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Genetic analysis of the NEUROG2 gene in patients with Parkinson's disease.

Identifieur interne : 000104 ( PubMed/Curation ); précédent : 000103; suivant : 000105

Genetic analysis of the NEUROG2 gene in patients with Parkinson's disease.

Auteurs : Sheng Deng [République populaire de Chine] ; Hao Deng ; Weidong Le ; Hongbo Xu ; Huarong Yang ; Xiong Deng ; Hongwei Lv ; Wenjie Xie ; Shaihong Zhu ; Joseph Jankovic

Source :

Neuroscience letters ; 2010.

RBID : pubmed:19879328

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Basic Helix-Loop-Helix Transcription Factors (genetics), Genetic Association Studies, Humans, Male, Middle Aged, Mutation, Nerve Tissue Proteins (genetics), Parkinson Disease (genetics).
MESH :
- chemical , genetics : Basic Helix-Loop-Helix Transcription Factors, Nerve Tissue Proteins.
- genetics : Parkinson Disease.
- Aged, Aged, 80 and over, Genetic Association Studies, Humans, Male, Middle Aged, Mutation.

Abstract

The proneural protein Neurogenin 2 (NEUROG2) is a transcription factor of importance for the differentiation and survival of midbrain dopaminergic neurons. To determine whether genetic variation in the coding region of the NEUROG2 gene plays a role in the etiology of Parkinson's disease (PD), we screened DNA samples from 202 PD patients and 201 normal controls. No mutation in the NEUROG2 gene was identified in our PD cohort, except that novel compound heterozygous variants (Gly56Arg and Asp206Glu) were found in a 91-year normal male, suggesting that mutations in the coding region of the NEUROG2 gene play little or no role in the development of PD.

DOI: 10.1016/j.neulet.2009.10.078
PubMed: 19879328

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Le document en format XML

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<author><name sortKey="Deng, Sheng" sort="Deng, Sheng" uniqKey="Deng S" first="Sheng" last="Deng">Sheng Deng</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Experimental Medicine and Department of Neurology, the Third Xiangya Hospital, Central South University, Changsha, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Center for Experimental Medicine and Department of Neurology, the Third Xiangya Hospital, Central South University, Changsha</wicri:regionArea>
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<author><name sortKey="Le, Weidong" sort="Le, Weidong" uniqKey="Le W" first="Weidong" last="Le">Weidong Le</name>
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<author><name sortKey="Yang, Huarong" sort="Yang, Huarong" uniqKey="Yang H" first="Huarong" last="Yang">Huarong Yang</name>
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<author><name sortKey="Deng, Xiong" sort="Deng, Xiong" uniqKey="Deng X" first="Xiong" last="Deng">Xiong Deng</name>
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<author><name sortKey="Zhu, Shaihong" sort="Zhu, Shaihong" uniqKey="Zhu S" first="Shaihong" last="Zhu">Shaihong Zhu</name>
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<front><div type="abstract" xml:lang="en">The proneural protein Neurogenin 2 (NEUROG2) is a transcription factor of importance for the differentiation and survival of midbrain dopaminergic neurons. To determine whether genetic variation in the coding region of the NEUROG2 gene plays a role in the etiology of Parkinson's disease (PD), we screened DNA samples from 202 PD patients and 201 normal controls. No mutation in the NEUROG2 gene was identified in our PD cohort, except that novel compound heterozygous variants (Gly56Arg and Asp206Glu) were found in a 91-year normal male, suggesting that mutations in the coding region of the NEUROG2 gene play little or no role in the development of PD.</div>
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Serveur d'exploration autour de Joseph Jankovic

Genetic analysis of the NEUROG2 gene in patients with Parkinson's disease.

Genetic analysis of the NEUROG2 gene in patients with Parkinson's disease.

Source :

English descriptors

Abstract

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Links to Exploration step

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