Transcription factor PITX3 gene in Parkinson's disease.
Identifieur interne : 000120 ( PubMed/Curation ); précédent : 000119; suivant : 000121Transcription factor PITX3 gene in Parkinson's disease.
Auteurs : Weidong Le [États-Unis] ; Deanne Nguyen ; Xiyao Lin ; Pawan Rawal ; Maosheng Huang ; Yujian Ding ; Wenjie Xie ; Hao Deng ; Joseph JankovicSource :
- Neurobiology of aging ; 2011.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Homeodomain Proteins, Transcription Factors.
- genetics : Parkinson Disease.
- Alleles, Female, Gene Frequency, Genetic Association Studies, Genetic Predisposition to Disease, Genotype, Humans, Male, Polymorphism, Single Nucleotide.
Abstract
PITX3 is a transcription factor important for the differentiation and survival of midbrain dopaminergic neurons during the development. Recent reports suggest that single nucleotide polymorphisms (SNP) in the gene may be associated with Parkinson's disease (PD). To verify their findings and to determine the nature of the association in a subset of our PD patients we have analyzed two PITX3 SNPs (rs2281983 and rs4919621) in 265 PD patients and compared them with 210 age-matched healthy controls. Our data show that the substitutions of C/T in SNP1 and A/T in SNP2 are significantly higher in PD, and this finding is even more robust in young onset and familial PD as compared with age-matched healthy controls. Our findings indicate that PITX3 may play a role in the pathogenesis of PD.
DOI: 10.1016/j.neurobiolaging.2009.03.015
PubMed: 19394114
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000120
Links to Exploration step
pubmed:19394114Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Transcription factor PITX3 gene in Parkinson's disease.</title>
<author><name sortKey="Le, Weidong" sort="Le, Weidong" uniqKey="Le W" first="Weidong" last="Le">Weidong Le</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA. weidongl@bcm.edu</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Baylor College of Medicine, Houston, TX 77030</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nguyen, Deanne" sort="Nguyen, Deanne" uniqKey="Nguyen D" first="Deanne" last="Nguyen">Deanne Nguyen</name>
</author>
<author><name sortKey="Lin, Xiyao Wendy" sort="Lin, Xiyao Wendy" uniqKey="Lin X" first="Xiyao" last="Lin">Xiyao Lin</name>
</author>
<author><name sortKey="Rawal, Pawan" sort="Rawal, Pawan" uniqKey="Rawal P" first="Pawan" last="Rawal">Pawan Rawal</name>
</author>
<author><name sortKey="Huang, Maosheng" sort="Huang, Maosheng" uniqKey="Huang M" first="Maosheng" last="Huang">Maosheng Huang</name>
</author>
<author><name sortKey="Ding, Yujian" sort="Ding, Yujian" uniqKey="Ding Y" first="Yujian" last="Ding">Yujian Ding</name>
</author>
<author><name sortKey="Xie, Wenjie" sort="Xie, Wenjie" uniqKey="Xie W" first="Wenjie" last="Xie">Wenjie Xie</name>
</author>
<author><name sortKey="Deng, Hao" sort="Deng, Hao" uniqKey="Deng H" first="Hao" last="Deng">Hao Deng</name>
</author>
<author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2011">2011</date>
<idno type="doi">10.1016/j.neurobiolaging.2009.03.015</idno>
<idno type="RBID">pubmed:19394114</idno>
<idno type="pmid">19394114</idno>
<idno type="wicri:Area/PubMed/Corpus">000120</idno>
<idno type="wicri:Area/PubMed/Curation">000120</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Transcription factor PITX3 gene in Parkinson's disease.</title>
<author><name sortKey="Le, Weidong" sort="Le, Weidong" uniqKey="Le W" first="Weidong" last="Le">Weidong Le</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA. weidongl@bcm.edu</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Baylor College of Medicine, Houston, TX 77030</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nguyen, Deanne" sort="Nguyen, Deanne" uniqKey="Nguyen D" first="Deanne" last="Nguyen">Deanne Nguyen</name>
</author>
<author><name sortKey="Lin, Xiyao Wendy" sort="Lin, Xiyao Wendy" uniqKey="Lin X" first="Xiyao" last="Lin">Xiyao Lin</name>
</author>
<author><name sortKey="Rawal, Pawan" sort="Rawal, Pawan" uniqKey="Rawal P" first="Pawan" last="Rawal">Pawan Rawal</name>
</author>
<author><name sortKey="Huang, Maosheng" sort="Huang, Maosheng" uniqKey="Huang M" first="Maosheng" last="Huang">Maosheng Huang</name>
</author>
<author><name sortKey="Ding, Yujian" sort="Ding, Yujian" uniqKey="Ding Y" first="Yujian" last="Ding">Yujian Ding</name>
</author>
<author><name sortKey="Xie, Wenjie" sort="Xie, Wenjie" uniqKey="Xie W" first="Wenjie" last="Xie">Wenjie Xie</name>
</author>
<author><name sortKey="Deng, Hao" sort="Deng, Hao" uniqKey="Deng H" first="Hao" last="Deng">Hao Deng</name>
</author>
<author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name>
</author>
</analytic>
<series><title level="j">Neurobiology of aging</title>
<idno type="e-ISSN">1558-1497</idno>
<imprint><date when="2011" type="published">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alleles</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genetic Association Studies</term>
<term>Genetic Predisposition to Disease</term>
<term>Genotype</term>
<term>Homeodomain Proteins (genetics)</term>
<term>Humans</term>
<term>Male</term>
<term>Parkinson Disease (genetics)</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Transcription Factors (genetics)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Homeodomain Proteins</term>
<term>Transcription Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Alleles</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genetic Association Studies</term>
<term>Genetic Predisposition to Disease</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Polymorphism, Single Nucleotide</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">PITX3 is a transcription factor important for the differentiation and survival of midbrain dopaminergic neurons during the development. Recent reports suggest that single nucleotide polymorphisms (SNP) in the gene may be associated with Parkinson's disease (PD). To verify their findings and to determine the nature of the association in a subset of our PD patients we have analyzed two PITX3 SNPs (rs2281983 and rs4919621) in 265 PD patients and compared them with 210 age-matched healthy controls. Our data show that the substitutions of C/T in SNP1 and A/T in SNP2 are significantly higher in PD, and this finding is even more robust in young onset and familial PD as compared with age-matched healthy controls. Our findings indicate that PITX3 may play a role in the pathogenesis of PD.</div>
</front>
</TEI>
<pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">19394114</PMID>
<DateCreated><Year>2011</Year>
<Month>03</Month>
<Day>30</Day>
</DateCreated>
<DateCompleted><Year>2011</Year>
<Month>08</Month>
<Day>08</Day>
</DateCompleted>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1558-1497</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>32</Volume>
<Issue>4</Issue>
<PubDate><Year>2011</Year>
<Month>Apr</Month>
</PubDate>
</JournalIssue>
<Title>Neurobiology of aging</Title>
<ISOAbbreviation>Neurobiol. Aging</ISOAbbreviation>
</Journal>
<ArticleTitle>Transcription factor PITX3 gene in Parkinson's disease.</ArticleTitle>
<Pagination><MedlinePgn>750-3</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.neurobiolaging.2009.03.015</ELocationID>
<Abstract><AbstractText>PITX3 is a transcription factor important for the differentiation and survival of midbrain dopaminergic neurons during the development. Recent reports suggest that single nucleotide polymorphisms (SNP) in the gene may be associated with Parkinson's disease (PD). To verify their findings and to determine the nature of the association in a subset of our PD patients we have analyzed two PITX3 SNPs (rs2281983 and rs4919621) in 265 PD patients and compared them with 210 age-matched healthy controls. Our data show that the substitutions of C/T in SNP1 and A/T in SNP2 are significantly higher in PD, and this finding is even more robust in young onset and familial PD as compared with age-matched healthy controls. Our findings indicate that PITX3 may play a role in the pathogenesis of PD.</AbstractText>
<CopyrightInformation>Copyright © 2009 Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Le</LastName>
<ForeName>Weidong</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA. weidongl@bcm.edu</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nguyen</LastName>
<ForeName>Deanne</ForeName>
<Initials>D</Initials>
</Author>
<Author ValidYN="Y"><LastName>Lin</LastName>
<ForeName>Xiyao Wendy</ForeName>
<Initials>XW</Initials>
</Author>
<Author ValidYN="Y"><LastName>Rawal</LastName>
<ForeName>Pawan</ForeName>
<Initials>P</Initials>
</Author>
<Author ValidYN="Y"><LastName>Huang</LastName>
<ForeName>Maosheng</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Ding</LastName>
<ForeName>Yujian</ForeName>
<Initials>Y</Initials>
</Author>
<Author ValidYN="Y"><LastName>Xie</LastName>
<ForeName>Wenjie</ForeName>
<Initials>W</Initials>
</Author>
<Author ValidYN="Y"><LastName>Deng</LastName>
<ForeName>Hao</ForeName>
<Initials>H</Initials>
</Author>
<Author ValidYN="Y"><LastName>Jankovic</LastName>
<ForeName>Joseph</ForeName>
<Initials>J</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2009</Year>
<Month>04</Month>
<Day>24</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Neurobiol Aging</MedlineTA>
<NlmUniqueID>8100437</NlmUniqueID>
<ISSNLinking>0197-4580</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D018398">Homeodomain Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014157">Transcription Factors</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C433629">homeobox protein PITX3</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000483">Alleles</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D005787">Gene Frequency</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D056726">Genetic Association Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D020022">Genetic Predisposition to Disease</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D005838">Genotype</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D018398">Homeodomain Proteins</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="Y" UI="D020641">Polymorphism, Single Nucleotide</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D014157">Transcription Factors</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2008</Year>
<Month>11</Month>
<Day>10</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2009</Year>
<Month>3</Month>
<Day>17</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2009</Year>
<Month>3</Month>
<Day>22</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="aheadofprint"><Year>2009</Year>
<Month>4</Month>
<Day>24</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2009</Year>
<Month>4</Month>
<Day>28</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2009</Year>
<Month>4</Month>
<Day>28</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2011</Year>
<Month>8</Month>
<Day>9</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pii">S0197-4580(09)00112-2</ArticleId>
<ArticleId IdType="doi">10.1016/j.neurobiolaging.2009.03.015</ArticleId>
<ArticleId IdType="pubmed">19394114</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/JankovicV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000120 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 000120 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= JankovicV1 |flux= PubMed |étape= Curation |type= RBID |clé= pubmed:19394114 |texte= Transcription factor PITX3 gene in Parkinson's disease. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:19394114" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \ | NlmPubMed2Wicri -a JankovicV1
![]() | This area was generated with Dilib version V0.6.19. | ![]() |