Genetic analysis of the NEUROG2 gene in patients with Parkinson's disease.
Identifieur interne : 000104 ( PubMed/Curation ); précédent : 000103; suivant : 000105Genetic analysis of the NEUROG2 gene in patients with Parkinson's disease.
Auteurs : Sheng Deng [République populaire de Chine] ; Hao Deng ; Weidong Le ; Hongbo Xu ; Huarong Yang ; Xiong Deng ; Hongwei Lv ; Wenjie Xie ; Shaihong Zhu ; Joseph JankovicSource :
- Neuroscience letters ; 2010.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Basic Helix-Loop-Helix Transcription Factors, Nerve Tissue Proteins.
- genetics : Parkinson Disease.
- Aged, Aged, 80 and over, Genetic Association Studies, Humans, Male, Middle Aged, Mutation.
Abstract
The proneural protein Neurogenin 2 (NEUROG2) is a transcription factor of importance for the differentiation and survival of midbrain dopaminergic neurons. To determine whether genetic variation in the coding region of the NEUROG2 gene plays a role in the etiology of Parkinson's disease (PD), we screened DNA samples from 202 PD patients and 201 normal controls. No mutation in the NEUROG2 gene was identified in our PD cohort, except that novel compound heterozygous variants (Gly56Arg and Asp206Glu) were found in a 91-year normal male, suggesting that mutations in the coding region of the NEUROG2 gene play little or no role in the development of PD.
DOI: 10.1016/j.neulet.2009.10.078
PubMed: 19879328
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<front><div type="abstract" xml:lang="en">The proneural protein Neurogenin 2 (NEUROG2) is a transcription factor of importance for the differentiation and survival of midbrain dopaminergic neurons. To determine whether genetic variation in the coding region of the NEUROG2 gene plays a role in the etiology of Parkinson's disease (PD), we screened DNA samples from 202 PD patients and 201 normal controls. No mutation in the NEUROG2 gene was identified in our PD cohort, except that novel compound heterozygous variants (Gly56Arg and Asp206Glu) were found in a 91-year normal male, suggesting that mutations in the coding region of the NEUROG2 gene play little or no role in the development of PD.</div>
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