[Acro-ischemic injuries in children-adolescents during CoViD-19 pandemic: from lifestyle changes due to lockdown to interferone.]
Identifieur interne : 001756 ( Main/Corpus ); précédent : 001755; suivant : 001757[Acro-ischemic injuries in children-adolescents during CoViD-19 pandemic: from lifestyle changes due to lockdown to interferone.]
Auteurs : Federico Marchetti ; Claudia Guiducci ; Barbara Bigucci ; Alessandra Iacono ; Ombretta Calderoni ; Maria Rita Sorci ; Monica Sparacino ; Simona Semprini ; Gianluca VergineSource :
- Recenti progressi in medicina [ 2038-1840 ] ; 2020.
English descriptors
- KwdEn :
- Adolescent (MeSH), COVID-19 (MeSH), Chilblains (epidemiology), Chilblains (etiology), Chilblains (immunology), Child (MeSH), Coronavirus Infections (complications), Coronavirus Infections (epidemiology), Coronavirus Infections (immunology), Female (MeSH), Humans (MeSH), Interferons (immunology), Ischemia (epidemiology), Ischemia (etiology), Ischemia (immunology), Italy (epidemiology), Life Style (MeSH), Male (MeSH), Pandemics (MeSH), Pneumonia, Viral (complications), Pneumonia, Viral (epidemiology), Pneumonia, Viral (immunology), Quarantine (MeSH), Toes (MeSH).
- MESH :
- chemical , immunology : Interferons.
- geographic , epidemiology : Italy.
- complications : Coronavirus Infections, Pneumonia, Viral.
- epidemiology : Chilblains, Coronavirus Infections, Ischemia, Pneumonia, Viral.
- etiology : Chilblains, Ischemia.
- immunology : Chilblains, Coronavirus Infections, Ischemia, Pneumonia, Viral.
- Adolescent, COVID-19, Child, Female, Humans, Life Style, Male, Pandemics, Quarantine, Toes.
Abstract
At the end of March 2020, just over a month after the first ascertained case of CoViD-19 infection in Italy, the first reports of acute lesions of acro-ischemia appeared, especially in pre-adolescents and adolescents. These manifestations have been called in the course of these months in various ways, from "acro-ischemia acuta", "erythema pernio", "chilblains", up to characterize them more recently as "CoViD Toes". Clinical manifestations do not usually associate with other typical symptoms of Covid-19 and do not find a classical and defined serological antibody response (IgG and IgM). From a clinical point of view it is a localized and self-resolving problem of an interesting and relatively new pathogenetic model of disease in relation to a viral agent. Future studies must make us understand if there is in this specific condition a low viral load is not detectable by current methods and if this explains the inability to produce an adequate immune response for CoViD-19. It is important to determine whether the interferon immune response in some subjects can be the cause of both the low viremia and the endothelial damage so localized in the acral-site, as happens in other models of diseases (chilblain-lupus like). On the contrary, some authors believe that the acral lesions are attributable to chilblains caused by a series of favourable environmental conditions due to forced enclosure. We report the descriptive experience of 14 cases of acro-ischemia in children and adolescents observed in the territorial area of Ravenna and Rimini. The cases were subjected to the nasopharyngeal swab and to the search for antibodies with ELISA method for CoViD-19 both with negative results.
DOI: 10.1701/3421.34060
PubMed: 32914775
Links to Exploration step
pubmed:32914775Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[Acro-ischemic injuries in children-adolescents during CoViD-19 pandemic: from lifestyle changes due to lockdown to interferone.]</title><author><name sortKey="Marchetti, Federico" sort="Marchetti, Federico" uniqKey="Marchetti F" first="Federico" last="Marchetti">Federico Marchetti</name><affiliation><nlm:affiliation>UOC di Pediatria e Neonatologia, Ospedale di Ravenna.</nlm:affiliation></affiliation></author><author><name sortKey="Guiducci, Claudia" sort="Guiducci, Claudia" uniqKey="Guiducci C" first="Claudia" last="Guiducci">Claudia Guiducci</name><affiliation><nlm:affiliation>UOC di Pediatria e Neonatologia, Ospedale di Ravenna - Scuola di Specializzazione in Pediatria, Università di Ferrara.</nlm:affiliation></affiliation></author><author><name sortKey="Bigucci, Barbara" sort="Bigucci, Barbara" uniqKey="Bigucci B" first="Barbara" last="Bigucci">Barbara Bigucci</name><affiliation><nlm:affiliation>UOC di Pediatria, Ospedale di Rimini.</nlm:affiliation></affiliation></author><author><name sortKey="Iacono, Alessandra" sort="Iacono, Alessandra" uniqKey="Iacono A" first="Alessandra" last="Iacono">Alessandra Iacono</name><affiliation><nlm:affiliation>UOC di Pediatria e Neonatologia, Ospedale di Ravenna.</nlm:affiliation></affiliation></author><author><name sortKey="Calderoni, Ombretta" sort="Calderoni, Ombretta" uniqKey="Calderoni O" first="Ombretta" last="Calderoni">Ombretta Calderoni</name><affiliation><nlm:affiliation>UO di Dermatologia, Ospedale di Ravenna.</nlm:affiliation></affiliation></author><author><name sortKey="Sorci, Maria Rita" sort="Sorci, Maria Rita" uniqKey="Sorci M" first="Maria Rita" last="Sorci">Maria Rita Sorci</name><affiliation><nlm:affiliation>UO di Dermatologia, Ospedale di Rimini.</nlm:affiliation></affiliation></author><author><name sortKey="Sparacino, Monica" sort="Sparacino, Monica" uniqKey="Sparacino M" first="Monica" last="Sparacino">Monica Sparacino</name><affiliation><nlm:affiliation>UO Microbiologia, Laboratorio Unico, AUSL della Romagna.</nlm:affiliation></affiliation></author><author><name sortKey="Semprini, Simona" sort="Semprini, Simona" uniqKey="Semprini S" first="Simona" last="Semprini">Simona Semprini</name><affiliation><nlm:affiliation>UO Microbiologia, Laboratorio Unico, AUSL della Romagna.</nlm:affiliation></affiliation></author><author><name sortKey="Vergine, Gianluca" sort="Vergine, Gianluca" uniqKey="Vergine G" first="Gianluca" last="Vergine">Gianluca Vergine</name><affiliation><nlm:affiliation>UOC di Pediatria, Ospedale di Rimini.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32914775</idno><idno type="pmid">32914775</idno><idno type="doi">10.1701/3421.34060</idno><idno type="wicri:Area/Main/Corpus">001756</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">001756</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Acro-ischemic injuries in children-adolescents during CoViD-19 pandemic: from lifestyle changes due to lockdown to interferone.]</title><author><name sortKey="Marchetti, Federico" sort="Marchetti, Federico" uniqKey="Marchetti F" first="Federico" last="Marchetti">Federico Marchetti</name><affiliation><nlm:affiliation>UOC di Pediatria e Neonatologia, Ospedale di Ravenna.</nlm:affiliation></affiliation></author><author><name sortKey="Guiducci, Claudia" sort="Guiducci, Claudia" uniqKey="Guiducci C" first="Claudia" last="Guiducci">Claudia Guiducci</name><affiliation><nlm:affiliation>UOC di Pediatria e Neonatologia, Ospedale di Ravenna - Scuola di Specializzazione in Pediatria, Università di Ferrara.</nlm:affiliation></affiliation></author><author><name sortKey="Bigucci, Barbara" sort="Bigucci, Barbara" uniqKey="Bigucci B" first="Barbara" last="Bigucci">Barbara Bigucci</name><affiliation><nlm:affiliation>UOC di Pediatria, Ospedale di Rimini.</nlm:affiliation></affiliation></author><author><name sortKey="Iacono, Alessandra" sort="Iacono, Alessandra" uniqKey="Iacono A" first="Alessandra" last="Iacono">Alessandra Iacono</name><affiliation><nlm:affiliation>UOC di Pediatria e Neonatologia, Ospedale di Ravenna.</nlm:affiliation></affiliation></author><author><name sortKey="Calderoni, Ombretta" sort="Calderoni, Ombretta" uniqKey="Calderoni O" first="Ombretta" last="Calderoni">Ombretta Calderoni</name><affiliation><nlm:affiliation>UO di Dermatologia, Ospedale di Ravenna.</nlm:affiliation></affiliation></author><author><name sortKey="Sorci, Maria Rita" sort="Sorci, Maria Rita" uniqKey="Sorci M" first="Maria Rita" last="Sorci">Maria Rita Sorci</name><affiliation><nlm:affiliation>UO di Dermatologia, Ospedale di Rimini.</nlm:affiliation></affiliation></author><author><name sortKey="Sparacino, Monica" sort="Sparacino, Monica" uniqKey="Sparacino M" first="Monica" last="Sparacino">Monica Sparacino</name><affiliation><nlm:affiliation>UO Microbiologia, Laboratorio Unico, AUSL della Romagna.</nlm:affiliation></affiliation></author><author><name sortKey="Semprini, Simona" sort="Semprini, Simona" uniqKey="Semprini S" first="Simona" last="Semprini">Simona Semprini</name><affiliation><nlm:affiliation>UO Microbiologia, Laboratorio Unico, AUSL della Romagna.</nlm:affiliation></affiliation></author><author><name sortKey="Vergine, Gianluca" sort="Vergine, Gianluca" uniqKey="Vergine G" first="Gianluca" last="Vergine">Gianluca Vergine</name><affiliation><nlm:affiliation>UOC di Pediatria, Ospedale di Rimini.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Recenti progressi in medicina</title><idno type="eISSN">2038-1840</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term><term>COVID-19 (MeSH)</term><term>Chilblains (epidemiology)</term><term>Chilblains (etiology)</term><term>Chilblains (immunology)</term><term>Child (MeSH)</term><term>Coronavirus Infections (complications)</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (immunology)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Interferons (immunology)</term><term>Ischemia (epidemiology)</term><term>Ischemia (etiology)</term><term>Ischemia (immunology)</term><term>Italy (epidemiology)</term><term>Life Style (MeSH)</term><term>Male (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (complications)</term><term>Pneumonia, Viral (epidemiology)</term><term>Pneumonia, Viral (immunology)</term><term>Quarantine (MeSH)</term><term>Toes (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Interferons</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Italy</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Chilblains</term><term>Coronavirus Infections</term><term>Ischemia</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Chilblains</term><term>Ischemia</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Chilblains</term><term>Coronavirus Infections</term><term>Ischemia</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>COVID-19</term><term>Child</term><term>Female</term><term>Humans</term><term>Life Style</term><term>Male</term><term>Pandemics</term><term>Quarantine</term><term>Toes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">At the end of March 2020, just over a month after the first ascertained case of CoViD-19 infection in Italy, the first reports of acute lesions of acro-ischemia appeared, especially in pre-adolescents and adolescents. These manifestations have been called in the course of these months in various ways, from "acro-ischemia acuta", "erythema pernio", "chilblains", up to characterize them more recently as "CoViD Toes". Clinical manifestations do not usually associate with other typical symptoms of Covid-19 and do not find a classical and defined serological antibody response (IgG and IgM). From a clinical point of view it is a localized and self-resolving problem of an interesting and relatively new pathogenetic model of disease in relation to a viral agent. Future studies must make us understand if there is in this specific condition a low viral load is not detectable by current methods and if this explains the inability to produce an adequate immune response for CoViD-19. It is important to determine whether the interferon immune response in some subjects can be the cause of both the low viremia and the endothelial damage so localized in the acral-site, as happens in other models of diseases (chilblain-lupus like). On the contrary, some authors believe that the acral lesions are attributable to chilblains caused by a series of favourable environmental conditions due to forced enclosure. We report the descriptive experience of 14 cases of acro-ischemia in children and adolescents observed in the territorial area of Ravenna and Rimini. The cases were subjected to the nasopharyngeal swab and to the search for antibodies with ELISA method for CoViD-19 both with negative results.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32914775</PMID><DateCompleted><Year>2020</Year><Month>09</Month><Day>21</Day></DateCompleted><DateRevised><Year>2020</Year><Month>12</Month><Day>18</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2038-1840</ISSN><JournalIssue CitedMedium="Internet"><Volume>111</Volume><Issue>9</Issue><PubDate><Year>2020</Year><Month>09</Month></PubDate></JournalIssue><Title>Recenti progressi in medicina</Title><ISOAbbreviation>Recenti Prog Med</ISOAbbreviation></Journal><ArticleTitle>[Acro-ischemic injuries in children-adolescents during CoViD-19 pandemic: from lifestyle changes due to lockdown to interferone.]</ArticleTitle><Pagination><MedlinePgn>480-486</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1701/3421.34060</ELocationID><Abstract><AbstractText>At the end of March 2020, just over a month after the first ascertained case of CoViD-19 infection in Italy, the first reports of acute lesions of acro-ischemia appeared, especially in pre-adolescents and adolescents. These manifestations have been called in the course of these months in various ways, from "acro-ischemia acuta", "erythema pernio", "chilblains", up to characterize them more recently as "CoViD Toes". Clinical manifestations do not usually associate with other typical symptoms of Covid-19 and do not find a classical and defined serological antibody response (IgG and IgM). From a clinical point of view it is a localized and self-resolving problem of an interesting and relatively new pathogenetic model of disease in relation to a viral agent. Future studies must make us understand if there is in this specific condition a low viral load is not detectable by current methods and if this explains the inability to produce an adequate immune response for CoViD-19. It is important to determine whether the interferon immune response in some subjects can be the cause of both the low viremia and the endothelial damage so localized in the acral-site, as happens in other models of diseases (chilblain-lupus like). On the contrary, some authors believe that the acral lesions are attributable to chilblains caused by a series of favourable environmental conditions due to forced enclosure. We report the descriptive experience of 14 cases of acro-ischemia in children and adolescents observed in the territorial area of Ravenna and Rimini. The cases were subjected to the nasopharyngeal swab and to the search for antibodies with ELISA method for CoViD-19 both with negative results.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Marchetti</LastName><ForeName>Federico</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>UOC di Pediatria e Neonatologia, Ospedale di Ravenna.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guiducci</LastName><ForeName>Claudia</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>UOC di Pediatria e Neonatologia, Ospedale di Ravenna - Scuola di Specializzazione in Pediatria, Università di Ferrara.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bigucci</LastName><ForeName>Barbara</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>UOC di Pediatria, Ospedale di Rimini.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Iacono</LastName><ForeName>Alessandra</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>UOC di Pediatria e Neonatologia, Ospedale di Ravenna.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Calderoni</LastName><ForeName>Ombretta</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>UO di Dermatologia, Ospedale di Ravenna.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sorci</LastName><ForeName>Maria Rita</ForeName><Initials>MR</Initials><AffiliationInfo><Affiliation>UO di Dermatologia, Ospedale di Rimini.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sparacino</LastName><ForeName>Monica</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>UO Microbiologia, Laboratorio Unico, AUSL della Romagna.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Semprini</LastName><ForeName>Simona</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>UO Microbiologia, Laboratorio Unico, AUSL della Romagna.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vergine</LastName><ForeName>Gianluca</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>UOC di Pediatria, Ospedale di Rimini.</Affiliation></AffiliationInfo></Author></AuthorList><Language>ita</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><VernacularTitle>Le lesioni acro-ischemiche nei bambini-adolescenti in tempi di CoViD-19: dal micro-ambiente da clausura all’interferone.</VernacularTitle></Article><MedlineJournalInfo><Country>Italy</Country><MedlineTA>Recenti Prog Med</MedlineTA><NlmUniqueID>0401271</NlmUniqueID><ISSNLinking>0034-1193</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>9008-11-1</RegistryNumber><NameOfSubstance UI="D007372">Interferons</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002647" MajorTopicYN="N">Chilblains</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007372" MajorTopicYN="N">Interferons</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007511" MajorTopicYN="N">Ischemia</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007558" MajorTopicYN="N" Type="Geographic">Italy</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008019" MajorTopicYN="Y">Life Style</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011790" MajorTopicYN="N">Quarantine</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014034" MajorTopicYN="N">Toes</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>9</Month><Day>11</Day><Hour>8</Hour><Minute>39</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>9</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>9</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32914775</ArticleId><ArticleId IdType="doi">10.1701/3421.34060</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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