JankovicV1, PubMed, Curation, bibRecord, 000120

Transcription factor PITX3 gene in Parkinson's disease.

Identifieur interne : 000120 ( PubMed/Curation ); précédent : 000119; suivant : 000121

Transcription factor PITX3 gene in Parkinson's disease.

Auteurs : Weidong Le [États-Unis] ; Deanne Nguyen ; Xiyao Lin ; Pawan Rawal ; Maosheng Huang ; Yujian Ding ; Wenjie Xie ; Hao Deng ; Joseph Jankovic

Source :

Neurobiology of aging ; 2011.

RBID : pubmed:19394114

English descriptors

KwdEn :
- Alleles, Female, Gene Frequency, Genetic Association Studies, Genetic Predisposition to Disease, Genotype, Homeodomain Proteins (genetics), Humans, Male, Parkinson Disease (genetics), Polymorphism, Single Nucleotide, Transcription Factors (genetics).
MESH :
- chemical , genetics : Homeodomain Proteins, Transcription Factors.
- genetics : Parkinson Disease.
- Alleles, Female, Gene Frequency, Genetic Association Studies, Genetic Predisposition to Disease, Genotype, Humans, Male, Polymorphism, Single Nucleotide.

Abstract

PITX3 is a transcription factor important for the differentiation and survival of midbrain dopaminergic neurons during the development. Recent reports suggest that single nucleotide polymorphisms (SNP) in the gene may be associated with Parkinson's disease (PD). To verify their findings and to determine the nature of the association in a subset of our PD patients we have analyzed two PITX3 SNPs (rs2281983 and rs4919621) in 265 PD patients and compared them with 210 age-matched healthy controls. Our data show that the substitutions of C/T in SNP1 and A/T in SNP2 are significantly higher in PD, and this finding is even more robust in young onset and familial PD as compared with age-matched healthy controls. Our findings indicate that PITX3 may play a role in the pathogenesis of PD.

DOI: 10.1016/j.neurobiolaging.2009.03.015
PubMed: 19394114

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Le document en format XML

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<author><name sortKey="Le, Weidong" sort="Le, Weidong" uniqKey="Le W" first="Weidong" last="Le">Weidong Le</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA. weidongl@bcm.edu</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Baylor College of Medicine, Houston, TX 77030</wicri:regionArea>
</affiliation>
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<author><name sortKey="Nguyen, Deanne" sort="Nguyen, Deanne" uniqKey="Nguyen D" first="Deanne" last="Nguyen">Deanne Nguyen</name>
</author>
<author><name sortKey="Lin, Xiyao Wendy" sort="Lin, Xiyao Wendy" uniqKey="Lin X" first="Xiyao" last="Lin">Xiyao Lin</name>
</author>
<author><name sortKey="Rawal, Pawan" sort="Rawal, Pawan" uniqKey="Rawal P" first="Pawan" last="Rawal">Pawan Rawal</name>
</author>
<author><name sortKey="Huang, Maosheng" sort="Huang, Maosheng" uniqKey="Huang M" first="Maosheng" last="Huang">Maosheng Huang</name>
</author>
<author><name sortKey="Ding, Yujian" sort="Ding, Yujian" uniqKey="Ding Y" first="Yujian" last="Ding">Yujian Ding</name>
</author>
<author><name sortKey="Xie, Wenjie" sort="Xie, Wenjie" uniqKey="Xie W" first="Wenjie" last="Xie">Wenjie Xie</name>
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<author><name sortKey="Deng, Hao" sort="Deng, Hao" uniqKey="Deng H" first="Hao" last="Deng">Hao Deng</name>
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<author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name>
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<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA. weidongl@bcm.edu</nlm:affiliation>
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<author><name sortKey="Nguyen, Deanne" sort="Nguyen, Deanne" uniqKey="Nguyen D" first="Deanne" last="Nguyen">Deanne Nguyen</name>
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<author><name sortKey="Lin, Xiyao Wendy" sort="Lin, Xiyao Wendy" uniqKey="Lin X" first="Xiyao" last="Lin">Xiyao Lin</name>
</author>
<author><name sortKey="Rawal, Pawan" sort="Rawal, Pawan" uniqKey="Rawal P" first="Pawan" last="Rawal">Pawan Rawal</name>
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<series><title level="j">Neurobiology of aging</title>
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<term>Gene Frequency</term>
<term>Genetic Association Studies</term>
<term>Genetic Predisposition to Disease</term>
<term>Genotype</term>
<term>Homeodomain Proteins (genetics)</term>
<term>Humans</term>
<term>Male</term>
<term>Parkinson Disease (genetics)</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Transcription Factors (genetics)</term>
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<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Homeodomain Proteins</term>
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<term>Female</term>
<term>Gene Frequency</term>
<term>Genetic Association Studies</term>
<term>Genetic Predisposition to Disease</term>
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<front><div type="abstract" xml:lang="en">PITX3 is a transcription factor important for the differentiation and survival of midbrain dopaminergic neurons during the development. Recent reports suggest that single nucleotide polymorphisms (SNP) in the gene may be associated with Parkinson's disease (PD). To verify their findings and to determine the nature of the association in a subset of our PD patients we have analyzed two PITX3 SNPs (rs2281983 and rs4919621) in 265 PD patients and compared them with 210 age-matched healthy controls. Our data show that the substitutions of C/T in SNP1 and A/T in SNP2 are significantly higher in PD, and this finding is even more robust in young onset and familial PD as compared with age-matched healthy controls. Our findings indicate that PITX3 may play a role in the pathogenesis of PD.</div>
</front>
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<CopyrightInformation>Copyright © 2009 Elsevier Inc. All rights reserved.</CopyrightInformation>
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Transcription factor PITX3 gene in Parkinson's disease.

Transcription factor PITX3 gene in Parkinson's disease.

Source :

English descriptors

Abstract

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