiring large volume data extracts. ORCHID will support rapid data extraction, analysis, and dissemination with the aim of improving future research and development in general practice to positively impact patient care.</AbstractText><AbstractText Label="INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID)">DERR1-10.2196/19773.</AbstractText><CopyrightInformation>©Simon de Lusignan, Nicholas Jones, Jienchi Dorward, Rachel Byford, Harshana Liyanage, John Briggs, Filipa Ferreira, Oluwafunmi Akinyemi, Gayatri Amirthalingam, Chris Bates, Jamie Lopez Bernal, Gavin Dabrera, Alex Eavis, Alex J Elliot, Michael Feher, Else Krajenbrink, Uy Hoang, Gary Howsam, Jonathan Leach, Cecilia Okusi, Brian Nicholson, Philip Nieri, Julian Sherlock, Gillian Smith, Mark Thomas, Nicholas Thomas, Manasa Tripathy, William Victor, John Williams, Ian Wood, Maria Zambon, John Parry, Shaun O’Hanlon, Mark Joy, Chris Butler, Martin Marshall, FD Richard Hobbs. Originally published in JMIR Public Health and Surveillance (http://publichealth.jmir.org), 02.07.2020.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>de Lusignan</LastName><ForeName>Simon</ForeName><Initials>S</Initials><Identifier Source="ORCID">0000-0002-8553-2641</Identifier><AffiliationInfo><Affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Royal College of General Practitioners, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Jones</LastName><ForeName>Nicholas</ForeName><Initials>N</Initials><Identifier Source="ORCID">0000-0002-0352-3785</Identifier><AffiliationInfo><Affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dorward</LastName><ForeName>Jienchi</ForeName><Initials>J</Initials><Identifier Source="ORCID">0000-0001-6072-1430</Identifier><AffiliationInfo><Affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Byford</LastName><ForeName>Rachel</ForeName><Initials>R</Initials><Identifier Source="ORCID">0000-0002-4792-8995</Identifier><AffiliationInfo><Affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liyanage</LastName><ForeName>Harshana</ForeName><Initials>H</Initials><Identifier Source="ORCID">0000-0001-9738-6349</Identifier><AffiliationInfo><Affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Briggs</LastName><ForeName>John</ForeName><Initials>J</Initials><Identifier Source="ORCID">0000-0002-9832-5430</Identifier><AffiliationInfo><Affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ferreira</LastName><ForeName>Filipa</ForeName><Initials>F</Initials><Identifier Source="ORCID">0000-0002-7717-8486</Identifier><AffiliationInfo><Affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Akinyemi</LastName><ForeName>Oluwafunmi</ForeName><Initials>O</Initials><Identifier Source="ORCID">0000-0003-0401-0145</Identifier><AffiliationInfo><Affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Amirthalingam</LastName><ForeName>Gayatri</ForeName><Initials>G</Initials><Identifier Source="ORCID">0000-0003-2078-0975</Identifier><AffiliationInfo><Affiliation>Public Health England, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bates</LastName><ForeName>Chris</ForeName><Initials>C</Initials><Identifier Source="ORCID">0000-0003-0113-2593</Identifier><AffiliationInfo><Affiliation>TPP SystmOne, Leeds, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lopez Bernal</LastName><ForeName>Jamie</ForeName><Initials>J</Initials><Identifier Source="ORCID">0000-0002-1301-5653</Identifier><AffiliationInfo><Affiliation>Public Health England, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dabrera</LastName><ForeName>Gavin</ForeName><Initials>G</Initials><Identifier Source="ORCID">0000-0003-4606-5945</Identifier><AffiliationInfo><Affiliation>Public Health England, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eavis</LastName><ForeName>Alex</ForeName><Initials>A</Initials><Identifier Source="ORCID">0000-0003-3525-2198</Identifier><AffiliationInfo><Affiliation>EMIS Group, Leeds, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Elliot</LastName><ForeName>Alex J</ForeName><Initials>AJ</Initials><Identifier Source="ORCID">0000-0002-6414-3065</Identifier><AffiliationInfo><Affiliation>Real-time Syndromic Surveillance Team, Field Service, Public Health England, Birmingham, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Feher</LastName><ForeName>Michael</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0003-0631-6199</Identifier><AffiliationInfo><Affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krajenbrink</LastName><ForeName>Else</ForeName><Initials>E</Initials><Identifier Source="ORCID">0000-0002-6563-9441</Identifier><AffiliationInfo><Affiliation>Royal College of General Practitioners, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hoang</LastName><ForeName>Uy</ForeName><Initials>U</Initials><Identifier Source="ORCID">0000-0002-8428-5140</Identifier><AffiliationInfo><Affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Howsam</LastName><ForeName>Gary</ForeName><Initials>G</Initials><Identifier Source="ORCID">0000-0001-6699-5504</Identifier><AffiliationInfo><Affiliation>Royal College of General Practitioners, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leach</LastName><ForeName>Jonathan</ForeName><Initials>J</Initials><Identifier Source="ORCID">0000-0001-5142-4506</Identifier><AffiliationInfo><Affiliation>Royal College of General Practitioners, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Okusi</LastName><ForeName>Cecilia</ForeName><Initials>C</Initials><Identifier Source="ORCID">0000-0002-5575-8527</Identifier><AffiliationInfo><Affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nicholson</LastName><ForeName>Brian</ForeName><Initials>B</Initials><Identifier Source="ORCID">0000-0003-0661-7362</Identifier><AffiliationInfo><Affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nieri</LastName><ForeName>Philip</ForeName><Initials>P</Initials><Identifier Source="ORCID">0000-0003-0478-0190</Identifier><AffiliationInfo><Affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sherlock</LastName><ForeName>Julian</ForeName><Initials>J</Initials><Identifier Source="ORCID">0000-0001-7427-1936</Identifier><AffiliationInfo><Affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>Gillian</ForeName><Initials>G</Initials><Identifier Source="ORCID">0000-0002-4257-0568</Identifier><AffiliationInfo><Affiliation>Real-time Syndromic Surveillance Team, Field Service, Public Health England, Birmingham, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thomas</LastName><ForeName>Mark</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0002-6290-3948</Identifier><AffiliationInfo><Affiliation>Royal College of General Practitioners, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thomas</LastName><ForeName>Nicholas</ForeName><Initials>N</Initials><Identifier Source="ORCID">0000-0003-0460-6870</Identifier><AffiliationInfo><Affiliation>Royal College of General Practitioners, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tripathy</LastName><ForeName>Manasa</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0001-9840-3876</Identifier><AffiliationInfo><Affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Victor</LastName><ForeName>William</ForeName><Initials>W</Initials><Identifier Source="ORCID">0000-0003-3660-6517</Identifier><AffiliationInfo><Affiliation>Royal College of General Practitioners, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Williams</LastName><ForeName>John</ForeName><Initials>J</Initials><Identifier Source="ORCID">0000-0002-6118-0434</Identifier><AffiliationInfo><Affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wood</LastName><ForeName>Ian</ForeName><Initials>I</Initials><Identifier Source="ORCID">0000-0002-0080-6624</Identifier><AffiliationInfo><Affiliation>Royal College of General Practitioners, London, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>EMIS Group, Leeds, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zambon</LastName><ForeName>Maria</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0002-8897-7881</Identifier><AffiliationInfo><Affiliation>Public Health England, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Parry</LastName><ForeName>John</ForeName><Initials>J</Initials><Identifier Source="ORCID">0000-0002-0190-1121</Identifier><AffiliationInfo><Affiliation>TPP SystmOne, Leeds, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>O'Hanlon</LastName><ForeName>Shaun</ForeName><Initials>S</Initials><Identifier Source="ORCID">0000-0002-0731-5211</Identifier><AffiliationInfo><Affiliation>EMIS Group, Leeds, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Joy</LastName><ForeName>Mark</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0002-4974-3724</Identifier><AffiliationInfo><Affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Butler</LastName><ForeName>Chris</ForeName><Initials>C</Initials><Identifier Source="ORCID">0000-0002-0102-3453</Identifier><AffiliationInfo><Affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marshall</LastName><ForeName>Martin</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0001-8575-5442</Identifier><AffiliationInfo><Affiliation>Royal College of General Practitioners, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hobbs</LastName><ForeName>F D Richard</ForeName><Initials>FDR</Initials><Identifier Source="ORCID">0000-0001-7976-7172</Identifier><AffiliationInfo><Affiliation>Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>02</Day></ArticleDate></Article><MedlineJournalInfo><Country>Canada</Country><MedlineTA>JMIR Public Health Surveill</MedlineTA><NlmUniqueID>101669345</NlmUniqueID><ISSNLinking>2369-2960</ISSNLinking></MedlineJournalInfo><CitationSubset>H</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002986" MajorTopicYN="Y">Clinical Trials as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058006" MajorTopicYN="N">General Practice</DescriptorName><QualifierName UI="Q000458" MajorTopicYN="Y">organization & administration</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016347" MajorTopicYN="Y">Medical Records Systems, Computerized</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011320" MajorTopicYN="N">Primary Health Care</DescriptorName><QualifierName UI="Q000458" MajorTopicYN="N">organization & administration</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D062486" MajorTopicYN="Y">Public Health Surveillance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012955" MajorTopicYN="N">Societies, Medical</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006113" MajorTopicYN="N" Type="Geographic">United Kingdom</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">COVID-19</Keyword><Keyword MajorTopicYN="Y">adaptive clinical trials</Keyword><Keyword MajorTopicYN="Y">clinical trials as a topic</Keyword><Keyword MajorTopicYN="Y">general practice</Keyword><Keyword MajorTopicYN="Y">medical record systems, computerized</Keyword><Keyword MajorTopicYN="Y">primary health care</Keyword><Keyword MajorTopicYN="Y">public health surveillance</Keyword><Keyword MajorTopicYN="Y">sentinel surveillance</Keyword><Keyword MajorTopicYN="Y">severe acute respiratory syndrome coronavirus 2</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>04</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>06</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>05</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>6</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>7</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>6</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32484782</ArticleId><ArticleId IdType="pii">v6i3e19773</ArticleId><ArticleId IdType="doi">10.2196/19773</ArticleId><ArticleId 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|texte= The Oxford Royal College of General Practitioners Clinical Informatics Digital Hub: Protocol to Develop Extended COVID-19 Surveillance and Trial Platforms.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Corpus/RBID.i -Sk "pubmed:32484782" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a LockdownV1
| This area was generated with Dilib version V0.6.38. |  |